Skin science article
alpyn beauty Super Peptide & Ghostberry Moisturizer Versus iNNBEAUTY PROJECT Extreme Cream Firming & Lifting Moisturizer
alpyn beauty Super Peptide & Ghostberry Moisturizer Versus iNNBEAUTY PROJECT Extreme Cream Firming & Lifting Moisturizer This anti-aging moisturizer is formulated around Acetyl Hexapeptide-8 and Ceramide NP to soften the look of wrinkles and strengthen the ski
alpyn beauty Super Peptide & Ghostberry Moisturizer Versus iNNBEAUTY PROJECT Extreme Cream Firming & Lifting Moisturizer
This anti-aging moisturizer is formulated around Acetyl Hexapeptide-8 and Ceramide NP to soften the look of wrinkles and strengthen the skin barrier.
This anti-aging moisturizer is formulated around Squalane and Nicotiana Benthamiana Hexapeptide-40 Sh-Polypeptide-76 to soften the look of wrinkles and strengthen the skin barrier.
What's inside
Key Ingredients
Benefits
Concerns
Ingredients Side-by-side
Water
Glycerin
Caprylic/Capric/Myristic/Stearic Triglyceride
Caprylic/Capric Triglyceride
Squalane
Candelilla/Jojoba/Rice Bran Polyglyceryl-3 Esters
Coconut Alkanes
C12-16 Alcohols
Propanediol
Polyhydroxystearic Acid
Behenyl Alcohol
Glyceryl Stearate
Cetearyl Alcohol
Symphoricarpos Albus Fruit Extract
Acetyl Hexapeptide-8
Acetyl Octapeptide-3
Ceramide NP
Ceramide EOP
Ceramide Ns
Ceramide As
Ceramide AP
Glyceryl Citrate/Lactate/Linoleate/Oleate
1,2-Hexanediol
Cetearyl Olivate
Hydrogenated Lecithin
Nephelium Lappaceum Peel Extract
Palmitic Acid
Sodium Stearoyl Lactylate
Sorbitan Olivate
Caprylhydroxamic Acid
Coco-Caprylate/Caprate
Xanthan Gum
Simmondsia Chinensis Seed Oil
Tasmannia Lanceolata Fruit/Leaf Extract
Bisabolol
Sodium Hyaluronate
Hydrolyzed Sodium Hyaluronate
Tripeptide-29
Hydrolyzed Pea Protein
2,3-Butanediol
Leuconostoc/Radish Root Ferment Filtrate
Hydrolyzed Rice Protein
Cholesterol
Sodium Benzoate
Water, Glycerin, Caprylic/Capric/Myristic/Stearic Triglyceride, Caprylic/Capric Triglyceride, Squalane, Candelilla/Jojoba/Rice Bran Polyglyceryl-3 Esters, Coconut Alkanes, C12-16 Alcohols, Propanediol, Polyhydroxystearic Acid, Behenyl Alcohol, Glyceryl Stearate, Cetearyl Alcohol, Symphoricarpos Albus Fruit Extract, Acetyl Hexapeptide-8, Acetyl Octapeptide-3, Ceramide NP, Ceramide EOP, Ceramide Ns, Ceramide As, Ceramide AP, Glyceryl Citrate/Lactate/Linoleate/Oleate, 1,2-Hexanediol, Cetearyl Olivate, Hydrogenated Lecithin, Nephelium Lappaceum Peel Extract, Palmitic Acid, Sodium Stearoyl Lactylate, Sorbitan Olivate, Caprylhydroxamic Acid, Coco-Caprylate/Caprate, Xanthan Gum, Simmondsia Chinensis Seed Oil, Tasmannia Lanceolata Fruit/Leaf Extract, Bisabolol, Sodium Hyaluronate, Hydrolyzed Sodium Hyaluronate, Tripeptide-29, Hydrolyzed Pea Protein, 2,3-Butanediol, Leuconostoc/Radish Root Ferment Filtrate, Hydrolyzed Rice Protein, Cholesterol, Sodium Benzoate
C13-15 Alkane
Polyglyceryl-5 Polyricinoleate
Magnesium Sulfate
Panthenol
Glyceryl Behenate
Butylene Glycol
Heptapeptide-7
Acetyl Sh-Hexapeptide-5 Amide Acetate
Nicotiana Benthamiana Hexapeptide-40 Sh-Polypeptide-76
Tremella Fuciformis Extract
Allantoin
Oryza Sativa Bran Oil
Arginine
Glycosphingolipids
Phytosphingosine
Tetraacetylphytosphingosine
Polyglyceryl-6 Octastearate
Stearic Acid
Glyceryl Glucoside
Hydrogenated Polydecene
Lecithin
Tocopherol
Carnosine
Potassium Sorbate
Phenoxyethanol
Citric Acid
Quaternium-90 Bentonite
Mica
Triethyl Citrate
Zinc Stearate
Ethylhexylglycerin
Gluconolactone
Calcium Gluconate
Hydroxyacetophenone
