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Skin science article

CeraVe Hydrating Hyaluronic Acid Serum Versus Stratia Liquid Gold

CeraVe Hydrating Hyaluronic Acid Serum Versus Stratia Liquid Gold This hydrating serum is formulated around Sodium Hyaluronate and Ceramide NP to hydrate skin and strengthen the skin barrier. This barrier-repair serum is formulated around Niacinamide and Hippo

CeraVe Hydrating Hyaluronic Acid Serum Versus Stratia Liquid Gold

This hydrating serum is formulated around Sodium Hyaluronate and Ceramide NP to hydrate skin and strengthen the skin barrier.

This barrier-repair serum is formulated around Niacinamide and Hippophae Rhamnoides Fruit Oil to strengthen the skin barrier and hydrate skin.

What's inside

Key Ingredients

Benefits

Concerns

Ingredients Side-by-side

Water

Glycerin

Cetearyl Ethylhexanoate

Dimethicone

Ammonium Polyacryloyldimethyl Taurate

Sodium Hyaluronate

Panthenol

Ceramide NP

Ceramide AP

Ceramide EOP

Carbomer

Cetearyl Alcohol

Behentrimonium Methosulfate

Sodium Hydroxide

Sodium Lauroyl Lactylate

Cholesterol

Phenoxyethanol

Disodium EDTA

Isopropyl Myristate

Caprylyl Glycol

Citric Acid

Xanthan Gum

Phytosphingosine

Ethylhexylglycerin

Water, Glycerin, Cetearyl Ethylhexanoate, Dimethicone, Ammonium Polyacryloyldimethyl Taurate, Sodium Hyaluronate, Panthenol, Ceramide NP, Ceramide AP, Ceramide EOP, Carbomer, Cetearyl Alcohol, Behentrimonium Methosulfate, Sodium Hydroxide, Sodium Lauroyl Lactylate, Cholesterol, Phenoxyethanol, Disodium EDTA, Isopropyl Myristate, Caprylyl Glycol, Citric Acid, Xanthan Gum, Phytosphingosine, Ethylhexylglycerin

Propylene Glycol

Ethoxydiglycol

Niacinamide

Polyglyceryl-3 Methylglucose Distearate

Rosa Canina Fruit Oil

Hippophae Rhamnoides Seed Oil

Hippophae Rhamnoides Fruit Oil

Squalane

Cetyl Alcohol

Vaccinium Macrocarpon Seed Oil

Tocopherol

Camellia Sinensis Leaf Extract

Diazolidinyl Urea

Methylparaben

Propylparaben

Water, Propylene Glycol, Ethoxydiglycol, Niacinamide, Polyglyceryl-3 Methylglucose Distearate, Rosa Canina Fruit Oil, Hippophae Rhamnoides Seed Oil, Hippophae Rhamnoides Fruit Oil, Panthenol, Dimethicone, Glycerin, Squalane, Cetyl Alcohol, Vaccinium Macrocarpon Seed Oil, Tocopherol, Camellia Sinensis Leaf Extract, Ceramide NP, Ceramide AP, Ceramide EOP, Phytosphingosine, Cholesterol, Sodium Hyaluronate, Sodium Lauroyl Lactylate, Carbomer, Xanthan Gum, Diazolidinyl Urea, Methylparaben, Propylparaben, Disodium EDTA

Reviews

Alternatives

Ingredients Explained

These ingredients are found in both products.

Ingredients higher up in an ingredient list are typically present in a larger amount.

Carbomer is a synthetic thickening and gelling agent. It's basically the ingredient that gives a lot of serums, gels, creams, and sunscreens their smooth, non-sticky texture.

Although legally permitted at very high levels, carbomers are normally used at concentrations below 1%.

It also needs to be neutralized to actually thicken, and because it is a large molecule, it doesn't really penetrate the skin barrier.

Allergy-wise, the risk is very low. Clinical studies show carbomers have low potential for skin irritation/sensitization even at concentrations up to 100%.

A 2024 UK study patch-tested 1,302 patients and found true allergy to the parent group of carbomer to be rare with no confirmed relevant reactions.

Ceramide AP is is a skin-identical lipid that mimics what your skin already makes naturally. Ceramides help maintain epidermal integrity and barrier function.

You'll often see this ingredient paired with other ceramides (like ceramide NP), cholesterol, or fatty acids because this combination best mimics the natural lipid mix your skin already has.

