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Alastin Regenerating Skin Nectar Versus The Ordinary Multi-Peptide + HA Serum

Alastin Regenerating Skin Nectar Versus The Ordinary Multi-Peptide + HA Serum This anti-aging serum is formulated around Palmitoyl Tripeptide-1 and Palmitoyl Hexapeptide-12 to soften the look of wrinkles. This anti-aging serum is formulated around Lactococcus

By Peptide Skincare & Beauty Editorial TeamPublished

Alastin Regenerating Skin Nectar Versus The Ordinary Multi-Peptide + HA Serum

This anti-aging serum is formulated around Palmitoyl Tripeptide-1 and Palmitoyl Hexapeptide-12 to soften the look of wrinkles.

This anti-aging serum is formulated around Lactococcus Ferment Lysate and Acetyl Hexapeptide-8 to soften the look of wrinkles and hydrate skin.

What's inside

Key Ingredients

Benefits

Concerns

Ingredients Side-by-side

Cyclopentasiloxane

Dimethicone Crosspolymer

Pentaerythrityl Tetraisostearate

Heptyl Undecylenate

Glycine Soja Oil

Panthenyl Triacetate

Palmitoyl Tripeptide-1

Palmitoyl Hexapeptide-12

Naringenin

Oleuropein

Olea Europaea Leaf Extract

Phosphatidylserine

Arnica Montana Extract

Phospholipids

Dunaliella Salina Extract

Tocopherol

Ascorbyl Palmitate

Squalane

Caprylic/Capric Triglyceride

Caprylyl Methicone

Propylene Carbonate

Stearalkonium Hectorite

Cyclopentasiloxane, Dimethicone Crosspolymer, Pentaerythrityl Tetraisostearate, Heptyl Undecylenate, Glycine Soja Oil, Panthenyl Triacetate, Palmitoyl Tripeptide-1, Palmitoyl Hexapeptide-12, Naringenin, Oleuropein, Olea Europaea Leaf Extract, Phosphatidylserine, Arnica Montana Extract, Phospholipids, Dunaliella Salina Extract, Tocopherol, Ascorbyl Palmitate, Squalane, Caprylic/Capric Triglyceride, Caprylyl Methicone, Propylene Carbonate, Stearalkonium Hectorite

Water

Glycerin

Lactococcus Ferment Lysate

Acetyl Hexapeptide-8

Pentapeptide-18

Palmitoyl Tetrapeptide-7

Palmitoyl Tripeptide-38

Dipeptide Diaminobutyroyl Benzylamide Diacetate

Acetylarginyltryptophyl Diphenylglycine

Sodium Hyaluronate Crosspolymer

Sodium Hyaluronate

Allantoin

Glycine

Alanine

Serine

Valine

Isoleucine

Proline

Threonine

Histidine

Phenylalanine

Arginine

Aspartic Acid

Trehalose

Fructose

Glucose

Maltose

Urea

Sodium PCA

PCA

Sodium Lactate

Citric Acid

Hydroxypropyl Cyclodextrin

Sodium Chloride

Sodium Hydroxide

Butylene Glycol

Pentylene Glycol

Acacia Senegal Gum

Xanthan Gum

Carbomer

Polysorbate 20

PPG-26-Buteth-26

PEG-40 Hydrogenated Castor Oil

Trisodium Ethylenediamine Disuccinate

Ethoxydiglycol

Sodium Benzoate

Caprylyl Glycol

Ethylhexylglycerin

Phenoxyethanol

Chlorphenesin

Water, Glycerin, Lactococcus Ferment Lysate, Acetyl Hexapeptide-8, Pentapeptide-18, Palmitoyl Tripeptide-1, Palmitoyl Tetrapeptide-7, Palmitoyl Tripeptide-38, Dipeptide Diaminobutyroyl Benzylamide Diacetate, Acetylarginyltryptophyl Diphenylglycine, Sodium Hyaluronate Crosspolymer, Sodium Hyaluronate, Allantoin, Glycine, Alanine, Serine, Valine, Isoleucine, Proline, Threonine, Histidine, Phenylalanine, Arginine, Aspartic Acid, Trehalose, Fructose, Glucose, Maltose, Urea, Sodium PCA, PCA, Sodium Lactate, Citric Acid, Hydroxypropyl Cyclodextrin, Sodium Chloride, Sodium Hydroxide, Butylene Glycol, Pentylene Glycol, Acacia Senegal Gum, Xanthan Gum, Carbomer, Polysorbate 20, PPG-26-Buteth-26, PEG-40 Hydrogenated Castor Oil, Trisodium Ethylenediamine Disuccinate, Ethoxydiglycol, Sodium Benzoate, Caprylyl Glycol, Ethylhexylglycerin, Phenoxyethanol, Chlorphenesin

Reviews

Alternatives

Ingredients Explained

These ingredients are found in both products.

