Peptide Skincare & BeautySkin science and ingredient guides

Skin science article

ananné Solacium Fine Molecular Repair Serum Versus ananné Nutricium Glow Lifting Serum

ananné Solacium Fine Molecular Repair Serum Versus ananné Nutricium Glow Lifting Serum This barrier-repair serum is formulated around Limnanthes Alba Seed Oil and Simmondsia Chinensis Seed Oil to strengthen the skin barrier and hydrate skin. This hydrating ser

ananné Solacium Fine Molecular Repair Serum Versus ananné Nutricium Glow Lifting Serum

This barrier-repair serum is formulated around Limnanthes Alba Seed Oil and Simmondsia Chinensis Seed Oil to strengthen the skin barrier and hydrate skin.

This hydrating serum is formulated around Limnanthes Alba Seed Oil and Simmondsia Chinensis Seed Oil to hydrate skin and strengthen the skin barrier.

What's inside

Key Ingredients

Benefits

Concerns

Ingredients Side-by-side

Limnanthes Alba Seed Oil

Simmondsia Chinensis Seed Oil

Pistacia Vera Seed Oil

Prunus Amygdalus Dulcis Oil

Caprylic/Capric Triglyceride

Argania Spinosa Kernel Oil

Oenothera Biennis Oil

Punica Granatum Seed Oil

Persea Gratissima Oil

Citrus Aurantium Amara Peel

Bisabolol

Laminaria Ochroleuca Extract

Limonene

Alaria Esculenta Extract

Butyrospermum Parkii Butter

Tocopherol

Linalool

Hydrogenated Vegetable Oil

Polygonum Fagopyrum Seed Extract

Citral

Limnanthes Alba Seed Oil, Simmondsia Chinensis Seed Oil, Pistacia Vera Seed Oil, Prunus Amygdalus Dulcis Oil, Caprylic/Capric Triglyceride, Argania Spinosa Kernel Oil, Oenothera Biennis Oil, Punica Granatum Seed Oil, Persea Gratissima Oil, Citrus Aurantium Amara Peel, Bisabolol, Laminaria Ochroleuca Extract, Limonene, Alaria Esculenta Extract, Butyrospermum Parkii Butter, Tocopherol, Linalool, Hydrogenated Vegetable Oil, Polygonum Fagopyrum Seed Extract, Citral

Prunus Armeniaca Kernel Oil

Limnanthes Alba Seed Oil, Prunus Amygdalus Dulcis Oil, Simmondsia Chinensis Seed Oil, Argania Spinosa Kernel Oil, Pistacia Vera Seed Oil, Prunus Armeniaca Kernel Oil, Caprylic/Capric Triglyceride, Oenothera Biennis Oil, Persea Gratissima Oil, Alaria Esculenta Extract, Bisabolol, Butyrospermum Parkii Butter, Tocopherol, Hydrogenated Vegetable Oil, Polygonum Fagopyrum Seed Extract

Alternatives

Ingredients Explained

These ingredients are found in both products.

Ingredients higher up in an ingredient list are typically present in a larger amount.

Alaria Esculenta Extract is derived from a brown seaweed called badderlocks.

Alaria Esculenta Extract has antioxidant and hydrating properties.

You may know this ingredient as argan oil. It has emollient and skin conditioning properties that help soften skin and reinforce the lipid barrier.

The fatty acid profile of argan oil is roughly 45-55% oleic acid, 28-36% linoleic acid, 10-15% palmitic acid, and 5-7% stearic acid. It also contains vitamin E, sterols, squalene, and polyphenols like ferulic acid.

Two clinical studies in postmenopausal women found that applying argan oil for 60 days significantly improved skin elasticity and moisturization (reduced transepidermal water loss and increased epidermal water content).

Since it is high in oleic and linoleic acid, this ingredient may not be fungal acne safe. Both of these fall in the C11-C24 range that Malassezia yeast can metabolize.

Bisabolol is a gentle skin conditioner, antioxidant, and soothing ingredient.

It's primary claim to fame is soothing and research shows topically applied bisabolol can quiet the chemical messengers that cause your skin to become inflamed, helping to sooth any irritation.

A clinical study found that applying 0.5% bisabolol daily for 8 weeks produced an average 9% decrease in skin pigmentation. Researchers found it can also suppress the process that leads to excess melanin production in skin.

