Skin science article
Aestura Regederm 365 Retinoid Eye Serum Versus Beauty of Joseon Revive Eye Serum : Ginseng + Retinal
Aestura Regederm 365 Retinoid Eye Serum Versus Beauty of Joseon Revive Eye Serum : Ginseng + Retinal This anti-aging eye moisturizer is formulated around Niacinamide and Hydroxypinacolone Retinoate to soften the look of wrinkles and refine skin texture. This a
Aestura Regederm 365 Retinoid Eye Serum Versus Beauty of Joseon Revive Eye Serum : Ginseng + Retinal
This anti-aging eye moisturizer is formulated around Niacinamide and Hydroxypinacolone Retinoate to soften the look of wrinkles and refine skin texture.
This anti-aging eye moisturizer is formulated around Panax Ginseng Root Extract and Niacinamide to soften the look of wrinkles and refine skin texture.
What's inside
Key Ingredients
Benefits
Concerns
Ingredients Side-by-side
Water
Butylene Glycol
Glycerin
Dimethicone
Niacinamide
Ethylhexyl Stearate
1,2-Hexanediol
Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer
Cetearyl Alcohol
Betaine
Panthenol
Glyceryl Polymethacrylate
Sodium Hyaluronate
Glyceryl Stearate
Acrylates/C10-30 Alkyl Acrylate Crosspolymer
Dimethicone/Vinyl Dimethicone Crosspolymer
Dimethiconol
Hydrogenated Lecithin
Cellulose Gum
Glyceryl Caprylate
Glucosyl Hesperidin
Stearic Acid
Tromethamine
Polyglyceryl-3 Methylglucose Distearate
Palmitic Acid
Sorbitan Isostearate
Ethylhexylglycerin
Dimethyl Isosorbide
Adenosine
Sodium Polyacrylate
Sodium Metaphosphate
Polyglyceryl-6 Caprylate
Hydroxypropyl Bispalmitamide Mea
Mannitol
Hydroxypinacolone Retinoate
Myristic Acid
3-O-Ethyl Ascorbic Acid
Acrylates/Ammonium Methacrylate Copolymer
Lauric Acid
Thymol Trimethoxycinnamate
Cholesterol
Silica
Oleanolic Acid
Caprylyl Glycol
Pullulan
Acetyl Heptapeptide-4
Zein
Pectin
Acetyl Hexapeptide-8
Hydrolyzed Extensin
Simmondsia Chinensis Seed Oil
Sodium Hydroxide
Polyglyceryl-10 Laurate
Acetyl Octapeptide-3
Citric Acid
Water, Butylene Glycol, Glycerin, Dimethicone, Niacinamide, Ethylhexyl Stearate, 1,2-Hexanediol, Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, Cetearyl Alcohol, Betaine, Panthenol, Glyceryl Polymethacrylate, Sodium Hyaluronate, Glyceryl Stearate, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Dimethicone/Vinyl Dimethicone Crosspolymer, Dimethiconol, Hydrogenated Lecithin, Cellulose Gum, Glyceryl Caprylate, Glucosyl Hesperidin, Stearic Acid, Tromethamine, Polyglyceryl-3 Methylglucose Distearate, Palmitic Acid, Sorbitan Isostearate, Ethylhexylglycerin, Dimethyl Isosorbide, Adenosine, Sodium Polyacrylate, Sodium Metaphosphate, Polyglyceryl-6 Caprylate, Hydroxypropyl Bispalmitamide Mea, Mannitol, Hydroxypinacolone Retinoate, Myristic Acid, 3-O-Ethyl Ascorbic Acid, Acrylates/Ammonium Methacrylate Copolymer, Lauric Acid, Thymol Trimethoxycinnamate, Cholesterol, Silica, Oleanolic Acid, Caprylyl Glycol, Pullulan, Acetyl Heptapeptide-4, Zein, Pectin, Acetyl Hexapeptide-8, Hydrolyzed Extensin, Simmondsia Chinensis Seed Oil, Sodium Hydroxide, Polyglyceryl-10 Laurate, Acetyl Octapeptide-3, Citric Acid
Panax Ginseng Root Extract
Dipropylene Glycol
Caprylic/Capric Triglyceride
Pentaerythrityl Tetraethylhexanoate
Butylene Glycol Dicaprylate/Dicaprate
Sorbitan Olivate
Cetearyl Olivate
Carbomer