Ingredients higher up in an ingredient list are typically present in a larger amount.

Palmitoyl Tripeptide-1 (aka Pal-GHK) is a synthetic signal peptide made of three amino acids attached to palmitic acid.

That fatty acid attachment is the key: it boosts the peptide's ability to penetrate the skin barrier. This puts it closer to the dermal cells where it can actually make a difference.

Once there, it acts as a matrikine, a signaling peptide that prompts fibroblasts to produce more collagen, fibronectin, and hyaluronic acid.

In vitro studies show it can boost collagen production in skin cells even when UV-damaged skin samples were treated with it at a tiny concentration (it almost fully restored dermal collagen at 5ppm). It achieved this at 100x lower concentration than retinoic acid, which needed 500 ppm to do the same thing.

Human clinical data is promising, but modest:

A study of 23 female volunteers found a small but statistically significant increase (~4%) in skin thickness after treatment at 4 ppm.

A separate small trial of 15 women showed statistically significant reductions in wrinkle length, depth, and skin roughness after applying it twice daily for four weeks.

You'll likely see Pal-GHK paired with Palmitoyl Tetrapeptide-7 as part of the Matrixyl 3000 complex.

Fungal acne note: Usually a palmitic acid component can feed Malassezia in unbound form, but here is is covalently bonded to the peptide. This means it is very difficult for Malassezia to access, and therefore very unlikely to cause fungal acne.

Similar Comparisons

The reference edit

Ingredients, questions
& further reading.

Connected source records selected through this article’s public topic index.

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Formula cabinet

Ingredients & structured notes

Ingredient index

Ingredients Explained

  1. 01These ingredients are found in both products.
  2. 02Ingredients higher up in an ingredient list are typically present in a larger amount.
  3. 03Alanine is an amino acid and is already found in the human body. Our skin uses alanine to build collagen, elastin, and keratin.
  4. 04Allantoin is a soothing ingredient known for its protective and moisturizing properties; it's basically a quiet workhorse ingredient you can find in a huge range of cosmetics.
  5. 05Though it can be derived from the comfrey plant, allantoin is produced synthetically for cosmetic products to ensure purity.
  6. 06Research shows it can encourage your skin cells to turn over and renew by stimulating keratinocyte and fibroblast proliferation.
  7. 07It also has mild keratolytic properties to help loosen and shed dead skin cells without being harsh.
  8. 08Studies also suggest allantoin can help calm inflammation by dialing down some of the chemical signals your skin sends out when it is irritated.
  9. 09This ingredient is typically used in the 0.1-0.5% range, and the FDA recognizes it as a skin protectant in OTC products up to 2%.
  10. 10Overall, allantoin is a wonderful addition to most routines; it is stable across a wide pH range (~4-8), works well with other ingredients, and is considered non-sensitizing/non-irritating.
  11. 11Fun fact: Allantoin is naturally occurring in comfrey root, beets, chamomile, and wheat sprouts. Our bodies even produce it as a byproduct of uric acid metabolism.
  12. 12Arginine is a semi-essential amino acid. This just means our bodies can product a bit on its own, but sometimes needs a little boost from food sources.
  13. 13It is a part of your skin's natural moisturizing factor (NMF), or the water-loving molecules in your outermost layer of skin (stratum corneum) that keeps everything hydrated and happy.
  14. 14Here's an interesting thing about Arginine: your skin converts it into urea through the Krebs-Henseleit urea cycle. Urea is one of the most effective humectants your skin naturally produces.
  15. 15A clinical study showed applying 2.5% arginine hydrochloride to atopic dermatitis skin showed significant urea levels in the stratum corneum and improved moisture in just four weeks.
  16. 16Arginine is also a precursor to nitric oxide; nitric oxide improves microcirculation and supports wound healing and collagen synthesis.
  17. 17One study found that an amino acid complex containing Arginine reduced skin irritation, improved hydration, and accelerated skin repair in clinical / in-vivo studies.
  18. 18Arginine itself is an amino acid and not a fatty acid, oil, or ester. On its own, it's not a direct food source for Malassezia, or the yeast that causes fungal acne.
  19. 19Butylene Glycol (or BG) is used within cosmetic products for a few different reasons:
  20. 20Overall, Butylene Glycol is a safe and well-rounded ingredient that works well with other ingredients.
Source · skinsort.com ⟶
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Product index

Related product references

Product

The Ordinary Multi-peptide + Ha Serum

The Ordinary Multi-peptide + Ha Serum The Ordinary Multi-peptide + Ha Serum ingredients explained: Aqua (Water), Glycerin, Lactococcus Ferment Lysate, Acetyl Hexapeptide-8, Pentapeptide-18,…

Source: incidecoder.comView reference →
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Comparison edit

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