Cetaphil Healthy Renew Purified Peptides Face Serum Versus MediCube Age-R Booster Gel Serum

Cetaphil Healthy Renew Purified Peptides Face Serum Versus MediCube Age-R Booster Gel Serum

This anti-aging serum is formulated around Panthenol and Niacinamide to soften the look of wrinkles and strengthen the skin barrier.

This anti-aging serum is formulated around Niacinamide and Sodium Hyaluronate to soften the look of wrinkles and hydrate skin.

What's inside

Key Ingredients

Benefits

Ingredients Side-by-side

Water

Butylene Glycol

Glycerin

Panthenol

1,2-Hexanediol

Niacinamide

Cetyl Ethylhexanoate

Hydrogenated Polydecene

Acrylates/C10-30 Alkyl Acrylate Crosspolymer

Tromethamine

Oryza Sativa Lees Extract

Leontopodium Alpinum Extract

Calcium Alginate

Propanediol

Hydrolyzed Soy Flour

Ethylhexylglycerin

Agar

Adenosine

Trisodium Ethylenediamine Disuccinate

Synthetic Fluorphlogopite

Caprylyl Glycol

Iron Oxides

Citric Acid

Sodium Benzoate

Potassium Sorbate

Buddleja Davidii Extract

Thymus Vulgaris Extract

Tocopherol

Water, Butylene Glycol, Glycerin, Panthenol, 1,2-Hexanediol, Niacinamide, Cetyl Ethylhexanoate, Hydrogenated Polydecene, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Tromethamine, Oryza Sativa Lees Extract, Leontopodium Alpinum Extract, Calcium Alginate, Propanediol, Hydrolyzed Soy Flour, Ethylhexylglycerin, Agar, Adenosine, Trisodium Ethylenediamine Disuccinate, Synthetic Fluorphlogopite, Caprylyl Glycol, Iron Oxides, Citric Acid, Sodium Benzoate, Potassium Sorbate, Buddleja Davidii Extract, Thymus Vulgaris Extract, Tocopherol

Adenium Obesum Leaf Cell Extract

Jasminum Sambac Leaf Cell Extract

Sodium Hyaluronate

Soluble Collagen

Hydrolyzed Hyaluronic Acid

Hyaluronic Acid

Pentylene Glycol

Sodium Polyacryloyldimethyl Taurate

Dipotassium Glycyrrhizate

Sodium Phytate

Glyceryl Acrylate/Acrylic Acid Copolymer

Pvm/Ma Copolymer

Sodium Polyacrylate

Sodium Chloride

Sodium Bicarbonate

Calcium Chloride

Potassium Chloride

Hydroxypropyltrimonium Hyaluronate

Sodium Acetylated Hyaluronate

Hydrolyzed Sodium Hyaluronate

Sodium Hyaluronate Crosspolymer

Potassium Hyaluronate

Water, Propanediol, Niacinamide, 1,2-Hexanediol, Adenium Obesum Leaf Cell Extract, Jasminum Sambac Leaf Cell Extract, Sodium Hyaluronate, Soluble Collagen, Hydrolyzed Hyaluronic Acid, Hyaluronic Acid, Pentylene Glycol, Sodium Polyacryloyldimethyl Taurate, Glycerin, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Tromethamine, Caprylyl Glycol, Ethylhexylglycerin, Dipotassium Glycyrrhizate, Adenosine, Sodium Phytate, Glyceryl Acrylate/Acrylic Acid Copolymer, Pvm/Ma Copolymer, Sodium Polyacrylate, Butylene Glycol, Sodium Chloride, Tocopherol, Sodium Bicarbonate, Calcium Chloride, Potassium Chloride, Hydroxypropyltrimonium Hyaluronate, Sodium Acetylated Hyaluronate, Hydrolyzed Sodium Hyaluronate, Sodium Hyaluronate Crosspolymer, Potassium Hyaluronate

Reviews

Alternatives

Ingredients Explained

These ingredients are found in both products.

Ingredients higher up in an ingredient list are typically present in a larger amount.

1,2-Hexanediol is a synthetic liquid and another multi-functional powerhouse.

It is a:

Humectant, drawing moisture into the skin

Emollient, helping to soften skin

Solvent, dispersing and stabilizing formulas

Preservative booster, enhancing the antimicrobial activity of other preservatives

Acrylates/C10-30 Alkyl Acrylate Crosspolymer is a synthetic polymer. It is used to thicken, emulsify, and improve the texture of products.

As an emulsifier, it helps stabilize oil-in-water emulsions to give products an elegant feel when applied.

It can also form a thin protective film on skin. One study found that a formula using this polymer helped slow down how quickly other ingredients (like DEET) were absorbed through skin.

A 2024 study of over 1,300 patients confirmed that sensitization to this ingredient is rare. It is also non-mutagenic and has a clean track record.

Adenosine is a purine nucleoside that your body already makes in every cell. In skincare, it acts mainly as a skin conditioning and anti-aging agent.

The way it works is fairly well mapped out:

Your skin has cells called fibroblasts that build collagen (the stuff that keeps skin firm and smooth). Adenosine basically flips a switch on these cells that tells them to get to work making more collagen and other proteins. These cells slow down on their own as skin ages, so Adenosine helps give them a little nudge to keep going.

