Allies of Skin Molecular Barrier Recovery Cream Balm Versus Regimen Lab C.R.E.A.M 2.0

Allies of Skin Molecular Barrier Recovery Cream Balm Versus Regimen Lab C.R.E.A.M 2.0

This barrier-repair night moisturizer is formulated around Squalane and Niacinamide to strengthen the skin barrier and calm redness.

This barrier-repair moisturizer is formulated around Petrolatum and Panthenol to strengthen the skin barrier and hydrate skin.

What's inside

Key Ingredients

Benefits

Concerns

Ingredients Side-by-side

Water

Glycerin

Squalane

Helianthus Annuus Seed Oil

Methylsilanol Hydroxyproline Aspartate

Sodium Acrylates Copolymer

C12-15 Alkyl Benzoate

Nigella Sativa Seed Oil

Isomalt

Acacia Senegal Gum

Sodium Stearoyl Glutamate

Canola Oil

Helianthus Annuus Seed Wax

Panthenol

Pentaerythrityl Tetraisostearate

Candelilla/Jojoba/Rice Bran Polyglyceryl-3 Esters

Ethyl Macadamiate

Caprylic/Capric Triglyceride

Niacinamide

Ceramide NP

Allantoin

Bisabolol

Hyaluronic Acid

Lecithin

Hydrolyzed Oat Protein

Aloe Barbadensis Leaf Juice Powder

C10-30 Cholesterol/Lanosterol Esters

Adenosine Triphosphate

Camellia Sinensis Leaf Extract

Tocopherol

Hydroxyphenyl Propamidobenzoic Acid

Opuntia Ficus-Indica Stem Extract

Crocus Chrysanthus Bulb Extract

Phytol

Palmitoyl Tripeptide-8

Xanthan Gum

Silica

Dextran

Zea Mays Starch

Sodium Gluconate

Cetearyl Alcohol

Ethylhexylglycerin

Citric Acid

Glyceryl Stearate

Pentylene Glycol

Sodium Stearoyl Lactylate

Sodium Hydroxide

O-Cymen-5-Ol

Potassium Sorbate

Salicylic Acid

Malic Acid

Butylene Glycol

Phenoxyethanol

Water, Glycerin, Squalane, Helianthus Annuus Seed Oil, Methylsilanol Hydroxyproline Aspartate, Sodium Acrylates Copolymer, C12-15 Alkyl Benzoate, Nigella Sativa Seed Oil, Isomalt, Acacia Senegal Gum, Sodium Stearoyl Glutamate, Canola Oil, Helianthus Annuus Seed Wax, Panthenol, Pentaerythrityl Tetraisostearate, Candelilla/Jojoba/Rice Bran Polyglyceryl-3 Esters, Ethyl Macadamiate, Caprylic/Capric Triglyceride, Niacinamide, Ceramide NP, Allantoin, Bisabolol, Hyaluronic Acid, Lecithin, Hydrolyzed Oat Protein, Aloe Barbadensis Leaf Juice Powder, C10-30 Cholesterol/Lanosterol Esters, Adenosine Triphosphate, Camellia Sinensis Leaf Extract, Tocopherol, Hydroxyphenyl Propamidobenzoic Acid, Opuntia Ficus-Indica Stem Extract, Crocus Chrysanthus Bulb Extract, Phytol, Palmitoyl Tripeptide-8, Xanthan Gum, Silica, Dextran, Zea Mays Starch, Sodium Gluconate, Cetearyl Alcohol, Ethylhexylglycerin, Citric Acid, Glyceryl Stearate, Pentylene Glycol, Sodium Stearoyl Lactylate, Sodium Hydroxide, O-Cymen-5-Ol, Potassium Sorbate, Salicylic Acid, Malic Acid, Butylene Glycol, Phenoxyethanol

