Biologique Recherche Crème Biofixine Anti-Ageing Face Cream Versus SkinCeuticals P-Tiox Wrinkle Modulating Peptide Serum

Biologique Recherche Crème Biofixine Anti-Ageing Face Cream Versus SkinCeuticals P-Tiox Wrinkle Modulating Peptide Serum

This anti-aging moisturizer is formulated around Vitis Vinifera Seed Oil and Acetyl Hexapeptide-8 to soften the look of wrinkles and hydrate skin.

This anti-aging serum is formulated around Dipeptide Diaminobutyroyl Benzylamide Diacetate and Acetyl Hexapeptide-8 to soften the look of wrinkles and refine skin texture.

What's inside

Key Ingredients

Benefits

Concerns

Ingredients Side-by-side

Water

Stearic Acid

Propylene Glycol

Glycerin

Palmitic Acid

Vitis Vinifera Seed Oil

Polysorbate 40

Pentylene Glycol

Cetyl Alcohol

Helianthus Annuus Seed Oil

Butylene Glycol

Tea-Stearate

PEG-2 Stearate

Perfluorodecalin

Acetyl Hexapeptide-8

Polyperfluoromethylisopropyl Ether

Juglans Regia Seed Extract

Leontopodium Alpinum Flower/Leaf Extract

Nasturtium Officinale Extract

Pimpinella Anisum Fruit Extract

Tocopherol

Sodium Benzoate

Caprylyl Glycol

P-Anisic Acid

Poloxamer 188

Phenoxyethanol

Sodium Metabisulfite

Water, Stearic Acid, Propylene Glycol, Glycerin, Palmitic Acid, Vitis Vinifera Seed Oil, Polysorbate 40, Pentylene Glycol, Cetyl Alcohol, Helianthus Annuus Seed Oil, Butylene Glycol, Tea-Stearate, PEG-2 Stearate, Perfluorodecalin, Acetyl Hexapeptide-8, Polyperfluoromethylisopropyl Ether, Juglans Regia Seed Extract, Leontopodium Alpinum Flower/Leaf Extract, Nasturtium Officinale Extract, Pimpinella Anisum Fruit Extract, Tocopherol, Sodium Benzoate, Caprylyl Glycol, P-Anisic Acid, Poloxamer 188, Phenoxyethanol, Sodium Metabisulfite

Niacinamide

Gluconolactone

PEG/PPG/Polybutylene Glycol-8/5/3 Glycerin

Alcohol Denat.

Methyl Gluceth-20

Potassium Hydroxide

Hydroxyethylcellulose

Salicylic Acid

Chlorphenesin

Phytic Acid

Adenosine

Laminaria Digitata Extract

Dipeptide Diaminobutyroyl Benzylamide Diacetate

Water, Niacinamide, Gluconolactone, Butylene Glycol, PEG/PPG/Polybutylene Glycol-8/5/3 Glycerin, Alcohol Denat., Pentylene Glycol, Methyl Gluceth-20, Glycerin, Potassium Hydroxide, Hydroxyethylcellulose, Salicylic Acid, Chlorphenesin, Phytic Acid, Adenosine, Sodium Benzoate, Laminaria Digitata Extract, Dipeptide Diaminobutyroyl Benzylamide Diacetate, Acetyl Hexapeptide-8

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Alternatives

Ingredients Explained

These ingredients are found in both products.

Ingredients higher up in an ingredient list are typically present in a larger amount.

Acetyl Hexapeptide-8 (also known as Argireline) is a synthetic hexapeptide that is often called a "topical Botox alternative".

It works by mimicking how Botox relaxes muscles; it interferes with the signaling process that tells your facial muscles to contract. This can help soften expression lines like forehead wrinkles or crow's feet over time.

The comparison to Botox does have limits because the molecule is water-loving and relatively large.

Acetyl Hexapeptide-8 has a hard time absorbing deeply enough through the skin's outer barrier to actually reach the muscles.

So whether it truly works the way Botox does at a biological level is still up for debate, but early clinical outcomes are fairly encouraging.

A 12 week human study of a multi-ingredient regimen containing this ingredient saw:

While some studies have observed improvements in wrinkle appearance, it is important to note that more consistent results are seen in multi-ingredient formulations (vs just Acetyl Hexapeptide-8 alone).

Some research studies also used higher concentrations (up to 10%) while this ingredient is usually found in concentrations up to 0.005% in leave-on formulations.

Butylene Glycol (or BG) is used within cosmetic products for a few different reasons:

Overall, Butylene Glycol is a safe and well-rounded ingredient that works well with other ingredients.

Though this ingredient works well with most skin types, some people with sensitive skin may experience a reaction such as allergic rashes, closed comedones, or itchiness.

Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.

Topically, glycerin does several things at once:

Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.

Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.

This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.

Just know very high concentrations (>40%) can feel tacky in low humidity.

Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.

Pentylene Glycol (1,2-pentanediol) is a multitasking little diol with three main roles in a formula:

Research on alkanediols (the family pentylene glycol belongs to) show they work by disrupting microbial cell membranes. This disruption helps the primary preservative system in a product work more effectively at lower doses.

On the safety side, the Cosmetic Ingredient Review Expert Panel has concluded this ingredient to be safe as used in current cosmetic practices + concentrations.

Typical use levels in a formula run about 1-5%.

Sodium Benzoate is a preservative. It's used in both cosmetic and food products to inhibit the growth of mold and bacteria. It is typically produced synthetically.

Both the US FDA and EU Health Committee have approved the use of sodium benzoate. In the US, levels of 0.1% (of the total product) are allowed.

Sodium benzoate works as a preservative by inhibiting the growth of bacteria inside of cells. It prevents the cell from fermenting a type of sugar using an enzyme called phosphofructokinase.

It is the salt of benzoic acid. Foods containing sodium benzoate include soda, salad dressings, condiments, fruit juices, wines, and snack foods.

Studies for using ascorbic acid and sodium benzoate in cosmetics are lacking, especially in skincare routines with multiple steps.

We always recommend speaking with a professional, such as a dermatologist, if you have any concerns.

Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.

So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.

You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!

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