Peptide Skincare & BeautySkin science and ingredient guides

Skin science article

AXIS - Y Dark Spot Correcting Glow Serum Versus First Aid Beauty Ultra Repair Cream Intense Hydration

AXIS - Y Dark Spot Correcting Glow Serum Versus First Aid Beauty Ultra Repair Cream Intense Hydration This brightening serum is formulated around Niacinamide and Squalane to fade the look of dark spots and brighten dull-looking skin. This calming moisturizer i

AXIS - Y Dark Spot Correcting Glow Serum Versus First Aid Beauty Ultra Repair Cream Intense Hydration

This brightening serum is formulated around Niacinamide and Squalane to fade the look of dark spots and brighten dull-looking skin.

This calming moisturizer is formulated around Colloidal Oatmeal and Squalane to calm redness and hydrate skin.

What's inside

Key Ingredients

Benefits

Concerns

Ingredients Side-by-side

Water

Glycerin

Niacinamide

Sodium Hyaluronate

Propanediol

Erythritol

Butylene Glycol

Squalane

Oryza Sativa Bran Extract

Calendula Officinalis Flower Extract

Carica Papaya Fruit Extract

Hippophae Rhamnoides Fruit Extract

Malpighia Glabra Fruit Extract

Polyglyceryl-10 Laurate

Chlorphenesin

Arginine

Ethylhexylglycerin

Carbomer

Glutathione

1,2-Hexanediol

Hydroxypropyl Cyclodextrin

Disodium EDTA

Hydroxyethylcellulose

Allantoin

Rosmarinus Officinalis Leaf Oil

Water, Glycerin, Niacinamide, Sodium Hyaluronate, Propanediol, Erythritol, Butylene Glycol, Squalane, Oryza Sativa Bran Extract, Calendula Officinalis Flower Extract, Carica Papaya Fruit Extract, Hippophae Rhamnoides Fruit Extract, Malpighia Glabra Fruit Extract, Polyglyceryl-10 Laurate, Chlorphenesin, Arginine, Ethylhexylglycerin, Carbomer, Glutathione, 1,2-Hexanediol, Hydroxypropyl Cyclodextrin, Disodium EDTA, Hydroxyethylcellulose, Allantoin, Rosmarinus Officinalis Leaf Oil

Colloidal Oatmeal 0.5%

Stearic Acid

C12-15 Alkyl Benzoate

Caprylic/Capric Triglyceride

Glyceryl Stearate Se

Glyceryl Stearate

Cetearyl Alcohol

Dimethicone

Butyrospermum Parkii Butter

Phenoxyethanol

Caprylyl Glycol

Xanthan Gum

Sodium Hydroxide

Tetrasodium EDTA

Chrysanthemum Parthenium Extract

Camellia Sinensis Leaf Extract

Glycyrrhiza Glabra Root Extract

Ceramide NP

Eucalyptus Globulus Leaf Oil

Colloidal Oatmeal 0.5%, Water, Stearic Acid, Glycerin, C12-15 Alkyl Benzoate, Caprylic/Capric Triglyceride, Glyceryl Stearate Se, Glyceryl Stearate, Cetearyl Alcohol, Dimethicone, Squalane, Butyrospermum Parkii Butter, Phenoxyethanol, Caprylyl Glycol, Xanthan Gum, Allantoin, Sodium Hydroxide, Tetrasodium EDTA, Chrysanthemum Parthenium Extract, Camellia Sinensis Leaf Extract, Glycyrrhiza Glabra Root Extract, Ceramide NP, Eucalyptus Globulus Leaf Oil

Reviews

Alternatives

Ingredients Explained

These ingredients are found in both products.

Ingredients higher up in an ingredient list are typically present in a larger amount.

Allantoin is a soothing ingredient known for its protective and moisturizing properties; it's basically a quiet workhorse ingredient you can find in a huge range of cosmetics.

Though it can be derived from the comfrey plant, allantoin is produced synthetically for cosmetic products to ensure purity.

Research shows it can encourage your skin cells to turn over and renew by stimulating keratinocyte and fibroblast proliferation.

It also has mild keratolytic properties to help loosen and shed dead skin cells without being harsh.

Studies also suggest allantoin can help calm inflammation by dialing down some of the chemical signals your skin sends out when it is irritated.

This ingredient is typically used in the 0.1-0.5% range, and the FDA recognizes it as a skin protectant in OTC products up to 2%.

Overall, allantoin is a wonderful addition to most routines; it is stable across a wide pH range (~4-8), works well with other ingredients, and is considered non-sensitizing/non-irritating.

Fun fact: Allantoin is naturally occurring in comfrey root, beets, chamomile, and wheat sprouts. Our bodies even produce it as a byproduct of uric acid metabolism.

Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.

Topically, glycerin does several things at once:

Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.

Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.

This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.

Just know very high concentrations (>40%) can feel tacky in low humidity.

Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.

Squalane is the hydrogenated and shelf-stable form of squalene (a lipid that naturally occurs in human sebum).

It is an emollient and skin conditioning agent that is able to integrate seamlessly into the skin's lipid barrier without clogging pores.

This is due to how structurally similar it is to what your skin already produces.

Though it is mostly an emollient that helps soften and hydrate skin, it also has some humectant and occlusive action. Humectants help the skin retain moisture while occlusives seal it in, making squalane a triple-threat moisturizer.

Research shows it has antioxidant capabilities that help protect against stressors like UV exposure, specifically UVA induced oxidative stress. This study also found that it supports collagen biosynthesis in human dermal fibroblasts.

No clinical study has reported significant adverse effects and irritation reactions are very rare from this ingredient (even at 100% concentration).

Overall, it's a fantastic ingredient for hydration and is suitable for all skin types.

This depends on the source. Squalane can be derived from both plants and animals. Most squalane used in skincare comes from plants.

Please note: the source of squalane is only known if disclosed by the brand. We recommend reaching out to the brand if you have any questions about their squalane.

Read more about squalene with an "e".

Though squalane is often called an oil, it’s technically not one. It is a hydrocarbon, meaning it is only made of carbon and hydrogen. True oils are triglycerides and made of fatty acids and glycerol.

The term “oil-free” isn’t regulated so companies can define it however they want. Some exclude all oils, while others just avoid mineral oil or comedogenic oils.

Squalane has a comedogenic rating of 1 from the original 1972 study that tested raw ingredients under occlusion on rabbit ears. This system is not standardized or peer-reviewed, and using the raw ingredients is very different from how diluted cosmetic formulations are used on human skin.

A comedogenic rating of 1 means it is "unlikely to clog pores" according to the original rating system.

The overall formula of a product matters more than the individual ingredients on whether or not it will cause clogged pores.

Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.

So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.

You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!

Similar Comparisons

The reference edit

Ingredients, questions
& further reading.

Connected source records selected through this article’s public topic index.

01

Formula cabinet

Ingredients & structured notes

Ingredient index

Ingredients Explained

  1. 01These ingredients are found in both products.
  2. 02Ingredients higher up in an ingredient list are typically present in a larger amount.
  3. 03Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.
  4. 04So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.
  5. 05You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!
Source · skinsort.com
02

Product index

Related product references

03

Comparison edit

Read side by side