Peptide Skincare & BeautySkin science and ingredient guides

Skin science article

Anua Nano Retinol 0.3% + Niacin Renewing Serum Versus Beauty of Joseon Glow Serum: Propolis + Niacinamide

Anua Nano Retinol 0.3% + Niacin Renewing Serum Versus Beauty of Joseon Glow Serum: Propolis + Niacinamide This anti-aging serum is formulated around Niacinamide and Retinol to soften the look of wrinkles and refine skin texture. This acne serum is formulated a

Anua Nano Retinol 0.3% + Niacin Renewing Serum Versus Beauty of Joseon Glow Serum: Propolis + Niacinamide

This anti-aging serum is formulated around Niacinamide and Retinol to soften the look of wrinkles and refine skin texture.

This acne serum is formulated around Propolis Extract and Niacinamide to clear breakouts and brighten dull-looking skin.

What's inside

Key Ingredients

Benefits

Concerns

Ingredients Side-by-side

Water

Glycereth-26

Niacinamide 5%

Pyrus Malus Fruit Extract

Glycerin

1,2-Hexanediol

Caprylic/Capric Triglyceride

Castanea Crenata Shell Extract

Glyceryl Citrate/Lactate/Linoleate/Oleate

Diospyros Kaki Leaf Extract

Coptis Japonica Root Extract

Potentilla Anserina Extract

Avena Sativa Kernel Extract

Cynara Scolymus Leaf Extract

Portulaca Oleracea Extract

Melaleuca Alternifolia Leaf Extract

Ficus Carica Fruit Extract

Centella Asiatica Extract

Camellia Sinensis Leaf Extract

Artemisia Capillaris Flower Extract

Arnica Montana Flower Extract

Houttuynia Cordata Extract

Melia Azadirachta Leaf Extract

Lavandula Angustifolia Flower Extract

Chamomilla Recutita Flower/Leaf Extract

Borago Officinalis Extract

Centaurea Cyanus Flower Extract

Hydrogenated Lecithin

Camellia Sinensis Leaf Water

Centaurea Cyanus Flower Water

Sodium Hyaluronate

Melaleuca Alternifolia Leaf Oil

Carapa Guaianensis Seed Oil

Hippophae Rhamnoides Acid

Tocopherol

Cetyl Ethylhexanoate

Ammonium Acryloyldimethyltaurate/Vp Copolymer

Pentaerythrityl Tetra-Di-T-Butyl Hydroxyhydrocinnamate

Polyacrylate Crosspolymer-6

Methylpropanediol

Butylene Glycol

Polysorbate 20

Retinol 0.1%

Ceramide NP

Pentylene Glycol

Carbomer

Tromethamine

Dipotassium Glycyrrhizate

Ethylhexylglycerin

Adenosine

Disodium EDTA

Polyquaternium-51

Squalane

Panthenol

Hydrolyzed Sodium Hyaluronate

BHT

Oleic Acid

Dipropylene Glycol

BHA

Allantoin

Maltodextrin

Saccharide Hydrolysate

Sorbitan Laurate

Glyceryl Stearate

Butyrospermum Parkii Butter

Octyldodecanol

Phytosterols

Madecassoside

Ceramide As

Ceramide AP

Capryloyl Salicylic Acid

Cholesterol

Hydroxyethylcellulose

Acetyl Dipeptide-1 Cetyl Ester

Ceramide Ns

Ceramide Ng

Caprylyl Glycol

Guaiazulene

Sucrose Distearate

Nonapeptide-1

Acetyl Hexapeptide-8

Copper Tripeptide-1

Tripeptide-1

Palmitoyl Tetrapeptide-7

Palmitoyl Tripeptide-1

Palmitoyl Pentapeptide-4

Hydroxypropyl Cyclodextrin

Hexapeptide-9

Ceramide EOP