The skin's ability to produce ceramides gets disrupted in skin conditions like eczema. This in turn weakens the skin barrier and applying ceramides topically has been shown to replenish what's been lost to restore barrier function.

Most of the studies with Ceramide AP test it as part of a multi-ceramide complex; studies reinforce ceramide AP's role in rebalancing ceramides in skin and improving skin hydration.

Ceramide EOP is formally known as Ceramide 1.

It is naturally found in skin and part of the intercellular "mortar" holding everything together in your outermost layer.

EOP stands for a linked Ester fatty acid, a linked Omega hydroxy fatty acid, and the Phytosphingosine base.

What makes Ceramide EOP special is its ultra-long fatty acid chain; this unique structure allows it to bridge the lipid layers in your skin barrier to prevent water loss (something no other ceramide can do).

Low levels of Ceramide EOP have been found in people with eczema and psoriasis.

Using it together with other ceramides, cholesterol, and linoleic acid have been shown to meaningfully improve hydration and reduce water loss.

In one clinical study, a regimen using Ceramide EOP, NP, and AP led to significant symptom improvements in patients with eczema, psoriasis, and dry skin in just 4 weeks.

You'll usually see concentrations between 0.1-0.5% in formulations. Overall, this is a well-tolerated and safe ingredient for cosmetic use.

Ceramide NP (formerly known as Ceramide 3) is one of the skin's naturally occurring lipids.

Since ceramides are the major lipid components of the skin, they are crucial for maintaining skin barrier and hydration. Ceramide NP most closely mirrors the dominant kind in human skin amongst ceramide subtypes.

This ceramide works by slotting into gaps within the stratum corneum's lipid matrix to limit trans-epidermal water loss (TEWL) and shield the skin against external irritants.

A study with 312 patients found that using a ceramide-containing routine for 4 weeks reduced the severity of atopic dermatitis by over 61%.

Another clinical study in subjects aged 60 and older found that a ceramide body wash and moisturizer improved skin dryness and itchy skin in 15 days.

Overall, ceramides are considered non-irritating and safety tests have found little to no observable adverse effects from using this ingredient.

Ceramide NP is usually sourced from plants (like soybean or rice bran), or produced synthetically.

Cholesterol is a lipid that is naturally found in human skin and is one of the three key components of your skin barrier. In skincare, it is an emollient and barrier-repairing ingredient.

It works by fitting directly into the lipid layers of skin to help restore structure and reduce transepidermal water loss (TEWL).

This is a great ingredient for dry, compromised, or aging skin; our skin starts to produce less cholesterol with age.

Research shows cholesterol works best in combination with ceramides and fatty acids, the other two major components in your skin barrier.

Cholesterol is also a well-establish penetration enhancer and can help other actives absorb more effectively.

Cosmetic-grade cholesterol is usually derived from lanolin but plant and synthetic options also exist. We recommend reaching out to the brand if you have questions about their source of cholesterol.

Dimethicone is a type of synthetic silicone created from natural materials such as quartz. It is also known as polydimethylsiloxane.

What it does:

Dimethicone comes in different viscosities:

Depending on the viscosity, dimethicone has different properties.

Ingredients lists don't always show which type is used, so we recommend reaching out to the brand if you have questions about the viscosity.

This ingredient is unlikely to cause irritation because it does not get absorbed into skin. However, people with silicone allergies should be careful about using this ingredient.

Note: Dimethicone may contribute to pilling. This is because it is not oil or water soluble, so pilling may occur when layered with products. When mixed with heavy oils in a formula, the outcome is also quite greasy.

Disodium EDTA is a chelating agent. It grabs onto and deactivates metal ions that sneak into your products from water, packaging, or air.

This ingredient mainly works behind the scenes and helps with:

On top of that, this ingredient can counteract the effects of hard water by binding to the minerals in it.

One thing worth knowing is that Disodium EDTA has been shown to be a mild penetration enhancer. It can help other ingredients absorb into skin more effectively which can be a double-edged sword (great for actives, but can also make the active too strong if you have sensitive skin).

Clinical patch testing showed no significant skin irritation at typical use concentrations and minimal dermal absorption.

You'll most likely see this ingredient near the end of an ingredient list. It's typically found in concentrations less than 1%.

Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.

Topically, glycerin does several things at once:

Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.

Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.

