Peptide Skincare & BeautySkin science and ingredient guides

Skin science article

AXIS - Y Dark Spot Correcting Glow Serum Versus Elizavecca Milky Piggy EGF Elastic Retinol Cream

AXIS - Y Dark Spot Correcting Glow Serum Versus Elizavecca Milky Piggy EGF Elastic Retinol Cream This brightening serum is formulated around Niacinamide and Squalane to fade the look of dark spots and brighten dull-looking skin. This anti-aging night moisturiz

AXIS - Y Dark Spot Correcting Glow Serum Versus Elizavecca Milky Piggy EGF Elastic Retinol Cream

This brightening serum is formulated around Niacinamide and Squalane to fade the look of dark spots and brighten dull-looking skin.

This anti-aging night moisturizer is formulated around Retinol and Sh-Oligopeptide-1 to soften the look of wrinkles and refine skin texture.

What's inside

Key Ingredients

Benefits

Concerns

Ingredients Side-by-side

Water

Glycerin

Niacinamide

Sodium Hyaluronate

Propanediol

Erythritol

Butylene Glycol

Squalane

Oryza Sativa Bran Extract

Calendula Officinalis Flower Extract

Carica Papaya Fruit Extract

Hippophae Rhamnoides Fruit Extract

Malpighia Glabra Fruit Extract

Polyglyceryl-10 Laurate

Chlorphenesin

Arginine

Ethylhexylglycerin

Carbomer

Glutathione

1,2-Hexanediol

Hydroxypropyl Cyclodextrin

Disodium EDTA

Hydroxyethylcellulose

Allantoin

Rosmarinus Officinalis Leaf Oil

Water, Glycerin, Niacinamide, Sodium Hyaluronate, Propanediol, Erythritol, Butylene Glycol, Squalane, Oryza Sativa Bran Extract, Calendula Officinalis Flower Extract, Carica Papaya Fruit Extract, Hippophae Rhamnoides Fruit Extract, Malpighia Glabra Fruit Extract, Polyglyceryl-10 Laurate, Chlorphenesin, Arginine, Ethylhexylglycerin, Carbomer, Glutathione, 1,2-Hexanediol, Hydroxypropyl Cyclodextrin, Disodium EDTA, Hydroxyethylcellulose, Allantoin, Rosmarinus Officinalis Leaf Oil

Swiftlet Nest Extract

Macadamia Integrifolia Seed Oil

Beeswax

Cetyl Alcohol

Polysorbate 60

Dipropylene Glycol

Retinol

Sh-Oligopeptide-1

Sodium Polyacrylate

PEG-100 Stearate

Adenosine

Betaine

Propylene Glycol

Caprylic/Capric Triglyceride

Polysorbate 20

Alcohol

Ceteth-3

Brassica Campestris Sterols

Tocopheryl Acetate

Cetyl Phosphate

Cholesterol

PEG-5 Rapeseed Sterol

Hydrogenated Lecithin

Sorbitan Sesquioleate

Ceteth-5

Glyceryl Stearate

Parfum

Swiftlet Nest Extract, Macadamia Integrifolia Seed Oil, Beeswax, Cetyl Alcohol, Glycerin, Polysorbate 60, Dipropylene Glycol, Retinol, Sh-Oligopeptide-1, Sodium Polyacrylate, Allantoin, PEG-100 Stearate, Adenosine, Carbomer, Betaine, Propylene Glycol, Caprylic/Capric Triglyceride, Polysorbate 20, Arginine, Alcohol, 1,2-Hexanediol, Ceteth-3, Brassica Campestris Sterols, Tocopheryl Acetate, Cetyl Phosphate, Cholesterol, PEG-5 Rapeseed Sterol, Hydrogenated Lecithin, Ethylhexylglycerin, Water, Sorbitan Sesquioleate, Ceteth-5, Disodium EDTA, Glyceryl Stearate, Parfum

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Alternatives

Ingredients Explained

These ingredients are found in both products.

Ingredients higher up in an ingredient list are typically present in a larger amount.

1,2-Hexanediol is a synthetic liquid and another multi-functional powerhouse.

