Skin science article
Allies of Skin Tranexamic & Arbutin Advanced Brightening Serum Versus Naturium Alpha Arbutin Serum 2%
Allies of Skin Tranexamic & Arbutin Advanced Brightening Serum Versus Naturium Alpha Arbutin Serum 2% This brightening serum is formulated around Tranexamic Acid and Alpha-Arbutin to fade the look of dark spots and brighten dull-looking skin. This brightening
Allies of Skin Tranexamic & Arbutin Advanced Brightening Serum Versus Naturium Alpha Arbutin Serum 2%
This brightening serum is formulated around Tranexamic Acid and Alpha-Arbutin to fade the look of dark spots and brighten dull-looking skin.
This brightening serum is formulated around Alpha-Arbutin and Niacinamide to fade the look of dark spots and brighten dull-looking skin.
What's inside
Key Ingredients
Benefits
Concerns
No concerns
Ingredients Side-by-side
Water
Caprylic/Capric Triglyceride
C13-15 Alkane
Tranexamic Acid
Glycerin
Alpha-Arbutin
Pentylene Glycol
Tocopheryl Acetate
Palmaria Palmata Extract
Hydrolyzed Pea
Asparagopsis Armata Extract
Ascophyllum Nodosum Extract
Glycyrrhiza Glabra Root Extract
Pancratium Maritimum Extract
Ganoderma Lucidum Extract
Lentinus Edodes Extract
Lactobacillus Ferment
Hydrolyzed Pea Protein
Diacetyl Boldine
Dipotassium Glycyrrhizate
Lactobacillus
Bisabolol
Panthenol
Tocopherol
Glucose
Arginine/Lysine Polypeptide
Pentapeptide-34 Trifluoroacetate
C14-22 Alcohols
Xanthan Gum
Hydrogenated Starch Hydrolysate
Hydroxyacetophenone
Sorbitan Caprylate
1,2-Hexanediol
Caprylyl Glycol
C12-20 Alkyl Glucoside
Propanediol
Carbomer
Sodium Phytate
Butylene Glycol
Sodium Chloride
Sodium Succinate
Sorbic Acid
Sodium Benzoate
Potassium Sorbate
Phenoxyethanol
Water, Caprylic/Capric Triglyceride, C13-15 Alkane, Tranexamic Acid, Glycerin, Alpha-Arbutin, Pentylene Glycol, Tocopheryl Acetate, Palmaria Palmata Extract, Hydrolyzed Pea, Asparagopsis Armata Extract, Ascophyllum Nodosum Extract, Glycyrrhiza Glabra Root Extract, Pancratium Maritimum Extract, Ganoderma Lucidum Extract, Lentinus Edodes Extract, Lactobacillus Ferment, Hydrolyzed Pea Protein, Diacetyl Boldine, Dipotassium Glycyrrhizate, Lactobacillus, Bisabolol, Panthenol, Tocopherol, Glucose, Arginine/Lysine Polypeptide, Pentapeptide-34 Trifluoroacetate, C14-22 Alcohols, Xanthan Gum, Hydrogenated Starch Hydrolysate, Hydroxyacetophenone, Sorbitan Caprylate, 1,2-Hexanediol, Caprylyl Glycol, C12-20 Alkyl Glucoside, Propanediol, Carbomer, Sodium Phytate, Butylene Glycol, Sodium Chloride, Sodium Succinate, Sorbic Acid, Sodium Benzoate, Potassium Sorbate, Phenoxyethanol
Niacinamide
Sodium Hyaluronate
Citrus Limon Fruit Extract
Polyacrylate Crosspolymer-6
Tremella Fuciformis Sporocarp Extract
Ethylhexylglycerin
Citric Acid
Disodium EDTA
Betaine
Water, Butylene Glycol, Alpha-Arbutin, Niacinamide, Sodium Hyaluronate, Hydroxyacetophenone, Citrus Limon Fruit Extract, Polyacrylate Crosspolymer-6, Glycerin, Panthenol, Tremella Fuciformis Sporocarp Extract, Phenoxyethanol, Xanthan Gum, Ethylhexylglycerin, Sodium Phytate, Citric Acid, Disodium EDTA, Betaine, Potassium Sorbate, Tocopherol
Reviews
Alternatives
Ingredients Explained
These ingredients are found in both products.
Ingredients higher up in an ingredient list are typically present in a larger amount.
Alpha-Arbutin is a brightening active used to fade dark spots, melasma, and post-acne marks. Structurally, it is a hydroquinone with a sugar molecule attached (but is much gentler than raw hydroquinone).
It has a pretty elegant way of working; it slots into tyrosinase, or the key enzyme that your skin uses to make melanin), and competitively blocks it so your skin produces less pigment over time.
There are two forms of arbutin and alpha is the better one to reach for: it works at lower amounts, absorbs into skin more easily, and has a strong safety record.
The science backs this up too: lab and animal studies confirm it lowers melanin by blocking tyosinase and the more you use (up to a point), the more it works.
Human studies look good too.
A 2024 trial found a cream with 5% alpha-arbutin and 2% kojic acid worked about as well as a prescription melasma cream but with fewer side effects. Another study showed 2% alpha-arbutin paired with 10% Trihydroxybenzoic Acid Glucoside and sunscreen faded dark spots and melasma without causing irritation.
Concentration-wise, most serums land in the 1-2% range.
The EU's Scientific Committee on Consumer Safety concluded that alpha-arbutin is safe in face creams up to 2% and body lotions up to 0.5%.
Overall, this is a well-studied and low-irritation brightener that's a great pick for anyone dealing with uneven skin tone. It also pairs well with vitamin C, niacinamide, and sunscreen.
