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Skin science article

Advanced Clinicals Collagen Serum Versus Olay Regenerist Collagen Peptide 24 Serum (Fragrance Free)

Advanced Clinicals Collagen Serum Versus Olay Regenerist Collagen Peptide 24 Serum (Fragrance Free) This anti-aging serum is formulated around Squalane to soften the look of wrinkles and hydrate skin. This anti-aging serum is formulated around Niacinamide and

Advanced Clinicals Collagen Serum Versus Olay Regenerist Collagen Peptide 24 Serum (Fragrance Free)

This anti-aging serum is formulated around Squalane to soften the look of wrinkles and hydrate skin.

This anti-aging serum is formulated around Niacinamide and Panthenol to soften the look of wrinkles and refine skin texture.

What's inside

Key Ingredients

Benefits

Concerns

Ingredients Side-by-side

Water

Isopropyl Myristate

Ethylhexyl Olivate

Glycerin

Pyrus Malus Fruit Extract

Cetearyl Alcohol

Aloe Barbadensis Leaf Juice

Hydrolyzed Soybean Fiber

Cyamopsis Tetragonoloba Gum

Squalane

Soluble Collagen

Chlorella Vulgaris Extract

Oryza Sativa Bran Extract

Rosmarinus Officinalis Leaf Extract

Helianthus Annuus Extract

Tocopherol

Avena Sativa Bran Extract

Citrus Aurantium Dulcis Peel Extract

Tetrasodium Glutamate Diacetate

Ammonium Acryloyldimethyltaurate/Vp Copolymer

Maltodextrin

Phenoxyethanol

Parfum

Caprylyl Glycol

Ethylhexylglycerin

Hexylene Glycol

Hydroxyisohexyl 3-Cyclohexene Carboxaldehyde

Linalool

Hydroxycitronellal

Water, Isopropyl Myristate, Ethylhexyl Olivate, Glycerin, Pyrus Malus Fruit Extract, Cetearyl Alcohol, Aloe Barbadensis Leaf Juice, Hydrolyzed Soybean Fiber, Cyamopsis Tetragonoloba Gum, Squalane, Soluble Collagen, Chlorella Vulgaris Extract, Oryza Sativa Bran Extract, Rosmarinus Officinalis Leaf Extract, Helianthus Annuus Extract, Tocopherol, Avena Sativa Bran Extract, Citrus Aurantium Dulcis Peel Extract, Tetrasodium Glutamate Diacetate, Ammonium Acryloyldimethyltaurate/Vp Copolymer, Maltodextrin, Phenoxyethanol, Parfum, Caprylyl Glycol, Ethylhexylglycerin, Hexylene Glycol, Hydroxyisohexyl 3-Cyclohexene Carboxaldehyde, Linalool, Hydroxycitronellal

Dimethicone

Niacinamide

Panthenol

Palmitoyl Pentapeptide-4

Tremella Fuciformis Sporocarp Extract

Hydroxyacetophenone

C13-14 Isoparaffin

Laureth-4

Polysorbate 20

Laureth-7

Disodium EDTA

Polyacrylamide

Dimethicone Crosspolymer

Water, Dimethicone, Niacinamide, Glycerin, Panthenol, Palmitoyl Pentapeptide-4, Tremella Fuciformis Sporocarp Extract, Hydroxyacetophenone, C13-14 Isoparaffin, Laureth-4, Polysorbate 20, Laureth-7, Disodium EDTA, Polyacrylamide, Dimethicone Crosspolymer, Phenoxyethanol

Alternatives

Ingredients Explained

These ingredients are found in both products.

Ingredients higher up in an ingredient list are typically present in a larger amount.

Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.

Topically, glycerin does several things at once:

Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.

Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.

This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.

Just know very high concentrations (>40%) can feel tacky in low humidity.

Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.

Phenoxyethanol is one of the most widely used preservatives in skincare (and for good reason!).

It has a large spectrum of antimicrobial activity and especially effective bacteria, yeast, and mold while only having a weak effect on your skin's natural microbiome.

On a cellular level, it disrupts the cell membranes of microbes by poking holes that make the cell leak. This shuts down the chemical reactions the microbe needs to make energy so it can no longer survive.

Another perk of this ingredient is that it stays functional across a wide pH range (3-10).

You'll often see it paired with boosters like Ethylhexylglycerin; one study showed that a 1:9 ratio of Ethylhexylglycerin to Phenoxyethanol damages bacterial membranes as effectively as doubling the Phenoxyethanol concentration on its own.

Typical use concentrations range from 0.3-1% depending on the formula, and this ingredient is capped at 1% int the EU.

Safety-wise, the fear mongering does not hold up to the evidence. The EU's Scientific Committee on Consumer Safety and FDA consider it safe as a preservative at up to 1%, including for children of all ages.

Adverse systemic effects only showed up in animal studies at exposures roughly 200x higher than what people get from cosmetics. And despite its very widespread use, this ingredient is a rare sensitizer and allergic reactions are uncommon.

Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.

So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.

You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!

Similar Comparisons

The reference edit

Ingredients, questions
& further reading.

Connected source records selected through this article’s public topic index.

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Formula cabinet

Ingredients & structured notes

Ingredient index

Ingredients Explained

  1. 01These ingredients are found in both products.
  2. 02Ingredients higher up in an ingredient list are typically present in a larger amount.
  3. 03C13-14 Isoparaffin is a synthetic emollient, solvent, and thickening agent. It helps soften skin and improves spreadability without leaving a greasy residue.
  4. 04This ingredient has been found to be non-sensitizing and safe for use in cosmetics.
  5. 05Two things floating around online that cause fear-mongering:
  6. 06There's one scary-sounding study related to kidney tumors in male rats; this depends on a protein called alpha-2u-globulin that binds the ingredient and clogs up kidney cells. Female rats barely make this protein, and humans don't make it at all so …
  7. 07The other thing you'll see is 1,4-dioxane being a trace byproduct that can form during manufacturing of petroleum-derived ingredients. This is a real, but heavily managed/monitored issue. This byproduct is removed through purification steps before t…
  8. 08One last thing to note: this ingredient is a pure hydrocarbon with no fatty-acid or ester chains for Malassezia to feed on, so it's considered fungal acne safe.
  9. 09Dimethicone is a type of synthetic silicone created from natural materials such as quartz. It is also known as polydimethylsiloxane.
  10. 10What it does:
  11. 11Dimethicone comes in different viscosities:
  12. 12Depending on the viscosity, dimethicone has different properties.
  13. 13Ingredients lists don't always show which type is used, so we recommend reaching out to the brand if you have questions about the viscosity.
  14. 14This ingredient is unlikely to cause irritation because it does not get absorbed into skin. However, people with silicone allergies should be careful about using this ingredient.
  15. 15Note: Dimethicone may contribute to pilling. This is because it is not oil or water soluble, so pilling may occur when layered with products. When mixed with heavy oils in a formula, the outcome is also quite greasy.
  16. 16Dimethicone Crosspolymer is a silicone created by modifying dimethicone with hydrocarbon side chains. Due to its large size, it does not penetrate skin. It is considered non-occlusive.
  17. 17Dimethicone Crosspolymer is used to stabilize and thicken products. It also helps give products a silky feel.
  18. 18Disodium EDTA is a chelating agent. It grabs onto and deactivates metal ions that sneak into your products from water, packaging, or air.
  19. 19This ingredient mainly works behind the scenes and helps with:
  20. 20On top of that, this ingredient can counteract the effects of hard water by binding to the minerals in it.
Source · skinsort.com
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Product index

Related product references

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Comparison edit

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