Skin science article
Beauty of Joseon Dynasty Cream Versus Numbuzin No. 5 Daily Multi-Vitamin Cream
Beauty of Joseon Dynasty Cream Versus Numbuzin No. 5 Daily Multi-Vitamin Cream This barrier-repair moisturizer is formulated around Panax Ginseng Root Water and Niacinamide to strengthen the skin barrier. This brightening moisturizer is formulated around Panth
Beauty of Joseon Dynasty Cream Versus Numbuzin No. 5 Daily Multi-Vitamin Cream
This barrier-repair moisturizer is formulated around Panax Ginseng Root Water and Niacinamide to strengthen the skin barrier.
This brightening moisturizer is formulated around Panthenol and Niacinamide to brighten dull-looking skin and fade the look of dark spots.
What's inside
Key Ingredients
Benefits
Concerns
Ingredients Side-by-side
Water
Oryza Sativa Bran Water
Glycerin
Panax Ginseng Root Water
Hydrogenated Polydecene
1,2-Hexanediol
Niacinamide
Squalane
Butylene Glycol
Propanediol
Propylene Glycol Dicaprylate/Dicaprate
Cetearyl Olivate
Sorbitan Olivate
Ammonium Acryloyldimethyltaurate/Vp Copolymer
Xanthan Gum
Acrylates/C10-30 Alkyl Acrylate Crosspolymer
Tromethamine
Carthamus Tinctorius Seed Oil
Hydrogenated Coconut Oil
Glyceryl Acrylate/Acrylic Acid Copolymer
Ethylhexylglycerin
Adenosine
Caprylic/Capric Triglyceride
Disodium EDTA
Hyaluronic Acid
Hydrolyzed Hyaluronic Acid
Sodium Hyaluronate
Honey Extract
Ceramide NP
Hydrogenated Lecithin
Coptis Japonica Root Extract
Raphanus Sativus Seed Extract
Lycium Chinense Fruit Extract
Theobroma Cacao Seed Extract
Phellinus Linteus Extract
Dextrin
Scutellaria Baicalensis Root Extract
Water, Oryza Sativa Bran Water, Glycerin, Panax Ginseng Root Water, Hydrogenated Polydecene, 1,2-Hexanediol, Niacinamide, Squalane, Butylene Glycol, Propanediol, Propylene Glycol Dicaprylate/Dicaprate, Cetearyl Olivate, Sorbitan Olivate, Ammonium Acryloyldimethyltaurate/Vp Copolymer, Xanthan Gum, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Tromethamine, Carthamus Tinctorius Seed Oil, Hydrogenated Coconut Oil, Glyceryl Acrylate/Acrylic Acid Copolymer, Ethylhexylglycerin, Adenosine, Caprylic/Capric Triglyceride, Disodium EDTA, Hyaluronic Acid, Hydrolyzed Hyaluronic Acid, Sodium Hyaluronate, Honey Extract, Ceramide NP, Hydrogenated Lecithin, Coptis Japonica Root Extract, Raphanus Sativus Seed Extract, Lycium Chinense Fruit Extract, Theobroma Cacao Seed Extract, Phellinus Linteus Extract, Dextrin, Scutellaria Baicalensis Root Extract
Terminalia Ferdinandiana Fruit Extract
Methylpropanediol
Cetyl Ethylhexanoate
Cetearyl Alcohol
Panthenol
Betaine
Vinyldimethicone
Methyl Trimethicone
Butyrospermum Parkii Butter
Polymethylsilsesquioxane
Melia Azadirachta Flower Extract
Melia Azadirachta Leaf Extract
Curcuma Longa Root Extract
Ocimum Sanctum Leaf Extract
Corallina Officinalis Extract
Olea Europaea Leaf Extract
Phaseolus Lunatus Seed Extract
Citrus Aurantium Dulcis Oil
Citrus Nobilis Peel Oil
Litsea Cubeba Fruit Oil
Rosa Canina Fruit Oil
Camellia Sinensis Leaf Water
Glyceryl Linolenate
Glyceryl Linoleate
Tocopheryl Acetate
Polyglyceryl-2 Stearate
Isononyl Isononanoate
Glyceryl Stearate Se
Glyceryl Stearate
Bisabolol
Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer
Stearyl Alcohol
3-O-Ethyl Ascorbic Acid
Behenyl Alcohol
Ascorbyl Tetraisopalmitate
Sorbitan Isostearate
Cholesterol
Hydroxydecyl Ubiquinone
Cyamopsis Tetragonoloba Gum
Agar
7-Dehydrocholesterol
Magnesium Myristate
Magnesium Stearate
Sea Salt
Acetyl Glucosamine
Zinc Gluconate
Calcium Stearate
Lactic Acid
Cetyl Hydroxyethylcellulose
Rutin
Ascorbyl Glucoside
Zinc PCA
Glycine
Glutamic Acid
Glutamine
Dipotassium Phosphate
Lysine
Leucine
Methionine
Valine
Serine
Cysteine
Citrulline
Ascorbic Acid
Asparagine
Aspartic Acid
Isoleucine
Alanine
Arginine
Ornithine
Copper Tripeptide-1
Taurine
Tyrosine
Threonine
Tryptophan
Pantothenic Acid
Phenylalanine
Proline
Histidine
Retinyl Palmitate
Repagermanium
Linolenic Acid
Riboflavin
Magnesium Ascorbyl Phosphate
Menadione
Biotin
Bioflavonoids
Cyanocobalamin
Sodium Ascorbyl Phosphate
Tocopherol
Thiamine Hcl
Palmitoyl Tetrapeptide-7
Palmitoyl Tripeptide-1
Folic Acid
Pyridoxine
Hesperidin
Limonene
Citral
Terminalia Ferdinandiana Fruit Extract, Methylpropanediol, Glycerin, Cetyl Ethylhexanoate, Cetearyl Alcohol, Panthenol, Niacinamide, Betaine, Vinyldimethicone, Squalane, Caprylic/Capric Triglyceride, 1,2-Hexanediol, Methyl Trimethicone, Butyrospermum Parkii Butter, Polymethylsilsesquioxane, Propanediol, Melia Azadirachta Flower Extract, Melia Azadirachta Leaf Extract, Curcuma Longa Root Extract, Ocimum Sanctum Leaf Extract, Theobroma Cacao Seed Extract, Corallina Officinalis Extract, Olea Europaea Leaf Extract, Phaseolus Lunatus Seed Extract, Citrus Aurantium Dulcis Oil, Hydrogenated Lecithin, Citrus Nobilis Peel Oil, Litsea Cubeba Fruit Oil, Rosa Canina Fruit Oil, Camellia Sinensis Leaf Water, Water, Glyceryl Linolenate, Glyceryl Linoleate, Tocopheryl Acetate, Polyglyceryl-2 Stearate, Isononyl Isononanoate, Glyceryl Stearate Se, Glyceryl Stearate, Bisabolol, Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, Stearyl Alcohol, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Tromethamine, Xanthan Gum, 3-O-Ethyl Ascorbic Acid, Behenyl Alcohol, Ascorbyl Tetraisopalmitate, Adenosine, Disodium EDTA, Butylene Glycol, Sorbitan Isostearate, Cholesterol, Hydroxydecyl Ubiquinone, Cyamopsis Tetragonoloba Gum, Agar, Dextrin, Ceramide NP, 7-Dehydrocholesterol, Magnesium Myristate, Magnesium Stearate, Sea Salt, Acetyl Glucosamine, Zinc Gluconate, Calcium Stearate, Lactic Acid, Cetyl Hydroxyethylcellulose, Rutin, Ascorbyl Glucoside, Zinc PCA, Glycine, Glutamic Acid, Glutamine, Dipotassium Phosphate, Lysine, Leucine, Methionine, Valine, Serine, Cysteine, Citrulline, Ascorbic Acid, Asparagine, Aspartic Acid, Isoleucine, Alanine, Arginine, Ornithine, Copper Tripeptide-1, Taurine, Tyrosine, Threonine, Tryptophan, Pantothenic Acid, Phenylalanine, Proline, Histidine, Retinyl Palmitate, Repagermanium, Linolenic Acid, Riboflavin, Magnesium Ascorbyl Phosphate, Menadione, Biotin, Bioflavonoids, Cyanocobalamin, Sodium Ascorbyl Phosphate, Tocopherol, Thiamine Hcl, Palmitoyl Tetrapeptide-7, Palmitoyl Tripeptide-1, Folic Acid, Pyridoxine, Hesperidin, Ethylhexylglycerin, Limonene, Citral
Reviews
Alternatives
Ingredients Explained
These ingredients are found in both products.
