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Skin science article

BYOMA Barrier+ Repair Treatment Versus Naturium Multi-Peptide Moisturizer

BYOMA Barrier+ Repair Treatment Versus Naturium Multi-Peptide Moisturizer This barrier-repair treatment is formulated around Ectoin and Sphingolipids to strengthen the skin barrier and hydrate skin. This anti-aging moisturizer is formulated around Palmitoyl Tr

BYOMA Barrier+ Repair Treatment Versus Naturium Multi-Peptide Moisturizer

This barrier-repair treatment is formulated around Ectoin and Sphingolipids to strengthen the skin barrier and hydrate skin.

This anti-aging moisturizer is formulated around Palmitoyl Tripeptide-5 and Palmitoyl Tripeptide-1 to soften the look of wrinkles.

What's inside

Key Ingredients

Benefits

Concerns

Ingredients Side-by-side

Water

Glycerin

Butylene Glycol

Pentaerythrityl Tetraisostearate

Butylene Glycol Dicaprylate/Dicaprate

Diisostearyl Malate

Cetyl Ethylhexanoate

Methyl Trimethicone

Butyrospermum Parkii Butter

Phenyl Trimethicone

Behenyl Alcohol

Cetearyl Olivate

Cetearyl Alcohol

Squalane

Persea Gratissima Oil

Sorbitan Olivate

C14-22 Alcohols

Ectoin

Dipropylene Glycol

Simethicone

Ethylhexylglycerin

Sphingolipids

Arachidyl Glucoside

1,2-Hexanediol

Glucose

Ceramide NP

Polyacrylate-13

Hydroxyacetophenone

Palmitic Acid

Arachidyl Alcohol

C11-13 Isoparaffin

Stearic Acid

C12-20 Alkyl Glucoside

Hydrogenated Polyisobutene

Isohexadecane

Caprylyl Glycol

Dimethiconol

Allantoin

Carbomer

Ammonium Acryloyldimethyltaurate/Vp Copolymer

Tromethamine

Sodium Hyaluronate

Polyglyceryl-10 Laurate

Ethylhexyl Palmitate

Sorbitan Isostearate

Sodium Phytate

Cyanocobalamin

Dipotassium Glycyrrhizate

Tocopherol

Water, Glycerin, Butylene Glycol, Pentaerythrityl Tetraisostearate, Butylene Glycol Dicaprylate/Dicaprate, Diisostearyl Malate, Cetyl Ethylhexanoate, Methyl Trimethicone, Butyrospermum Parkii Butter, Phenyl Trimethicone, Behenyl Alcohol, Cetearyl Olivate, Cetearyl Alcohol, Squalane, Persea Gratissima Oil, Sorbitan Olivate, C14-22 Alcohols, Ectoin, Dipropylene Glycol, Simethicone, Ethylhexylglycerin, Sphingolipids, Arachidyl Glucoside, 1,2-Hexanediol, Glucose, Ceramide NP, Polyacrylate-13, Hydroxyacetophenone, Palmitic Acid, Arachidyl Alcohol, C11-13 Isoparaffin, Stearic Acid, C12-20 Alkyl Glucoside, Hydrogenated Polyisobutene, Isohexadecane, Caprylyl Glycol, Dimethiconol, Allantoin, Carbomer, Ammonium Acryloyldimethyltaurate/Vp Copolymer, Tromethamine, Sodium Hyaluronate, Polyglyceryl-10 Laurate, Ethylhexyl Palmitate, Sorbitan Isostearate, Sodium Phytate, Cyanocobalamin, Dipotassium Glycyrrhizate, Tocopherol

