Peptide Skincare & BeautySkin science and ingredient guides

Skin science article

Beauty of Joseon Dynasty Cream Versus Anua PDRN Hyaluronic Acid 100 Moisturizing Cream

Beauty of Joseon Dynasty Cream Versus Anua PDRN Hyaluronic Acid 100 Moisturizing Cream This barrier-repair moisturizer is formulated around Panax Ginseng Root Water and Niacinamide to strengthen the skin barrier. This anti-aging moisturizer is formulated aroun

Beauty of Joseon Dynasty Cream Versus Anua PDRN Hyaluronic Acid 100 Moisturizing Cream

This barrier-repair moisturizer is formulated around Panax Ginseng Root Water and Niacinamide to strengthen the skin barrier.

This anti-aging moisturizer is formulated around Niacinamide and Sodium DNA to soften the look of wrinkles and hydrate skin.

What's inside

Key Ingredients

Benefits

Concerns

No concerns

Ingredients Side-by-side

Water

Oryza Sativa Bran Water

Glycerin

Panax Ginseng Root Water

Hydrogenated Polydecene

1,2-Hexanediol

Niacinamide

Squalane

Butylene Glycol

Propanediol

Propylene Glycol Dicaprylate/Dicaprate

Cetearyl Olivate

Sorbitan Olivate

Ammonium Acryloyldimethyltaurate/Vp Copolymer

Xanthan Gum

Acrylates/C10-30 Alkyl Acrylate Crosspolymer

Tromethamine

Carthamus Tinctorius Seed Oil

Hydrogenated Coconut Oil

Glyceryl Acrylate/Acrylic Acid Copolymer

Ethylhexylglycerin

Adenosine

Caprylic/Capric Triglyceride

Disodium EDTA

Hyaluronic Acid

Hydrolyzed Hyaluronic Acid

Sodium Hyaluronate

Honey Extract

Ceramide NP

Hydrogenated Lecithin

Coptis Japonica Root Extract

Raphanus Sativus Seed Extract

Lycium Chinense Fruit Extract

Theobroma Cacao Seed Extract

Phellinus Linteus Extract

Dextrin

Scutellaria Baicalensis Root Extract

Water, Oryza Sativa Bran Water, Glycerin, Panax Ginseng Root Water, Hydrogenated Polydecene, 1,2-Hexanediol, Niacinamide, Squalane, Butylene Glycol, Propanediol, Propylene Glycol Dicaprylate/Dicaprate, Cetearyl Olivate, Sorbitan Olivate, Ammonium Acryloyldimethyltaurate/Vp Copolymer, Xanthan Gum, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Tromethamine, Carthamus Tinctorius Seed Oil, Hydrogenated Coconut Oil, Glyceryl Acrylate/Acrylic Acid Copolymer, Ethylhexylglycerin, Adenosine, Caprylic/Capric Triglyceride, Disodium EDTA, Hyaluronic Acid, Hydrolyzed Hyaluronic Acid, Sodium Hyaluronate, Honey Extract, Ceramide NP, Hydrogenated Lecithin, Coptis Japonica Root Extract, Raphanus Sativus Seed Extract, Lycium Chinense Fruit Extract, Theobroma Cacao Seed Extract, Phellinus Linteus Extract, Dextrin, Scutellaria Baicalensis Root Extract

