Peptide Skincare & BeautySkin science and ingredient guides

Skin science article

artnaturals Hyaluronic Acid Serum Versus Advanced Clinicals Hyaluronic Acid Hydrating Face Serum

artnaturals Hyaluronic Acid Serum Versus Advanced Clinicals Hyaluronic Acid Hydrating Face Serum This hydrating serum is formulated around Aloe Barbadensis Leaf Juice and Sodium Ascorbyl Phosphate to hydrate skin and calm redness. This hydrating serum is formu

artnaturals Hyaluronic Acid Serum Versus Advanced Clinicals Hyaluronic Acid Hydrating Face Serum

This hydrating serum is formulated around Aloe Barbadensis Leaf Juice and Sodium Ascorbyl Phosphate to hydrate skin and calm redness.

This hydrating serum is formulated around Aloe Barbadensis Leaf Juice and Sodium Hyaluronate to hydrate skin and calm redness.

What's inside

Key Ingredients

Benefits

Concerns

Ingredients Side-by-side

Water

Aloe Barbadensis Leaf Juice

Sodium Ascorbyl Phosphate

Glycerin

Phenethyl Alcohol

Caprylyl Glycol

Ethylhexylglycerin

Hydroxyethylcellulose

Xanthan Gum

Citrus Limon Fruit Oil

Sodium Hyaluronate

Hydroxypropyl Cyclodextrin

Palmitoyl Tripeptide-38

Camellia Sinensis Leaf Extract

Glycine Soja Protein

Hydrolyzed Rice Protein

Superoxide Dismutase

Simmondsia Chinensis Seed Oil

Tocopheryl Acetate

Water, Aloe Barbadensis Leaf Juice, Sodium Ascorbyl Phosphate, Glycerin, Phenethyl Alcohol, Caprylyl Glycol, Ethylhexylglycerin, Hydroxyethylcellulose, Xanthan Gum, Citrus Limon Fruit Oil, Sodium Hyaluronate, Hydroxypropyl Cyclodextrin, Palmitoyl Tripeptide-38, Camellia Sinensis Leaf Extract, Glycine Soja Protein, Hydrolyzed Rice Protein, Superoxide Dismutase, Simmondsia Chinensis Seed Oil, Tocopheryl Acetate

Ethoxydiglycol

Pyrus Malus Fruit Extract

PEG-12 Dimethicone

Chondrus Crispus Extract

Sodium Carboxymethyl Beta-Glucan

Epilobium Angustifolium Flower/Leaf/Stem Extract

Parfum

Phenoxyethanol

Maltodextrin

Tetrasodium Glutamate Diacetate

Hexylene Glycol

Citric Acid

Water, Ethoxydiglycol, Glycerin, Pyrus Malus Fruit Extract, PEG-12 Dimethicone, Aloe Barbadensis Leaf Juice, Chondrus Crispus Extract, Sodium Hyaluronate, Sodium Carboxymethyl Beta-Glucan, Camellia Sinensis Leaf Extract, Epilobium Angustifolium Flower/Leaf/Stem Extract, Tocopheryl Acetate, Xanthan Gum, Parfum, Phenoxyethanol, Maltodextrin, Tetrasodium Glutamate Diacetate, Caprylyl Glycol, Ethylhexylglycerin, Hexylene Glycol, Citric Acid

Reviews

Alternatives

Ingredients Explained

These ingredients are found in both products.

Ingredients higher up in an ingredient list are typically present in a larger amount.

Aloe Barbadensis Leaf Juice is the filtered, stabilized liquid pressed from the inner gel of the aloe vera leaf.

In cosmetics, it shows up as either soothing active or a water-replacement base. It is roughly 98-99% water and the last 1-2% is an interesting mix of polysaccharides, amino acids, vitamins, minerals, and enzymes.

The polysaccharides do most of the work: they bind water at the skin surface for a light, non-greasy hydration boost. And one of the polysaccharides, glycomannan, is linked to fibroblast stimulation + collagen synthesis. This is also why aloe has such a long track record in wound and burn healing.

This ingredient is also calming with anti-inflammatory and mild antimicrobial activity, making it a great pick for sensitive, irritated, or post-sun skin.

Realistic expectations matter though; the solid evidence is mostly limited to hydration, soothing, and wound support. Deeper claims about anti-aging or sun protection are not well backed, and science reviews note it does not prevent radiation-induced skin injury.

Because it plays well with almost everything, it's commonly used as a base alongside other actives like niacinamide or vitamin C.

Typical usage concentrations range from 0.5% (where hydration benefits already show up) all the way to 90%+ (where it replaces water as the main base).

The safety for this ingredient is well-establish as well. Overall, this is a great supporting ingredient for those who want a boost in hydration.

Camellia Sinensis Leaf Extract (tea extract) is one of the most well-researched plant extracts in skincare with an impressive resume.

Black tea, green tea, and oolong tea are all harvested from the Camellia Sinensis plant.