Ingredients higher up in an ingredient list are typically present in a larger amount.
1,2-Hexanediol is a synthetic liquid and another multi-functional powerhouse.
It is a:
Humectant, drawing moisture into the skin
Emollient, helping to soften skin
Solvent, dispersing and stabilizing formulas
Preservative booster, enhancing the antimicrobial activity of other preservatives
Acrylates/C10-30 Alkyl Acrylate Crosspolymer is a synthetic polymer. It is used to thicken, emulsify, and improve the texture of products.
As an emulsifier, it helps stabilize oil-in-water emulsions to give products an elegant feel when applied.
It can also form a thin protective film on skin. One study found that a formula using this polymer helped slow down how quickly other ingredients (like DEET) were absorbed through skin.
A 2024 study of over 1,300 patients confirmed that sensitization to this ingredient is rare. It is also non-mutagenic and has a clean track record.
Adenosine is a purine nucleoside that your body already makes in every cell. In skincare, it acts mainly as a skin conditioning and anti-aging agent.
The way it works is fairly well mapped out:
Your skin has cells called fibroblasts that build collagen (the stuff that keeps skin firm and smooth). Adenosine basically flips a switch on these cells that tells them to get to work making more collagen and other proteins. These cells slow down on their own as skin ages, so Adenosine helps give them a little nudge to keep going.
The clinical backing is pretty solid too.
A blind, randomized, placebo-controlled trial of 126 women aged 45-65 tested a 0.1% cream twice daily and found real improvements in crow's feet and frown lines using a precise 3D skin-mapping technique; these changes showed up by week 3 and held at 2 months.
A later study using Adenosine-loaded dissolving microneedle patches reported gains in wrinkle depth, dermal density, elasticity, and hydration.
On concentrations, South Korea's Ministry of Food and Drug Safety has set 0.04% as the approved functional anti-wrinkle level. You'll typically see this ingredient used somewhere in the 0.04-0.1% range since it works at low doses.
This ingredient has been found safe for cosmetics with the data showing no irritation or sensitization.
Overall, this is a great ingredient for any anti-aging routine and has no photosensitizing effect, so it suits both AM and PM use.
Butylene Glycol (or BG) is used within cosmetic products for a few different reasons:
Overall, Butylene Glycol is a safe and well-rounded ingredient that works well with other ingredients.
Though this ingredient works well with most skin types, some people with sensitive skin may experience a reaction such as allergic rashes, closed comedones, or itchiness.
Caprylic/Capric Triglyceride (aka MCT Oil) is a lightweight emollient, solvent, and texture enhancer. It is considered a skin-softener by helping to prevent moisture loss.
Though it behaves like an oil, it is not technically one due to its chemical composition. One perk of this ingredient is that it is very stable, resistant to oxidation, and unlikely to go rancid.
In practice, that translates to a long shelf life and a consistently elegant skin feel.
While there is an assumption Caprylic Triglyceride can clog pores due to it being derived from coconut oil, there is no research supporting this. Just patch test if you have concerns.
Fractionated coconut oil and MCT Oil are both listed as Caprylic/Capric Triglyceride according to INCI. This is because INCI names are based on the ingredient’s final chemical composition and not its marketing name or source.
This ingredient is treated as the gold standard fungal acne safe oil. Even though it is coconut derived, the problematic lauric acid is stripped out.
This leaves just caprylic (C8) and capric (C10) acid. These chain lengths actually trend antifungal; a 2020 study found caprylic acid was enough to disrupt Malassezia furfur cell membrane, with a caprylic acid derivative damaging membrane structures at concentrations as low as 0.2%.
Ceramide NP (formerly known as Ceramide 3) is one of the skin's naturally occurring lipids.