Water, C13-15 Alkane, Squalane, Propanediol, Polyglyceryl-5 Polyricinoleate, Bisabolol, Coco-Caprylate/Caprate, Glycerin, Magnesium Sulfate, Panthenol, Glyceryl Behenate, 1,2-Hexanediol, Butylene Glycol, Heptapeptide-7, Acetyl Sh-Hexapeptide-5 Amide Acetate, Nicotiana Benthamiana Hexapeptide-40 Sh-Polypeptide-76, Ceramide AP, Ceramide EOP, Ceramide NP, Tremella Fuciformis Extract, Allantoin, Oryza Sativa Bran Oil, Arginine, Glycosphingolipids, Phytosphingosine, Cholesterol, Tetraacetylphytosphingosine, Polyglyceryl-6 Octastearate, Stearic Acid, Cetearyl Alcohol, Glyceryl Glucoside, Glyceryl Stearate, Hydrogenated Polydecene, Hydrogenated Lecithin, Lecithin, Xanthan Gum, Tocopherol, Carnosine, Potassium Sorbate, Sodium Benzoate, Phenoxyethanol, Citric Acid, Quaternium-90 Bentonite, Mica, Triethyl Citrate, Zinc Stearate, Ethylhexylglycerin, Gluconolactone, Calcium Gluconate, Hydroxyacetophenone
Reviews
Alternatives
Ingredients Explained
These ingredients are found in both products.
Ingredients higher up in an ingredient list are typically present in a larger amount.
1,2-Hexanediol is a synthetic liquid and another multi-functional powerhouse.
It is a:
Humectant, drawing moisture into the skin
Emollient, helping to soften skin
Solvent, dispersing and stabilizing formulas
Preservative booster, enhancing the antimicrobial activity of other preservatives
Bisabolol is a gentle skin conditioner, antioxidant, and soothing ingredient.
It's primary claim to fame is soothing and research shows topically applied bisabolol can quiet the chemical messengers that cause your skin to become inflamed, helping to sooth any irritation.
A clinical study found that applying 0.5% bisabolol daily for 8 weeks produced an average 9% decrease in skin pigmentation. Researchers found it can also suppress the process that leads to excess melanin production in skin.
In vitro studies found that bisabolol combined with propylene glycol significantly increased skin permeability by increasing lipid fluidity in the stratum corneum.
You'll likely see use concentrations quite low, usually 0.1-0.2%.
Overall, this is a well-tolerated ingredient that works well in formulas designed for sensitive, reactive, or post-procedure skin.
Ceramide AP is is a skin-identical lipid that mimics what your skin already makes naturally. Ceramides help maintain epidermal integrity and barrier function.
You'll often see this ingredient paired with other ceramides (like ceramide NP), cholesterol, or fatty acids because this combination best mimics the natural lipid mix your skin already has.
The skin's ability to produce ceramides gets disrupted in skin conditions like eczema. This in turn weakens the skin barrier and applying ceramides topically has been shown to replenish what's been lost to restore barrier function.
Most of the studies with Ceramide AP test it as part of a multi-ceramide complex; studies reinforce ceramide AP's role in rebalancing ceramides in skin and improving skin hydration.
Ceramide EOP is formally known as Ceramide 1.
It is naturally found in skin and part of the intercellular "mortar" holding everything together in your outermost layer.
EOP stands for a linked Ester fatty acid, a linked Omega hydroxy fatty acid, and the Phytosphingosine base.
What makes Ceramide EOP special is its ultra-long fatty acid chain; this unique structure allows it to bridge the lipid layers in your skin barrier to prevent water loss (something no other ceramide can do).
Low levels of Ceramide EOP have been found in people with eczema and psoriasis.
Using it together with other ceramides, cholesterol, and linoleic acid have been shown to meaningfully improve hydration and reduce water loss.
In one clinical study, a regimen using Ceramide EOP, NP, and AP led to significant symptom improvements in patients with eczema, psoriasis, and dry skin in just 4 weeks.
You'll usually see concentrations between 0.1-0.5% in formulations. Overall, this is a well-tolerated and safe ingredient for cosmetic use.
