Skin science article
Anua Retinol 0.1 Caffeine Revitalizing Eye Cream Versus COSRX Advanced Snail Peptide Eye Cream
Anua Retinol 0.1 Caffeine Revitalizing Eye Cream Versus COSRX Advanced Snail Peptide Eye Cream This anti-aging eye moisturizer is formulated around Niacinamide and Caffeine to soften the look of wrinkles and strengthen the skin barrier. This anti-aging eye moi
Anua Retinol 0.1 Caffeine Revitalizing Eye Cream Versus COSRX Advanced Snail Peptide Eye Cream
This anti-aging eye moisturizer is formulated around Niacinamide and Caffeine to soften the look of wrinkles and strengthen the skin barrier.
This anti-aging eye moisturizer is formulated around Snail Secretion Filtrate and Niacinamide to soften the look of wrinkles and hydrate skin.
What's inside
Key Ingredients
Benefits
Concerns
Ingredients Side-by-side
Water
Propanediol
Dipropylene Glycol
Niacinamide
Glycerin
Limnanthes Alba Seed Oil
Pentylene Glycol
Cyclohexasiloxane
Polyglyceryl-3 Methylglucose Distearate
Polyglyceryl-3 Distearate
1,2-Hexanediol
Caffeine
Panthenol
Soluble Collagen
Squalane
Adenosine
Ceramide NP
Ceramide Ng
Ceramide Ns
Ceramide AP
Ceramide As
Ceramide EOP
Hexapeptide-2
Copper Tripeptide-1
Acetyl Hexapeptide-8
Acetyl Dipeptide-1 Cetyl Ester
Retinol
Hydrolyzed Hyaluronic Acid
Hyaluronic Acid
Sodium Hyaluronate
Sodium Hyaluronate Crosspolymer
Dimethylsilanol Hyaluronate
Hydrolyzed Sodium Hyaluronate
Potassium Hyaluronate
Hydroxypropyltrimonium Hyaluronate
Sodium Hyaluronate Dimethylsilanol
Sodium Acetylated Hyaluronate
Hippophae Rhamnoides Oil
Macadamia Ternifolia Seed Oil
Chitosan
Butyrospermum Parkii Butter
Hippophae Rhamnoides Fruit Oil
Pentaerythrityl Tetraethylhexanoate
Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer
Diglycerin
Polymethylsilsesquioxane
Tocopheryl Acetate
Sodium Polyacryloyldimethyl Taurate
Hydrogenated Polydecene
Hydroxyacetophenone
Glyceryl Stearate Citrate
Caprylic/Capric Triglyceride
Sodium Phytate
Butylene Glycol
Trideceth-10
Hydrogenated Lecithin
Sorbitan Isostearate
Palmitic Acid
Stearic Acid
Brassica Campestris Sterols
Cholesterol
Polyglyceryl-10 Laurate
Phytosteryl/Behenyl/Octyldodecyl Lauroyl Glutamate
Aluminum/Magnesium Hydroxide Stearate
Pentaerythrityl Tetra-Di-T-Butyl Hydroxyhydrocinnamate
Oleic Acid
Potassium Cetyl Phosphate
Tris(Tetramethylhydroxypiperidinol)Citrate
Octyldodecanol
Phytosterols
Sorbitan Laurate
Hydroxyethylcellulose
Phytosphingosine
Biotin
Cetearyl Alcohol
Xanthan Gum
Water, Propanediol, Dipropylene Glycol, Niacinamide, Glycerin, Limnanthes Alba Seed Oil, Pentylene Glycol, Cyclohexasiloxane, Polyglyceryl-3 Methylglucose Distearate, Polyglyceryl-3 Distearate, 1,2-Hexanediol, Caffeine, Panthenol, Soluble Collagen, Squalane, Adenosine, Ceramide NP, Ceramide Ng, Ceramide Ns, Ceramide AP, Ceramide As, Ceramide EOP, Hexapeptide-2, Copper Tripeptide-1, Acetyl Hexapeptide-8, Acetyl Dipeptide-1 Cetyl Ester, Retinol, Hydrolyzed Hyaluronic Acid, Hyaluronic Acid, Sodium Hyaluronate, Sodium Hyaluronate Crosspolymer, Dimethylsilanol Hyaluronate, Hydrolyzed Sodium Hyaluronate, Potassium Hyaluronate, Hydroxypropyltrimonium Hyaluronate, Sodium Hyaluronate Dimethylsilanol, Sodium Acetylated Hyaluronate, Hippophae Rhamnoides Oil, Macadamia Ternifolia Seed Oil, Chitosan, Butyrospermum Parkii Butter, Hippophae Rhamnoides Fruit Oil, Pentaerythrityl Tetraethylhexanoate, Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, Diglycerin, Polymethylsilsesquioxane, Tocopheryl Acetate, Sodium Polyacryloyldimethyl Taurate, Hydrogenated Polydecene, Hydroxyacetophenone, Glyceryl Stearate Citrate, Caprylic/Capric Triglyceride, Sodium Phytate, Butylene Glycol, Trideceth-10, Hydrogenated Lecithin, Sorbitan Isostearate, Palmitic Acid, Stearic Acid, Brassica Campestris Sterols, Cholesterol, Polyglyceryl-10 Laurate, Phytosteryl/Behenyl/Octyldodecyl Lauroyl Glutamate, Aluminum/Magnesium Hydroxide Stearate, Pentaerythrityl Tetra-Di-T-Butyl Hydroxyhydrocinnamate, Oleic Acid, Potassium Cetyl Phosphate, Tris(Tetramethylhydroxypiperidinol)Citrate, Octyldodecanol, Phytosterols, Sorbitan Laurate, Hydroxyethylcellulose, Phytosphingosine, Biotin, Cetearyl Alcohol, Xanthan Gum