Water, Glycereth-26, Niacinamide 5%, Pyrus Malus Fruit Extract, Glycerin, 1,2-Hexanediol, Caprylic/Capric Triglyceride, Castanea Crenata Shell Extract, Glyceryl Citrate/Lactate/Linoleate/Oleate, Diospyros Kaki Leaf Extract, Coptis Japonica Root Extract, Potentilla Anserina Extract, Avena Sativa Kernel Extract, Cynara Scolymus Leaf Extract, Portulaca Oleracea Extract, Melaleuca Alternifolia Leaf Extract, Ficus Carica Fruit Extract, Centella Asiatica Extract, Camellia Sinensis Leaf Extract, Artemisia Capillaris Flower Extract, Arnica Montana Flower Extract, Houttuynia Cordata Extract, Melia Azadirachta Leaf Extract, Lavandula Angustifolia Flower Extract, Chamomilla Recutita Flower/Leaf Extract, Borago Officinalis Extract, Centaurea Cyanus Flower Extract, Hydrogenated Lecithin, Camellia Sinensis Leaf Water, Centaurea Cyanus Flower Water, Sodium Hyaluronate, Melaleuca Alternifolia Leaf Oil, Carapa Guaianensis Seed Oil, Hippophae Rhamnoides Acid, Tocopherol, Cetyl Ethylhexanoate, Ammonium Acryloyldimethyltaurate/Vp Copolymer, Pentaerythrityl Tetra-Di-T-Butyl Hydroxyhydrocinnamate, Polyacrylate Crosspolymer-6, Methylpropanediol, Butylene Glycol, Polysorbate 20, Retinol 0.1%, Ceramide NP, Pentylene Glycol, Carbomer, Tromethamine, Dipotassium Glycyrrhizate, Ethylhexylglycerin, Adenosine, Disodium EDTA, Polyquaternium-51, Squalane, Panthenol, Hydrolyzed Sodium Hyaluronate, BHT, Oleic Acid, Dipropylene Glycol, BHA, Allantoin, Maltodextrin, Saccharide Hydrolysate, Sorbitan Laurate, Glyceryl Stearate, Butyrospermum Parkii Butter, Octyldodecanol, Phytosterols, Madecassoside, Ceramide As, Ceramide AP, Capryloyl Salicylic Acid, Cholesterol, Hydroxyethylcellulose, Acetyl Dipeptide-1 Cetyl Ester, Ceramide Ns, Ceramide Ng, Caprylyl Glycol, Guaiazulene, Sucrose Distearate, Nonapeptide-1, Acetyl Hexapeptide-8, Copper Tripeptide-1, Tripeptide-1, Palmitoyl Tetrapeptide-7, Palmitoyl Tripeptide-1, Palmitoyl Pentapeptide-4, Hydroxypropyl Cyclodextrin, Hexapeptide-9, Ceramide EOP

Propolis Extract

Niacinamide

Melia Azadirachta Flower Extract

Curcuma Longa Root Extract

Ocimum Sanctum Leaf Extract

Theobroma Cacao Seed Extract

Corallina Officinalis Extract

Lotus Corniculatus Seed Extract

Calophyllum Inophyllum Seed Oil

Betaine Salicylate

Sodium Polyacryloyldimethyl Taurate

Polyglyceryl-10 Laurate

Dextrin

Octanediol

Xanthan Gum

Propolis Extract, Dipropylene Glycol, Glycerin, Butylene Glycol, Water, Niacinamide, 1,2-Hexanediol, Melia Azadirachta Flower Extract, Melia Azadirachta Leaf Extract, Sodium Hyaluronate, Curcuma Longa Root Extract, Ocimum Sanctum Leaf Extract, Theobroma Cacao Seed Extract, Melaleuca Alternifolia Leaf Extract, Centella Asiatica Extract, Corallina Officinalis Extract, Lotus Corniculatus Seed Extract, Calophyllum Inophyllum Seed Oil, Betaine Salicylate, Sodium Polyacryloyldimethyl Taurate, Tromethamine, Polyglyceryl-10 Laurate, Caprylyl Glycol, Ethylhexylglycerin, Dextrin, Pentylene Glycol, Octanediol, Tocopherol, Xanthan Gum, Carbomer

Reviews

Alternatives

Ingredients Explained

These ingredients are found in both products.

Ingredients higher up in an ingredient list are typically present in a larger amount.

1,2-Hexanediol is a synthetic liquid and another multi-functional powerhouse.

