Skin science article
Cetaphil Healthy Renew Night Cream Versus Cetaphil Bright Healthy Radiance Instant Radiance Mask
Cetaphil Healthy Renew Night Cream Versus Cetaphil Bright Healthy Radiance Instant Radiance Mask This anti-aging night moisturizer is formulated around Panthenol and Niacinamide to soften the look of wrinkles and strengthen the skin barrier. This brightening s
Cetaphil Healthy Renew Night Cream Versus Cetaphil Bright Healthy Radiance Instant Radiance Mask
This anti-aging night moisturizer is formulated around Panthenol and Niacinamide to soften the look of wrinkles and strengthen the skin barrier.
This brightening sheet mask is formulated around Niacinamide and Sodium Ascorbyl Phosphate to brighten dull-looking skin and fade the look of dark spots.
What's inside
Key Ingredients
Benefits
Concerns
Ingredients Side-by-side
Water
Propanediol
Cetyl Ethylhexanoate
Dibutyl Adipate
Hydrogenated Polydecene
Coco-Caprylate/Caprate
Panthenol
Polyglyceryl-6 Stearate
Glycerin
Beeswax
Cetearyl Alcohol
Niacinamide
Palmitic Acid
Stearic Acid
Butyrospermum Parkii Butter
Glyceryl Stearate
Sodium Acrylate/Sodium Acryloyldimethyl Taurate Copolymer
Caprylyl Glycol
Isohexadecane
Leontopodium Alpinum Extract
Polyglyceryl-6 Behenate
Ethylhexylglycerin
Carbomer
Tromethamine
Hydrogenated Olive Oil Unsaponifiables
Oryza Sativa Lees Extract
Tocopheryl Acetate
Polysorbate 80
1,2-Hexanediol
Adenosine
Sorbitan Oleate
Citric Acid
Sodium Benzoate
Potassium Sorbate
Hydrolyzed Soy Flour
Buddleja Davidii Extract
Thymus Vulgaris Extract
Water, Propanediol, Cetyl Ethylhexanoate, Dibutyl Adipate, Hydrogenated Polydecene, Coco-Caprylate/Caprate, Panthenol, Polyglyceryl-6 Stearate, Glycerin, Beeswax, Cetearyl Alcohol, Niacinamide, Palmitic Acid, Stearic Acid, Butyrospermum Parkii Butter, Glyceryl Stearate, Sodium Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, Caprylyl Glycol, Isohexadecane, Leontopodium Alpinum Extract, Polyglyceryl-6 Behenate, Ethylhexylglycerin, Carbomer, Tromethamine, Hydrogenated Olive Oil Unsaponifiables, Oryza Sativa Lees Extract, Tocopheryl Acetate, Polysorbate 80, 1,2-Hexanediol, Adenosine, Sorbitan Oleate, Citric Acid, Sodium Benzoate, Potassium Sorbate, Hydrolyzed Soy Flour, Buddleja Davidii Extract, Thymus Vulgaris Extract
Alcohol Denat.
Butylene Glycol
Sodium Ascorbyl Phosphate
Pancratium Maritimum Extract
Hyaluronic Acid
Hydrolyzed Hyaluronic Acid
Sodium Hyaluronate
Glycereth-26
Hydroxyacetophenone
Chondrus Crispus Powder
Xanthan Gum
Biosaccharide Gum-1
Ammonium Polyacryloyldimethyl Taurate
Portulaca Oleracea Extract
Hydroxyethylcellulose
Water, Glycerin, Niacinamide, Alcohol Denat., Butylene Glycol, Sodium Ascorbyl Phosphate, Pancratium Maritimum Extract, Hyaluronic Acid, Hydrolyzed Hyaluronic Acid, Sodium Hyaluronate, Glycereth-26, 1,2-Hexanediol, Hydroxyacetophenone, Carbomer, Tromethamine, Chondrus Crispus Powder, Xanthan Gum, Propanediol, Ethylhexylglycerin, Biosaccharide Gum-1, Ammonium Polyacryloyldimethyl Taurate, Portulaca Oleracea Extract, Hydroxyethylcellulose
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Alternatives
Ingredients Explained
These ingredients are found in both products.