It is a:

Humectant, drawing moisture into the skin

Emollient, helping to soften skin

Solvent, dispersing and stabilizing formulas

Preservative booster, enhancing the antimicrobial activity of other preservatives

Allantoin is a soothing ingredient known for its protective and moisturizing properties; it's basically a quiet workhorse ingredient you can find in a huge range of cosmetics.

Though it can be derived from the comfrey plant, allantoin is produced synthetically for cosmetic products to ensure purity.

Research shows it can encourage your skin cells to turn over and renew by stimulating keratinocyte and fibroblast proliferation.

It also has mild keratolytic properties to help loosen and shed dead skin cells without being harsh.

Studies also suggest allantoin can help calm inflammation by dialing down some of the chemical signals your skin sends out when it is irritated.

This ingredient is typically used in the 0.1-0.5% range, and the FDA recognizes it as a skin protectant in OTC products up to 2%.

Overall, allantoin is a wonderful addition to most routines; it is stable across a wide pH range (~4-8), works well with other ingredients, and is considered non-sensitizing/non-irritating.

Fun fact: Allantoin is naturally occurring in comfrey root, beets, chamomile, and wheat sprouts. Our bodies even produce it as a byproduct of uric acid metabolism.

Arginine is a semi-essential amino acid. This just means our bodies can product a bit on its own, but sometimes needs a little boost from food sources.

It is a part of your skin's natural moisturizing factor (NMF), or the water-loving molecules in your outermost layer of skin (stratum corneum) that keeps everything hydrated and happy.

Here's an interesting thing about Arginine: your skin converts it into urea through the Krebs-Henseleit urea cycle. Urea is one of the most effective humectants your skin naturally produces.

A clinical study showed applying 2.5% arginine hydrochloride to atopic dermatitis skin showed significant urea levels in the stratum corneum and improved moisture in just four weeks.

Arginine is also a precursor to nitric oxide; nitric oxide improves microcirculation and supports wound healing and collagen synthesis.

One study found that an amino acid complex containing Arginine reduced skin irritation, improved hydration, and accelerated skin repair in clinical / in-vivo studies.

Arginine itself is an amino acid and not a fatty acid, oil, or ester. On its own, it's not a direct food source for Malassezia, or the yeast that causes fungal acne.

Carbomer is a synthetic thickening and gelling agent. It's basically the ingredient that gives a lot of serums, gels, creams, and sunscreens their smooth, non-sticky texture.

Although legally permitted at very high levels, carbomers are normally used at concentrations below 1%.

It also needs to be neutralized to actually thicken, and because it is a large molecule, it doesn't really penetrate the skin barrier.

Allergy-wise, the risk is very low. Clinical studies show carbomers have low potential for skin irritation/sensitization even at concentrations up to 100%.

A 2024 UK study patch-tested 1,302 patients and found true allergy to the parent group of carbomer to be rare with no confirmed relevant reactions.

Disodium EDTA is a chelating agent. It grabs onto and deactivates metal ions that sneak into your products from water, packaging, or air.

This ingredient mainly works behind the scenes and helps with:

On top of that, this ingredient can counteract the effects of hard water by binding to the minerals in it.

One thing worth knowing is that Disodium EDTA has been shown to be a mild penetration enhancer. It can help other ingredients absorb into skin more effectively which can be a double-edged sword (great for actives, but can also make the active too strong if you have sensitive skin).

Clinical patch testing showed no significant skin irritation at typical use concentrations and minimal dermal absorption.

You'll most likely see this ingredient near the end of an ingredient list. It's typically found in concentrations less than 1%.

Ethylhexylglycerin is created from glycerin. It is a multitasker ingredient that:

The CIR Expert Panel found minimal skin absorption or sensitization of any kind in a safety assessment. Though this ingredient is considered well-tolerated, a small number of cases of allergic dermatitis have been published since 2002. Just be sure to patch test if you are unsure.

Industry-reported use ranges from 8% in rinse-off products and 2% in leave-on formulations.

Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.

Topically, glycerin does several things at once:

Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.

Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.

This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.

Just know very high concentrations (>40%) can feel tacky in low humidity.

Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.

Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.

So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.

You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!

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