In vitro studies found that bisabolol combined with propylene glycol significantly increased skin permeability by increasing lipid fluidity in the stratum corneum.

You'll likely see use concentrations quite low, usually 0.1-0.2%.

Overall, this is a well-tolerated ingredient that works well in formulas designed for sensitive, reactive, or post-procedure skin.

This ingredient is also known as shea butter. It is a plant-derived extract from the nuts of the Africa shea tree and one of the most well-studied emollients.

Because it has a high concentration of fatty acids (primarily oleic, stearic, and linoleic) it is able to form a protective barrier on the skin's surface. This helps seal in moisture and prevents transepidermal water loss (TEWL).

In vitro research found an increase in skin hydration by 58% and a decrease in TEWL by 37.8% after 24 hours of applying this ingredient (pretty impressive for a single ingredient!).

Besides hydration, shea butter also contains triterpenes that have anti-inflammatory potential. In particule, lupeol cinnamate has shown the highest anti-inflammatory activity in vivo.

Shea butter also contains vitamins A and E which may contribute to antioxidant activity.

While Shea Butter has an SPF rating of about 3-4, it is not a sunscreen replacement.

This ingredient may not be fungal acne safe because its fatty acids fall within the C11-C24 range that the Malassezia yeast can metabolize.

Caprylic/Capric Triglyceride (aka MCT Oil) is a lightweight emollient, solvent, and texture enhancer. It is considered a skin-softener by helping to prevent moisture loss.

Though it behaves like an oil, it is not technically one due to its chemical composition. One perk of this ingredient is that it is very stable, resistant to oxidation, and unlikely to go rancid.

In practice, that translates to a long shelf life and a consistently elegant skin feel.

While there is an assumption Caprylic Triglyceride can clog pores due to it being derived from coconut oil, there is no research supporting this. Just patch test if you have concerns.

Fractionated coconut oil and MCT Oil are both listed as Caprylic/Capric Triglyceride according to INCI. This is because INCI names are based on the ingredient’s final chemical composition and not its marketing name or source.

This ingredient is treated as the gold standard fungal acne safe oil. Even though it is coconut derived, the problematic lauric acid is stripped out.

This leaves just caprylic (C8) and capric (C10) acid. These chain lengths actually trend antifungal; a 2020 study found caprylic acid was enough to disrupt Malassezia furfur cell membrane, with a caprylic acid derivative damaging membrane structures at concentrations as low as 0.2%.

Hydrogenated Vegetable Oil is created by adding hydrogen to vegetable oil in order to give it more stability. This process also raises the melting point of vegetable oil. In cosmetics, it is an emollient.

Emollients help soothe and soften the skin. They do this by creating a protective film on your skin. This barrier helps trap moisture and keeps your skin hydrated. Emollients may be effective at treating dry or itchy skin.

The term "Hydrogenated Vegetable Oil" is an umbrella term and can refer to a variety of vegetable oils and blends of: sunflower oil, soybean oil, olive oil, coconut oil, palm oil, and more.

Due to the differences in vegetables, the benefits may vary.

Limnanthes Alba Seed Oil is from the seeds of the meadowfoam plant. It is a skin conditioning agent and emollient that sits on top of skin to soften and hydrate it.

Over 98% of the oil is made up of long-chain fatty acids, mostly aachidic acid (61%), docosenoic acid (~16%), and docosadienoic acid (~18%).

This combination is not really found in any other plant oil and is the reason this is one of the most stable botanical oils available.

Some studies show it to be more stable than jojoba oil, helps a product resist going rancid, and can help extend the shelf life of a formula.

It also naturally contains vitamin E and phytosterols that give it a mild antioxidant benefit.

This ingredient is typically used from around 1% to fairly high levels since it's gentle; it's well-tolerated and low on the irritation scale.

Oenothera Biennis Oil (aka Evening Primrose Oil) is a non-fragrant oil from the evening primrose. Like other botanical oils, it is an emollient that helps hydrate and nourish skin.

It has an interesting fatty acid profile: linoleic (70-74%) and γ-linolenic (8-10%), with some amounts ofoleic palmitic, and stearic acids.

The gamma-linoleic acid (GLA) is the headliner here; it's relatively rare in plant oils and acts as a precursor for anti-inflammatory signaling molecules in the skin.