Snail Secretion Filtrate
Helianthus Annuus Seed Oil
Arginine
Carbomer
Betaine
Cetearyl Olivate
Sorbitan Olivate
Sodium Polyacrylate
Allantoin
Myristic Acid
Palmitoyl Pentapeptide-4
Palmitoyl Tripeptide-1
Palmitoyl Tetrapeptide-7
Snail Secretion Filtrate, Butylene Glycol, Glycerin, Helianthus Annuus Seed Oil, 1,2-Hexanediol, Niacinamide, Water, Palmitic Acid, Arginine, Carbomer, Stearic Acid, Betaine, Cetearyl Olivate, Sorbitan Olivate, Sodium Polyacrylate, Allantoin, Tocopheryl Acetate, Panthenol, Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, Sodium Hyaluronate, Adenosine, Xanthan Gum, Myristic Acid, Copper Tripeptide-1, Acetyl Hexapeptide-8, Palmitoyl Pentapeptide-4, Palmitoyl Tripeptide-1, Palmitoyl Tetrapeptide-7
Reviews
Alternatives
Ingredients Explained
These ingredients are found in both products.
Ingredients higher up in an ingredient list are typically present in a larger amount.
1,2-Hexanediol is a synthetic liquid and another multi-functional powerhouse.
It is a:
Humectant, drawing moisture into the skin
Emollient, helping to soften skin
Solvent, dispersing and stabilizing formulas
Preservative booster, enhancing the antimicrobial activity of other preservatives
Acetyl Hexapeptide-8 (also known as Argireline) is a synthetic hexapeptide that is often called a "topical Botox alternative".
It works by mimicking how Botox relaxes muscles; it interferes with the signaling process that tells your facial muscles to contract. This can help soften expression lines like forehead wrinkles or crow's feet over time.
The comparison to Botox does have limits because the molecule is water-loving and relatively large.
Acetyl Hexapeptide-8 has a hard time absorbing deeply enough through the skin's outer barrier to actually reach the muscles.
So whether it truly works the way Botox does at a biological level is still up for debate, but early clinical outcomes are fairly encouraging.
A 12 week human study of a multi-ingredient regimen containing this ingredient saw:
While some studies have observed improvements in wrinkle appearance, it is important to note that more consistent results are seen in multi-ingredient formulations (vs just Acetyl Hexapeptide-8 alone).
Some research studies also used higher concentrations (up to 10%) while this ingredient is usually found in concentrations up to 0.005% in leave-on formulations.
Adenosine is a purine nucleoside that your body already makes in every cell. In skincare, it acts mainly as a skin conditioning and anti-aging agent.
The way it works is fairly well mapped out:
Your skin has cells called fibroblasts that build collagen (the stuff that keeps skin firm and smooth). Adenosine basically flips a switch on these cells that tells them to get to work making more collagen and other proteins. These cells slow down on their own as skin ages, so Adenosine helps give them a little nudge to keep going.
The clinical backing is pretty solid too.
A blind, randomized, placebo-controlled trial of 126 women aged 45-65 tested a 0.1% cream twice daily and found real improvements in crow's feet and frown lines using a precise 3D skin-mapping technique; these changes showed up by week 3 and held at 2 months.