Studies show green tea extract and its catechins (like epigallocatechin gallate (EGCG)) help your skin cells product energy more efficiently and reducing the number of free-radicals that can damage your skin from the inside.

In lab-grown skin models, this translated to younger, healthier, and stronger skin.

There's also good sun protection data; researchers saw less DNA damage and redness on human skin when green tea was applied before UVB exposure. And the more they applied, the better the protection.

Needless to say, this ingredient shouldn't replace your sunscreen. But it is a great supportive ingredient that you can already find in many sunscreens and antioxidant serums.

A 2009 study found a 2% green tea lotion was effective for mild-to-moderate acne thanks to its anti-inflammatory and mild antimicrobial activity.

The quality of the extract matters a lot here:

Good extracts contain 50-90% catechins while lower quality ones are mostly there for marketing. We recommend reaching out to the brand if you have questions about the quality or source of their ingredients.

Human Repeated Insult Patch Testing showed no irritation or sensitization at use concentrations (0.86% in leave-on products and up to 30% as leaf water).

Caprylyl Glycol is a humectant, skin conditioner, emollient, and preservative booster derived from either caprylic acid or synthetically created.

Typical use levels vary from 0.3-1% as a preservative booster and go up to 2% to condition skin.

Because it is not a free-fatty acid, this ingredient is fungal acne safe (there's nothing for Malassezia to feed on).

Ethylhexylglycerin is created from glycerin. It is a multitasker ingredient that:

The CIR Expert Panel found minimal skin absorption or sensitization of any kind in a safety assessment. Though this ingredient is considered well-tolerated, a small number of cases of allergic dermatitis have been published since 2002. Just be sure to patch test if you are unsure.

Industry-reported use ranges from 8% in rinse-off products and 2% in leave-on formulations.

Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.

Topically, glycerin does several things at once:

Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.

Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.

This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.

Just know very high concentrations (>40%) can feel tacky in low humidity.

Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.

Sodium Hyaluronate is the salt form of hyaluronic acid. It is a long sugar chain that is naturally found in your skin, joints, and connective tissue that maintains hydration and elasticity.

In skincare, it works as a humectant. It pulls water from the environment and deeper layers of skin and binds it to the surface.

Interestingly, the size of the molecule affects its behavior:

Some clinical evidence links low molecular weight versions to improved wrinkle depth, elasticity, anti-inflammatory effects, and barrier repair.

Many serums use a blend of both weights so you can get surface hydration plus longer-lasting and deeper effects.

You'll typically see concentrations between 0.1-2% for this ingredient.

Tocopheryl Acetate is a stable, shelf-friendly form of vitamin E.

Formulators love it because plain vitamin E oxidizes quickly once it hits air. This acetate version stays stable and resists going off, helping to extend a product's shelf life.

It's actually inactive on its own and works like a slow-release "storage" form; the enzymes in your skin called esterases gradually convert it into active vitamin E over time.

One in vivo study showed 5% of the acetate in the living layer of the epidermis converted to vitamin E after 5 days of application. This study also found the skin gained protection against UV damage even though the conversion was slow and small.

Once converted, vitamin E acts as a skin's main fat-soluble antioxidant that fights free radicals to protect skin from damage.

Topical vitamin E generally boosts the skin's photoprotection, and it reduced UV-damage in animal models.

This ingredient has some brightening potential but it's more of a prevention ingredient than spot-fader. Cell studies show it can slow down melanin production but it's worth noting that it's not the most powerful brightener out there.

Overall, it has a pretty solid safety profile and has been found to be non-irritating and non-comedogenic. Allergic reactions may happen but stay rare due to how widely the ingredient gets used.

The concentration will vary depending on the formula; industry data shows 0.1% in baby lotions, 3% in lipsticks, and 5% in foot powders. You can also find this ingredient at 100% in a pure vitamin E oil.

Most leave-on skincare keeps it at the lower end, often between 0.5-1%.

Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.

So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.

You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!

Xanthan gum is used as a stabilizer and thickener within cosmetic products. It helps give products a sticky, thick feeling - preventing them from being too runny.

On the technical side of things, xanthan gum is a polysaccharide - a combination consisting of multiple sugar molecules bonded together.

Xanthan gum is a pretty common and great ingredient. It is a natural, non-toxic, non-irritating ingredient that is also commonly used in food products.

Similar Comparisons

The reference edit

Ingredients, questions
& further reading.

Connected source records selected through this article’s public topic index.

