Peptide Skincare & BeautySkin science and ingredient guides

Skin science article

Allies of Skin Mandelic Pigmentation Corrector Night Serum Versus Allies of Skin Tranexamic & Arbutin Advanced Brightening Serum

Allies of Skin Mandelic Pigmentation Corrector Night Serum Versus Allies of Skin Tranexamic & Arbutin Advanced Brightening Serum This brightening serum is formulated around Mandelic Acid and Niacinamide to fade the look of dark spots and refine skin texture. T

Allies of Skin Mandelic Pigmentation Corrector Night Serum Versus Allies of Skin Tranexamic & Arbutin Advanced Brightening Serum

This brightening serum is formulated around Mandelic Acid and Niacinamide to fade the look of dark spots and refine skin texture.

This brightening serum is formulated around Tranexamic Acid and Alpha-Arbutin to fade the look of dark spots and brighten dull-looking skin.

What's inside

Key Ingredients

Benefits

Concerns

No concerns

Ingredients Side-by-side

Water

Mandelic Acid

Glycerin

Butylene Glycol

Niacinamide

Polysorbate 20

Lactic Acid

Rosa Canina Fruit Oil

Calophyllum Inophyllum Seed Oil

Salicylic Acid

Superoxide Dismutase

Bakuchiol

Sodium Hyaluronate

Rumex Occidentalis Extract

Ascophyllum Nodosum Extract

Nonapeptide-1

Palmitoyl Tripeptide-5

Acetyl Tetrapeptide-40

Pterocarpus Marsupium Bark Extract

Glutamic Acid

Phenyl T-Butylnitrone

Resveratrol Dimethyl Ether

Camellia Sinensis Leaf Extract

Panthenol

Tocopheryl Acetate

Ascorbic Acid

Tocopherol

Caprylic/Capric Triglyceride

Xanthan Gum

Sclerotium Gum

Ethylhexylglycerin

Caprylyl Glycol

Sorbitol

Dextran

Sodium Gluconate

Disodium Succinate

Acetyl Tributyl Citrate

O-Cymen-5-Ol

Sodium Hydroxide

Phenoxyethanol

Water, Mandelic Acid, Glycerin, Butylene Glycol, Niacinamide, Polysorbate 20, Lactic Acid, Rosa Canina Fruit Oil, Calophyllum Inophyllum Seed Oil, Salicylic Acid, Superoxide Dismutase, Bakuchiol, Sodium Hyaluronate, Rumex Occidentalis Extract, Ascophyllum Nodosum Extract, Nonapeptide-1, Palmitoyl Tripeptide-5, Acetyl Tetrapeptide-40, Pterocarpus Marsupium Bark Extract, Glutamic Acid, Phenyl T-Butylnitrone, Resveratrol Dimethyl Ether, Camellia Sinensis Leaf Extract, Panthenol, Tocopheryl Acetate, Ascorbic Acid, Tocopherol, Caprylic/Capric Triglyceride, Xanthan Gum, Sclerotium Gum, Ethylhexylglycerin, Caprylyl Glycol, Sorbitol, Dextran, Sodium Gluconate, Disodium Succinate, Acetyl Tributyl Citrate, O-Cymen-5-Ol, Sodium Hydroxide, Phenoxyethanol

C13-15 Alkane

Tranexamic Acid

Alpha-Arbutin

Pentylene Glycol

Palmaria Palmata Extract

Hydrolyzed Pea

Asparagopsis Armata Extract

Glycyrrhiza Glabra Root Extract

Pancratium Maritimum Extract

Ganoderma Lucidum Extract

Lentinus Edodes Extract

Lactobacillus Ferment

Hydrolyzed Pea Protein

Diacetyl Boldine

Dipotassium Glycyrrhizate

Lactobacillus

Bisabolol

Glucose

Arginine/Lysine Polypeptide

Pentapeptide-34 Trifluoroacetate

C14-22 Alcohols

Hydrogenated Starch Hydrolysate

Hydroxyacetophenone

Sorbitan Caprylate

1,2-Hexanediol

C12-20 Alkyl Glucoside

Propanediol

Carbomer

Sodium Phytate

Sodium Chloride

Sodium Succinate

Sorbic Acid

Sodium Benzoate

Potassium Sorbate

Water, Caprylic/Capric Triglyceride, C13-15 Alkane, Tranexamic Acid, Glycerin, Alpha-Arbutin, Pentylene Glycol, Tocopheryl Acetate, Palmaria Palmata Extract, Hydrolyzed Pea, Asparagopsis Armata Extract, Ascophyllum Nodosum Extract, Glycyrrhiza Glabra Root Extract, Pancratium Maritimum Extract, Ganoderma Lucidum Extract, Lentinus Edodes Extract, Lactobacillus Ferment, Hydrolyzed Pea Protein, Diacetyl Boldine, Dipotassium Glycyrrhizate, Lactobacillus, Bisabolol, Panthenol, Tocopherol, Glucose, Arginine/Lysine Polypeptide, Pentapeptide-34 Trifluoroacetate, C14-22 Alcohols, Xanthan Gum, Hydrogenated Starch Hydrolysate, Hydroxyacetophenone, Sorbitan Caprylate, 1,2-Hexanediol, Caprylyl Glycol, C12-20 Alkyl Glucoside, Propanediol, Carbomer, Sodium Phytate, Butylene Glycol, Sodium Chloride, Sodium Succinate, Sorbic Acid, Sodium Benzoate, Potassium Sorbate, Phenoxyethanol

Reviews

Alternatives

Ingredients Explained

These ingredients are found in both products.