A later study using Adenosine-loaded dissolving microneedle patches reported gains in wrinkle depth, dermal density, elasticity, and hydration.
On concentrations, South Korea's Ministry of Food and Drug Safety has set 0.04% as the approved functional anti-wrinkle level. You'll typically see this ingredient used somewhere in the 0.04-0.1% range since it works at low doses.
This ingredient has been found safe for cosmetics with the data showing no irritation or sensitization.
Overall, this is a great ingredient for any anti-aging routine and has no photosensitizing effect, so it suits both AM and PM use.
Butylene Glycol (or BG) is used within cosmetic products for a few different reasons:
Overall, Butylene Glycol is a safe and well-rounded ingredient that works well with other ingredients.
Though this ingredient works well with most skin types, some people with sensitive skin may experience a reaction such as allergic rashes, closed comedones, or itchiness.
Copper Tripeptide-1 (GHK-Cu) is a skin repairing ingredient known for its ability to boost collagen, improve firmness, and support skin regeneration.
It is a complex made up of a naturally occurring peptide (glycine-histidine-lysine) and copper, an essential trace element.
While studying wound healing, researchers noticed GHK-Cu stimulated hair follicle enlargement and growth by keeping hair in its active growth phase longer. This has made it a promising ingredient for hair regrowth treatments.
Some people have reported increased facial hair. While GHK-Cu can make your hair follicles bigger, it usually doesn’t turn soft, barely-visible facial hairs into thick, dark ones.
Anecdotal reports suggest that overusing copper peptides might lead to premature aging due to excess free copper or enzyme imbalances. This claim isn’t backed by large-scale studies.
Unfortunately, there are limited human studies for this ingredient. While early results are promising, many studies are either small, in-vitro, or not rigorously controlled.
For example, there is a 1998 study that explored the effects of copper tripeptide, vitamin C, tretinoin, and melatonin on skin repair and collagen synthesis.
After one month, increased procollagen production was seen in 7 out of 10 participants using copper tripeptide (more than those using vitamin C, melatonin, or tretinoin.
While the study was exploratory, it offers early evidence that copper tripeptide may support collagen production. Larger, well-designed trials are still needed to confirm its potential and understand individual responses.
Read more about other common types of peptides here:
Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.
Topically, glycerin does several things at once:
Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.
Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.
This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.
Just know very high concentrations (>40%) can feel tacky in low humidity.
Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.
This is a synthetic polymer. It helps improve the texture of products by adding thickness and gel-like feel.
It is also an emulsifer, meaning it prevents ingredients such as oil and water from separating. It also helps evenly disperse other ingredients.
Niacinamide is a multitasking form of vitamin B3 that strengthens the skin barrier, reduces pores and dark spots, regulates oil, and improves signs of aging.
And the best part? It's gentle and well-tolerated by most skin types, including sensitive and reactive skin.
You might have heard of "niacin flush", or the reddening of skin that causes itchiness. Niacinamide has not been found to cause this.
In very rare cases, some individuals may not be able to tolerate niacinamide at all or experience an allergic reaction to it.
If you are experiencing flaking, irritation, and dryness with this ingredient, be sure to double check all your products as this ingredient can be found in all categories of skincare.
When incorporating niacinamide into your routine, look out for concentration amounts. Typically, 5% niacinamide provides benefits such as fading dark spots. However, if you have sensitive skin, it is better to begin with a smaller concentration.
When you apply niacinamide to your skin, your body converts it into nicotinamide adenine dinucleotide (NAD). NAD is an essential coenzyme that is already found in your cells as "fuel" and powers countless biological processes.
In your skin, NAD helps repair cell damage, produce new healthy cells, support collagen production, strengthen the skin barrier, and fight environmental stressors (like UV and pollution).
Our natural NAD levels start to decline with age, leading to slower skin repair, visible aging, and a weaker skin barrier. By providing your skin niacinamide, you're recharging your skin's NAD levels. This leads to stronger, healthier, and younger looking skin.
Another name for vitamin B3 is nicotinamide. This vitamin is water-soluble and our bodies don't store it. We obtain Vitamin B3 from either food or skincare. Meat, fish, wheat, yeast, and leafy greens contain vitamin B3.
The type of niacinamide used in skincare is synthetically created.
Palmitic Acid is a fatty acid naturally found in our skin and in many plant and animal sources.
In cosmetics, it is usually derived from palm oil. It serves many purposes in skincare, acting as a cleanser, emollient, and emulsifier.