Pentylene Glycol

Sodium DNA

Hydrolyzed Collagen

Melia Azadirachta Leaf Extract

Melia Azadirachta Flower Extract

Coccinia Indica Fruit Extract

Aloe Barbadensis Flower Extract

Solanum Melongena Fruit Extract

Ocimum Sanctum Leaf Extract

Corallina Officinalis Extract

Curcuma Longa Root Extract

Centella Asiatica Leaf Extract

Diphenylsiloxy Phenyl Trimethicone

PCA Dimethicone

Diglycerin

Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer

C12-20 Alkyl Glucoside

Methylpropanediol

Sodium Phytate

Aminomethyl Propanediol

Pvm/Ma Copolymer

Madecassoside

C12-13 Alketh-9

Dimethylsilanol Hyaluronate

Hydrolyzed Sodium Hyaluronate

Asiaticoside

Potassium Hyaluronate

Hydroxypropyltrimonium Hyaluronate

Sodium Hyaluronate Crosspolymer

Sodium Hyaluronate Dimethylsilanol

Sodium Acetylated Hyaluronate

Behenyl Alcohol

C14-22 Alcohols

Carbomer

Water, Squalane, Glycerin, Niacinamide, Pentylene Glycol, 1,2-Hexanediol, Sodium DNA, Hydrolyzed Collagen, Sodium Hyaluronate, Melia Azadirachta Leaf Extract, Hydrolyzed Hyaluronic Acid, Melia Azadirachta Flower Extract, Coccinia Indica Fruit Extract, Hyaluronic Acid, Aloe Barbadensis Flower Extract, Solanum Melongena Fruit Extract, Ocimum Sanctum Leaf Extract, Corallina Officinalis Extract, Curcuma Longa Root Extract, Centella Asiatica Leaf Extract, Diphenylsiloxy Phenyl Trimethicone, PCA Dimethicone, Butylene Glycol, Propanediol, Ammonium Acryloyldimethyltaurate/Vp Copolymer, Diglycerin, Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, C12-20 Alkyl Glucoside, Methylpropanediol, Ethylhexylglycerin, Adenosine, Sodium Phytate, Aminomethyl Propanediol, Pvm/Ma Copolymer, Madecassoside, C12-13 Alketh-9, Dimethylsilanol Hyaluronate, Hydrolyzed Sodium Hyaluronate, Asiaticoside, Potassium Hyaluronate, Hydroxypropyltrimonium Hyaluronate, Sodium Hyaluronate Crosspolymer, Sodium Hyaluronate Dimethylsilanol, Sodium Acetylated Hyaluronate, Behenyl Alcohol, C14-22 Alcohols, Carbomer

Reviews

Alternatives

Ingredients Explained

These ingredients are found in both products.

Ingredients higher up in an ingredient list are typically present in a larger amount.

1,2-Hexanediol is a synthetic liquid and another multi-functional powerhouse.

It is a:

Humectant, drawing moisture into the skin

Emollient, helping to soften skin

Solvent, dispersing and stabilizing formulas

Preservative booster, enhancing the antimicrobial activity of other preservatives

Acrylates/C10-30 Alkyl Acrylate Crosspolymer is a synthetic polymer. It is used to thicken, emulsify, and improve the texture of products.

As an emulsifier, it helps stabilize oil-in-water emulsions to give products an elegant feel when applied.

It can also form a thin protective film on skin. One study found that a formula using this polymer helped slow down how quickly other ingredients (like DEET) were absorbed through skin.

A 2024 study of over 1,300 patients confirmed that sensitization to this ingredient is rare. It is also non-mutagenic and has a clean track record.

Adenosine is a purine nucleoside that your body already makes in every cell. In skincare, it acts mainly as a skin conditioning and anti-aging agent.

The way it works is fairly well mapped out:

Your skin has cells called fibroblasts that build collagen (the stuff that keeps skin firm and smooth). Adenosine basically flips a switch on these cells that tells them to get to work making more collagen and other proteins. These cells slow down on their own as skin ages, so Adenosine helps give them a little nudge to keep going.

The clinical backing is pretty solid too.

A blind, randomized, placebo-controlled trial of 126 women aged 45-65 tested a 0.1% cream twice daily and found real improvements in crow's feet and frown lines using a precise 3D skin-mapping technique; these changes showed up by week 3 and held at 2 months.

A later study using Adenosine-loaded dissolving microneedle patches reported gains in wrinkle depth, dermal density, elasticity, and hydration.

On concentrations, South Korea's Ministry of Food and Drug Safety has set 0.04% as the approved functional anti-wrinkle level. You'll typically see this ingredient used somewhere in the 0.04-0.1% range since it works at low doses.

This ingredient has been found safe for cosmetics with the data showing no irritation or sensitization.

Overall, this is a great ingredient for any anti-aging routine and has no photosensitizing effect, so it suits both AM and PM use.

Ammonium Acryloyldimethyltaurate/Vp Copolymer is a synthetically created polymer. It's used as a film-forming agent and used to thicken the consistency of products.

Think of it as a supportive ingredient that helps your gel-creams feel silky, "cloud cream-like", and spread evenly without being greasy.

The Cosmetic Ingredient Review (CIR) Expert Panel evaluated it (along with 22 other acryloyldimethyltaurate polymers) and concluded it's:

Due to its large molecular size, it sits on the surface of skin rather than penetrating it.

Butylene Glycol (or BG) is used within cosmetic products for a few different reasons:

Overall, Butylene Glycol is a safe and well-rounded ingredient that works well with other ingredients.

Though this ingredient works well with most skin types, some people with sensitive skin may experience a reaction such as allergic rashes, closed comedones, or itchiness.

