Peptide Skincare & BeautySkin science and ingredient guides

Skin science article

Beauty of Joseon Dynasty Cream (Old Formulation) Versus CeraVe SA Smoothing Cream

Beauty of Joseon Dynasty Cream (Old Formulation) Versus CeraVe SA Smoothing Cream This barrier-repair moisturizer is formulated around Niacinamide and Adenosine to strengthen the skin barrier and hydrate skin. This smoothing moisturizer is formulated around Ur

Beauty of Joseon Dynasty Cream (Old Formulation) Versus CeraVe SA Smoothing Cream

This barrier-repair moisturizer is formulated around Niacinamide and Adenosine to strengthen the skin barrier and hydrate skin.

This smoothing moisturizer is formulated around Urea and Niacinamide to refine skin texture and strengthen the skin barrier.

What's inside

Key Ingredients

Benefits

Concerns

Ingredients Side-by-side

Water

Glycerin

Butylene Glycol

Niacinamide

Dipentaerythrityl Hexa C5-9 Acid Esters

Sodium Hyaluronate

Xanthan Gum

Cyclopentasiloxane

Cyclohexasiloxane

Polyacrylate-13

Polyisobutene

Polysorbate 20

Hydrogenated Lecithin

C14-28 Alkyl Acid

Stearyl Alcohol

Behenyl Alcohol

Dimethicone/Vinyl Dimethicone Crosspolymer

Dimethicone

Adenosine

Glyceryl Stearate Se

Cetearyl Alcohol

Polyglyceryl-3 Methylglucose Distearate

Cetyl PEG/PPG-10/1 Dimethicone

Stearic Acid

Tocopheryl Acetate

Sodium Polyacrylate

Olea Europaea Fruit Oil

Helianthus Annuus Seed Oil

Centella Asiatica Extract

Hippophae Rhamnoides Oil

Argania Spinosa Kernel Oil

Butyrospermum Parkii Butter

Ceramide NP

Trehalose

Calendula Officinalis Flower Extract

Caprylhydroxamic Acid

1,2-Hexanediol

Raphanus Sativus Leaf Extract

Oryza Sativa Bran Extract

Cucurbitaceae Extract

Orchid Extract

Honey Extract

Panax Ginseng Root Extract

Carthamus Tinctorius Seed Oil

Phytosphingosine

Ceteareth-20

Glyceryl Citrate/Lactate/Linoleate/Oleate

Parfum

Water, Glycerin, Butylene Glycol, Niacinamide, Dipentaerythrityl Hexa C5-9 Acid Esters, Sodium Hyaluronate, Xanthan Gum, Cyclopentasiloxane, Cyclohexasiloxane, Polyacrylate-13, Polyisobutene, Polysorbate 20, Hydrogenated Lecithin, C14-28 Alkyl Acid, Stearyl Alcohol, Behenyl Alcohol, Dimethicone/Vinyl Dimethicone Crosspolymer, Dimethicone, Adenosine, Glyceryl Stearate Se, Cetearyl Alcohol, Polyglyceryl-3 Methylglucose Distearate, Cetyl PEG/PPG-10/1 Dimethicone, Stearic Acid, Tocopheryl Acetate, Sodium Polyacrylate, Olea Europaea Fruit Oil, Helianthus Annuus Seed Oil, Centella Asiatica Extract, Hippophae Rhamnoides Oil, Argania Spinosa Kernel Oil, Butyrospermum Parkii Butter, Ceramide NP, Trehalose, Calendula Officinalis Flower Extract, Caprylhydroxamic Acid, 1,2-Hexanediol, Raphanus Sativus Leaf Extract, Oryza Sativa Bran Extract, Cucurbitaceae Extract, Orchid Extract, Honey Extract, Panax Ginseng Root Extract, Carthamus Tinctorius Seed Oil, Phytosphingosine, Ceteareth-20, Glyceryl Citrate/Lactate/Linoleate/Oleate, Parfum

Urea

Cetyl Alcohol

C12-13 Alkyl Lactate

PEG-100 Stearate

Behentrimonium Methosulfate

Triacetin

Ceramide AP

Ceramide EOP

Carbomer

Sodium Lactate

Salicylic Acid

Sodium Hydroxide

Sodium Lauroyl Lactylate

Cholesterol

Phenoxyethanol

Disodium EDTA

Capryloyl Salicylic Acid

Hydroxyacetophenone

Citric Acid

Lactic Acid

Ethylhexylglycerin

Water, Urea, Cetyl Alcohol, Glyceryl Stearate Se, Cetearyl Alcohol, Niacinamide, Butyrospermum Parkii Butter, C12-13 Alkyl Lactate, PEG-100 Stearate, Glycerin, Behentrimonium Methosulfate, Dimethicone, Triacetin, Ceramide NP, Ceramide AP, Ceramide EOP, Carbomer, Sodium Lactate, Salicylic Acid, Sodium Hydroxide, Sodium Lauroyl Lactylate, Sodium Hyaluronate, Cholesterol, Phenoxyethanol, Disodium EDTA, Capryloyl Salicylic Acid, Hydroxyacetophenone, Citric Acid, Lactic Acid, Phytosphingosine, Xanthan Gum, Ethylhexylglycerin

Reviews

Be the first to review

Alternatives

Ingredients Explained

These ingredients are found in both products.