01

Formula cabinet

Ingredients & structured notes

Ingredient index

Bondi Sands Thirsty Skin Hyaluronic Acid SerumIngredients explained

  1. 01Good old water, aka H2O. The most common skincare ingredient of all. You can usually find it right in the very first spot of the ingredient list, meaning it’s the biggest thing out of all the stuff that makes up the product.
  2. 02It’s mainly a solvent for ingredients that do not like to dissolve in oils but rather in water.
  3. 03Expand to read more
  4. 04Once inside the skin, it hydrates, but not from the outside - putting pure water on the skin (hello long baths!) is drying.
  5. 05One more thing: the water used in cosmetics is purified and deionized (it means that almost all of the mineral ions inside it is removed). Like this, the products can stay more stable over time.
  6. 06Butylene glycol, or let’s just call it BG, is a multi-tasking colorless, syrupy liquid. It’s a great pick for creating a nice feeling product.
  7. 07BG’s main job is usually to be a solvent for the other ingredients. Other tasks include helping the product to absorb faster and deeper into the skin (penetration enhancer), making the product spread nicely over the skin (slip agent), and attracting…
  8. 08It’s an ingredient whose safety hasn’t been questioned so far by anyone (at least not that we know about). BG is approved by Ecocert and is also used enthusiastically in natural products. BTW, it’s also a food additive.
  9. 09It’s the - sodium form - cousin of the famous NMF, hyaluronic acid (HA). If HA does not tell you anything we have a super detailed, geeky explanation about it here. The TL; DR version of HA is that it's a huge polymer (big molecule from repeated sub…
  10. 10As far as skincare goes, sodium hyaluronate and hyaluronic acid are pretty much the same and the two names are used interchangeably. As cosmetic chemist kindofstephen writes on reddit "sodium hyaluronate disassociates into hyaluronic acid molecule a…
  11. 11In spite of this, if you search for "hyaluronic acid vs sodium hyaluronate" you will find on multiple places that sodium hyaluronate is smaller and can penetrate the skin better. Chemically, this is definitely not true, as the two forms are almost t…
  12. 12What seems to be a true difference, though, is that the salt form is more stable, easier to formulate and cheaper so it pops up more often on the ingredient lists.
  13. 13If you wanna become a real HA-and-the-skin expert you can read way more about the topic at hyaluronic acid (including penetration-questions, differences between high and low molecular weight versions and a bunch of references to scientific literature).
  14. 14A nice odorless liquid used mainly as a superior solubilizer and efficacy booster for cosmetic active ingredients such as skincare bigshot vitamin C, self-tanning active DHA or the anti-acne gold standard, benzoyl peroxide.
  15. 15Other than that it can also be used in hair care products where it gives a longer-lasting and more uniform coloring. According to a manufacturer, it might even prevent the formation of split ends.
  16. 16It’s pretty much the current IT-preservative. It’s safe and gentle, but even more importantly, it’s not a feared-by-everyone-mostly-without-scientific-reason paraben.
  17. 17It’s not something new: it was introduced around 1950 and today it can be used up to 1% worldwide. It can be found in nature - in green tea - but the version used in cosmetics is synthetic.
  18. 18Other than having a good safety profile and being quite gentle to the skin it has some other advantages too. It can be used in many types of formulations as it has great thermal stability (can be heated up to 85°C) and works on a wide range of pH le…
  19. 19It’s often used together with ethylhexylglycerin as it nicely improves the preservative activity of phenoxyethanol.
  20. 20A handy multifunctional ingredient that works as a preservative booster, as well as an antioxidant and soothing agent.
Source · incidecoder.com
02

Product index

Related product references

Product

Tree of Life Hyaluronic Acid Serum

Tree of Life Hyaluronic Acid Serum Tree of Life Hyaluronic Acid Serum ingredients explained: Aqua (Water), Hamamelis Virginiana Water (Witch Hazel), Cassia Angustifolia Seed Polysaccharide …

Source: incidecoder.comView reference →

Product

Kylie Skin Hyaluronic Acid Serum

Kylie Skin Hyaluronic Acid Serum Ingredients in Kylie Skin Hyaluronic Acid Serum explained: benefits, concerns, and detailed analysis of 35 ingredients including Water, Glycerin, and Propan…

Source: skinsort.comView reference →
03

Comparison edit

Read side by side

04

Ask the journal

Related questions

01How to Apply Face Serums

Skincare rules can get confusing, but when it comes to application the general rule of thumb is to pay attention to the product’s consistency. “Apply the lightest, thinnest product first and the heaviest, and more dense products last, since thinner products can’t penetrate thicker products,”says Dr. Lewis. After cleansing the face and following up with a toner, let the skin dry before using a serum. You can layer different serums on top of each other or opt for a product that has a precise mix of multiple hero ingredients, such as hyaluronic acid and vitamin C.

Source · www.skincare.com
02What Skin Types Should Use Hyaluronic Acid?

“Hyaluronic acid is particularly helpful for those experiencing dry skin, and for those desiring a plumping effect,” explains Dr. King. But, if you have an oily skin type, don’t discredit hyaluronic acid from your routine just yet. Despite the excess sebum that you may experience, it’s important to keep your skin hydrated so that it doesn’t overcompensate and produce even more oil as a result. Besides your skin type, you should also look at the condition of your skin to decide if it’s time to begin using hyaluronic acid. “If your skin is starting to look dull, flaky and you’re seeing more pronounced fine lines and wrinkles, that’s a pretty good indication that it’s time to add this ingredient to your routine,” adds O’Conner.

Source · www.skincare.com