Macadamia Ternifolia Seed Oil
Theobroma Cacao Extract
Dextrin
Polyglyceryl-10 Oleate
Retinal
Brassica Campestris Sterols
Phytosteryl/Behenyl/Octyldodecyl Lauroyl Glutamate
Tocopherol
Aluminum/Magnesium Hydroxide Stearate
Potassium Cetyl Phosphate
Pentaerythrityl Tetra-Di-T-Butyl Hydroxyhydrocinnamate
Ceramide NP
Palmitoyl Tripeptide-5
Disodium EDTA
Water, Panax Ginseng Root Extract, Glycerin, Dipropylene Glycol, Caprylic/Capric Triglyceride, 1,2-Hexanediol, Pentaerythrityl Tetraethylhexanoate, Niacinamide, Butylene Glycol Dicaprylate/Dicaprate, Cetearyl Alcohol, Sorbitan Olivate, Cetearyl Olivate, Butylene Glycol, Hydrogenated Lecithin, Tromethamine, Carbomer, Glyceryl Stearate, Macadamia Ternifolia Seed Oil, Adenosine, Theobroma Cacao Extract, Dextrin, Cholesterol, Polyglyceryl-10 Oleate, Retinal, Brassica Campestris Sterols, Phytosteryl/Behenyl/Octyldodecyl Lauroyl Glutamate, Silica, Sodium Hyaluronate, Tocopherol, Aluminum/Magnesium Hydroxide Stearate, Potassium Cetyl Phosphate, Pentaerythrityl Tetra-Di-T-Butyl Hydroxyhydrocinnamate, Ceramide NP, Palmitoyl Tripeptide-5, Disodium EDTA, Ethylhexylglycerin
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Alternatives
Ingredients Explained
These ingredients are found in both products.
Ingredients higher up in an ingredient list are typically present in a larger amount.
1,2-Hexanediol is a synthetic liquid and another multi-functional powerhouse.
It is a:
Humectant, drawing moisture into the skin
Emollient, helping to soften skin
Solvent, dispersing and stabilizing formulas
Preservative booster, enhancing the antimicrobial activity of other preservatives
Adenosine is a purine nucleoside that your body already makes in every cell. In skincare, it acts mainly as a skin conditioning and anti-aging agent.
The way it works is fairly well mapped out:
Your skin has cells called fibroblasts that build collagen (the stuff that keeps skin firm and smooth). Adenosine basically flips a switch on these cells that tells them to get to work making more collagen and other proteins. These cells slow down on their own as skin ages, so Adenosine helps give them a little nudge to keep going.
The clinical backing is pretty solid too.
A blind, randomized, placebo-controlled trial of 126 women aged 45-65 tested a 0.1% cream twice daily and found real improvements in crow's feet and frown lines using a precise 3D skin-mapping technique; these changes showed up by week 3 and held at 2 months.
A later study using Adenosine-loaded dissolving microneedle patches reported gains in wrinkle depth, dermal density, elasticity, and hydration.
On concentrations, South Korea's Ministry of Food and Drug Safety has set 0.04% as the approved functional anti-wrinkle level. You'll typically see this ingredient used somewhere in the 0.04-0.1% range since it works at low doses.
This ingredient has been found safe for cosmetics with the data showing no irritation or sensitization.
Overall, this is a great ingredient for any anti-aging routine and has no photosensitizing effect, so it suits both AM and PM use.
Butylene Glycol (or BG) is used within cosmetic products for a few different reasons:
Overall, Butylene Glycol is a safe and well-rounded ingredient that works well with other ingredients.