Ethylhexylglycerin is created from glycerin. It is a multitasker ingredient that:

The CIR Expert Panel found minimal skin absorption or sensitization of any kind in a safety assessment. Though this ingredient is considered well-tolerated, a small number of cases of allergic dermatitis have been published since 2002. Just be sure to patch test if you are unsure.

Industry-reported use ranges from 8% in rinse-off products and 2% in leave-on formulations.

Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.

Topically, glycerin does several things at once:

Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.

Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.

This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.

Just know very high concentrations (>40%) can feel tacky in low humidity.

Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.

Hyaluronic acid (HA) is a glycosaminoglycan (basically a long sugar chain) that your skin already makes on its own. In your skin, HA lives in the extracellular matrix and acts as the body's moisture reservoir.

Topically, HA is a humectant that binds water and helps skin look more plump, smooth, and hydrated.

The only catch is that HA isn't a single thing; it actually comes in a wide range of molecular weights (~50 - 2,000+ kDA) and size matters.

Some clinical evidence links low molecular weight versions to improved wrinkle depth, elasticity, anti-inflammatory effects, and barrier repair.

This is why the best HA serums blend the two sizes together so you get the best of both worlds.

The majority of cosmetic HA is produced by bacterial fermentation, typically using Streptococcus or Bacillus strains. Typical use levels in skincare sit around 0.1-2%.

A clinical study using a 0.2% low-molecular weight HA gel showed improvement in facial seborrheic dermatitis with excellent tolerance.

These are some other common types of Hyaluronic Acid:

Hydrolyzed Hyaluronic Acid is hyaluronic acid (HA) that is broken down into lower molecular weight fragments.

It's a humectant that pulls and holds water in the skin to help with hydration, plumpness, and reduce transepidermal water loss.

Because hydrolyzed hyaluronic acid is smaller in size, it can slip past your outermost layer of skin more easily than full-sized HA.

Most formulations will combine all sizes to get the best of both worlds.

Typical usage levels range from 0.01-1%. Any percentage higher than 2% might become goopy and tacky.

Niacinamide is a multitasking form of vitamin B3 that strengthens the skin barrier, reduces pores and dark spots, regulates oil, and improves signs of aging.

And the best part? It's gentle and well-tolerated by most skin types, including sensitive and reactive skin.

You might have heard of "niacin flush", or the reddening of skin that causes itchiness. Niacinamide has not been found to cause this.

In very rare cases, some individuals may not be able to tolerate niacinamide at all or experience an allergic reaction to it.

If you are experiencing flaking, irritation, and dryness with this ingredient, be sure to double check all your products as this ingredient can be found in all categories of skincare.

When incorporating niacinamide into your routine, look out for concentration amounts. Typically, 5% niacinamide provides benefits such as fading dark spots. However, if you have sensitive skin, it is better to begin with a smaller concentration.

When you apply niacinamide to your skin, your body converts it into nicotinamide adenine dinucleotide (NAD). NAD is an essential coenzyme that is already found in your cells as "fuel" and powers countless biological processes.

In your skin, NAD helps repair cell damage, produce new healthy cells, support collagen production, strengthen the skin barrier, and fight environmental stressors (like UV and pollution).

Our natural NAD levels start to decline with age, leading to slower skin repair, visible aging, and a weaker skin barrier. By providing your skin niacinamide, you're recharging your skin's NAD levels. This leads to stronger, healthier, and younger looking skin.

Another name for vitamin B3 is nicotinamide. This vitamin is water-soluble and our bodies don't store it. We obtain Vitamin B3 from either food or skincare. Meat, fish, wheat, yeast, and leafy greens contain vitamin B3.

The type of niacinamide used in skincare is synthetically created.

Propanediol is an all-star ingredient. It softens, hydrates, and smooths the skin.

It’s often used to:

Propanediol is not likely to cause sensitivity and considered safe to use. It is derived from corn or petroleum with a clear color and no scent.

Sodium Hyaluronate is the salt form of hyaluronic acid. It is a long sugar chain that is naturally found in your skin, joints, and connective tissue that maintains hydration and elasticity.

In skincare, it works as a humectant. It pulls water from the environment and deeper layers of skin and binds it to the surface.

Interestingly, the size of the molecule affects its behavior:

Many serums use a blend of both weights so you can get surface hydration plus longer-lasting and deeper effects.

You'll typically see concentrations between 0.1-2% for this ingredient.

Squalane is the hydrogenated and shelf-stable form of squalene (a lipid that naturally occurs in human sebum).

It is an emollient and skin conditioning agent that is able to integrate seamlessly into the skin's lipid barrier without clogging pores.

This is due to how structurally similar it is to what your skin already produces.

