Peptide Skincare & BeautySkin science and ingredient guides

Skin science article

Allies of Skin Tranexamic & Arbutin Advanced Brightening Serum Versus Skin Functional Melanoclear

Allies of Skin Tranexamic & Arbutin Advanced Brightening Serum Versus Skin Functional Melanoclear This brightening serum is formulated around Tranexamic Acid and Alpha-Arbutin to fade the look of dark spots and brighten dull-looking skin. This brightening seru

Allies of Skin Tranexamic & Arbutin Advanced Brightening Serum Versus Skin Functional Melanoclear

This brightening serum is formulated around Tranexamic Acid and Alpha-Arbutin to fade the look of dark spots and brighten dull-looking skin.

This brightening serum is formulated around Tranexamic Acid and Mandelic Acid to fade the look of dark spots and refine skin texture.

What's inside

Key Ingredients

Benefits

Concerns

No concerns

Ingredients Side-by-side

Water

Caprylic/Capric Triglyceride

C13-15 Alkane

Tranexamic Acid

Glycerin

Alpha-Arbutin

Pentylene Glycol

Tocopheryl Acetate

Palmaria Palmata Extract

Hydrolyzed Pea

Asparagopsis Armata Extract

Ascophyllum Nodosum Extract

Glycyrrhiza Glabra Root Extract

Pancratium Maritimum Extract

Ganoderma Lucidum Extract

Lentinus Edodes Extract

Lactobacillus Ferment

Hydrolyzed Pea Protein

Diacetyl Boldine

Dipotassium Glycyrrhizate

Lactobacillus

Bisabolol

Panthenol

Tocopherol

Glucose

Arginine/Lysine Polypeptide

Pentapeptide-34 Trifluoroacetate

C14-22 Alcohols

Xanthan Gum

Hydrogenated Starch Hydrolysate

Hydroxyacetophenone

Sorbitan Caprylate

1,2-Hexanediol

Caprylyl Glycol

C12-20 Alkyl Glucoside

Propanediol

Carbomer

Sodium Phytate

Butylene Glycol

Sodium Chloride

Sodium Succinate

Sorbic Acid

Sodium Benzoate

Potassium Sorbate

Phenoxyethanol

Water, Caprylic/Capric Triglyceride, C13-15 Alkane, Tranexamic Acid, Glycerin, Alpha-Arbutin, Pentylene Glycol, Tocopheryl Acetate, Palmaria Palmata Extract, Hydrolyzed Pea, Asparagopsis Armata Extract, Ascophyllum Nodosum Extract, Glycyrrhiza Glabra Root Extract, Pancratium Maritimum Extract, Ganoderma Lucidum Extract, Lentinus Edodes Extract, Lactobacillus Ferment, Hydrolyzed Pea Protein, Diacetyl Boldine, Dipotassium Glycyrrhizate, Lactobacillus, Bisabolol, Panthenol, Tocopherol, Glucose, Arginine/Lysine Polypeptide, Pentapeptide-34 Trifluoroacetate, C14-22 Alcohols, Xanthan Gum, Hydrogenated Starch Hydrolysate, Hydroxyacetophenone, Sorbitan Caprylate, 1,2-Hexanediol, Caprylyl Glycol, C12-20 Alkyl Glucoside, Propanediol, Carbomer, Sodium Phytate, Butylene Glycol, Sodium Chloride, Sodium Succinate, Sorbic Acid, Sodium Benzoate, Potassium Sorbate, Phenoxyethanol

Mandelic Acid

Lactic Acid

Hydroxyethyl Urea

Glyceryl Polyacrylate

Kojic Acid

Beta-Glucan

Oryza Sativa Bran Extract

Rhodiola Rosea Extract

Hexylresorcinol

Lecithin

Niacinamide

Salicylic Acid

Polydextrose

Sodium Acrylates Copolymer

Dextrin

Ethylhexylglycerin

Amylopectin

Water, Butylene Glycol, Tranexamic Acid, Mandelic Acid, Lactic Acid, Glycerin, Hydroxyethyl Urea, Glyceryl Polyacrylate, Caprylic/Capric Triglyceride, Kojic Acid, Beta-Glucan, Oryza Sativa Bran Extract, Rhodiola Rosea Extract, Hexylresorcinol, Lecithin, Niacinamide, Salicylic Acid, Polydextrose, Sodium Acrylates Copolymer, Dextrin, Ethylhexylglycerin, Amylopectin, Phenoxyethanol

Reviews

Alternatives

Ingredients Explained

These ingredients are found in both products.

Ingredients higher up in an ingredient list are typically present in a larger amount.

Butylene Glycol (or BG) is used within cosmetic products for a few different reasons:

Overall, Butylene Glycol is a safe and well-rounded ingredient that works well with other ingredients.

Though this ingredient works well with most skin types, some people with sensitive skin may experience a reaction such as allergic rashes, closed comedones, or itchiness.

Caprylic/Capric Triglyceride (aka MCT Oil) is a lightweight emollient, solvent, and texture enhancer. It is considered a skin-softener by helping to prevent moisture loss.

Though it behaves like an oil, it is not technically one due to its chemical composition. One perk of this ingredient is that it is very stable, resistant to oxidation, and unlikely to go rancid.

In practice, that translates to a long shelf life and a consistently elegant skin feel.

While there is an assumption Caprylic Triglyceride can clog pores due to it being derived from coconut oil, there is no research supporting this. Just patch test if you have concerns.

Fractionated coconut oil and MCT Oil are both listed as Caprylic/Capric Triglyceride according to INCI. This is because INCI names are based on the ingredient’s final chemical composition and not its marketing name or source.

This ingredient is treated as the gold standard fungal acne safe oil. Even though it is coconut derived, the problematic lauric acid is stripped out.