Dimethicone

Simmondsia Chinensis Seed Oil

Glyceryl Stearate

Cetyl Alcohol

Niacinamide

Stearyl Alcohol

Palmitoyl Tripeptide-5

Pantolactone

Palmitoyl Tripeptide-1

Palmitoyl Tetrapeptide-7

Hydrolyzed Plukenetia Volubilis Seed Extract

Dunaliella Salina Extract

3-O-Ethyl Ascorbic Acid

Panthenol

Caryodendron Orinocense Seed Oil

Honokiol

Magnolol

Sorbitan Oleate

Aluminum Starch Octenylsuccinate

Acrylamide/Sodium Acryloyldimethyltaurate Copolymer

Polyglyceryl-6 Laurate

Boron Nitride

Polyglyceryl-10 Oleate

Chlorphenesin

Acrylates/C10-30 Alkyl Acrylate Crosspolymer

Tocopheryl Acetate

Polysorbate 80

Sorbitan Palmitate

Sodium Hydroxide

Sodium Benzoate

Sodium Lactate

Phenoxyethanol

Polysorbate 20

Citric Acid

Potassium Sorbate

Water, Glycerin, Dimethicone, Simmondsia Chinensis Seed Oil, Squalane, Glyceryl Stearate, Cetyl Alcohol, Niacinamide, Stearyl Alcohol, Palmitoyl Tripeptide-5, Pantolactone, Palmitoyl Tripeptide-1, Palmitoyl Tetrapeptide-7, Hydrolyzed Plukenetia Volubilis Seed Extract, Dunaliella Salina Extract, Sodium Hyaluronate, 3-O-Ethyl Ascorbic Acid, Panthenol, Caryodendron Orinocense Seed Oil, Honokiol, Magnolol, Palmitic Acid, Sorbitan Oleate, Aluminum Starch Octenylsuccinate, Hydroxyacetophenone, Stearic Acid, Acrylamide/Sodium Acryloyldimethyltaurate Copolymer, Polyglyceryl-6 Laurate, 1,2-Hexanediol, Boron Nitride, Caprylyl Glycol, Polyglyceryl-10 Oleate, Isohexadecane, Butylene Glycol, Chlorphenesin, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Tocopheryl Acetate, Polysorbate 80, Sorbitan Palmitate, Sodium Hydroxide, Sodium Benzoate, Carbomer, Sodium Lactate, Phenoxyethanol, Polysorbate 20, Citric Acid, Ethylhexylglycerin, Potassium Sorbate

Reviews

Alternatives

Ingredients Explained

These ingredients are found in both products.

Ingredients higher up in an ingredient list are typically present in a larger amount.

1,2-Hexanediol is a synthetic liquid and another multi-functional powerhouse.

It is a:

Humectant, drawing moisture into the skin

Emollient, helping to soften skin

Solvent, dispersing and stabilizing formulas

Preservative booster, enhancing the antimicrobial activity of other preservatives

Butylene Glycol (or BG) is used within cosmetic products for a few different reasons:

Overall, Butylene Glycol is a safe and well-rounded ingredient that works well with other ingredients.

Though this ingredient works well with most skin types, some people with sensitive skin may experience a reaction such as allergic rashes, closed comedones, or itchiness.

Caprylyl Glycol is a humectant, skin conditioner, emollient, and preservative booster derived from either caprylic acid or synthetically created.

Typical use levels vary from 0.3-1% as a preservative booster and go up to 2% to condition skin.

Because it is not a free-fatty acid, this ingredient is fungal acne safe (there's nothing for Malassezia to feed on).

Carbomer is a synthetic thickening and gelling agent. It's basically the ingredient that gives a lot of serums, gels, creams, and sunscreens their smooth, non-sticky texture.

Although legally permitted at very high levels, carbomers are normally used at concentrations below 1%.

It also needs to be neutralized to actually thicken, and because it is a large molecule, it doesn't really penetrate the skin barrier.

Allergy-wise, the risk is very low. Clinical studies show carbomers have low potential for skin irritation/sensitization even at concentrations up to 100%.

A 2024 UK study patch-tested 1,302 patients and found true allergy to the parent group of carbomer to be rare with no confirmed relevant reactions.

Ethylhexylglycerin is created from glycerin. It is a multitasker ingredient that:

The CIR Expert Panel found minimal skin absorption or sensitization of any kind in a safety assessment. Though this ingredient is considered well-tolerated, a small number of cases of allergic dermatitis have been published since 2002. Just be sure to patch test if you are unsure.

Industry-reported use ranges from 8% in rinse-off products and 2% in leave-on formulations.

Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.

Topically, glycerin does several things at once:

Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.

Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.

This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.

Just know very high concentrations (>40%) can feel tacky in low humidity.

Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.

Hydroxyacetophenone is a small phenolic molecule that earns its place in a formulas as an antioxidant and preservative booster.

As a phenol, it is able to neutralize free radicals to protect both the product and the skin from oxidative stress.