Butylene Glycol (or BG) is used within cosmetic products for a few different reasons:
Overall, Butylene Glycol is a safe and well-rounded ingredient that works well with other ingredients.
Though this ingredient works well with most skin types, some people with sensitive skin may experience a reaction such as allergic rashes, closed comedones, or itchiness.
Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.
Topically, glycerin does several things at once:
Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.
Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.
This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.
Just know very high concentrations (>40%) can feel tacky in low humidity.
Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.
Hydroxyacetophenone is a small phenolic molecule that earns its place in a formulas as an antioxidant and preservative booster.
As a phenol, it is able to neutralize free radicals to protect both the product and the skin from oxidative stress.
Though it can't kill microbes on its own, it works as a good supporting agent when combined with other preservatives like Phenoxyethanol or 1,2-Hexanediol.
This ingredient naturally occurs as piceol in Norwegian spruce needles (~0.4-1.1% dry weight and in cloudberries). Though the cosmetic-grade material is synthesized for purity and consistency.
You'll usually see it used at low levels and suppliers recommend up to 1% added to a water phase.
Safety testing was done at concentrations like 0.05% in SPF products and 0.5% in a Human Repeated Insult Patch Test. The safety evidence is assuring; this ingredient is safe for cosmetics in current use and also holds safety status as a food flavoring as well.
An honest caveat: the "soothing" and "anti-inflammatory" claims come mostly from supplier marketing rather than published clinical trials. The Cosmetic Ingredient Review's own literature search found no useful efficacy studies on this ingredient.
So the antioxidant and preservative-boosting roles are the well supported ones while the calming benefit is plausible but thinly evidenced.
Overall, this is a well-tolerated, low-irritation multitasker that quietly helps a formula stay fresh and stable.
Panthenol is a common ingredient that helps hydrate and soothe the skin. It is found naturally in our skin and hair.
There are two forms of panthenol: D and L.
D-panthenol is also known as dexpanthenol. Most cosmetics use dexpanthenol or a mixture of D and L-panthenol.
Panthenol is famous due to its ability to go deeper into the skin's layers. Using this ingredient has numerous pros (and no cons):
Like hyaluronic acid, panthenol is a humectant. Humectants are able to bind and hold large amounts of water to keep skin hydrated.
This ingredient works well for wound healing. It works by increasing tissue in the wound and helps close open wounds.
Once oxidized, panthenol converts to pantothenic acid. Panthothenic acid is found in all living cells.
This ingredient is also referred to as pro-vitamin B5.
Phenoxyethanol is one of the most widely used preservatives in skincare (and for good reason!).
It has a large spectrum of antimicrobial activity and especially effective bacteria, yeast, and mold while only having a weak effect on your skin's natural microbiome.
On a cellular level, it disrupts the cell membranes of microbes by poking holes that make the cell leak. This shuts down the chemical reactions the microbe needs to make energy so it can no longer survive.
Another perk of this ingredient is that it stays functional across a wide pH range (3-10).
You'll often see it paired with boosters like Ethylhexylglycerin; one study showed that a 1:9 ratio of Ethylhexylglycerin to Phenoxyethanol damages bacterial membranes as effectively as doubling the Phenoxyethanol concentration on its own.
Typical use concentrations range from 0.3-1% depending on the formula, and this ingredient is capped at 1% int the EU.
Safety-wise, the fear mongering does not hold up to the evidence. The EU's Scientific Committee on Consumer Safety and FDA consider it safe as a preservative at up to 1%, including for children of all ages.
Adverse systemic effects only showed up in animal studies at exposures roughly 200x higher than what people get from cosmetics. And despite its very widespread use, this ingredient is a rare sensitizer and allergic reactions are uncommon.
Potassium Sorbate is a preservative used to prevent yeast and mold in products. It is commonly found in both cosmetic and food products.
This ingredient comes from potassium salt derived from sorbic acid. Sorbic acid is a natural antibiotic and effective against fungus.
Both potassium sorbate and sorbic acid can be found in baked goods, cheeses, dried meats, dried fruit, ice cream, pickles, wine, yogurt, and more.
You'll often find this ingredient used with other preservatives.
Sodium Phytate is the synthetic salt form of phytic acid. Phytic acid is an antioxidant and can be found in plant seeds.
Sodium Phytate is a chelating agent. Chelating agents help prevent metals from binding to water. This helps stabilize the ingredients and the product.
Tocopherol is a fat-soluble antioxidant known as Vitamin E.
You'll find this ingredient in the vast majority of skincare (for good reason). It works to neutralize free radicals, or unstable molecules generated by UV exposure, pollution, and other environmental stressors, before they can cause oxidative damage to your skin cells.
Topically applied tocopherol has been shown to protect against UV damage by ramping up the skin's own natural defense enzymes.
It also acts as a skin conditioning agent; some studies show that regular topical use can improve the skin's water-binding capacity over 2-4 weeks.
This ingredient is especially loved for being a team player. When combined with Vitamin C, the photoprotective effect of both ingredients roughly doubles and the combo also helps reduce UV-induced DNA damage.
This ingredient has some brightening potential but it's more of a prevention ingredient than spot-fader. Cell studies show it can slow down melanin production but it's worth noting that it's not the most powerful brightener out there.
In formulations, it also serves as a stabilizer that helps protect other oxidation-prone ingredients from degrading.
Concentrations usually range from 0.1-1% in most leave-on products.
Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.
So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.
You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!
Xanthan gum is used as a stabilizer and thickener within cosmetic products. It helps give products a sticky, thick feeling - preventing them from being too runny.
On the technical side of things, xanthan gum is a polysaccharide - a combination consisting of multiple sugar molecules bonded together.
Xanthan gum is a pretty common and great ingredient. It is a natural, non-toxic, non-irritating ingredient that is also commonly used in food products.