Petrolatum

Behenyl Alcohol

Dimethicone

Decyl Glucoside

Polysilicone-11

Isosorbide Dicaprylate

Arachidyl Alcohol

Arachidyl Glucoside

Cetearyl Glucoside

Ceramide EOP

4-T-Butylcyclohexanol

Avena Sativa Kernel Flour

Glycyrrhetinic Acid

Linoleic Acid

Linolenic Acid

Palmitamide Mea

Cholesterol

Myristic Acid

Hydroxystearic Acid

Zingiber Officinale Root Extract

Avena Sativa Kernel Extract

Avenanthramides

Hydroxymethoxyphenyl Decanone

Lactic Acid

Polyacrylamide

C13-14 Isoparaffin

Tetrasodium Glutamate Diacetate

Laureth-7

Water, Glycerin, Petrolatum, Panthenol, Pentylene Glycol, Behenyl Alcohol, Butylene Glycol, Dimethicone, Decyl Glucoside, Polysilicone-11, Isosorbide Dicaprylate, Arachidyl Alcohol, Arachidyl Glucoside, Cetearyl Alcohol, Cetearyl Glucoside, Bisabolol, Ceramide EOP, Ceramide NP, 4-T-Butylcyclohexanol, Avena Sativa Kernel Flour, Glycyrrhetinic Acid, Allantoin, Linoleic Acid, Linolenic Acid, Palmitamide Mea, Cholesterol, Myristic Acid, Hydroxystearic Acid, Zingiber Officinale Root Extract, Avena Sativa Kernel Extract, Avenanthramides, Hydroxymethoxyphenyl Decanone, Tocopherol, Lactic Acid, Polyacrylamide, C13-14 Isoparaffin, Tetrasodium Glutamate Diacetate, Laureth-7, Potassium Sorbate

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Alternatives

Ingredients Explained

These ingredients are found in both products.

Ingredients higher up in an ingredient list are typically present in a larger amount.

Allantoin is a soothing ingredient known for its protective and moisturizing properties; it's basically a quiet workhorse ingredient you can find in a huge range of cosmetics.

Though it can be derived from the comfrey plant, allantoin is produced synthetically for cosmetic products to ensure purity.

Research shows it can encourage your skin cells to turn over and renew by stimulating keratinocyte and fibroblast proliferation.

It also has mild keratolytic properties to help loosen and shed dead skin cells without being harsh.

Studies also suggest allantoin can help calm inflammation by dialing down some of the chemical signals your skin sends out when it is irritated.

This ingredient is typically used in the 0.1-0.5% range, and the FDA recognizes it as a skin protectant in OTC products up to 2%.

Overall, allantoin is a wonderful addition to most routines; it is stable across a wide pH range (~4-8), works well with other ingredients, and is considered non-sensitizing/non-irritating.

Fun fact: Allantoin is naturally occurring in comfrey root, beets, chamomile, and wheat sprouts. Our bodies even produce it as a byproduct of uric acid metabolism.

Bisabolol is a gentle skin conditioner, antioxidant, and soothing ingredient.

It's primary claim to fame is soothing and research shows topically applied bisabolol can quiet the chemical messengers that cause your skin to become inflamed, helping to sooth any irritation.

A clinical study found that applying 0.5% bisabolol daily for 8 weeks produced an average 9% decrease in skin pigmentation. Researchers found it can also suppress the process that leads to excess melanin production in skin.

In vitro studies found that bisabolol combined with propylene glycol significantly increased skin permeability by increasing lipid fluidity in the stratum corneum.

You'll likely see use concentrations quite low, usually 0.1-0.2%.

Overall, this is a well-tolerated ingredient that works well in formulas designed for sensitive, reactive, or post-procedure skin.

Butylene Glycol (or BG) is used within cosmetic products for a few different reasons:

Overall, Butylene Glycol is a safe and well-rounded ingredient that works well with other ingredients.

Though this ingredient works well with most skin types, some people with sensitive skin may experience a reaction such as allergic rashes, closed comedones, or itchiness.

Ceramide NP (formerly known as Ceramide 3) is one of the skin's naturally occurring lipids.

Since ceramides are the major lipid components of the skin, they are crucial for maintaining skin barrier and hydration. Ceramide NP most closely mirrors the dominant kind in human skin amongst ceramide subtypes.

This ceramide works by slotting into gaps within the stratum corneum's lipid matrix to limit trans-epidermal water loss (TEWL) and shield the skin against external irritants.

A study with 312 patients found that using a ceramide-containing routine for 4 weeks reduced the severity of atopic dermatitis by over 61%.

Another clinical study in subjects aged 60 and older found that a ceramide body wash and moisturizer improved skin dryness and itchy skin in 15 days.

Overall, ceramides are considered non-irritating and safety tests have found little to no observable adverse effects from using this ingredient.

Ceramide NP is usually sourced from plants (like soybean or rice bran), or produced synthetically.

