Peptide Skincare & BeautySkin science and ingredient guides

Skin science article

Beauty of Joseon Dynasty Cream Versus Round Lab 1025 Dokdo Lotion

Beauty of Joseon Dynasty Cream Versus Round Lab 1025 Dokdo Lotion This barrier-repair moisturizer is formulated around Panax Ginseng Root Water and Niacinamide to strengthen the skin barrier. This barrier-repair moisturizer is formulated around Macadamia Integ

Beauty of Joseon Dynasty Cream Versus Round Lab 1025 Dokdo Lotion

This barrier-repair moisturizer is formulated around Panax Ginseng Root Water and Niacinamide to strengthen the skin barrier.

This barrier-repair moisturizer is formulated around Macadamia Integrifolia Seed Oil and Panthenol to strengthen the skin barrier and hydrate skin.

What's inside

Key Ingredients

Benefits

Concerns

Ingredients Side-by-side

Water

Oryza Sativa Bran Water

Glycerin

Panax Ginseng Root Water

Hydrogenated Polydecene

1,2-Hexanediol

Niacinamide

Squalane

Butylene Glycol

Propanediol

Propylene Glycol Dicaprylate/Dicaprate

Cetearyl Olivate

Sorbitan Olivate

Ammonium Acryloyldimethyltaurate/Vp Copolymer

Xanthan Gum

Acrylates/C10-30 Alkyl Acrylate Crosspolymer

Tromethamine

Carthamus Tinctorius Seed Oil

Hydrogenated Coconut Oil

Glyceryl Acrylate/Acrylic Acid Copolymer

Ethylhexylglycerin

Adenosine

Caprylic/Capric Triglyceride

Disodium EDTA

Hyaluronic Acid

Hydrolyzed Hyaluronic Acid

Sodium Hyaluronate

Honey Extract

Ceramide NP

Hydrogenated Lecithin

Coptis Japonica Root Extract

Raphanus Sativus Seed Extract

Lycium Chinense Fruit Extract

Theobroma Cacao Seed Extract

Phellinus Linteus Extract

Dextrin

Scutellaria Baicalensis Root Extract

Water, Oryza Sativa Bran Water, Glycerin, Panax Ginseng Root Water, Hydrogenated Polydecene, 1,2-Hexanediol, Niacinamide, Squalane, Butylene Glycol, Propanediol, Propylene Glycol Dicaprylate/Dicaprate, Cetearyl Olivate, Sorbitan Olivate, Ammonium Acryloyldimethyltaurate/Vp Copolymer, Xanthan Gum, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Tromethamine, Carthamus Tinctorius Seed Oil, Hydrogenated Coconut Oil, Glyceryl Acrylate/Acrylic Acid Copolymer, Ethylhexylglycerin, Adenosine, Caprylic/Capric Triglyceride, Disodium EDTA, Hyaluronic Acid, Hydrolyzed Hyaluronic Acid, Sodium Hyaluronate, Honey Extract, Ceramide NP, Hydrogenated Lecithin, Coptis Japonica Root Extract, Raphanus Sativus Seed Extract, Lycium Chinense Fruit Extract, Theobroma Cacao Seed Extract, Phellinus Linteus Extract, Dextrin, Scutellaria Baicalensis Root Extract

Macadamia Integrifolia Seed Oil

Pentylene Glycol

Chondrus Crispus Extract

Saccharum Officinarum Extract

Sea Water

Panthenol

Polyglyceryl-3 Methylglucose Distearate

Glyceryl Stearate

Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer

Jojoba Esters

Caprylyl Glycol

Sodium Phytate

Tocopherol

Sodium Carboxymethyl Beta-Glucan

Cetearyl Alcohol

Carbomer

Water, Glycerin, Macadamia Integrifolia Seed Oil, 1,2-Hexanediol, Pentylene Glycol, Chondrus Crispus Extract, Saccharum Officinarum Extract, Sea Water, Hyaluronic Acid, Hydrolyzed Hyaluronic Acid, Sodium Hyaluronate, Panthenol, Squalane, Butylene Glycol, Polyglyceryl-3 Methylglucose Distearate, Glyceryl Stearate, Hydrogenated Polydecene, Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, Jojoba Esters, Caprylyl Glycol, Tromethamine, Sodium Phytate, Tocopherol, Sodium Carboxymethyl Beta-Glucan, Ethylhexylglycerin, Cetearyl Alcohol, Carbomer

Reviews

Alternatives

Ingredients Explained

These ingredients are found in both products.

Ingredients higher up in an ingredient list are typically present in a larger amount.

1,2-Hexanediol is a synthetic liquid and another multi-functional powerhouse.

It is a:

Humectant, drawing moisture into the skin

Emollient, helping to soften skin

Solvent, dispersing and stabilizing formulas

Preservative booster, enhancing the antimicrobial activity of other preservatives

Butylene Glycol (or BG) is used within cosmetic products for a few different reasons:

Overall, Butylene Glycol is a safe and well-rounded ingredient that works well with other ingredients.

Though this ingredient works well with most skin types, some people with sensitive skin may experience a reaction such as allergic rashes, closed comedones, or itchiness.

Ethylhexylglycerin is created from glycerin. It is a multitasker ingredient that:

The CIR Expert Panel found minimal skin absorption or sensitization of any kind in a safety assessment. Though this ingredient is considered well-tolerated, a small number of cases of allergic dermatitis have been published since 2002. Just be sure to patch test if you are unsure.

Industry-reported use ranges from 8% in rinse-off products and 2% in leave-on formulations.

Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.

Topically, glycerin does several things at once:

Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.

Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.

This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.

Just know very high concentrations (>40%) can feel tacky in low humidity.

Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.