The clinical backing is pretty solid too.

A blind, randomized, placebo-controlled trial of 126 women aged 45-65 tested a 0.1% cream twice daily and found real improvements in crow's feet and frown lines using a precise 3D skin-mapping technique; these changes showed up by week 3 and held at 2 months.

A later study using Adenosine-loaded dissolving microneedle patches reported gains in wrinkle depth, dermal density, elasticity, and hydration.

On concentrations, South Korea's Ministry of Food and Drug Safety has set 0.04% as the approved functional anti-wrinkle level. You'll typically see this ingredient used somewhere in the 0.04-0.1% range since it works at low doses.

This ingredient has been found safe for cosmetics with the data showing no irritation or sensitization.

Overall, this is a great ingredient for any anti-aging routine and has no photosensitizing effect, so it suits both AM and PM use.

Butylene Glycol (or BG) is used within cosmetic products for a few different reasons:

Overall, Butylene Glycol is a safe and well-rounded ingredient that works well with other ingredients.

Though this ingredient works well with most skin types, some people with sensitive skin may experience a reaction such as allergic rashes, closed comedones, or itchiness.

Caprylyl Glycol is a humectant, skin conditioner, emollient, and preservative booster derived from either caprylic acid or synthetically created.

Typical use levels vary from 0.3-1% as a preservative booster and go up to 2% to condition skin.

Because it is not a free-fatty acid, this ingredient is fungal acne safe (there's nothing for Malassezia to feed on).

Ethylhexylglycerin is created from glycerin. It is a multitasker ingredient that:

The CIR Expert Panel found minimal skin absorption or sensitization of any kind in a safety assessment. Though this ingredient is considered well-tolerated, a small number of cases of allergic dermatitis have been published since 2002. Just be sure to patch test if you are unsure.

Industry-reported use ranges from 8% in rinse-off products and 2% in leave-on formulations.

Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.

Topically, glycerin does several things at once:

Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.

Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.

This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.

Just know very high concentrations (>40%) can feel tacky in low humidity.

Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.

Niacinamide is a multitasking form of vitamin B3 that strengthens the skin barrier, reduces pores and dark spots, regulates oil, and improves signs of aging.

And the best part? It's gentle and well-tolerated by most skin types, including sensitive and reactive skin.

You might have heard of "niacin flush", or the reddening of skin that causes itchiness. Niacinamide has not been found to cause this.

In very rare cases, some individuals may not be able to tolerate niacinamide at all or experience an allergic reaction to it.

If you are experiencing flaking, irritation, and dryness with this ingredient, be sure to double check all your products as this ingredient can be found in all categories of skincare.

When incorporating niacinamide into your routine, look out for concentration amounts. Typically, 5% niacinamide provides benefits such as fading dark spots. However, if you have sensitive skin, it is better to begin with a smaller concentration.

When you apply niacinamide to your skin, your body converts it into nicotinamide adenine dinucleotide (NAD). NAD is an essential coenzyme that is already found in your cells as "fuel" and powers countless biological processes.

In your skin, NAD helps repair cell damage, produce new healthy cells, support collagen production, strengthen the skin barrier, and fight environmental stressors (like UV and pollution).

Our natural NAD levels start to decline with age, leading to slower skin repair, visible aging, and a weaker skin barrier. By providing your skin niacinamide, you're recharging your skin's NAD levels. This leads to stronger, healthier, and younger looking skin.

Another name for vitamin B3 is nicotinamide. This vitamin is water-soluble and our bodies don't store it. We obtain Vitamin B3 from either food or skincare. Meat, fish, wheat, yeast, and leafy greens contain vitamin B3.

The type of niacinamide used in skincare is synthetically created.

Propanediol is an all-star ingredient. It softens, hydrates, and smooths the skin.

It’s often used to:

Propanediol is not likely to cause sensitivity and considered safe to use. It is derived from corn or petroleum with a clear color and no scent.

Tocopherol is a fat-soluble antioxidant known as Vitamin E.

You'll find this ingredient in the vast majority of skincare (for good reason). It works to neutralize free radicals, or unstable molecules generated by UV exposure, pollution, and other environmental stressors, before they can cause oxidative damage to your skin cells.

Topically applied tocopherol has been shown to protect against UV damage by ramping up the skin's own natural defense enzymes.

It also acts as a skin conditioning agent; some studies show that regular topical use can improve the skin's water-binding capacity over 2-4 weeks.

This ingredient is especially loved for being a team player. When combined with Vitamin C, the photoprotective effect of both ingredients roughly doubles and the combo also helps reduce UV-induced DNA damage.

This ingredient has some brightening potential but it's more of a prevention ingredient than spot-fader. Cell studies show it can slow down melanin production but it's worth noting that it's not the most powerful brightener out there.

In formulations, it also serves as a stabilizer that helps protect other oxidation-prone ingredients from degrading.

Concentrations usually range from 0.1-1% in most leave-on products.

Tromethamine (aka THAM) is a synthetic amino acid that shows up in skincare as a helper ingredient.

It functions as a pH adjuster to help neutralize acidic ingredients and set a formula's pH to the right spot.

This matters a lot because a lot of actives (like vitamin C) needs a specific pH to work well and feel comfortable on skin.

Concentration use ranges from 0.1-1.0% depending on the formula.

Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.

So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.

You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!

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