Though this ingredient works well with most skin types, some people with sensitive skin may experience a reaction such as allergic rashes, closed comedones, or itchiness.
Cetearyl alcohol is a waxy mixture of two fatty alcohols: cetyl alcohol and stearyl alcohol. It is an emollient and emulsifier.
Despite having "alcohol" in its name, it has nothing to do with drying solvent alcohols; the FDA also allows "alcohol-free" products to contain fatty alcohols like this ingredient.
It plays several roles in a formula:
Typical use levels for this ingredient sit around 1-10% and the Cosmetic Ingredient Review Expert Panel has affirmed safety at concentrations up to 25% in leave-on products.
Multiple assessments have found it to be non-irritating and non-sensitizing to most people.
However, there have been some cases of allergic contact dermatitis in patients with chronically compromised skin barriers.
Cetearyl alcohol has a comedogenic rating of 2 and irritancy rating of 1. Both of these numbers come from the 1989 study that used rabbit ears; a "2" means mildly comedogenic and a "1" means low irritancy.
Here's the catch: rabbit skin is more sensitive than human skin and throws a lot of false positives. A 1996 reappraisal found that ingredients rated 1-2 in the rabbit ear tests are generally safe for humans.
Remember comedogenic ratings are unable to assess the entire formula of a product or how it will react on your skin. Just be sure to patch test if you are unsure about certain ingredients.
This ingredient is not fungal acne safe. Cetearyl alcohol is a fatty alcohol with chain lengths that fall within the range that Malassezia can metabolize.
A 2019 study has also observed Malassezia growth in the presence of this ingredient, confirming it to be not-fungal acne safe.
Cholesterol is a lipid that is naturally found in human skin and is one of the three key components of your skin barrier. In skincare, it is an emollient and barrier-repairing ingredient.
It works by fitting directly into the lipid layers of skin to help restore structure and reduce transepidermal water loss (TEWL).
This is a great ingredient for dry, compromised, or aging skin; our skin starts to produce less cholesterol with age.
Research shows cholesterol works best in combination with ceramides and fatty acids, the other two major components in your skin barrier.
Cholesterol is also a well-establish penetration enhancer and can help other actives absorb more effectively.
Cosmetic-grade cholesterol is usually derived from lanolin but plant and synthetic options also exist. We recommend reaching out to the brand if you have questions about their source of cholesterol.
Ethylhexylglycerin is created from glycerin. It is a multitasker ingredient that:
The CIR Expert Panel found minimal skin absorption or sensitization of any kind in a safety assessment. Though this ingredient is considered well-tolerated, a small number of cases of allergic dermatitis have been published since 2002. Just be sure to patch test if you are unsure.
Industry-reported use ranges from 8% in rinse-off products and 2% in leave-on formulations.
Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.
Topically, glycerin does several things at once:
Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.
Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.
This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.
Just know very high concentrations (>40%) can feel tacky in low humidity.
Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.
Glyceryl Stearate is made by reacting glycerin with stearic acid (typically sourced from plant oils like palm or coconut). It's an emulsifier, emollient, and mild occlusive.
Emulsifiers help ingredients like oil and water stay mixed so your formula stays nicely blended and uniform in texture.
This ingredient is typically used in concentrations between 1-10%. Studies have found it to be non-sensitizing, non-phototoxic, and non-photoallergenic.
A close cousin of this ingredient is Glyceryl Stearate SE ("self-emulsifying"). This just has a small amount of sodium or potassium stearate added so it can emulsify without a co-emulsifier.
Since this ingredient is an ester of a C18 fatty acid, it may not be fungal acne safe. The Malassezia yeast can potentially metabolize within the C11-C24 range.
Fun fact: The human body also creates Glyceryl Stearate naturally.
Hydrogenated Lecithin is a more stable version of lecithin.