There's a mixed body of clinical research with this ingredient as well, mostly on eczema/atopic dermatitis skin.

Some controlled trials showed improvement in inflammation, dryness, scaling, and overall severity. Other studies and large meta-analysis failed to show a significant effect; the honest takeaway here is "promising but inconsistent" rather than "miracle oil".

On the safety front, this ingredient is found to be safe as used in cosmetics and even has a history of safe food use.

Since this oil is contains oleic acid and palmitic acid, it may not be fungal acne safe. The Malassezia yeast feeds on fatty acids with carbon chain lengths between C11-C24. Oleic Acid sits at C18 and Palmitic acid sits at C16.

In vitro studies have shown that oleic acid and palmitic acid are some of the fatty acids that induce rapid Malassezia growth in lab settings.

This ingredient is also known as Avocado oil. It's the cold-pressed oil from the flesh of the avocado fruit packed with fatty acids (mostly oleic acid).

The rich fatty acid profile allows it to function as a skin conditioning agent and emollient; it helps soften and smooth skin while reducing water loss.

Preclinical research has found that topical avocado oil increased collagen synthesis and reduced inflammation during wound healing, giving it some skin-repairing credibility.

The unsaponifiable fraction of the oil is also interesting: studies on avocado unsaponifiables showed that it helped skin produce more collagen and other structural compounds that support healing.

The CIR Expert Panel has found this ingredient to be non-irritating in formulations.

It's a great ingredient for dry or compromised skin. Just know it may not be fungal acne safe. This is because the oleic acid content falls within the range that Malassezia can use as a food source.

This ingredient is also known as pistachio seed oil.

We don't have a description for Polygonum Fagopyrum Seed Extract yet.

This ingredient is also known as sweet almond oil. It is a lightweight, cold-pressed oil from the ripe seeds of the sweet almond tree.

Sweet almond oil is rich in skin-nourishing fatty acids such as oleic acid (55-86%) and linolenic acid (7-35%).

As an emollient, it softens and hydrates skin by forming a thin barrier that locks in moisture.

Clinical studies have found it to be non-irritating and non-sensitizing. The CIR Expert Panel has evaluated the available safety data and concluded it is safe for topical use.

Because of the oleic acid content, this ingredient may not be fungal acne safe.

Jojoba oil is one of the most well-studied plant-derived ingredients in cosmetics. It is an emollient with a special structure.

Because it is made up of 97-98% wax esters, it closely mirrors the linear monoesters found in human sebum. This makes it skin compatible, non-greasy, and lightweight.

Unlike other plant oils, jojoba wax doesn't easily penetrate skin. It mostly works in the uppermost layers as an emollient. This just means it forms a light barrier on the skin to help retain moisture.

Formulations with jojoba esters up to 90% reduced transepidermal water loss (TEWL) and increased barrier recovery by 81% (outperforming bisabolol at 47%).

Besides barrier support, the science also suggests jojoba to have anti-inflammatory effects and potential applications for skin infections, aging, and wound healing.

Fun fact: Indigenous cultures have used jojoba as a moisturizer and to help treat burns for centuries.

Fungal acne: The Malassezia yeast is known to metabolize fatty acids in the C11-24 range and jojoba's dominant fatty acid components fall into this range. This ingredient may not be fungal acne safe.

Tocopherol is a fat-soluble antioxidant known as Vitamin E.

You'll find this ingredient in the vast majority of skincare (for good reason). It works to neutralize free radicals, or unstable molecules generated by UV exposure, pollution, and other environmental stressors, before they can cause oxidative damage to your skin cells.

Topically applied tocopherol has been shown to protect against UV damage by ramping up the skin's own natural defense enzymes.

It also acts as a skin conditioning agent; some studies show that regular topical use can improve the skin's water-binding capacity over 2-4 weeks.

This ingredient is especially loved for being a team player. When combined with Vitamin C, the photoprotective effect of both ingredients roughly doubles and the combo also helps reduce UV-induced DNA damage.

This ingredient has some brightening potential but it's more of a prevention ingredient than spot-fader. Cell studies show it can slow down melanin production but it's worth noting that it's not the most powerful brightener out there.

In formulations, it also serves as a stabilizer that helps protect other oxidation-prone ingredients from degrading.

