Cetaphil Healthy Renew Purified Peptides Face Serum Versus Peter Thomas Roth Peptide 21 Wrinkle Resist Moisturizer

Cetaphil Healthy Renew Purified Peptides Face Serum Versus Peter Thomas Roth Peptide 21 Wrinkle Resist Moisturizer

This anti-aging serum is formulated around Panthenol and Niacinamide to soften the look of wrinkles and strengthen the skin barrier.

This anti-aging moisturizer is formulated around Hexapeptide-11 and Dipeptide Diaminobutyroyl Benzylamide Diacetate to soften the look of wrinkles.

What's inside

Key Ingredients

Benefits

Concerns

No concerns

Ingredients Side-by-side

Water

Butylene Glycol

Glycerin

Panthenol

1,2-Hexanediol

Niacinamide

Cetyl Ethylhexanoate

Hydrogenated Polydecene

Acrylates/C10-30 Alkyl Acrylate Crosspolymer

Tromethamine

Oryza Sativa Lees Extract

Leontopodium Alpinum Extract

Calcium Alginate

Propanediol

Hydrolyzed Soy Flour

Ethylhexylglycerin

Agar

Adenosine

Trisodium Ethylenediamine Disuccinate

Synthetic Fluorphlogopite

Caprylyl Glycol

Iron Oxides

Citric Acid

Sodium Benzoate

Potassium Sorbate

Buddleja Davidii Extract

Thymus Vulgaris Extract

Tocopherol

Water, Butylene Glycol, Glycerin, Panthenol, 1,2-Hexanediol, Niacinamide, Cetyl Ethylhexanoate, Hydrogenated Polydecene, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Tromethamine, Oryza Sativa Lees Extract, Leontopodium Alpinum Extract, Calcium Alginate, Propanediol, Hydrolyzed Soy Flour, Ethylhexylglycerin, Agar, Adenosine, Trisodium Ethylenediamine Disuccinate, Synthetic Fluorphlogopite, Caprylyl Glycol, Iron Oxides, Citric Acid, Sodium Benzoate, Potassium Sorbate, Buddleja Davidii Extract, Thymus Vulgaris Extract, Tocopherol