Though it is mostly an emollient that helps soften and hydrate skin, it also has some humectant and occlusive action. Humectants help the skin retain moisture while occlusives seal it in, making squalane a triple-threat moisturizer.

Research shows it has antioxidant capabilities that help protect against stressors like UV exposure, specifically UVA induced oxidative stress. This study also found that it supports collagen biosynthesis in human dermal fibroblasts.

No clinical study has reported significant adverse effects and irritation reactions are very rare from this ingredient (even at 100% concentration).

Overall, it's a fantastic ingredient for hydration and is suitable for all skin types.

This depends on the source. Squalane can be derived from both plants and animals. Most squalane used in skincare comes from plants.

Please note: the source of squalane is only known if disclosed by the brand. We recommend reaching out to the brand if you have any questions about their squalane.

Read more about squalene with an "e".

Though squalane is often called an oil, it’s technically not one. It is a hydrocarbon, meaning it is only made of carbon and hydrogen. True oils are triglycerides and made of fatty acids and glycerol.

The term “oil-free” isn’t regulated so companies can define it however they want. Some exclude all oils, while others just avoid mineral oil or comedogenic oils.

Squalane has a comedogenic rating of 1 from the original 1972 study that tested raw ingredients under occlusion on rabbit ears. This system is not standardized or peer-reviewed, and using the raw ingredients is very different from how diluted cosmetic formulations are used on human skin.

A comedogenic rating of 1 means it is "unlikely to clog pores" according to the original rating system.

The overall formula of a product matters more than the individual ingredients on whether or not it will cause clogged pores.

Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.

So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.

You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!

Similar Comparisons

The reference edit

Ingredients, questions
& further reading.

Connected source records selected through this article’s public topic index.

01

Formula cabinet

Ingredients & structured notes

Ingredient index

Ingredients Explained

  1. 01These ingredients are found in both products.
  2. 02Ingredients higher up in an ingredient list are typically present in a larger amount.
  3. 03Butylene Glycol (or BG) is used within cosmetic products for a few different reasons:
  4. 04Overall, Butylene Glycol is a safe and well-rounded ingredient that works well with other ingredients.
  5. 05Though this ingredient works well with most skin types, some people with sensitive skin may experience a reaction such as allergic rashes, closed comedones, or itchiness.
  6. 06Centella Asiatica Extract (Centella) is one of the most researched botanical extracts in skincare with decades of studies backing its effects on inflammation, collagen, and the skin barrier.
  7. 07That research keeps pointing back to the same four triterpenoid saponins: Asiaticoside, Madecassoside, Asiatic Acid, and Madecassic Acid.
  8. 08These compounds allow centella to dial back inflammation, encourage the skin to build and hold onto collagen, support the barrier and hydration, and bring solid antioxidant activity to protect against signs of aging.
  9. 09Centella also carries a nice supporting cast of Vitamin A, vitamin C, several B vitamins, and amino acids. Put it all together and you get an ingredient that soothes, hydrates, and protects, all at once.
  10. 10Most of centella's magic comes from the four big compounds (Asiaticoside, Madecassoside, Asiatic Acid, and Madecassic Acid). These are the actives doing the heavy lifting in almost every centella study.
  11. 11Here is the short version of what they do in the skin:
  12. 12So it is not just soothing for the sake of soothing. Centella calms the skin AND helps it rebuild.
  13. 13Just FYI, not all centella on an ingredient list is the same. What you are getting actually depends on the extract:
  14. 14Fun fact on the ratios: the leaves tend to be richest in Madecassoside and Asiaticoside, and lower in the two acids. The exact amounts shift with where the plant is grown and how it is processed. This means purity really does vary brand to brand.
  15. 15Centella is one of the most easygoing actives out there.
  16. 16It layers well with basically everything: niacinamide, hyaluronic acid, peptides, and vitamin C, and also pairs nicely with stronger actives like retinoids and exfoliating acids where it can help take the edge off irritation.
  17. 17On the safety side, centella and its triterpenes are classified as weak sensitizers, meaning allergic reactions are possible but uncommon.
  18. 18Patch tests at 1% and 5% came back negative in test panels, and creams at typical use levels did not cause allergic reactions across large groups of people.
  19. 19But as with any new active, a patch test is still a smart move for very reactive skin.
  20. 20Centella is widely used because it is effective at low percentages. For context, human safety testing found no meaningful irritation from creams containing centella extract at everyday use levels (the tested amounts were well under 1%).
Source · skinsort.com
02

Product index

Related product references

03

Comparison edit

Read side by side