Since ceramides are the major lipid components of the skin, they are crucial for maintaining skin barrier and hydration. Ceramide NP most closely mirrors the dominant kind in human skin amongst ceramide subtypes.
This ceramide works by slotting into gaps within the stratum corneum's lipid matrix to limit trans-epidermal water loss (TEWL) and shield the skin against external irritants.
A study with 312 patients found that using a ceramide-containing routine for 4 weeks reduced the severity of atopic dermatitis by over 61%.
Another clinical study in subjects aged 60 and older found that a ceramide body wash and moisturizer improved skin dryness and itchy skin in 15 days.
Overall, ceramides are considered non-irritating and safety tests have found little to no observable adverse effects from using this ingredient.
Ceramide NP is usually sourced from plants (like soybean or rice bran), or produced synthetically.
Dextrin is a starch-derived polysaccharide. It's made by partially breaking down corn, potato, or other plant starches.
Think of it as "half-processed" starch; it's less complex than the original but not fully broken down into sugar like maltodextrin.
In cosmetics, it mainly functions as a bulking agent, viscosity controller, binder, and absorbent. It helps thicken products, stabilize powders, and get certain textures a less "wet" feel.
This ingredient has a pretty solid safety profile; it's recognized as a safe food additive and its large molecular size means it doesn't meaningfully penetrate skin.
Human repeat insult patch tests using a rinse-off facial product containing 42.69% dextrin found no skin irritation or sensitization in 54 subjects.
Typical real-world usage is much lower: usually under 1% as a texture modifier and up to 40% in masks (rinse off products use less).
Disodium EDTA is a chelating agent. It grabs onto and deactivates metal ions that sneak into your products from water, packaging, or air.
This ingredient mainly works behind the scenes and helps with:
On top of that, this ingredient can counteract the effects of hard water by binding to the minerals in it.
One thing worth knowing is that Disodium EDTA has been shown to be a mild penetration enhancer. It can help other ingredients absorb into skin more effectively which can be a double-edged sword (great for actives, but can also make the active too strong if you have sensitive skin).
Clinical patch testing showed no significant skin irritation at typical use concentrations and minimal dermal absorption.
You'll most likely see this ingredient near the end of an ingredient list. It's typically found in concentrations less than 1%.
Ethylhexylglycerin is created from glycerin. It is a multitasker ingredient that:
The CIR Expert Panel found minimal skin absorption or sensitization of any kind in a safety assessment. Though this ingredient is considered well-tolerated, a small number of cases of allergic dermatitis have been published since 2002. Just be sure to patch test if you are unsure.
Industry-reported use ranges from 8% in rinse-off products and 2% in leave-on formulations.
Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.
Topically, glycerin does several things at once:
Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.
Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.
This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.
Just know very high concentrations (>40%) can feel tacky in low humidity.
Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.
Hydrogenated Lecithin is a more stable version of lecithin.
It's made by taking lecithin (a phospholipid commonly found in soybeans and egg yolks) and hydrogenating it. This just means the unsaturated fatty acids are turned into saturated ones so they don't go bad as easily.
This ingredient is an emollient, emulsifier, and penetration enhancer. As an emollient, it helps soften and hydrate skin by trapping moisture within. As an emulsifier, it prevents oil and water ingredients from separating.
Hydrogenated Lecithin can form tiny spherical structures made of phospholipid bilayers called liposomes. These liposomes are able to capture compounds inside their structure and deliver them through the skin barrier.
Because phospholipids are a natural component of our cell membranes, this ingredient is inherently compatible with skin.
A 2021 study found lecithin-based surfactants were less harsh and more tolerable comared to Sodium Lauryl Sulfate (SLS).
Niacinamide is a multitasking form of vitamin B3 that strengthens the skin barrier, reduces pores and dark spots, regulates oil, and improves signs of aging.
And the best part? It's gentle and well-tolerated by most skin types, including sensitive and reactive skin.
You might have heard of "niacin flush", or the reddening of skin that causes itchiness. Niacinamide has not been found to cause this.
In very rare cases, some individuals may not be able to tolerate niacinamide at all or experience an allergic reaction to it.
If you are experiencing flaking, irritation, and dryness with this ingredient, be sure to double check all your products as this ingredient can be found in all categories of skincare.