It's made by taking lecithin (a phospholipid commonly found in soybeans and egg yolks) and hydrogenating it. This just means the unsaturated fatty acids are turned into saturated ones so they don't go bad as easily.
This ingredient is an emollient, emulsifier, and penetration enhancer. As an emollient, it helps soften and hydrate skin by trapping moisture within. As an emulsifier, it prevents oil and water ingredients from separating.
Hydrogenated Lecithin can form tiny spherical structures made of phospholipid bilayers called liposomes. These liposomes are able to capture compounds inside their structure and deliver them through the skin barrier.
Because phospholipids are a natural component of our cell membranes, this ingredient is inherently compatible with skin.
A 2021 study found lecithin-based surfactants were less harsh and more tolerable comared to Sodium Lauryl Sulfate (SLS).
Niacinamide is a multitasking form of vitamin B3 that strengthens the skin barrier, reduces pores and dark spots, regulates oil, and improves signs of aging.
And the best part? It's gentle and well-tolerated by most skin types, including sensitive and reactive skin.
You might have heard of "niacin flush", or the reddening of skin that causes itchiness. Niacinamide has not been found to cause this.
In very rare cases, some individuals may not be able to tolerate niacinamide at all or experience an allergic reaction to it.
If you are experiencing flaking, irritation, and dryness with this ingredient, be sure to double check all your products as this ingredient can be found in all categories of skincare.
When incorporating niacinamide into your routine, look out for concentration amounts. Typically, 5% niacinamide provides benefits such as fading dark spots. However, if you have sensitive skin, it is better to begin with a smaller concentration.
When you apply niacinamide to your skin, your body converts it into nicotinamide adenine dinucleotide (NAD). NAD is an essential coenzyme that is already found in your cells as "fuel" and powers countless biological processes.
In your skin, NAD helps repair cell damage, produce new healthy cells, support collagen production, strengthen the skin barrier, and fight environmental stressors (like UV and pollution).
Our natural NAD levels start to decline with age, leading to slower skin repair, visible aging, and a weaker skin barrier. By providing your skin niacinamide, you're recharging your skin's NAD levels. This leads to stronger, healthier, and younger looking skin.
Another name for vitamin B3 is nicotinamide. This vitamin is water-soluble and our bodies don't store it. We obtain Vitamin B3 from either food or skincare. Meat, fish, wheat, yeast, and leafy greens contain vitamin B3.
The type of niacinamide used in skincare is synthetically created.
Silica, also known as silicon dioxide, is a naturally occurring mineral. It is used as a fine, spherical, and porous powder in cosmetics.
Though it has exfoliant properties, the function of silica varies depending on the product.
The unique structure of silica enhances the spreadability and adds smoothness, making it a great texture enhancer.
It is also used as an active carrier, emulsifier, and mattifier due to its ability to absorb excess oil.
In some products, tiny microneedles called spicules are made from silica or hydrolyzed sponge. When you rub them in, they lightly polish away dead skin layers and enhance the penetration of active ingredients.
Sodium Hyaluronate is the salt form of hyaluronic acid. It is a long sugar chain that is naturally found in your skin, joints, and connective tissue that maintains hydration and elasticity.
In skincare, it works as a humectant. It pulls water from the environment and deeper layers of skin and binds it to the surface.
Interestingly, the size of the molecule affects its behavior:
Some clinical evidence links low molecular weight versions to improved wrinkle depth, elasticity, anti-inflammatory effects, and barrier repair.
Many serums use a blend of both weights so you can get surface hydration plus longer-lasting and deeper effects.
You'll typically see concentrations between 0.1-2% for this ingredient.
Tromethamine (aka THAM) is a synthetic amino acid that shows up in skincare as a helper ingredient.
It functions as a pH adjuster to help neutralize acidic ingredients and set a formula's pH to the right spot.
This matters a lot because a lot of actives (like vitamin C) needs a specific pH to work well and feel comfortable on skin.
Concentration use ranges from 0.1-1.0% depending on the formula.
Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.
So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.
You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!