Ingredients higher up in an ingredient list are typically present in a larger amount.

This ingredient is also known as shea butter. It is a plant-derived extract from the nuts of the Africa shea tree and one of the most well-studied emollients.

Because it has a high concentration of fatty acids (primarily oleic, stearic, and linoleic) it is able to form a protective barrier on the skin's surface. This helps seal in moisture and prevents transepidermal water loss (TEWL).

In vitro research found an increase in skin hydration by 58% and a decrease in TEWL by 37.8% after 24 hours of applying this ingredient (pretty impressive for a single ingredient!).

Besides hydration, shea butter also contains triterpenes that have anti-inflammatory potential. In particule, lupeol cinnamate has shown the highest anti-inflammatory activity in vivo.

Shea butter also contains vitamins A and E which may contribute to antioxidant activity.

While Shea Butter has an SPF rating of about 3-4, it is not a sunscreen replacement.

This ingredient may not be fungal acne safe because its fatty acids fall within the C11-C24 range that the Malassezia yeast can metabolize.

Ceramide NP (formerly known as Ceramide 3) is one of the skin's naturally occurring lipids.

Since ceramides are the major lipid components of the skin, they are crucial for maintaining skin barrier and hydration. Ceramide NP most closely mirrors the dominant kind in human skin amongst ceramide subtypes.

This ceramide works by slotting into gaps within the stratum corneum's lipid matrix to limit trans-epidermal water loss (TEWL) and shield the skin against external irritants.

A study with 312 patients found that using a ceramide-containing routine for 4 weeks reduced the severity of atopic dermatitis by over 61%.

Another clinical study in subjects aged 60 and older found that a ceramide body wash and moisturizer improved skin dryness and itchy skin in 15 days.

Overall, ceramides are considered non-irritating and safety tests have found little to no observable adverse effects from using this ingredient.

Ceramide NP is usually sourced from plants (like soybean or rice bran), or produced synthetically.

Cetearyl alcohol is a waxy mixture of two fatty alcohols: cetyl alcohol and stearyl alcohol. It is an emollient and emulsifier.

Despite having "alcohol" in its name, it has nothing to do with drying solvent alcohols; the FDA also allows "alcohol-free" products to contain fatty alcohols like this ingredient.

It plays several roles in a formula:

Typical use levels for this ingredient sit around 1-10% and the Cosmetic Ingredient Review Expert Panel has affirmed safety at concentrations up to 25% in leave-on products.

Multiple assessments have found it to be non-irritating and non-sensitizing to most people.

However, there have been some cases of allergic contact dermatitis in patients with chronically compromised skin barriers.

Cetearyl alcohol has a comedogenic rating of 2 and irritancy rating of 1. Both of these numbers come from the 1989 study that used rabbit ears; a "2" means mildly comedogenic and a "1" means low irritancy.

Here's the catch: rabbit skin is more sensitive than human skin and throws a lot of false positives. A 1996 reappraisal found that ingredients rated 1-2 in the rabbit ear tests are generally safe for humans.

Remember comedogenic ratings are unable to assess the entire formula of a product or how it will react on your skin. Just be sure to patch test if you are unsure about certain ingredients.

This ingredient is not fungal acne safe. Cetearyl alcohol is a fatty alcohol with chain lengths that fall within the range that Malassezia can metabolize.

A 2019 study has also observed Malassezia growth in the presence of this ingredient, confirming it to be not-fungal acne safe.

Dimethicone is a type of synthetic silicone created from natural materials such as quartz. It is also known as polydimethylsiloxane.

What it does:

Dimethicone comes in different viscosities:

Depending on the viscosity, dimethicone has different properties.

Ingredients lists don't always show which type is used, so we recommend reaching out to the brand if you have questions about the viscosity.

This ingredient is unlikely to cause irritation because it does not get absorbed into skin. However, people with silicone allergies should be careful about using this ingredient.

Note: Dimethicone may contribute to pilling. This is because it is not oil or water soluble, so pilling may occur when layered with products. When mixed with heavy oils in a formula, the outcome is also quite greasy.

Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.

Topically, glycerin does several things at once:

Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.

Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.

This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.

Just know very high concentrations (>40%) can feel tacky in low humidity.

Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.