When incorporating niacinamide into your routine, look out for concentration amounts. Typically, 5% niacinamide provides benefits such as fading dark spots. However, if you have sensitive skin, it is better to begin with a smaller concentration.
When you apply niacinamide to your skin, your body converts it into nicotinamide adenine dinucleotide (NAD). NAD is an essential coenzyme that is already found in your cells as "fuel" and powers countless biological processes.
In your skin, NAD helps repair cell damage, produce new healthy cells, support collagen production, strengthen the skin barrier, and fight environmental stressors (like UV and pollution).
Our natural NAD levels start to decline with age, leading to slower skin repair, visible aging, and a weaker skin barrier. By providing your skin niacinamide, you're recharging your skin's NAD levels. This leads to stronger, healthier, and younger looking skin.
Another name for vitamin B3 is nicotinamide. This vitamin is water-soluble and our bodies don't store it. We obtain Vitamin B3 from either food or skincare. Meat, fish, wheat, yeast, and leafy greens contain vitamin B3.
The type of niacinamide used in skincare is synthetically created.
Propanediol is an all-star ingredient. It softens, hydrates, and smooths the skin.
It’s often used to:
Propanediol is not likely to cause sensitivity and considered safe to use. It is derived from corn or petroleum with a clear color and no scent.
Squalane is the hydrogenated and shelf-stable form of squalene (a lipid that naturally occurs in human sebum).
It is an emollient and skin conditioning agent that is able to integrate seamlessly into the skin's lipid barrier without clogging pores.
This is due to how structurally similar it is to what your skin already produces.
Though it is mostly an emollient that helps soften and hydrate skin, it also has some humectant and occlusive action. Humectants help the skin retain moisture while occlusives seal it in, making squalane a triple-threat moisturizer.
Research shows it has antioxidant capabilities that help protect against stressors like UV exposure, specifically UVA induced oxidative stress. This study also found that it supports collagen biosynthesis in human dermal fibroblasts.
No clinical study has reported significant adverse effects and irritation reactions are very rare from this ingredient (even at 100% concentration).
Overall, it's a fantastic ingredient for hydration and is suitable for all skin types.
This depends on the source. Squalane can be derived from both plants and animals. Most squalane used in skincare comes from plants.
Please note: the source of squalane is only known if disclosed by the brand. We recommend reaching out to the brand if you have any questions about their squalane.
Read more about squalene with an "e".
Though squalane is often called an oil, it’s technically not one. It is a hydrocarbon, meaning it is only made of carbon and hydrogen. True oils are triglycerides and made of fatty acids and glycerol.
The term “oil-free” isn’t regulated so companies can define it however they want. Some exclude all oils, while others just avoid mineral oil or comedogenic oils.
Squalane has a comedogenic rating of 1 from the original 1972 study that tested raw ingredients under occlusion on rabbit ears. This system is not standardized or peer-reviewed, and using the raw ingredients is very different from how diluted cosmetic formulations are used on human skin.
A comedogenic rating of 1 means it is "unlikely to clog pores" according to the original rating system.
The overall formula of a product matters more than the individual ingredients on whether or not it will cause clogged pores.
Theobroma Cacao Seed Extract comes from the Theobroma cacoa, or Cacao tree. Cacao trees are native to tropical landscapes.
Cacao seed extract contains antioxidants known as polyphenols.
Tromethamine (aka THAM) is a synthetic amino acid that shows up in skincare as a helper ingredient.
It functions as a pH adjuster to help neutralize acidic ingredients and set a formula's pH to the right spot.
This matters a lot because a lot of actives (like vitamin C) needs a specific pH to work well and feel comfortable on skin.
Concentration use ranges from 0.1-1.0% depending on the formula.
Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.
So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.
You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!
Xanthan gum is used as a stabilizer and thickener within cosmetic products. It helps give products a sticky, thick feeling - preventing them from being too runny.
On the technical side of things, xanthan gum is a polysaccharide - a combination consisting of multiple sugar molecules bonded together.
Xanthan gum is a pretty common and great ingredient. It is a natural, non-toxic, non-irritating ingredient that is also commonly used in food products.