It is a:

Humectant, drawing moisture into the skin

Emollient, helping to soften skin

Solvent, dispersing and stabilizing formulas

Preservative booster, enhancing the antimicrobial activity of other preservatives

Butylene Glycol (or BG) is used within cosmetic products for a few different reasons:

Overall, Butylene Glycol is a safe and well-rounded ingredient that works well with other ingredients.

Though this ingredient works well with most skin types, some people with sensitive skin may experience a reaction such as allergic rashes, closed comedones, or itchiness.

Caprylyl Glycol is a humectant, skin conditioner, emollient, and preservative booster derived from either caprylic acid or synthetically created.

Typical use levels vary from 0.3-1% as a preservative booster and go up to 2% to condition skin.

Because it is not a free-fatty acid, this ingredient is fungal acne safe (there's nothing for Malassezia to feed on).

Carbomer is a synthetic thickening and gelling agent. It's basically the ingredient that gives a lot of serums, gels, creams, and sunscreens their smooth, non-sticky texture.

Although legally permitted at very high levels, carbomers are normally used at concentrations below 1%.

It also needs to be neutralized to actually thicken, and because it is a large molecule, it doesn't really penetrate the skin barrier.

Allergy-wise, the risk is very low. Clinical studies show carbomers have low potential for skin irritation/sensitization even at concentrations up to 100%.

A 2024 UK study patch-tested 1,302 patients and found true allergy to the parent group of carbomer to be rare with no confirmed relevant reactions.

Centella Asiatica Extract (Centella) is one of the most researched botanical extracts in skincare with decades of studies backing its effects on inflammation, collagen, and the skin barrier.

That research keeps pointing back to the same four triterpenoid saponins: Asiaticoside, Madecassoside, Asiatic Acid, and Madecassic Acid.

These compounds allow centella to dial back inflammation, encourage the skin to build and hold onto collagen, support the barrier and hydration, and bring solid antioxidant activity to protect against signs of aging.

Centella also carries a nice supporting cast of Vitamin A, vitamin C, several B vitamins, and amino acids. Put it all together and you get an ingredient that soothes, hydrates, and protects, all at once.

Most of centella's magic comes from the four big compounds (Asiaticoside, Madecassoside, Asiatic Acid, and Madecassic Acid). These are the actives doing the heavy lifting in almost every centella study.

Here is the short version of what they do in the skin:

So it is not just soothing for the sake of soothing. Centella calms the skin AND helps it rebuild.

Just FYI, not all centella on an ingredient list is the same. What you are getting actually depends on the extract:

Fun fact on the ratios: the leaves tend to be richest in Madecassoside and Asiaticoside, and lower in the two acids. The exact amounts shift with where the plant is grown and how it is processed. This means purity really does vary brand to brand.

Centella is one of the most easygoing actives out there.

It layers well with basically everything: niacinamide, hyaluronic acid, peptides, and vitamin C, and also pairs nicely with stronger actives like retinoids and exfoliating acids where it can help take the edge off irritation.

On the safety side, centella and its triterpenes are classified as weak sensitizers, meaning allergic reactions are possible but uncommon.

Patch tests at 1% and 5% came back negative in test panels, and creams at typical use levels did not cause allergic reactions across large groups of people.

But as with any new active, a patch test is still a smart move for very reactive skin.

Centella is widely used because it is effective at low percentages. For context, human safety testing found no meaningful irritation from creams containing centella extract at everyday use levels (the tested amounts were well under 1%).

The irritancy threshold in animal testing was also above 30% (so real-world formulas sit far below anything concerning).

In collagen lab studies, higher concentrations drove more collagen synthesis, so serums built around centella tend to feature it more prominently.

Bottom line: you will find centella working nicely anywhere from a fraction of a percent up to hero-ingredient levels depending on whether it is a supporting soother or the main event.

Fun fact: Centella has been used as a medicine and in food for many centuries. As a medicine, it is used to treat burns, scratches, and wounds.

Dipropylene Glycol is a synthetically created humectant, stabilizer, and solvent.

This ingredient helps:

Dipropylene glycol is technically an alcohol, but it belongs to the glycol family (often considered part of the ‘good’ alcohols). This means it is hydrating and gentle on skin unlike drying solvent alcohols like denatured alcohol.