Glyceryl Stearate Se is a self-emulsifying (SE) form of glyceryl stearate. Self-emusifying means this ingredient automatically blends with water. It is an emulsifier, emollient, and cleansing agent.

As an emulsifier, Glyceryl Stearate Se prevents ingredients such as oil and water from separating. It is also a surfactant, meaning it helps cleanse the skin. Surfactants help gather oil, dirt, and other pollutants so they may be rinsed away easily.

Emollients help your skin stay smooth and soft. It does so by creating a film on top of the skin that helps trap moisture in.

Niacinamide is a multitasking form of vitamin B3 that strengthens the skin barrier, reduces pores and dark spots, regulates oil, and improves signs of aging.

And the best part? It's gentle and well-tolerated by most skin types, including sensitive and reactive skin.

You might have heard of "niacin flush", or the reddening of skin that causes itchiness. Niacinamide has not been found to cause this.

In very rare cases, some individuals may not be able to tolerate niacinamide at all or experience an allergic reaction to it.

If you are experiencing flaking, irritation, and dryness with this ingredient, be sure to double check all your products as this ingredient can be found in all categories of skincare.

When incorporating niacinamide into your routine, look out for concentration amounts. Typically, 5% niacinamide provides benefits such as fading dark spots. However, if you have sensitive skin, it is better to begin with a smaller concentration.

When you apply niacinamide to your skin, your body converts it into nicotinamide adenine dinucleotide (NAD). NAD is an essential coenzyme that is already found in your cells as "fuel" and powers countless biological processes.

In your skin, NAD helps repair cell damage, produce new healthy cells, support collagen production, strengthen the skin barrier, and fight environmental stressors (like UV and pollution).

Our natural NAD levels start to decline with age, leading to slower skin repair, visible aging, and a weaker skin barrier. By providing your skin niacinamide, you're recharging your skin's NAD levels. This leads to stronger, healthier, and younger looking skin.

Another name for vitamin B3 is nicotinamide. This vitamin is water-soluble and our bodies don't store it. We obtain Vitamin B3 from either food or skincare. Meat, fish, wheat, yeast, and leafy greens contain vitamin B3.

The type of niacinamide used in skincare is synthetically created.

Phytosphingosine is a phospholipid naturally found in our skin as a building block for ceramides.. It helps moisturize, soothe, and protect skin.

Phytosphingosine contributes to your skin's natural moisturizing factor (NMF). The NMF is responsible for hydration, a strong barrier, and plasticity. Our NMF decreases with age. Increasing NMF leads to more healthy and hydrated skin.

Studies show products formulated with NMF ingredients help strengthen our skin's barrier. Having a healthy skin barrier reduces irritation and increases hydration. Our skin barrier is responsible for having plump and firm skin. It also helps protect our skin against infection, allergies, and inflammation.

Fun fact: Phytosphingosine is abundant in plants and fungi.

More ingredients that help boost collagen in skin:

Sodium Hyaluronate is the salt form of hyaluronic acid. It is a long sugar chain that is naturally found in your skin, joints, and connective tissue that maintains hydration and elasticity.

In skincare, it works as a humectant. It pulls water from the environment and deeper layers of skin and binds it to the surface.

Interestingly, the size of the molecule affects its behavior:

Some clinical evidence links low molecular weight versions to improved wrinkle depth, elasticity, anti-inflammatory effects, and barrier repair.

Many serums use a blend of both weights so you can get surface hydration plus longer-lasting and deeper effects.

You'll typically see concentrations between 0.1-2% for this ingredient.

Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.

So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.

You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!

Xanthan gum is used as a stabilizer and thickener within cosmetic products. It helps give products a sticky, thick feeling - preventing them from being too runny.

On the technical side of things, xanthan gum is a polysaccharide - a combination consisting of multiple sugar molecules bonded together.

Xanthan gum is a pretty common and great ingredient. It is a natural, non-toxic, non-irritating ingredient that is also commonly used in food products.

Similar Comparisons

The reference edit

Ingredients, questions
& further reading.

Connected source records selected through this article’s public topic index.

01

Formula cabinet

Ingredients & structured notes

Ingredient index

Ingredients Explained

  1. 01These ingredients are found in both products.
  2. 02Ingredients higher up in an ingredient list are typically present in a larger amount.
  3. 03Sorbeth-30 Tetraoleate is a surfactant and emulsifier.
  4. 04This ingredient is a tetraester from oleic acid and polyethylene glycol ether of sorbitol.
  5. 05As an emulsifier, it helps ingredients such as oil and water mix together. This allows the dirt and oils in your skin to be washed away.
  6. 06One study found pumpkin oil containing Sorbeth-30 Tetraoleate helped hydrate the skin and did not cause any irritation.
Source · skinsort.com
02

Product index

Related product references

03

Comparison edit

Read side by side