Peptide Skincare & BeautySkin science and ingredient guides

Skin science article

Allies of Skin Peptides & Omegas Firming Eye Cream Versus Paula's Choice Omega+ Complex Eye Cream

Allies of Skin Peptides & Omegas Firming Eye Cream Versus Paula's Choice Omega+ Complex Eye Cream This anti-aging eye moisturizer is formulated around Squalane and Bakuchiol to soften the look of wrinkles and strengthen the skin barrier. This barrier-repair ey

Allies of Skin Peptides & Omegas Firming Eye Cream Versus Paula's Choice Omega+ Complex Eye Cream

This anti-aging eye moisturizer is formulated around Squalane and Bakuchiol to soften the look of wrinkles and strengthen the skin barrier.

This barrier-repair eye moisturizer is formulated around Borago Officinalis Seed Oil and Niacinamide to strengthen the skin barrier and hydrate skin.

What's inside

Key Ingredients

Benefits

Concerns

Ingredients Side-by-side

Water

Glycerin

Tribehenin

Caprylic/Capric Triglyceride

Isodecyl Neopentanoate

Glyceryl Stearate

Propanediol

Squalane

Acrylamide/Sodium Acryloyldimethyltaurate Copolymer

Leuconostoc/Radish Root Ferment Filtrate

Caprylyl Glycol

Bakuchiol

Sodium Ascorbyl Phosphate

Ceramide NP

Rosa Canina Seed Oil

Adansonia Digitata Seed Oil

Argania Spinosa Kernel Oil

Glycyrrhiza Glabra Root Extract

Pfaffia Paniculata Root Extract

Ptychopetalum Olacoides Bark/Stem Extract

Calanthe Discolor Extract

Lilium Candidum Flower Extract

Ubiquinone

Superoxide Dismutase

Ergothioneine

Tocopheryl Acetate

Bisabolol

Allantoin

Biotin

Hesperidin Methyl Chalcone

Methylglucoside Phosphate

Copper Lysinate/Prolinate

Palmitoyl Tetrapeptide-7

Chrysin

Gluconolactone

Dipeptide-2

Palmitoyl Tripeptide-1

N-Prolyl Palmitoyl Tripeptide-56 Acetate

Calcium Gluconate

N-Hydroxysuccinimide

Caprylyl/Capryl Glucoside

Citric Acid

Glyceryl Polyacrylate

Isohexadecane

Pentylene Glycol

Polysorbate 80

Sodium Citrate

Sodium Gluconate

Sodium Hydroxide

Sorbitan Oleate

Steareth-20

Xanthan Gum

Benzyl Alcohol

Chlorhexidine Digluconate

Sodium Benzoate

Potassium Sorbate

Phenoxyethanol

Water, Glycerin, Tribehenin, Caprylic/Capric Triglyceride, Isodecyl Neopentanoate, Glyceryl Stearate, Propanediol, Squalane, Acrylamide/Sodium Acryloyldimethyltaurate Copolymer, Leuconostoc/Radish Root Ferment Filtrate, Caprylyl Glycol, Bakuchiol, Sodium Ascorbyl Phosphate, Ceramide NP, Rosa Canina Seed Oil, Adansonia Digitata Seed Oil, Argania Spinosa Kernel Oil, Glycyrrhiza Glabra Root Extract, Pfaffia Paniculata Root Extract, Ptychopetalum Olacoides Bark/Stem Extract, Calanthe Discolor Extract, Lilium Candidum Flower Extract, Ubiquinone, Superoxide Dismutase, Ergothioneine, Tocopheryl Acetate, Bisabolol, Allantoin, Biotin, Hesperidin Methyl Chalcone, Methylglucoside Phosphate, Copper Lysinate/Prolinate, Palmitoyl Tetrapeptide-7, Chrysin, Gluconolactone, Dipeptide-2, Palmitoyl Tripeptide-1, N-Prolyl Palmitoyl Tripeptide-56 Acetate, Calcium Gluconate, N-Hydroxysuccinimide, Caprylyl/Capryl Glucoside, Citric Acid, Glyceryl Polyacrylate, Isohexadecane, Pentylene Glycol, Polysorbate 80, Sodium Citrate, Sodium Gluconate, Sodium Hydroxide, Sorbitan Oleate, Steareth-20, Xanthan Gum, Benzyl Alcohol, Chlorhexidine Digluconate, Sodium Benzoate, Potassium Sorbate, Phenoxyethanol