As a masking agent, Dipropylene Glycol can be used to cover the smell of other ingredients. However, it does not have a scent.

Studies show Dipropylene Glycol is considered safe to use in skincare.

Ethylhexylglycerin is created from glycerin. It is a multitasker ingredient that:

The CIR Expert Panel found minimal skin absorption or sensitization of any kind in a safety assessment. Though this ingredient is considered well-tolerated, a small number of cases of allergic dermatitis have been published since 2002. Just be sure to patch test if you are unsure.

Industry-reported use ranges from 8% in rinse-off products and 2% in leave-on formulations.

Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.

Topically, glycerin does several things at once:

Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.

Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.

This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.

Just know very high concentrations (>40%) can feel tacky in low humidity.

Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.

Melaleuca Alternifolia Leaf Extract comes from the Tea Tree, Melaleuca alternifolia, Myrtaceae. This tea tree is native to Australia.

Tea Leaf extract contains antimicrobial and anti-acne properties.

This ingredient has perfuming properties and contains linalool and limonene. These fragrance and terpinen components can cause skin sensitivity.

Learn more about the benefits of Tea Tree Oil here.

This ingredient is also known as neem leaf extract. It contains natural compounds like nimbidin, quercetin, and other polyphenols that give it antibacterial, antifungal, and anti-inflammatory activity.

Lab studies have shown neem leaf extract can inhibit acne-related bacteria and help calm skin. Animal studies on wound gels using 1-3% neem leaf extract found it sped up healing without causing irritation.

A wound-healing study testing gels with the extract at 1%, 2%, and 3% concentrations and found none of them irritated the skin.

Most commercial products also use it in a similar low range (typically under 5%).

Allergy-wise, there are some case reports on neem oil causing allergic contact dermatitis so people with plant/botanical sensitivities may want to patch test first.

Niacinamide is a multitasking form of vitamin B3 that strengthens the skin barrier, reduces pores and dark spots, regulates oil, and improves signs of aging.

And the best part? It's gentle and well-tolerated by most skin types, including sensitive and reactive skin.

You might have heard of "niacin flush", or the reddening of skin that causes itchiness. Niacinamide has not been found to cause this.

In very rare cases, some individuals may not be able to tolerate niacinamide at all or experience an allergic reaction to it.

If you are experiencing flaking, irritation, and dryness with this ingredient, be sure to double check all your products as this ingredient can be found in all categories of skincare.

When incorporating niacinamide into your routine, look out for concentration amounts. Typically, 5% niacinamide provides benefits such as fading dark spots. However, if you have sensitive skin, it is better to begin with a smaller concentration.

When you apply niacinamide to your skin, your body converts it into nicotinamide adenine dinucleotide (NAD). NAD is an essential coenzyme that is already found in your cells as "fuel" and powers countless biological processes.

In your skin, NAD helps repair cell damage, produce new healthy cells, support collagen production, strengthen the skin barrier, and fight environmental stressors (like UV and pollution).

Our natural NAD levels start to decline with age, leading to slower skin repair, visible aging, and a weaker skin barrier. By providing your skin niacinamide, you're recharging your skin's NAD levels. This leads to stronger, healthier, and younger looking skin.

Another name for vitamin B3 is nicotinamide. This vitamin is water-soluble and our bodies don't store it. We obtain Vitamin B3 from either food or skincare. Meat, fish, wheat, yeast, and leafy greens contain vitamin B3.

The type of niacinamide used in skincare is synthetically created.

Pentylene Glycol (1,2-pentanediol) is a multitasking little diol with three main roles in a formula:

Research on alkanediols (the family pentylene glycol belongs to) show they work by disrupting microbial cell membranes. This disruption helps the primary preservative system in a product work more effectively at lower doses.

On the safety side, the Cosmetic Ingredient Review Expert Panel has concluded this ingredient to be safe as used in current cosmetic practices + concentrations.

Typical use levels in a formula run about 1-5%.

Sodium Hyaluronate is the salt form of hyaluronic acid. It is a long sugar chain that is naturally found in your skin, joints, and connective tissue that maintains hydration and elasticity.