Ingredients higher up in an ingredient list are typically present in a larger amount.

Ascophyllum Nodosum Extract is from brown seaweed that grows in the northern Atlantic Ocean. It is an antioxidant. Antioxidants help fight off free-radicals. Free-radicals are molecules that may damage our skin cells.

Ascophyllum Nodosum Extract is also used to enhance the texture of products.

Butylene Glycol (or BG) is used within cosmetic products for a few different reasons:

Overall, Butylene Glycol is a safe and well-rounded ingredient that works well with other ingredients.

Though this ingredient works well with most skin types, some people with sensitive skin may experience a reaction such as allergic rashes, closed comedones, or itchiness.

Caprylic/Capric Triglyceride (aka MCT Oil) is a lightweight emollient, solvent, and texture enhancer. It is considered a skin-softener by helping to prevent moisture loss.

Though it behaves like an oil, it is not technically one due to its chemical composition. One perk of this ingredient is that it is very stable, resistant to oxidation, and unlikely to go rancid.

In practice, that translates to a long shelf life and a consistently elegant skin feel.

While there is an assumption Caprylic Triglyceride can clog pores due to it being derived from coconut oil, there is no research supporting this. Just patch test if you have concerns.

Fractionated coconut oil and MCT Oil are both listed as Caprylic/Capric Triglyceride according to INCI. This is because INCI names are based on the ingredient’s final chemical composition and not its marketing name or source.

This ingredient is treated as the gold standard fungal acne safe oil. Even though it is coconut derived, the problematic lauric acid is stripped out.

This leaves just caprylic (C8) and capric (C10) acid. These chain lengths actually trend antifungal; a 2020 study found caprylic acid was enough to disrupt Malassezia furfur cell membrane, with a caprylic acid derivative damaging membrane structures at concentrations as low as 0.2%.

Caprylyl Glycol is a humectant, skin conditioner, emollient, and preservative booster derived from either caprylic acid or synthetically created.

Typical use levels vary from 0.3-1% as a preservative booster and go up to 2% to condition skin.

Because it is not a free-fatty acid, this ingredient is fungal acne safe (there's nothing for Malassezia to feed on).

Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.

Topically, glycerin does several things at once:

Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.

Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.

This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.

Just know very high concentrations (>40%) can feel tacky in low humidity.

Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.

Panthenol is a common ingredient that helps hydrate and soothe the skin. It is found naturally in our skin and hair.

There are two forms of panthenol: D and L.

D-panthenol is also known as dexpanthenol. Most cosmetics use dexpanthenol or a mixture of D and L-panthenol.

Panthenol is famous due to its ability to go deeper into the skin's layers. Using this ingredient has numerous pros (and no cons):

Like hyaluronic acid, panthenol is a humectant. Humectants are able to bind and hold large amounts of water to keep skin hydrated.

This ingredient works well for wound healing. It works by increasing tissue in the wound and helps close open wounds.

Once oxidized, panthenol converts to pantothenic acid. Panthothenic acid is found in all living cells.

This ingredient is also referred to as pro-vitamin B5.

Phenoxyethanol is one of the most widely used preservatives in skincare (and for good reason!).

It has a large spectrum of antimicrobial activity and especially effective bacteria, yeast, and mold while only having a weak effect on your skin's natural microbiome.

On a cellular level, it disrupts the cell membranes of microbes by poking holes that make the cell leak. This shuts down the chemical reactions the microbe needs to make energy so it can no longer survive.

Another perk of this ingredient is that it stays functional across a wide pH range (3-10).

You'll often see it paired with boosters like Ethylhexylglycerin; one study showed that a 1:9 ratio of Ethylhexylglycerin to Phenoxyethanol damages bacterial membranes as effectively as doubling the Phenoxyethanol concentration on its own.

Typical use concentrations range from 0.3-1% depending on the formula, and this ingredient is capped at 1% int the EU.

Safety-wise, the fear mongering does not hold up to the evidence. The EU's Scientific Committee on Consumer Safety and FDA consider it safe as a preservative at up to 1%, including for children of all ages.

Adverse systemic effects only showed up in animal studies at exposures roughly 200x higher than what people get from cosmetics. And despite its very widespread use, this ingredient is a rare sensitizer and allergic reactions are uncommon.

Tocopherol is a fat-soluble antioxidant known as Vitamin E.