Though it can't kill microbes on its own, it works as a good supporting agent when combined with other preservatives like Phenoxyethanol or 1,2-Hexanediol.

This ingredient naturally occurs as piceol in Norwegian spruce needles (~0.4-1.1% dry weight and in cloudberries). Though the cosmetic-grade material is synthesized for purity and consistency.

You'll usually see it used at low levels and suppliers recommend up to 1% added to a water phase.

Safety testing was done at concentrations like 0.05% in SPF products and 0.5% in a Human Repeated Insult Patch Test. The safety evidence is assuring; this ingredient is safe for cosmetics in current use and also holds safety status as a food flavoring as well.

An honest caveat: the "soothing" and "anti-inflammatory" claims come mostly from supplier marketing rather than published clinical trials. The Cosmetic Ingredient Review's own literature search found no useful efficacy studies on this ingredient.

So the antioxidant and preservative-boosting roles are the well supported ones while the calming benefit is plausible but thinly evidenced.

Overall, this is a well-tolerated, low-irritation multitasker that quietly helps a formula stay fresh and stable.

Isohexadecane is added to enhance texture, emulsify, and to help cleanse. It is an isoparrafin. It is a component of petrolatum.

Due to its large size, Isohexadecane is not absorbed by the skin. Instead, it sits on top and acts as an emollient. Emollients help keep your skin soft and smooth by trapping moisture within.

Isohexadecane is often used in products designed to help oily skin. It is lightweight and non-greasy while helping to moisturize. When mixed with silicones, it gives a product a silky feel.

Palmitic Acid is a fatty acid naturally found in our skin and in many plant and animal sources.

In cosmetics, it is usually derived from palm oil. It serves many purposes in skincare, acting as a cleanser, emollient, and emulsifier.

Interestingly, topically applied Palmitic Acid can be elongated into longer chain fatty acids and ceramides. A 2019 study found low levels of Palmitic Acid lead to slower development of cells, suggesting it plays a role in keeping your skin's renewal process on track.

The CIR (Cosmetic Ingredient Review) panel determined it safe as used in cosmetics at concentrations up to 13%. It is non-irritating and non-sensitizing in clinical studies.

The culprit behind fungal acne, the Malassezia yeast, feeds on fatty acids with carbon chain lengths between C11-C24. Palmitic Acid, at C16, falls right into that sweet spot.

In vitro studies have shown that Palmitic Acid is one of the fatty acids that induce rapid Malassezia growth in lab settings.

It's worth noting that what feeds yeast in a lab doesn't necessarily feed it on your face since formulation and your skin's chemistry play a bigger role.

Sodium Hyaluronate is the salt form of hyaluronic acid. It is a long sugar chain that is naturally found in your skin, joints, and connective tissue that maintains hydration and elasticity.

In skincare, it works as a humectant. It pulls water from the environment and deeper layers of skin and binds it to the surface.

Interestingly, the size of the molecule affects its behavior:

Some clinical evidence links low molecular weight versions to improved wrinkle depth, elasticity, anti-inflammatory effects, and barrier repair.

Many serums use a blend of both weights so you can get surface hydration plus longer-lasting and deeper effects.

You'll typically see concentrations between 0.1-2% for this ingredient.

Squalane is the hydrogenated and shelf-stable form of squalene (a lipid that naturally occurs in human sebum).

It is an emollient and skin conditioning agent that is able to integrate seamlessly into the skin's lipid barrier without clogging pores.

This is due to how structurally similar it is to what your skin already produces.

Though it is mostly an emollient that helps soften and hydrate skin, it also has some humectant and occlusive action. Humectants help the skin retain moisture while occlusives seal it in, making squalane a triple-threat moisturizer.

Research shows it has antioxidant capabilities that help protect against stressors like UV exposure, specifically UVA induced oxidative stress. This study also found that it supports collagen biosynthesis in human dermal fibroblasts.

No clinical study has reported significant adverse effects and irritation reactions are very rare from this ingredient (even at 100% concentration).

Overall, it's a fantastic ingredient for hydration and is suitable for all skin types.

This depends on the source. Squalane can be derived from both plants and animals. Most squalane used in skincare comes from plants.

Please note: the source of squalane is only known if disclosed by the brand. We recommend reaching out to the brand if you have any questions about their squalane.