Ceramide NP (formerly known as Ceramide 3) is one of the skin's naturally occurring lipids.
Since ceramides are the major lipid components of the skin, they are crucial for maintaining skin barrier and hydration. Ceramide NP most closely mirrors the dominant kind in human skin amongst ceramide subtypes.
This ceramide works by slotting into gaps within the stratum corneum's lipid matrix to limit trans-epidermal water loss (TEWL) and shield the skin against external irritants.
A study with 312 patients found that using a ceramide-containing routine for 4 weeks reduced the severity of atopic dermatitis by over 61%.
Another clinical study in subjects aged 60 and older found that a ceramide body wash and moisturizer improved skin dryness and itchy skin in 15 days.
Overall, ceramides are considered non-irritating and safety tests have found little to no observable adverse effects from using this ingredient.
Ceramide NP is usually sourced from plants (like soybean or rice bran), or produced synthetically.
Cetearyl alcohol is a waxy mixture of two fatty alcohols: cetyl alcohol and stearyl alcohol. It is an emollient and emulsifier.
Despite having "alcohol" in its name, it has nothing to do with drying solvent alcohols; the FDA also allows "alcohol-free" products to contain fatty alcohols like this ingredient.
It plays several roles in a formula:
Typical use levels for this ingredient sit around 1-10% and the Cosmetic Ingredient Review Expert Panel has affirmed safety at concentrations up to 25% in leave-on products.
Multiple assessments have found it to be non-irritating and non-sensitizing to most people.
However, there have been some cases of allergic contact dermatitis in patients with chronically compromised skin barriers.
Cetearyl alcohol has a comedogenic rating of 2 and irritancy rating of 1. Both of these numbers come from the 1989 study that used rabbit ears; a "2" means mildly comedogenic and a "1" means low irritancy.
Here's the catch: rabbit skin is more sensitive than human skin and throws a lot of false positives. A 1996 reappraisal found that ingredients rated 1-2 in the rabbit ear tests are generally safe for humans.
Remember comedogenic ratings are unable to assess the entire formula of a product or how it will react on your skin. Just be sure to patch test if you are unsure about certain ingredients.
This ingredient is not fungal acne safe. Cetearyl alcohol is a fatty alcohol with chain lengths that fall within the range that Malassezia can metabolize.
A 2019 study has also observed Malassezia growth in the presence of this ingredient, confirming it to be not-fungal acne safe.
Cholesterol is a lipid that is naturally found in human skin and is one of the three key components of your skin barrier. In skincare, it is an emollient and barrier-repairing ingredient.
It works by fitting directly into the lipid layers of skin to help restore structure and reduce transepidermal water loss (TEWL).
This is a great ingredient for dry, compromised, or aging skin; our skin starts to produce less cholesterol with age.
Research shows cholesterol works best in combination with ceramides and fatty acids, the other two major components in your skin barrier.
Cholesterol is also a well-establish penetration enhancer and can help other actives absorb more effectively.
Cosmetic-grade cholesterol is usually derived from lanolin but plant and synthetic options also exist. We recommend reaching out to the brand if you have questions about their source of cholesterol.
Coco-Caprylate/Caprate is a lightweight ester created from coconut oil fatty acids, caprylic acid, and capric acid.
It is an emollient that helps soften skin and reduce transepidermal water loss (TEWL). What sets it apart from heavier emollients is its ultralight, non-greasy feel.
Once applied, this ingredient dries down quickly and leaves a dry, silky finish behind. This also helps improve spreadability and texture.
This ingredient has an excellent safety-record and is non-irritating.
Typical concentrations for cosmetics range from 0.5-62%.
Research on Malassezia growth found no growth on fatty acid esters with chain lengths shorter than 12 carbons (it prefers C11-24).
Since Coco-Caprylate/Caprate is built on C8 and C10 fatty acids, it is out of the range that Malassezia metabolizes, and therefore safe for fungal acne.
Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.
Topically, glycerin does several things at once:
Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.
Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.
This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.
Just know very high concentrations (>40%) can feel tacky in low humidity.
Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.
Glyceryl Stearate is made by reacting glycerin with stearic acid (typically sourced from plant oils like palm or coconut). It's an emulsifier, emollient, and mild occlusive.
Emulsifiers help ingredients like oil and water stay mixed so your formula stays nicely blended and uniform in texture.
This ingredient is typically used in concentrations between 1-10%. Studies have found it to be non-sensitizing, non-phototoxic, and non-photoallergenic.