You'll find this ingredient in the vast majority of skincare (for good reason). It works to neutralize free radicals, or unstable molecules generated by UV exposure, pollution, and other environmental stressors, before they can cause oxidative damage to your skin cells.

Topically applied tocopherol has been shown to protect against UV damage by ramping up the skin's own natural defense enzymes.

It also acts as a skin conditioning agent; some studies show that regular topical use can improve the skin's water-binding capacity over 2-4 weeks.

This ingredient is especially loved for being a team player. When combined with Vitamin C, the photoprotective effect of both ingredients roughly doubles and the combo also helps reduce UV-induced DNA damage.

This ingredient has some brightening potential but it's more of a prevention ingredient than spot-fader. Cell studies show it can slow down melanin production but it's worth noting that it's not the most powerful brightener out there.

In formulations, it also serves as a stabilizer that helps protect other oxidation-prone ingredients from degrading.

Concentrations usually range from 0.1-1% in most leave-on products.

Tocopheryl Acetate is a stable, shelf-friendly form of vitamin E.

Formulators love it because plain vitamin E oxidizes quickly once it hits air. This acetate version stays stable and resists going off, helping to extend a product's shelf life.

It's actually inactive on its own and works like a slow-release "storage" form; the enzymes in your skin called esterases gradually convert it into active vitamin E over time.

One in vivo study showed 5% of the acetate in the living layer of the epidermis converted to vitamin E after 5 days of application. This study also found the skin gained protection against UV damage even though the conversion was slow and small.

Once converted, vitamin E acts as a skin's main fat-soluble antioxidant that fights free radicals to protect skin from damage.

Topical vitamin E generally boosts the skin's photoprotection, and it reduced UV-damage in animal models.

Overall, it has a pretty solid safety profile and has been found to be non-irritating and non-comedogenic. Allergic reactions may happen but stay rare due to how widely the ingredient gets used.

The concentration will vary depending on the formula; industry data shows 0.1% in baby lotions, 3% in lipsticks, and 5% in foot powders. You can also find this ingredient at 100% in a pure vitamin E oil.

Most leave-on skincare keeps it at the lower end, often between 0.5-1%.

Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.

So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.

You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!

Xanthan gum is used as a stabilizer and thickener within cosmetic products. It helps give products a sticky, thick feeling - preventing them from being too runny.

On the technical side of things, xanthan gum is a polysaccharide - a combination consisting of multiple sugar molecules bonded together.

Xanthan gum is a pretty common and great ingredient. It is a natural, non-toxic, non-irritating ingredient that is also commonly used in food products.

Similar Comparisons

The reference edit

Ingredients, questions
& further reading.

Connected source records selected through this article’s public topic index.

01

Formula cabinet

Ingredients & structured notes

Ingredient index

Ingredients Explained

  1. 01These ingredients are found in both products.
  2. 02Ingredients higher up in an ingredient list are typically present in a larger amount.
  3. 031,2-Hexanediol is a synthetic liquid and another multi-functional powerhouse.
  4. 04It is a:
  5. 05Humectant, drawing moisture into the skin
  6. 06Emollient, helping to soften skin
  7. 07Solvent, dispersing and stabilizing formulas
  8. 08Preservative booster, enhancing the antimicrobial activity of other preservatives
  9. 09Acetyl Hexapeptide-8 (also known as Argireline) is a synthetic hexapeptide that is often called a "topical Botox alternative".
  10. 10It works by mimicking how Botox relaxes muscles; it interferes with the signaling process that tells your facial muscles to contract. This can help soften expression lines like forehead wrinkles or crow's feet over time.
  11. 11The comparison to Botox does have limits because the molecule is water-loving and relatively large.
  12. 12Acetyl Hexapeptide-8 has a hard time absorbing deeply enough through the skin's outer barrier to actually reach the muscles.
  13. 13So whether it truly works the way Botox does at a biological level is still up for debate, but early clinical outcomes are fairly encouraging.
  14. 14A 12 week human study of a multi-ingredient regimen containing this ingredient saw:
  15. 15While some studies have observed improvements in wrinkle appearance, it is important to note that more consistent results are seen in multi-ingredient formulations (vs just Acetyl Hexapeptide-8 alone).
  16. 16Some research studies also used higher concentrations (up to 10%) while this ingredient is usually found in concentrations up to 0.005% in leave-on formulations.
  17. 17Caprylyl Glycol is a humectant, skin conditioner, emollient, and preservative booster derived from either caprylic acid or synthetically created.
  18. 18Typical use levels vary from 0.3-1% as a preservative booster and go up to 2% to condition skin.
  19. 19Because it is not a free-fatty acid, this ingredient is fungal acne safe (there's nothing for Malassezia to feed on).
  20. 20Copper Tripeptide-1 (GHK-Cu) is a skin repairing ingredient known for its ability to boost collagen, improve firmness, and support skin regeneration.
Source · skinsort.com
02

Product index

Related product references

03

Comparison edit

Read side by side