Read more about squalene with an "e".

Though squalane is often called an oil, it’s technically not one. It is a hydrocarbon, meaning it is only made of carbon and hydrogen. True oils are triglycerides and made of fatty acids and glycerol.

The term “oil-free” isn’t regulated so companies can define it however they want. Some exclude all oils, while others just avoid mineral oil or comedogenic oils.

Squalane has a comedogenic rating of 1 from the original 1972 study that tested raw ingredients under occlusion on rabbit ears. This system is not standardized or peer-reviewed, and using the raw ingredients is very different from how diluted cosmetic formulations are used on human skin.

A comedogenic rating of 1 means it is "unlikely to clog pores" according to the original rating system.

The overall formula of a product matters more than the individual ingredients on whether or not it will cause clogged pores.

Stearic Acid is a fatty acid that is already found in your skin. It's one of the free fatty acids that works alongside ceramides and cholesterols to maintain your barrier.

In cosmetics, it is a multitasker:

Safety-wise, the CIR Expert Panel has concluded it to be safe in cosmetics when formulated to be non-irritating and non-sensitizing.

Free stearic acid is a C18 fatty acid that the Malassezia yeast can substrate, so this ingredient may not be fungal acne safe.

Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.

So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.

You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!

Similar Comparisons

The reference edit

Ingredients, questions
& further reading.

Connected source records selected through this article’s public topic index.

01

Formula cabinet

Ingredients & structured notes

Ingredient index

Ingredients Explained

  1. 01These ingredients are found in both products.
  2. 02Ingredients higher up in an ingredient list are typically present in a larger amount.
  3. 03Caprylyl Glycol is a humectant, skin conditioner, emollient, and preservative booster derived from either caprylic acid or synthetically created.
  4. 04Typical use levels vary from 0.3-1% as a preservative booster and go up to 2% to condition skin.
  5. 05Because it is not a free-fatty acid, this ingredient is fungal acne safe (there's nothing for Malassezia to feed on).
  6. 06Citric Acid is an alpha hydroxy acid (AHA) naturally found in citrus fruits like oranges, lemons, and limes.
  7. 07Like other AHAs, citric acid can exfoliate skin by breaking down the bonds that hold dead skin cells together. This helps reveal smoother and brighter skin underneath.
  8. 08However, this exfoliating effect only happens at high concentrations (20%) which can be hard to find in cosmetic products.
  9. 09Due to this, citric acid is usually included in small amounts as a pH adjuster. This helps keep products slightly more acidic and compatible with skin's natural pH.
  10. 10In skincare formulas, citric acid can:
  11. 11While it can provide some skin benefits, research shows lactic acid and glycolic acid are generally more effective and less irritating exfoliants.
  12. 12Most citric acid used in skincare today is made by fermenting sugars (usually from molasses). This synthetic version is identical to the natural citrus form but easier to stabilize and use in formulations.
  13. 13Rosacea skin has a lower threshold for acids generally, with 62.5% of rosacea subjects in one study reacting to lactic acid in a sting test. This is why we mark citric acid as a potential rosacea trigger.
  14. 14However, this ingredient shows up as a pH adjuster or chelator at roughly 0.1-1% in many products. These low levels are unlikely to be an issue for rosacea skin and becomes a potential trigger at exfoliating concentrations (20%). Because everybody's…
  15. 15Dimethicone is a type of synthetic silicone created from natural materials such as quartz. It is also known as polydimethylsiloxane.
  16. 16What it does:
  17. 17Dimethicone comes in different viscosities:
  18. 18Depending on the viscosity, dimethicone has different properties.
  19. 19Ingredients lists don't always show which type is used, so we recommend reaching out to the brand if you have questions about the viscosity.
  20. 20This ingredient is unlikely to cause irritation because it does not get absorbed into skin. However, people with silicone allergies should be careful about using this ingredient.
Source · skinsort.com
02

Product index

Related product references

Product

Naturium Multi-Peptide Moisturizer

Naturium Multi-Peptide Moisturizer Ingredients in Naturium Multi-Peptide Moisturizer explained: benefits, concerns, and detailed analysis of 48 ingredients including Water, Glycerin, and Di…

Source: skinsort.comView reference →
03

Comparison edit

Read side by side