Interestingly, topically applied Palmitic Acid can be elongated into longer chain fatty acids and ceramides. A 2019 study found low levels of Palmitic Acid lead to slower development of cells, suggesting it plays a role in keeping your skin's renewal process on track.
The CIR (Cosmetic Ingredient Review) panel determined it safe as used in cosmetics at concentrations up to 13%. It is non-irritating and non-sensitizing in clinical studies.
The culprit behind fungal acne, the Malassezia yeast, feeds on fatty acids with carbon chain lengths between C11-C24. Palmitic Acid, at C16, falls right into that sweet spot.
In vitro studies have shown that Palmitic Acid is one of the fatty acids that induce rapid Malassezia growth in lab settings.
It's worth noting that what feeds yeast in a lab doesn't necessarily feed it on your face since formulation and your skin's chemistry play a bigger role.
Panthenol is a common ingredient that helps hydrate and soothe the skin. It is found naturally in our skin and hair.
There are two forms of panthenol: D and L.
D-panthenol is also known as dexpanthenol. Most cosmetics use dexpanthenol or a mixture of D and L-panthenol.
Panthenol is famous due to its ability to go deeper into the skin's layers. Using this ingredient has numerous pros (and no cons):
Like hyaluronic acid, panthenol is a humectant. Humectants are able to bind and hold large amounts of water to keep skin hydrated.
This ingredient works well for wound healing. It works by increasing tissue in the wound and helps close open wounds.
Once oxidized, panthenol converts to pantothenic acid. Panthothenic acid is found in all living cells.
This ingredient is also referred to as pro-vitamin B5.
Sodium Hyaluronate is the salt form of hyaluronic acid. It is a long sugar chain that is naturally found in your skin, joints, and connective tissue that maintains hydration and elasticity.
In skincare, it works as a humectant. It pulls water from the environment and deeper layers of skin and binds it to the surface.
Interestingly, the size of the molecule affects its behavior:
Some clinical evidence links low molecular weight versions to improved wrinkle depth, elasticity, anti-inflammatory effects, and barrier repair.
Many serums use a blend of both weights so you can get surface hydration plus longer-lasting and deeper effects.
You'll typically see concentrations between 0.1-2% for this ingredient.
Stearic Acid is a fatty acid that is already found in your skin. It's one of the free fatty acids that works alongside ceramides and cholesterols to maintain your barrier.
In cosmetics, it is a multitasker:
Safety-wise, the CIR Expert Panel has concluded it to be safe in cosmetics when formulated to be non-irritating and non-sensitizing.
Free stearic acid is a C18 fatty acid that the Malassezia yeast can substrate, so this ingredient may not be fungal acne safe.
Tocopheryl Acetate is a stable, shelf-friendly form of vitamin E.
Formulators love it because plain vitamin E oxidizes quickly once it hits air. This acetate version stays stable and resists going off, helping to extend a product's shelf life.
It's actually inactive on its own and works like a slow-release "storage" form; the enzymes in your skin called esterases gradually convert it into active vitamin E over time.
One in vivo study showed 5% of the acetate in the living layer of the epidermis converted to vitamin E after 5 days of application. This study also found the skin gained protection against UV damage even though the conversion was slow and small.
Once converted, vitamin E acts as a skin's main fat-soluble antioxidant that fights free radicals to protect skin from damage.
Topical vitamin E generally boosts the skin's photoprotection, and it reduced UV-damage in animal models.
This ingredient has some brightening potential but it's more of a prevention ingredient than spot-fader. Cell studies show it can slow down melanin production but it's worth noting that it's not the most powerful brightener out there.
Overall, it has a pretty solid safety profile and has been found to be non-irritating and non-comedogenic. Allergic reactions may happen but stay rare due to how widely the ingredient gets used.
The concentration will vary depending on the formula; industry data shows 0.1% in baby lotions, 3% in lipsticks, and 5% in foot powders. You can also find this ingredient at 100% in a pure vitamin E oil.
Most leave-on skincare keeps it at the lower end, often between 0.5-1%.
Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.
So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.
You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!
Xanthan gum is used as a stabilizer and thickener within cosmetic products. It helps give products a sticky, thick feeling - preventing them from being too runny.
On the technical side of things, xanthan gum is a polysaccharide - a combination consisting of multiple sugar molecules bonded together.
Xanthan gum is a pretty common and great ingredient. It is a natural, non-toxic, non-irritating ingredient that is also commonly used in food products.