In skincare, it works as a humectant. It pulls water from the environment and deeper layers of skin and binds it to the surface.

Interestingly, the size of the molecule affects its behavior:

Some clinical evidence links low molecular weight versions to improved wrinkle depth, elasticity, anti-inflammatory effects, and barrier repair.

Many serums use a blend of both weights so you can get surface hydration plus longer-lasting and deeper effects.

You'll typically see concentrations between 0.1-2% for this ingredient.

Tocopherol is a fat-soluble antioxidant known as Vitamin E.

You'll find this ingredient in the vast majority of skincare (for good reason). It works to neutralize free radicals, or unstable molecules generated by UV exposure, pollution, and other environmental stressors, before they can cause oxidative damage to your skin cells.

Topically applied tocopherol has been shown to protect against UV damage by ramping up the skin's own natural defense enzymes.

It also acts as a skin conditioning agent; some studies show that regular topical use can improve the skin's water-binding capacity over 2-4 weeks.

This ingredient is especially loved for being a team player. When combined with Vitamin C, the photoprotective effect of both ingredients roughly doubles and the combo also helps reduce UV-induced DNA damage.

This ingredient has some brightening potential but it's more of a prevention ingredient than spot-fader. Cell studies show it can slow down melanin production but it's worth noting that it's not the most powerful brightener out there.

In formulations, it also serves as a stabilizer that helps protect other oxidation-prone ingredients from degrading.

Concentrations usually range from 0.1-1% in most leave-on products.

Tromethamine (aka THAM) is a synthetic amino acid that shows up in skincare as a helper ingredient.

It functions as a pH adjuster to help neutralize acidic ingredients and set a formula's pH to the right spot.

This matters a lot because a lot of actives (like vitamin C) needs a specific pH to work well and feel comfortable on skin.

Concentration use ranges from 0.1-1.0% depending on the formula.

Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.

So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.

You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!

Similar Comparisons

The reference edit

Ingredients, questions
& further reading.

Connected source records selected through this article’s public topic index.

01

Formula cabinet

Ingredients & structured notes

Ingredient index

Ingredients Explained

  1. 01These ingredients are found in both products.
  2. 02Ingredients higher up in an ingredient list are typically present in a larger amount.
  3. 03Butylene Glycol (or BG) is used within cosmetic products for a few different reasons:
  4. 04Overall, Butylene Glycol is a safe and well-rounded ingredient that works well with other ingredients.
  5. 05Though this ingredient works well with most skin types, some people with sensitive skin may experience a reaction such as allergic rashes, closed comedones, or itchiness.
  6. 06Camellia Sinensis Leaf Extract (tea extract) is one of the most well-researched plant extracts in skincare with an impressive resume.
  7. 07Black tea, green tea, and oolong tea are all harvested from the Camellia Sinensis plant.
  8. 08Studies show green tea extract and its catechins (like epigallocatechin gallate (EGCG)) help your skin cells product energy more efficiently and reducing the number of free-radicals that can damage your skin from the inside.
  9. 09In lab-grown skin models, this translated to younger, healthier, and stronger skin.
  10. 10There's also good sun protection data; researchers saw less DNA damage and redness on human skin when green tea was applied before UVB exposure. And the more they applied, the better the protection.
  11. 11Needless to say, this ingredient shouldn't replace your sunscreen. But it is a great supportive ingredient that you can already find in many sunscreens and antioxidant serums.
  12. 12A 2009 study found a 2% green tea lotion was effective for mild-to-moderate acne thanks to its anti-inflammatory and mild antimicrobial activity.
  13. 13The quality of the extract matters a lot here:
  14. 14Good extracts contain 50-90% catechins while lower quality ones are mostly there for marketing. We recommend reaching out to the brand if you have questions about the quality or source of their ingredients.
  15. 15Human Repeated Insult Patch Testing showed no irritation or sensitization at use concentrations (0.86% in leave-on products and up to 30% as leaf water).
  16. 16Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.
  17. 17Topically, glycerin does several things at once:
  18. 18Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.
  19. 19Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.
  20. 20This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.
Source · skinsort.com
02

Product index

Related product references

03

Comparison edit

Read side by side