Butylene Glycol

Neopentyl Glycol Diheptanoate

Cetyl Palmitate

Nylon-12

Ammonium Acryloyldimethyltaurate/Vp Copolymer

Propylene Glycol Dibenzoate

Persea Gratissima Oil

Borago Officinalis Seed Oil

Sodium Stearoyl Glutamate

Niacinamide

Salvia Hispanica Seed Oil

Linum Usitatissimum Seed Oil

Limnanthes Alba Seed Oil

Olea Europaea Fruit Oil

Passiflora Edulis Seed Oil

Ceramide EOP

Ceramide AP

Sodium Hyaluronate

Cholesterol

Morus Alba Root Extract

Arctostaphylos Uva-Ursi Leaf Extract

Linoleic Acid

Linolenic Acid

Serine

Alanine

Proline

Arginine

Threonine

Phytosphingosine

Phytosterols

Sodium PCA

Glycine

Oleic Acid

Glutamic Acid

Lysine Hcl

Lecithin

Adenosine

Sodium Lactate

Hydrogenated Olive Oil

Euterpe Oleracea Sterols

Olea Europaea Oil Unsaponifiables

Phytic Acid

Scutellaria Baicalensis Root Extract

Anastatica Hierochuntica Extract

PCA

Betaine

Pullulan

Carbomer

Sclerotium Gum

Ascorbyl Palmitate

Silica

Sodium Lauroyl Lactylate

Ethylhexylglycerin

Chlorphenesin

Water, Caprylic/Capric Triglyceride, Butylene Glycol, Neopentyl Glycol Diheptanoate, Cetyl Palmitate, Nylon-12, Propanediol, Ammonium Acryloyldimethyltaurate/Vp Copolymer, Propylene Glycol Dibenzoate, Persea Gratissima Oil, Borago Officinalis Seed Oil, Sodium Stearoyl Glutamate, Squalane, Niacinamide, Salvia Hispanica Seed Oil, Linum Usitatissimum Seed Oil, Limnanthes Alba Seed Oil, Olea Europaea Fruit Oil, Passiflora Edulis Seed Oil, Ceramide EOP, Ceramide NP, Ceramide AP, Sodium Hyaluronate, Cholesterol, Morus Alba Root Extract, Arctostaphylos Uva-Ursi Leaf Extract, Glycyrrhiza Glabra Root Extract, Linoleic Acid, Linolenic Acid, Serine, Alanine, Proline, Arginine, Threonine, Phytosphingosine, Phytosterols, Sodium PCA, Glycine, Oleic Acid, Glutamic Acid, Lysine Hcl, Lecithin, Adenosine, Sodium Lactate, Hydrogenated Olive Oil, Euterpe Oleracea Sterols, Olea Europaea Oil Unsaponifiables, Phytic Acid, Scutellaria Baicalensis Root Extract, Anastatica Hierochuntica Extract, Glycerin, PCA, Betaine, Pullulan, Carbomer, Sclerotium Gum, Sodium Citrate, Citric Acid, Ascorbyl Palmitate, Tocopheryl Acetate, Silica, Sorbitan Oleate, Xanthan Gum, Sodium Lauroyl Lactylate, Phenoxyethanol, Ethylhexylglycerin, Chlorphenesin

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Alternatives

Ingredients Explained

These ingredients are found in both products.

Ingredients higher up in an ingredient list are typically present in a larger amount.

Caprylic/Capric Triglyceride (aka MCT Oil) is a lightweight emollient, solvent, and texture enhancer. It is considered a skin-softener by helping to prevent moisture loss.

Though it behaves like an oil, it is not technically one due to its chemical composition. One perk of this ingredient is that it is very stable, resistant to oxidation, and unlikely to go rancid.

In practice, that translates to a long shelf life and a consistently elegant skin feel.

While there is an assumption Caprylic Triglyceride can clog pores due to it being derived from coconut oil, there is no research supporting this. Just patch test if you have concerns.

Fractionated coconut oil and MCT Oil are both listed as Caprylic/Capric Triglyceride according to INCI. This is because INCI names are based on the ingredient’s final chemical composition and not its marketing name or source.

This ingredient is treated as the gold standard fungal acne safe oil. Even though it is coconut derived, the problematic lauric acid is stripped out.

This leaves just caprylic (C8) and capric (C10) acid. These chain lengths actually trend antifungal; a 2020 study found caprylic acid was enough to disrupt Malassezia furfur cell membrane, with a caprylic acid derivative damaging membrane structures at concentrations as low as 0.2%.

Ceramide NP (formerly known as Ceramide 3) is one of the skin's naturally occurring lipids.