This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.

Just know very high concentrations (>40%) can feel tacky in low humidity.

Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.

Panthenol is a common ingredient that helps hydrate and soothe the skin. It is found naturally in our skin and hair.

There are two forms of panthenol: D and L.

D-panthenol is also known as dexpanthenol. Most cosmetics use dexpanthenol or a mixture of D and L-panthenol.

Panthenol is famous due to its ability to go deeper into the skin's layers. Using this ingredient has numerous pros (and no cons):

Like hyaluronic acid, panthenol is a humectant. Humectants are able to bind and hold large amounts of water to keep skin hydrated.

This ingredient works well for wound healing. It works by increasing tissue in the wound and helps close open wounds.

Once oxidized, panthenol converts to pantothenic acid. Panthothenic acid is found in all living cells.

This ingredient is also referred to as pro-vitamin B5.

Phytosphingosine is a phospholipid naturally found in our skin as a building block for ceramides.. It helps moisturize, soothe, and protect skin.

Phytosphingosine contributes to your skin's natural moisturizing factor (NMF). The NMF is responsible for hydration, a strong barrier, and plasticity. Our NMF decreases with age. Increasing NMF leads to more healthy and hydrated skin.

Studies show products formulated with NMF ingredients help strengthen our skin's barrier. Having a healthy skin barrier reduces irritation and increases hydration. Our skin barrier is responsible for having plump and firm skin. It also helps protect our skin against infection, allergies, and inflammation.

Fun fact: Phytosphingosine is abundant in plants and fungi.

More ingredients that help boost collagen in skin:

Sodium Hyaluronate is the salt form of hyaluronic acid. It is a long sugar chain that is naturally found in your skin, joints, and connective tissue that maintains hydration and elasticity.

In skincare, it works as a humectant. It pulls water from the environment and deeper layers of skin and binds it to the surface.

Interestingly, the size of the molecule affects its behavior:

Some clinical evidence links low molecular weight versions to improved wrinkle depth, elasticity, anti-inflammatory effects, and barrier repair.

Many serums use a blend of both weights so you can get surface hydration plus longer-lasting and deeper effects.

You'll typically see concentrations between 0.1-2% for this ingredient.

Sodium Lauroyl Lactylate (SLL) is a mild, plant-derived surfactant made by combining lauric acid with lactic acid.

It has two main jobs in a formula:

A perk of this ingredient is that it leaves skin feeling soft and silky after rinsing. This is why you'll even see it in baby washes.

Another perk? The lauric acid backbone gives it mild antimicrobial activity and lauric acid itself has been shown to suppress acne-causing bacteria in lab studies.

In 2023, scientists took a close look at how SLL behaves and found it can break apart the fatty outer layers of cells. This is basically why it cleans well and can fight off certain microbes.

The Cosmetic Ingredient Review (CIR) Expert Panel has reviewed it and concluded it's safe as used.

A 2017 survey showed concentrations up to 10% are used in rinse-off cleansers and roughly 0.5-5% being typical in skincare.

Animal and reconstructed-skin testing found it to be non-irritating at 10%, and it's well tolerated even on sensitive skin. The only caveat is to patch test if you have a lactic acid allergy.

As a lactylate salt used at low co-emulsifier concentrations, this ingredient is less likely to break down and release free lauric acid on skin. This ingredient is fungal acne safe.

Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.

So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.

You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!

Xanthan gum is used as a stabilizer and thickener within cosmetic products. It helps give products a sticky, thick feeling - preventing them from being too runny.

On the technical side of things, xanthan gum is a polysaccharide - a combination consisting of multiple sugar molecules bonded together.

Xanthan gum is a pretty common and great ingredient. It is a natural, non-toxic, non-irritating ingredient that is also commonly used in food products.

Similar Comparisons

The reference edit

Ingredients, questions
& further reading.

Connected source records selected through this article’s public topic index.