A close cousin of this ingredient is Glyceryl Stearate SE ("self-emulsifying"). This just has a small amount of sodium or potassium stearate added so it can emulsify without a co-emulsifier.
Since this ingredient is an ester of a C18 fatty acid, it may not be fungal acne safe. The Malassezia yeast can potentially metabolize within the C11-C24 range.
Fun fact: The human body also creates Glyceryl Stearate naturally.
Hydrogenated Lecithin is a more stable version of lecithin.
It's made by taking lecithin (a phospholipid commonly found in soybeans and egg yolks) and hydrogenating it. This just means the unsaturated fatty acids are turned into saturated ones so they don't go bad as easily.
This ingredient is an emollient, emulsifier, and penetration enhancer. As an emollient, it helps soften and hydrate skin by trapping moisture within. As an emulsifier, it prevents oil and water ingredients from separating.
Hydrogenated Lecithin can form tiny spherical structures made of phospholipid bilayers called liposomes. These liposomes are able to capture compounds inside their structure and deliver them through the skin barrier.
Because phospholipids are a natural component of our cell membranes, this ingredient is inherently compatible with skin.
A 2021 study found lecithin-based surfactants were less harsh and more tolerable comared to Sodium Lauryl Sulfate (SLS).
Propanediol is an all-star ingredient. It softens, hydrates, and smooths the skin.
It’s often used to:
Propanediol is not likely to cause sensitivity and considered safe to use. It is derived from corn or petroleum with a clear color and no scent.
Sodium Benzoate is a preservative. It's used in both cosmetic and food products to inhibit the growth of mold and bacteria. It is typically produced synthetically.
Both the US FDA and EU Health Committee have approved the use of sodium benzoate. In the US, levels of 0.1% (of the total product) are allowed.
Sodium benzoate works as a preservative by inhibiting the growth of bacteria inside of cells. It prevents the cell from fermenting a type of sugar using an enzyme called phosphofructokinase.
It is the salt of benzoic acid. Foods containing sodium benzoate include soda, salad dressings, condiments, fruit juices, wines, and snack foods.
Studies for using ascorbic acid and sodium benzoate in cosmetics are lacking, especially in skincare routines with multiple steps.
We always recommend speaking with a professional, such as a dermatologist, if you have any concerns.
Squalane is the hydrogenated and shelf-stable form of squalene (a lipid that naturally occurs in human sebum).
It is an emollient and skin conditioning agent that is able to integrate seamlessly into the skin's lipid barrier without clogging pores.
This is due to how structurally similar it is to what your skin already produces.
Though it is mostly an emollient that helps soften and hydrate skin, it also has some humectant and occlusive action. Humectants help the skin retain moisture while occlusives seal it in, making squalane a triple-threat moisturizer.
Research shows it has antioxidant capabilities that help protect against stressors like UV exposure, specifically UVA induced oxidative stress. This study also found that it supports collagen biosynthesis in human dermal fibroblasts.
No clinical study has reported significant adverse effects and irritation reactions are very rare from this ingredient (even at 100% concentration).
Overall, it's a fantastic ingredient for hydration and is suitable for all skin types.
This depends on the source. Squalane can be derived from both plants and animals. Most squalane used in skincare comes from plants.
Please note: the source of squalane is only known if disclosed by the brand. We recommend reaching out to the brand if you have any questions about their squalane.
Read more about squalene with an "e".
Though squalane is often called an oil, it’s technically not one. It is a hydrocarbon, meaning it is only made of carbon and hydrogen. True oils are triglycerides and made of fatty acids and glycerol.
The term “oil-free” isn’t regulated so companies can define it however they want. Some exclude all oils, while others just avoid mineral oil or comedogenic oils.
Squalane has a comedogenic rating of 1 from the original 1972 study that tested raw ingredients under occlusion on rabbit ears. This system is not standardized or peer-reviewed, and using the raw ingredients is very different from how diluted cosmetic formulations are used on human skin.
A comedogenic rating of 1 means it is "unlikely to clog pores" according to the original rating system.
The overall formula of a product matters more than the individual ingredients on whether or not it will cause clogged pores.
Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.
So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.
You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!
Xanthan gum is used as a stabilizer and thickener within cosmetic products. It helps give products a sticky, thick feeling - preventing them from being too runny.
On the technical side of things, xanthan gum is a polysaccharide - a combination consisting of multiple sugar molecules bonded together.
Xanthan gum is a pretty common and great ingredient. It is a natural, non-toxic, non-irritating ingredient that is also commonly used in food products.