Concentrations usually range from 0.1-1% in most leave-on products.

Similar Comparisons

The reference edit

Ingredients, questions
& further reading.

Connected source records selected through this article’s public topic index.

01

Formula cabinet

Ingredients & structured notes

Ingredient index

Dr. Barbara Stürm Lifting SerumIngredients explained

  1. 01Good old water, aka H2O. The most common skincare ingredient of all. You can usually find it right in the very first spot of the ingredient list, meaning it’s the biggest thing out of all the stuff that makes up the product.
  2. 02It’s mainly a solvent for ingredients that do not like to dissolve in oils but rather in water.
  3. 03Expand to read more
  4. 04Once inside the skin, it hydrates, but not from the outside - putting pure water on the skin (hello long baths!) is drying.
  5. 05One more thing: the water used in cosmetics is purified and deionized (it means that almost all of the mineral ions inside it is removed). Like this, the products can stay more stable over time.
  6. 06Butylene glycol, or let’s just call it BG, is a multi-tasking colorless, syrupy liquid. It’s a great pick for creating a nice feeling product.
  7. 07BG’s main job is usually to be a solvent for the other ingredients. Other tasks include helping the product to absorb faster and deeper into the skin (penetration enhancer), making the product spread nicely over the skin (slip agent), and attracting…
  8. 08It’s an ingredient whose safety hasn’t been questioned so far by anyone (at least not that we know about). BG is approved by Ecocert and is also used enthusiastically in natural products. BTW, it’s also a food additive.
  9. 09We don't have description for this ingredient yet.
  10. 10A handy helper ingredient (a polymer, i.e. big molecule from repeated subunits) that is used to stabilize emulsions as well as to thicken up products. It can also stabilize foam in cleansing products.
  11. 11If you ever wondered what those little Listerine breath strips were made of, you found your answer! Pullulan is a polysaccharide polymer, which basically means that it’s a big molecule made up of smaller sugar molecule units.
  12. 12It dissolves in water and can make a thin, elastic, and moisture-absorbing film when spread on the skin that can cause an instant tightening effect. It can also be used as a thickener to get a silicone-like feel and can be used in peel-off masks. Bt…
  13. 13It’s the - sodium form - cousin of the famous NMF, hyaluronic acid (HA). If HA does not tell you anything we have a super detailed, geeky explanation about it here. The TL; DR version of HA is that it's a huge polymer (big molecule from repeated sub…
  14. 14As far as skincare goes, sodium hyaluronate and hyaluronic acid are pretty much the same and the two names are used interchangeably. As cosmetic chemist kindofstephen writes on reddit "sodium hyaluronate disassociates into hyaluronic acid molecule a…
  15. 15In spite of this, if you search for "hyaluronic acid vs sodium hyaluronate" you will find on multiple places that sodium hyaluronate is smaller and can penetrate the skin better. Chemically, this is definitely not true, as the two forms are almost t…
  16. 16What seems to be a true difference, though, is that the salt form is more stable, easier to formulate and cheaper so it pops up more often on the ingredient lists.
  17. 17If you wanna become a real HA-and-the-skin expert you can read way more about the topic at hyaluronic acid (including penetration-questions, differences between high and low molecular weight versions and a bunch of references to scientific literature).
  18. 18It's an alternative, natural preservative that comes from radishes fermented with Leuconostoc kimchii, a lactic acid bacteria that has been used to make traditional Korean dish, kimchi. During the fermentation process, a peptide is secreted from the…
  19. 19It is one of the more promising natural preservatives that can be used even alone (recommended at 2-4%), but it's not as effective as more common alternatives, like parabens or phenoxyethanol.
  20. 20It’s pretty much the current IT-preservative. It’s safe and gentle, but even more importantly, it’s not a feared-by-everyone-mostly-without-scientific-reason paraben.
Source · incidecoder.com
02

Product index

Related product references

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Mediheal Pdrn Lifting Serum

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Source: incidecoder.comView reference →

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Omorovicza Rose Lifting Serum Omorovicza Rose Lifting Serum ingredients explained: Aqua (Hungarian Thermal Water), Glycerin, Corundum (Pro Ruby Crystal), Phospholipids, Ethyl Alcohol, Pheno…

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03

Comparison edit

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