This leaves just caprylic (C8) and capric (C10) acid. These chain lengths actually trend antifungal; a 2020 study found caprylic acid was enough to disrupt Malassezia furfur cell membrane, with a caprylic acid derivative damaging membrane structures at concentrations as low as 0.2%.

Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.

Topically, glycerin does several things at once:

Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.

Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.

This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.

Just know very high concentrations (>40%) can feel tacky in low humidity.

Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.

Phenoxyethanol is one of the most widely used preservatives in skincare (and for good reason!).

It has a large spectrum of antimicrobial activity and especially effective bacteria, yeast, and mold while only having a weak effect on your skin's natural microbiome.

On a cellular level, it disrupts the cell membranes of microbes by poking holes that make the cell leak. This shuts down the chemical reactions the microbe needs to make energy so it can no longer survive.

Another perk of this ingredient is that it stays functional across a wide pH range (3-10).

You'll often see it paired with boosters like Ethylhexylglycerin; one study showed that a 1:9 ratio of Ethylhexylglycerin to Phenoxyethanol damages bacterial membranes as effectively as doubling the Phenoxyethanol concentration on its own.

Typical use concentrations range from 0.3-1% depending on the formula, and this ingredient is capped at 1% int the EU.

Safety-wise, the fear mongering does not hold up to the evidence. The EU's Scientific Committee on Consumer Safety and FDA consider it safe as a preservative at up to 1%, including for children of all ages.

Adverse systemic effects only showed up in animal studies at exposures roughly 200x higher than what people get from cosmetics. And despite its very widespread use, this ingredient is a rare sensitizer and allergic reactions are uncommon.

Tranexamic Acid (TXA) is a synthetic lysine derivative that is becoming one of the most exciting brightening ingredients in skincare.

Originally used in medicine as an anti-hemorrhagic agent, its skin brightening potential was discovered by accident; patients taking it orally started noticing their melasma was fading.

Unlike most brighteners that target tyrosinase (the enzyme that synthesizes melanin), TXA works further upstream. It basically blocks your cells from receiving the signal to produce pigment.

This makes it one of the rare actives that works on three pathways at once:

This makes it effective for treating melasma, post-inflammatory hyperpigmentation (PIH), and sun-induced dark spots.

The most effective cosmetic concentration sits between 2-5% and going higher doesn't boost results.

Side effects are generally mild; occasional irritation, flaking, or dryness have been reported at the start of use. Overall, this ingredient is pretty well tolerated, even by sensitive skin types.

Another perk of this ingredient is that it does not cause photosensitivity, so it's safe to use in the AM and PM.

Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.

So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.

You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!

Similar Comparisons

The reference edit

Ingredients, questions
& further reading.

Connected source records selected through this article’s public topic index.

01

Formula cabinet

Ingredients & structured notes

Ingredient index

Ingredients Explained

  1. 01These ingredients are found in both products.
  2. 02Ingredients higher up in an ingredient list are typically present in a larger amount.
  3. 03This ingredient is a synthetic polymer used to stabilize formulas and give products a "gel-cream" feel.
  4. 04When applied, this ingredient mostly stays on the surface of skin. Safety reviews have found these polymers safe in cosmetics when made to proper quality standards. Testing also shows they’re unlikely to cause irritation or sensitization at normal u…
  5. 05Bisabolol is a gentle skin conditioner, antioxidant, and soothing ingredient.
  6. 06It's primary claim to fame is soothing and research shows topically applied bisabolol can quiet the chemical messengers that cause your skin to become inflamed, helping to sooth any irritation.
  7. 07A clinical study found that applying 0.5% bisabolol daily for 8 weeks produced an average 9% decrease in skin pigmentation. Researchers found it can also suppress the process that leads to excess melanin production in skin.
  8. 08In vitro studies found that bisabolol combined with propylene glycol significantly increased skin permeability by increasing lipid fluidity in the stratum corneum.
  9. 09You'll likely see use concentrations quite low, usually 0.1-0.2%.
  10. 10Overall, this is a well-tolerated ingredient that works well in formulas designed for sensitive, reactive, or post-procedure skin.
  11. 11Caffeine is a naturally occurring plant compound found in coffee beans, tea leaves, cocoa pods, and guarana.
  12. 12As an antioxidant, caffeine protects your skin from free radical damage caused by UV exposure and envionrmnetal stressors.
  13. 13Early research also shows that caffeine can help calm redness, soothe irritated skin, and support hair growth by stimulating microcirculation in the scalp.
  14. 14You might have seen eye creams marketing caffeine as a depuffing ingredient. This is because it is a vasoconstrictor meaning it can temporarily constrict blood vessels, though clinical evidence for this specific use is still limited.
  15. 15Most skincare products contain this ingredient at concentrations between 1-6%. It is able to penetrate skin easily regardless of skin type or thickness.
  16. 16Just so you know, a very small number of case reports describe caffeine-induced allergy. This ingredient is generally well-tolerated, non-irritating, and non-sensitizing for the majority of people.
  17. 17Caprylic/Capric Triglyceride (aka MCT Oil) is a lightweight emollient, solvent, and texture enhancer. It is considered a skin-softener by helping to prevent moisture loss.
  18. 18Though it behaves like an oil, it is not technically one due to its chemical composition. One perk of this ingredient is that it is very stable, resistant to oxidation, and unlikely to go rancid.
  19. 19In practice, that translates to a long shelf life and a consistently elegant skin feel.
  20. 20While there is an assumption Caprylic Triglyceride can clog pores due to it being derived from coconut oil, there is no research supporting this. Just patch test if you have concerns.
Source · skinsort.com
02

Product index

Related product references

03

Comparison edit

Read side by side