Hyaluronic acid (HA) is a glycosaminoglycan (basically a long sugar chain) that your skin already makes on its own. In your skin, HA lives in the extracellular matrix and acts as the body's moisture reservoir.

Topically, HA is a humectant that binds water and helps skin look more plump, smooth, and hydrated.

The only catch is that HA isn't a single thing; it actually comes in a wide range of molecular weights (~50 - 2,000+ kDA) and size matters.

Some clinical evidence links low molecular weight versions to improved wrinkle depth, elasticity, anti-inflammatory effects, and barrier repair.

This is why the best HA serums blend the two sizes together so you get the best of both worlds.

The majority of cosmetic HA is produced by bacterial fermentation, typically using Streptococcus or Bacillus strains. Typical use levels in skincare sit around 0.1-2%.

A clinical study using a 0.2% low-molecular weight HA gel showed improvement in facial seborrheic dermatitis with excellent tolerance.

These are some other common types of Hyaluronic Acid:

Hydrogenated Polydecene is a synthetic emollient. It forms a non-occlusive film on the skin's surface to provide a silky feel without being greasy.

In vivo studies in volunteers with atopic and dry skin showed no irritation or intolerance. The volunteers also saw a positive effect in dryness, scaling, and roughness after 28 days of use.

Concentrations up to 100% in guinea pig tests found it to be non-sensitizing and completely safe for use in cosmetics.

Hydrolyzed Hyaluronic Acid is hyaluronic acid (HA) that is broken down into lower molecular weight fragments.

It's a humectant that pulls and holds water in the skin to help with hydration, plumpness, and reduce transepidermal water loss.

Because hydrolyzed hyaluronic acid is smaller in size, it can slip past your outermost layer of skin more easily than full-sized HA.

Most formulations will combine all sizes to get the best of both worlds.

Typical usage levels range from 0.01-1%. Any percentage higher than 2% might become goopy and tacky.

Sodium Hyaluronate is the salt form of hyaluronic acid. It is a long sugar chain that is naturally found in your skin, joints, and connective tissue that maintains hydration and elasticity.

In skincare, it works as a humectant. It pulls water from the environment and deeper layers of skin and binds it to the surface.

Interestingly, the size of the molecule affects its behavior:

Many serums use a blend of both weights so you can get surface hydration plus longer-lasting and deeper effects.

You'll typically see concentrations between 0.1-2% for this ingredient.

Squalane is the hydrogenated and shelf-stable form of squalene (a lipid that naturally occurs in human sebum).

It is an emollient and skin conditioning agent that is able to integrate seamlessly into the skin's lipid barrier without clogging pores.

This is due to how structurally similar it is to what your skin already produces.

Though it is mostly an emollient that helps soften and hydrate skin, it also has some humectant and occlusive action. Humectants help the skin retain moisture while occlusives seal it in, making squalane a triple-threat moisturizer.

Research shows it has antioxidant capabilities that help protect against stressors like UV exposure, specifically UVA induced oxidative stress. This study also found that it supports collagen biosynthesis in human dermal fibroblasts.

No clinical study has reported significant adverse effects and irritation reactions are very rare from this ingredient (even at 100% concentration).

Overall, it's a fantastic ingredient for hydration and is suitable for all skin types.

This depends on the source. Squalane can be derived from both plants and animals. Most squalane used in skincare comes from plants.

Please note: the source of squalane is only known if disclosed by the brand. We recommend reaching out to the brand if you have any questions about their squalane.

Read more about squalene with an "e".

Though squalane is often called an oil, it’s technically not one. It is a hydrocarbon, meaning it is only made of carbon and hydrogen. True oils are triglycerides and made of fatty acids and glycerol.

The term “oil-free” isn’t regulated so companies can define it however they want. Some exclude all oils, while others just avoid mineral oil or comedogenic oils.

Squalane has a comedogenic rating of 1 from the original 1972 study that tested raw ingredients under occlusion on rabbit ears. This system is not standardized or peer-reviewed, and using the raw ingredients is very different from how diluted cosmetic formulations are used on human skin.

A comedogenic rating of 1 means it is "unlikely to clog pores" according to the original rating system.

The overall formula of a product matters more than the individual ingredients on whether or not it will cause clogged pores.

Tromethamine (aka THAM) is a synthetic amino acid that shows up in skincare as a helper ingredient.

It functions as a pH adjuster to help neutralize acidic ingredients and set a formula's pH to the right spot.

This matters a lot because a lot of actives (like vitamin C) needs a specific pH to work well and feel comfortable on skin.

Concentration use ranges from 0.1-1.0% depending on the formula.

Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.

So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.

You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!

Similar Comparisons

The reference edit

Ingredients, questions
& further reading.

Connected source records selected through this article’s public topic index.

01

Formula cabinet

Ingredients & structured notes

Ingredient index

Ingredients Side-by-side

  1. 01Propolis Extract
  2. 02Dipropylene Glycol
  3. 03Glycerin
  4. 04Butylene Glycol
  5. 05Water
  6. 06Niacinamide
  7. 071,2-Hexanediol
  8. 08Melia Azadirachta Flower Extract
  9. 09Melia Azadirachta Leaf Extract
  10. 10Sodium Hyaluronate
  11. 11Curcuma Longa Root Extract
  12. 12Ocimum Sanctum Leaf Extract
  13. 13Theobroma Cacao Seed Extract
  14. 14Melaleuca Alternifolia Leaf Extract
  15. 15Centella Asiatica Extract
  16. 16Corallina Officinalis Extract
  17. 17Lotus Corniculatus Seed Extract
  18. 18Calophyllum Inophyllum Seed Oil
  19. 19Betaine Salicylate
  20. 20Sodium Polyacryloyldimethyl Taurate
Source · skinsort.com
02

Product index

Related product references

03

Comparison edit

Read side by side