Ingredients higher up in an ingredient list are typically present in a larger amount.
1,2-Hexanediol is a synthetic liquid and another multi-functional powerhouse.
It is a:
Humectant, drawing moisture into the skin
Emollient, helping to soften skin
Solvent, dispersing and stabilizing formulas
Preservative booster, enhancing the antimicrobial activity of other preservatives
Carbomer is a synthetic thickening and gelling agent. It's basically the ingredient that gives a lot of serums, gels, creams, and sunscreens their smooth, non-sticky texture.
Although legally permitted at very high levels, carbomers are normally used at concentrations below 1%.
It also needs to be neutralized to actually thicken, and because it is a large molecule, it doesn't really penetrate the skin barrier.
Allergy-wise, the risk is very low. Clinical studies show carbomers have low potential for skin irritation/sensitization even at concentrations up to 100%.
A 2024 UK study patch-tested 1,302 patients and found true allergy to the parent group of carbomer to be rare with no confirmed relevant reactions.
Ethylhexylglycerin is created from glycerin. It is a multitasker ingredient that:
The CIR Expert Panel found minimal skin absorption or sensitization of any kind in a safety assessment. Though this ingredient is considered well-tolerated, a small number of cases of allergic dermatitis have been published since 2002. Just be sure to patch test if you are unsure.
Industry-reported use ranges from 8% in rinse-off products and 2% in leave-on formulations.
Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.
Topically, glycerin does several things at once:
Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.
Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.
This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.
Just know very high concentrations (>40%) can feel tacky in low humidity.
Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.
Niacinamide is a multitasking form of vitamin B3 that strengthens the skin barrier, reduces pores and dark spots, regulates oil, and improves signs of aging.
And the best part? It's gentle and well-tolerated by most skin types, including sensitive and reactive skin.
You might have heard of "niacin flush", or the reddening of skin that causes itchiness. Niacinamide has not been found to cause this.
In very rare cases, some individuals may not be able to tolerate niacinamide at all or experience an allergic reaction to it.
If you are experiencing flaking, irritation, and dryness with this ingredient, be sure to double check all your products as this ingredient can be found in all categories of skincare.
When incorporating niacinamide into your routine, look out for concentration amounts. Typically, 5% niacinamide provides benefits such as fading dark spots. However, if you have sensitive skin, it is better to begin with a smaller concentration.
When you apply niacinamide to your skin, your body converts it into nicotinamide adenine dinucleotide (NAD). NAD is an essential coenzyme that is already found in your cells as "fuel" and powers countless biological processes.
In your skin, NAD helps repair cell damage, produce new healthy cells, support collagen production, strengthen the skin barrier, and fight environmental stressors (like UV and pollution).
Our natural NAD levels start to decline with age, leading to slower skin repair, visible aging, and a weaker skin barrier. By providing your skin niacinamide, you're recharging your skin's NAD levels. This leads to stronger, healthier, and younger looking skin.
Another name for vitamin B3 is nicotinamide. This vitamin is water-soluble and our bodies don't store it. We obtain Vitamin B3 from either food or skincare. Meat, fish, wheat, yeast, and leafy greens contain vitamin B3.
The type of niacinamide used in skincare is synthetically created.
Propanediol is an all-star ingredient. It softens, hydrates, and smooths the skin.
It’s often used to:
Propanediol is not likely to cause sensitivity and considered safe to use. It is derived from corn or petroleum with a clear color and no scent.
Tromethamine (aka THAM) is a synthetic amino acid that shows up in skincare as a helper ingredient.
It functions as a pH adjuster to help neutralize acidic ingredients and set a formula's pH to the right spot.
This matters a lot because a lot of actives (like vitamin C) needs a specific pH to work well and feel comfortable on skin.
Concentration use ranges from 0.1-1.0% depending on the formula.
Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.
So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.
You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!