Since ceramides are the major lipid components of the skin, they are crucial for maintaining skin barrier and hydration. Ceramide NP most closely mirrors the dominant kind in human skin amongst ceramide subtypes.

This ceramide works by slotting into gaps within the stratum corneum's lipid matrix to limit trans-epidermal water loss (TEWL) and shield the skin against external irritants.

A study with 312 patients found that using a ceramide-containing routine for 4 weeks reduced the severity of atopic dermatitis by over 61%.

Another clinical study in subjects aged 60 and older found that a ceramide body wash and moisturizer improved skin dryness and itchy skin in 15 days.

Overall, ceramides are considered non-irritating and safety tests have found little to no observable adverse effects from using this ingredient.

Ceramide NP is usually sourced from plants (like soybean or rice bran), or produced synthetically.

Citric Acid is an alpha hydroxy acid (AHA) naturally found in citrus fruits like oranges, lemons, and limes.

Like other AHAs, citric acid can exfoliate skin by breaking down the bonds that hold dead skin cells together. This helps reveal smoother and brighter skin underneath.

However, this exfoliating effect only happens at high concentrations (20%) which can be hard to find in cosmetic products.

Due to this, citric acid is usually included in small amounts as a pH adjuster. This helps keep products slightly more acidic and compatible with skin's natural pH.

In skincare formulas, citric acid can:

While it can provide some skin benefits, research shows lactic acid and glycolic acid are generally more effective and less irritating exfoliants.

Most citric acid used in skincare today is made by fermenting sugars (usually from molasses). This synthetic version is identical to the natural citrus form but easier to stabilize and use in formulations.

Rosacea skin has a lower threshold for acids generally, with 62.5% of rosacea subjects in one study reacting to lactic acid in a sting test. This is why we mark citric acid as a potential rosacea trigger.

However, this ingredient shows up as a pH adjuster or chelator at roughly 0.1-1% in many products. These low levels are unlikely to be an issue for rosacea skin and becomes a potential trigger at exfoliating concentrations (20%). Because everybody's skin is unique, we recommend a patch test if you are unsure.

Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.

Topically, glycerin does several things at once:

Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.

Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.

This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.

Just know very high concentrations (>40%) can feel tacky in low humidity.

Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.

Glycyrrhiza Glabra Root Extract is an extract of the roots of Licorice. It has been found to have several benefits such as skin hydrating, conditioning, and soothing.

One component, glabridin, has extra potent antioxidant and soothing properties. It has also been found to block pigmentation from UVB rays in guinea pigs.

Licorice Root also contains a flavonoid. Flavonoids are a natural substance from in plants. Flavonoids also have antioxidant properties.

Another component, glycyrrhizin, has been found to have anti-inflammatory and antimicrobial benefits. This may make licorice root extract effective at treating acne. However, more research is needed to support this.

Liquiritin is one of the flavone compounds found in licorice. It has been found to help lighten skin by preventing tyrosinase from reacting with tyrosine. When the two react, protein is converted to melanin. Melanin is the substance in your body that gives your features pigmentation.

Phenoxyethanol is one of the most widely used preservatives in skincare (and for good reason!).

It has a large spectrum of antimicrobial activity and especially effective bacteria, yeast, and mold while only having a weak effect on your skin's natural microbiome.

On a cellular level, it disrupts the cell membranes of microbes by poking holes that make the cell leak. This shuts down the chemical reactions the microbe needs to make energy so it can no longer survive.

Another perk of this ingredient is that it stays functional across a wide pH range (3-10).

You'll often see it paired with boosters like Ethylhexylglycerin; one study showed that a 1:9 ratio of Ethylhexylglycerin to Phenoxyethanol damages bacterial membranes as effectively as doubling the Phenoxyethanol concentration on its own.

Typical use concentrations range from 0.3-1% depending on the formula, and this ingredient is capped at 1% int the EU.

Safety-wise, the fear mongering does not hold up to the evidence. The EU's Scientific Committee on Consumer Safety and FDA consider it safe as a preservative at up to 1%, including for children of all ages.

Adverse systemic effects only showed up in animal studies at exposures roughly 200x higher than what people get from cosmetics. And despite its very widespread use, this ingredient is a rare sensitizer and allergic reactions are uncommon.

Propanediol is an all-star ingredient. It softens, hydrates, and smooths the skin.

It’s often used to:

Propanediol is not likely to cause sensitivity and considered safe to use. It is derived from corn or petroleum with a clear color and no scent.