Dimethicone

Olive Oil Decyl Esters

Glycereth-26

Squalane

Behenyl Alcohol

Polysilicone-11

Batyl Alcohol

Simmondsia Chinensis Seed Oil

Hexapeptide-11

Dipeptide Diaminobutyroyl Benzylamide Diacetate

Palmitoyl Tripeptide-5

Tripeptide-10 Citrulline

Acetyl Hexapeptide-1

Acetyl Tetrapeptide-11

Acetyl Hexapeptide-8

Palmitoyl Hexapeptide-12

Acetyl Tetrapeptide-9

Palmitoyl Tetrapeptide-7

Acetyl Tetrapeptide-2

Acetyl Octapeptide-3

Palmitoyl Hexapeptide-19

Trifluoroacetyl Tripeptide-2

Tripeptide-1

Palmitoyl Oligopeptide

Palmitoyl Tripeptide-1

Potassium Hydrolyzed Polygamma-Glutamate

Sodium Polyglutamate

Squalene

Mica

Sodium Hyaluronate

Sorbic Acid

Cereus Grandiflorus Flower Extract

Pseudoalteromonas Ferment Extract

Leuconostoc/Radish Root Ferment Filtrate

Magnesium Chloride

Phenoxyethanol

Cetyl Alcohol

Stearyl Alcohol

Trehalose

Glyceryl Stearate

Silanetriol Trehalose Ether

Mannitol

Phytosterols

Caprylic/Capric Triglyceride

Hydrogenated Lecithin

Polyglyceryl-10 Myristate

Polysorbate 20

Dimethyl Isosorbide

Sodium Hydroxide

Laureth-12

Hydrolyzed Wheat Protein

Lecithin

Disodium Phosphate

Hydrolyzed Soy Protein

Carbomer

Dextran

Sodium Lactate

Tetradecyl Aminobutyroylvalylaminobutyric Urea Trifluoroacetate

Sodium Phosphate

Xanthan Gum

Triethanolamine

Acrylates Copolymer

Water, Glycerin, Dimethicone, Olive Oil Decyl Esters, Glycereth-26, Squalane, Butylene Glycol, Behenyl Alcohol, Polysilicone-11, Batyl Alcohol, Simmondsia Chinensis Seed Oil, Hexapeptide-11, Dipeptide Diaminobutyroyl Benzylamide Diacetate, Palmitoyl Tripeptide-5, Tripeptide-10 Citrulline, Acetyl Hexapeptide-1, Acetyl Tetrapeptide-11, Acetyl Hexapeptide-8, Palmitoyl Hexapeptide-12, Acetyl Tetrapeptide-9, Palmitoyl Tetrapeptide-7, Acetyl Tetrapeptide-2, Acetyl Octapeptide-3, Palmitoyl Hexapeptide-19, Trifluoroacetyl Tripeptide-2, Tripeptide-1, Palmitoyl Oligopeptide, Palmitoyl Tripeptide-1, Potassium Hydrolyzed Polygamma-Glutamate, Sodium Polyglutamate, Squalene, Mica, Sodium Hyaluronate, Sorbic Acid, Tocopherol, Cereus Grandiflorus Flower Extract, Pseudoalteromonas Ferment Extract, Leuconostoc/Radish Root Ferment Filtrate, Magnesium Chloride, Phenoxyethanol, Cetyl Alcohol, Stearyl Alcohol, Trehalose, Glyceryl Stearate, Silanetriol Trehalose Ether, Mannitol, Phytosterols, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Caprylic/Capric Triglyceride, Hydrogenated Lecithin, Polyglyceryl-10 Myristate, Polysorbate 20, Dimethyl Isosorbide, Sodium Benzoate, Potassium Sorbate, Caprylyl Glycol, Sodium Hydroxide, Laureth-12, Hydrolyzed Wheat Protein, Lecithin, Disodium Phosphate, Hydrolyzed Soy Protein, Carbomer, Dextran, Ethylhexylglycerin, Sodium Lactate, Tetradecyl Aminobutyroylvalylaminobutyric Urea Trifluoroacetate, Sodium Phosphate, Xanthan Gum, Triethanolamine, Acrylates Copolymer

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Alternatives

Ingredients Explained

These ingredients are found in both products.

Ingredients higher up in an ingredient list are typically present in a larger amount.

Acrylates/C10-30 Alkyl Acrylate Crosspolymer is a synthetic polymer. It is used to thicken, emulsify, and improve the texture of products.

As an emulsifier, it helps stabilize oil-in-water emulsions to give products an elegant feel when applied.

It can also form a thin protective film on skin. One study found that a formula using this polymer helped slow down how quickly other ingredients (like DEET) were absorbed through skin.

A 2024 study of over 1,300 patients confirmed that sensitization to this ingredient is rare. It is also non-mutagenic and has a clean track record.

Butylene Glycol (or BG) is used within cosmetic products for a few different reasons:

Overall, Butylene Glycol is a safe and well-rounded ingredient that works well with other ingredients.

Though this ingredient works well with most skin types, some people with sensitive skin may experience a reaction such as allergic rashes, closed comedones, or itchiness.

Caprylyl Glycol is a humectant, skin conditioner, emollient, and preservative booster derived from either caprylic acid or synthetically created.

Typical use levels vary from 0.3-1% as a preservative booster and go up to 2% to condition skin.

Because it is not a free-fatty acid, this ingredient is fungal acne safe (there's nothing for Malassezia to feed on).

Ethylhexylglycerin is created from glycerin. It is a multitasker ingredient that:

The CIR Expert Panel found minimal skin absorption or sensitization of any kind in a safety assessment. Though this ingredient is considered well-tolerated, a small number of cases of allergic dermatitis have been published since 2002. Just be sure to patch test if you are unsure.

Industry-reported use ranges from 8% in rinse-off products and 2% in leave-on formulations.

Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.

Topically, glycerin does several things at once:

Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.

Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.

This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.

Just know very high concentrations (>40%) can feel tacky in low humidity.

Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.

Potassium Sorbate is a preservative used to prevent yeast and mold in products. It is commonly found in both cosmetic and food products.

This ingredient comes from potassium salt derived from sorbic acid. Sorbic acid is a natural antibiotic and effective against fungus.

Both potassium sorbate and sorbic acid can be found in baked goods, cheeses, dried meats, dried fruit, ice cream, pickles, wine, yogurt, and more.

You'll often find this ingredient used with other preservatives.

Sodium Benzoate is a preservative. It's used in both cosmetic and food products to inhibit the growth of mold and bacteria. It is typically produced synthetically.

Both the US FDA and EU Health Committee have approved the use of sodium benzoate. In the US, levels of 0.1% (of the total product) are allowed.

Sodium benzoate works as a preservative by inhibiting the growth of bacteria inside of cells. It prevents the cell from fermenting a type of sugar using an enzyme called phosphofructokinase.

It is the salt of benzoic acid. Foods containing sodium benzoate include soda, salad dressings, condiments, fruit juices, wines, and snack foods.

Studies for using ascorbic acid and sodium benzoate in cosmetics are lacking, especially in skincare routines with multiple steps.

We always recommend speaking with a professional, such as a dermatologist, if you have any concerns.

Tocopherol is a fat-soluble antioxidant known as Vitamin E.

You'll find this ingredient in the vast majority of skincare (for good reason). It works to neutralize free radicals, or unstable molecules generated by UV exposure, pollution, and other environmental stressors, before they can cause oxidative damage to your skin cells.

Topically applied tocopherol has been shown to protect against UV damage by ramping up the skin's own natural defense enzymes.

It also acts as a skin conditioning agent; some studies show that regular topical use can improve the skin's water-binding capacity over 2-4 weeks.

This ingredient is especially loved for being a team player. When combined with Vitamin C, the photoprotective effect of both ingredients roughly doubles and the combo also helps reduce UV-induced DNA damage.

This ingredient has some brightening potential but it's more of a prevention ingredient than spot-fader. Cell studies show it can slow down melanin production but it's worth noting that it's not the most powerful brightener out there.

In formulations, it also serves as a stabilizer that helps protect other oxidation-prone ingredients from degrading.

Concentrations usually range from 0.1-1% in most leave-on products.

Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.

So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.

You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!

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