Cetearyl alcohol is a waxy mixture of two fatty alcohols: cetyl alcohol and stearyl alcohol. It is an emollient and emulsifier.

Despite having "alcohol" in its name, it has nothing to do with drying solvent alcohols; the FDA also allows "alcohol-free" products to contain fatty alcohols like this ingredient.

It plays several roles in a formula:

Typical use levels for this ingredient sit around 1-10% and the Cosmetic Ingredient Review Expert Panel has affirmed safety at concentrations up to 25% in leave-on products.

Multiple assessments have found it to be non-irritating and non-sensitizing to most people.

However, there have been some cases of allergic contact dermatitis in patients with chronically compromised skin barriers.

Cetearyl alcohol has a comedogenic rating of 2 and irritancy rating of 1. Both of these numbers come from the 1989 study that used rabbit ears; a "2" means mildly comedogenic and a "1" means low irritancy.

Here's the catch: rabbit skin is more sensitive than human skin and throws a lot of false positives. A 1996 reappraisal found that ingredients rated 1-2 in the rabbit ear tests are generally safe for humans.

Remember comedogenic ratings are unable to assess the entire formula of a product or how it will react on your skin. Just be sure to patch test if you are unsure about certain ingredients.

This ingredient is not fungal acne safe. Cetearyl alcohol is a fatty alcohol with chain lengths that fall within the range that Malassezia can metabolize.

A 2019 study has also observed Malassezia growth in the presence of this ingredient, confirming it to be not-fungal acne safe.

Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.

Topically, glycerin does several things at once:

Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.

Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.

This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.

Just know very high concentrations (>40%) can feel tacky in low humidity.

Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.

Panthenol is a common ingredient that helps hydrate and soothe the skin. It is found naturally in our skin and hair.

There are two forms of panthenol: D and L.

D-panthenol is also known as dexpanthenol. Most cosmetics use dexpanthenol or a mixture of D and L-panthenol.

Panthenol is famous due to its ability to go deeper into the skin's layers. Using this ingredient has numerous pros (and no cons):

Like hyaluronic acid, panthenol is a humectant. Humectants are able to bind and hold large amounts of water to keep skin hydrated.

This ingredient works well for wound healing. It works by increasing tissue in the wound and helps close open wounds.

Once oxidized, panthenol converts to pantothenic acid. Panthothenic acid is found in all living cells.

This ingredient is also referred to as pro-vitamin B5.

Pentylene Glycol (1,2-pentanediol) is a multitasking little diol with three main roles in a formula:

Research on alkanediols (the family pentylene glycol belongs to) show they work by disrupting microbial cell membranes. This disruption helps the primary preservative system in a product work more effectively at lower doses.

On the safety side, the Cosmetic Ingredient Review Expert Panel has concluded this ingredient to be safe as used in current cosmetic practices + concentrations.

Typical use levels in a formula run about 1-5%.

Potassium Sorbate is a preservative used to prevent yeast and mold in products. It is commonly found in both cosmetic and food products.

This ingredient comes from potassium salt derived from sorbic acid. Sorbic acid is a natural antibiotic and effective against fungus.

Both potassium sorbate and sorbic acid can be found in baked goods, cheeses, dried meats, dried fruit, ice cream, pickles, wine, yogurt, and more.

You'll often find this ingredient used with other preservatives.

Tocopherol is a fat-soluble antioxidant known as Vitamin E.

You'll find this ingredient in the vast majority of skincare (for good reason). It works to neutralize free radicals, or unstable molecules generated by UV exposure, pollution, and other environmental stressors, before they can cause oxidative damage to your skin cells.

Topically applied tocopherol has been shown to protect against UV damage by ramping up the skin's own natural defense enzymes.

It also acts as a skin conditioning agent; some studies show that regular topical use can improve the skin's water-binding capacity over 2-4 weeks.

This ingredient is especially loved for being a team player. When combined with Vitamin C, the photoprotective effect of both ingredients roughly doubles and the combo also helps reduce UV-induced DNA damage.

This ingredient has some brightening potential but it's more of a prevention ingredient than spot-fader. Cell studies show it can slow down melanin production but it's worth noting that it's not the most powerful brightener out there.

In formulations, it also serves as a stabilizer that helps protect other oxidation-prone ingredients from degrading.

Concentrations usually range from 0.1-1% in most leave-on products.

Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.

So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.

You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!

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