Sodium Citrate is the sodium salts of citric acid. In skincare, it is used to alter pH levels and acts as a preservative.

Its main functions are to maintain the pH of a product and neutralize metal ions.

The acidity of our skin is maintained by our glands and skin biome; normal pH level of skin is slightly acidic (~4.75-5.5).

Being slightly acidic allows our skin to create an "acid mantle". This acid mantle is a thin barrier that protects our skin from bacteria and contaminants.

Sorbitan Oleate is a PEG-free emulsifier made by esterifying sorbitol with oleic acid.

You'll likely see it paired with Polysorbate 80 to create the right emulsification balance.

Typical use levels in formulas range from 2-10%.

The CIR Expert Panel has concluded this ingredient to be safe as a cosmetic ingredient.

Since this ingredient is an ester of oleic acid, it may not be fungal acne safe. Oleic acid is a fatty acid that falls into the C11-24 range that Malassezia can metabolize.

Squalane is the hydrogenated and shelf-stable form of squalene (a lipid that naturally occurs in human sebum).

It is an emollient and skin conditioning agent that is able to integrate seamlessly into the skin's lipid barrier without clogging pores.

This is due to how structurally similar it is to what your skin already produces.

Though it is mostly an emollient that helps soften and hydrate skin, it also has some humectant and occlusive action. Humectants help the skin retain moisture while occlusives seal it in, making squalane a triple-threat moisturizer.

Research shows it has antioxidant capabilities that help protect against stressors like UV exposure, specifically UVA induced oxidative stress. This study also found that it supports collagen biosynthesis in human dermal fibroblasts.

No clinical study has reported significant adverse effects and irritation reactions are very rare from this ingredient (even at 100% concentration).

Overall, it's a fantastic ingredient for hydration and is suitable for all skin types.

This depends on the source. Squalane can be derived from both plants and animals. Most squalane used in skincare comes from plants.

Please note: the source of squalane is only known if disclosed by the brand. We recommend reaching out to the brand if you have any questions about their squalane.

Read more about squalene with an "e".

Though squalane is often called an oil, it’s technically not one. It is a hydrocarbon, meaning it is only made of carbon and hydrogen. True oils are triglycerides and made of fatty acids and glycerol.

The term “oil-free” isn’t regulated so companies can define it however they want. Some exclude all oils, while others just avoid mineral oil or comedogenic oils.

Squalane has a comedogenic rating of 1 from the original 1972 study that tested raw ingredients under occlusion on rabbit ears. This system is not standardized or peer-reviewed, and using the raw ingredients is very different from how diluted cosmetic formulations are used on human skin.

A comedogenic rating of 1 means it is "unlikely to clog pores" according to the original rating system.

The overall formula of a product matters more than the individual ingredients on whether or not it will cause clogged pores.

Tocopheryl Acetate is a stable, shelf-friendly form of vitamin E.

Formulators love it because plain vitamin E oxidizes quickly once it hits air. This acetate version stays stable and resists going off, helping to extend a product's shelf life.

It's actually inactive on its own and works like a slow-release "storage" form; the enzymes in your skin called esterases gradually convert it into active vitamin E over time.

One in vivo study showed 5% of the acetate in the living layer of the epidermis converted to vitamin E after 5 days of application. This study also found the skin gained protection against UV damage even though the conversion was slow and small.

Once converted, vitamin E acts as a skin's main fat-soluble antioxidant that fights free radicals to protect skin from damage.

Topical vitamin E generally boosts the skin's photoprotection, and it reduced UV-damage in animal models.

This ingredient has some brightening potential but it's more of a prevention ingredient than spot-fader. Cell studies show it can slow down melanin production but it's worth noting that it's not the most powerful brightener out there.

Overall, it has a pretty solid safety profile and has been found to be non-irritating and non-comedogenic. Allergic reactions may happen but stay rare due to how widely the ingredient gets used.

The concentration will vary depending on the formula; industry data shows 0.1% in baby lotions, 3% in lipsticks, and 5% in foot powders. You can also find this ingredient at 100% in a pure vitamin E oil.

Most leave-on skincare keeps it at the lower end, often between 0.5-1%.

Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.

So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.

You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!

Xanthan gum is used as a stabilizer and thickener within cosmetic products. It helps give products a sticky, thick feeling - preventing them from being too runny.

On the technical side of things, xanthan gum is a polysaccharide - a combination consisting of multiple sugar molecules bonded together.

Xanthan gum is a pretty common and great ingredient. It is a natural, non-toxic, non-irritating ingredient that is also commonly used in food products.

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