01

Formula cabinet

Ingredients & structured notes

Ingredient index

Ingredients Explained

  1. 01These ingredients are found in both products.
  2. 02Ingredients higher up in an ingredient list are typically present in a larger amount.
  3. 03Ascorbyl Glucoside (AA-2G) is one of the most stable vitamin C derivatives out there.
  4. 04It's made by attaching a glucose molecule to ascorbic acid; this glucose "cap" shields the vitamin C from air, light, heat, and metal ions that normally cause pure ascorbic acid to oxidize.
  5. 05Once on your skin, the enzyme alpha-glucosidase snips off the glucose and gradually releases active ascorbic acid right where it's needed. Basically, it behaves like a slow-release pro-vitamin C with less of a stinging that high-strength ascorbic ac…
  6. 06The research supports the classic vitamin C benefits as well. In lab and human studies, AA-2G slowed down the skin's production of melanin (the pigment behind dark spots) and helped shield skin cells against sun damage better than ascorbyl phosphate.
  7. 07These studies also showed AA-2G released vitamin C over a longer period.
  8. 08A frequently cited manufacturer trial found that a 2% AA-2G face cream significantly improved wrinkle depth and skin roughness after 45 days.
  9. 09And in 2009, a clinical trial showed it meaningfully lightened dark patches on the gums compared to a placebo.
  10. 10There's also collagen-synthesis support (since vitamin C is a required cofactor for that) and an antioxidant effect too.
  11. 11Typical usage is usually between 0.5-5% and most studies/products land around 2%.
  12. 12AA-2G performs best when formulated at a mildly acidic pH (~5-7) which is much gentler than the pH that pure vitamin C demands (~2.5-3.5).
  13. 13Just one thing worth knowing: the in-skin conversation rate is only about 55-60% by weight. So a 5% AA-2G product delivers roughly 2.75-3% of actual active vitamin C. On top of that, skin absorption is relatively low because the ingredient is water-…
  14. 14Calcium Pantothenate is calcium salt from Vitamin B5. It can be naturally found in plants and animals.
  15. 15Calcium Pantothenate is a potent antioxidant. Antioxidants help fight free-radical molecules. Free-radical molecules are capable of damaging our cells and other genetic material. Antioxidants help stabilize free-radicals by donating extra electrons.…
  16. 16Our bodies use Calcium Pantothenate for various metabolic functinos. These functions include metabolizing carbohydrates, proteins, and fatty acids.
  17. 17This small molecule peptide has similar benefits to Argireline, the "botox" peptide.
  18. 18According to the manufacturer, this peptide mimics snake venom to freeze muscles. This prevents muscle movement and contractions to prohibit the formation of fine lines and wrinkles.
  19. 19While this seems promising, research is lacking in proving this ingredient to be as effective as botox.
  20. 20Disodium EDTA is a chelating agent. It grabs onto and deactivates metal ions that sneak into your products from water, packaging, or air.
Source · skinsort.com
02

Product index

Related product references

Product

Compath Hyaluronic Acid Serum

Compath Hyaluronic Acid Serum Compath Hyaluronic Acid Serum ingredients explained: Organic Herbal Infusion, Organic Aloe, Witch Hazel, Botanical Hyaluronic Acid (5%), (Kosher) Hydroxyethyl …

Source: incidecoder.comView reference →

Product

Bioniva Hyaluronic Acid Serum

Bioniva Hyaluronic Acid Serum Bioniva Hyaluronic Acid Serum ingredients explained: Aqua, Cassia Angustifolia Seed Extract (Botanical Hyaluronic Acid), Glycerin, Hamamelis Virginiana Water, …

Source: incidecoder.comView reference →
03

Comparison edit

Read side by side

04

Ask the journal

Related questions

01Is Serum Good for All Skin Types?

Serums are a form of skincare that can be added to any routine no matter what your skin type is. All skin types can benefit from the use of a serum since there are so many different formulations that can target specific skincare concerns. “Serums are used for hydration,to aid [or] maintain the skin barrier, or treat skin issues like acne or rosacea,” says Dr. Lewis. The type of serum that you may use should depend on the skin issue you’re trying to target. Think of serums as a treatment for the skin. “Some serums can reverse damage and help prevent free radicals that cause the signs of aging skin,” adds Dr. Lewis.

Source · www.skincare.com
02When and How to Use Hyaluronic Acid in Your Routine

Products with hyaluronic acid can be used in the morning or at night (or both!). Applying the hydrating ingredient at night will restore your skin’s resilience while you sleep, and applying it in the morning will leave your skin feeling plump, hydrated and ready for makeup. Hyaluronic acid is great at providing topical hydration when it’s introduced into a balanced skincare routine. According to Dr. King, it’s important to pair your hyaluronic acid products with an emollient or occlusive moisturizer to lock in hydration.

Source · www.skincare.com