Chemist Confessions Inc. Mr. Reliable Lightweight Moisturizer Versus Skinfix Barrier+ Triple Lipid-Peptide Cream

Chemist Confessions Inc. Mr. Reliable Lightweight Moisturizer Versus Skinfix Barrier+ Triple Lipid-Peptide Cream

This barrier-repair moisturizer is formulated around Niacinamide and Panthenol to strengthen the skin barrier and hydrate skin.

This barrier-repair moisturizer is formulated around Butyrospermum Parkii Butter and Ceramide NP to strengthen the skin barrier and hydrate skin.

What's inside

Key Ingredients

Benefits

Concerns

Ingredients Side-by-side

Water

Glycerin

Ethyl Macadamiate

Caprylic/Capric Triglyceride

Isononyl Isononanoate

Propanediol

Ethoxydiglycol

Niacinamide

Dimethicone

Panthenol

Hydrogenated Lecithin

C12-16 Alcohols

Palmitic Acid

Vinyl Dimethicone/Methicone Silsesquioxane Crosspolymer

Ceramide NP

Ceramide AP

Ceramide EOP

Phytosphingosine

Cholesterol

Sodium Lauroyl Lactylate

Carbomer

Xanthan Gum

Sodium Hyaluronate Crosspolymer

Sodium Hyaluronate

Sodium Acetylated Hyaluronate

Hydrolyzed Sodium Hyaluronate

Phospholipids

Silybum Marianum Extract

Maltodextrin

Lactobacillus Ferment

Bisabolol

Jojoba Esters

Helianthus Annuus Seed Wax

Acacia Decurrens Flower Wax

Polyglycerin-3

Sodium Polyacryloyldimethyl Taurate

Behenyl Alcohol

Phenoxyethanol

Chlorphenesin

Disodium EDTA

Citric Acid

Chamaecyparis Obtusa Oil

Pelargonium Graveolens Leaf Oil

Pinus Sylvestris Oil

Water, Glycerin, Ethyl Macadamiate, Caprylic/Capric Triglyceride, Isononyl Isononanoate, Propanediol, Ethoxydiglycol, Niacinamide, Dimethicone, Panthenol, Hydrogenated Lecithin, C12-16 Alcohols, Palmitic Acid, Vinyl Dimethicone/Methicone Silsesquioxane Crosspolymer, Ceramide NP, Ceramide AP, Ceramide EOP, Phytosphingosine, Cholesterol, Sodium Lauroyl Lactylate, Carbomer, Xanthan Gum, Sodium Hyaluronate Crosspolymer, Sodium Hyaluronate, Sodium Acetylated Hyaluronate, Hydrolyzed Sodium Hyaluronate, Phospholipids, Silybum Marianum Extract, Maltodextrin, Lactobacillus Ferment, Bisabolol, Jojoba Esters, Helianthus Annuus Seed Wax, Acacia Decurrens Flower Wax, Polyglycerin-3, Sodium Polyacryloyldimethyl Taurate, Behenyl Alcohol, Phenoxyethanol, Chlorphenesin, Disodium EDTA, Citric Acid, Chamaecyparis Obtusa Oil, Pelargonium Graveolens Leaf Oil, Pinus Sylvestris Oil

Butyrospermum Parkii Butter

Olus Oil

Cetyl Lactate

Caprylyl Caprylate/Caprate

Jojoba Oil/Macadamia Seed Oil Esters

Glyceryl Stearate Citrate

Oryza Sativa Bran Extract

Dilinoleic Acid/Propanediol Copolymer

Squalene

Ophiopogon Japonicus Root Extract

Phytosteryl Sunflowerseedate

Glycine Soja Extract

Pentylene Glycol

Hydrolyzed Rice Protein

Chondrus Crispus Extract

Hydrogenated Vegetable Glycerides

Helianthus Annuus Extract

Phytosteryl Macadamiate

Tocopherol

Rosmarinus Officinalis Leaf Extract

Aloe Barbadensis Leaf Juice

Trisodium Ethylenediamine Disuccinate

Phytosterols

Gluconolactone

Phenethyl Alcohol

Potassium Sorbate

Ethylhexylglycerin

Sodium Benzoate

Water, Caprylic/Capric Triglyceride, Glycerin, Butyrospermum Parkii Butter, Olus Oil, Cetyl Lactate, Propanediol, C12-16 Alcohols, Caprylyl Caprylate/Caprate, Jojoba Oil/Macadamia Seed Oil Esters, Glyceryl Stearate Citrate, Palmitic Acid, Hydrogenated Lecithin, Oryza Sativa Bran Extract, Dilinoleic Acid/Propanediol Copolymer, Squalene, Ophiopogon Japonicus Root Extract, Xanthan Gum, Phytosteryl Sunflowerseedate, Glycine Soja Extract, Pentylene Glycol, Ceramide NP, Ceramide AP, Ceramide EOP, Hydrolyzed Rice Protein, Chondrus Crispus Extract, Hydrogenated Vegetable Glycerides, Helianthus Annuus Extract, Sodium Hyaluronate, Citric Acid, Phytosteryl Macadamiate, Tocopherol, Rosmarinus Officinalis Leaf Extract, Aloe Barbadensis Leaf Juice, Trisodium Ethylenediamine Disuccinate, Phytosterols, Sodium Lauroyl Lactylate, Gluconolactone, Phenethyl Alcohol, Phytosphingosine, Cholesterol, Carbomer, Potassium Sorbate, Ethylhexylglycerin, Sodium Benzoate, Phenoxyethanol

Reviews

Alternatives

Ingredients Explained

These ingredients are found in both products.

Ingredients higher up in an ingredient list are typically present in a larger amount.

We don't have a description for C12-16 Alcohols yet.

Caprylic/Capric Triglyceride (aka MCT Oil) is a lightweight emollient, solvent, and texture enhancer. It is considered a skin-softener by helping to prevent moisture loss.

Though it behaves like an oil, it is not technically one due to its chemical composition. One perk of this ingredient is that it is very stable, resistant to oxidation, and unlikely to go rancid.

In practice, that translates to a long shelf life and a consistently elegant skin feel.

While there is an assumption Caprylic Triglyceride can clog pores due to it being derived from coconut oil, there is no research supporting this. Just patch test if you have concerns.

Fractionated coconut oil and MCT Oil are both listed as Caprylic/Capric Triglyceride according to INCI. This is because INCI names are based on the ingredient’s final chemical composition and not its marketing name or source.

This ingredient is treated as the gold standard fungal acne safe oil. Even though it is coconut derived, the problematic lauric acid is stripped out.

This leaves just caprylic (C8) and capric (C10) acid. These chain lengths actually trend antifungal; a 2020 study found caprylic acid was enough to disrupt Malassezia furfur cell membrane, with a caprylic acid derivative damaging membrane structures at concentrations as low as 0.2%.

Carbomer is a synthetic thickening and gelling agent. It's basically the ingredient that gives a lot of serums, gels, creams, and sunscreens their smooth, non-sticky texture.

Although legally permitted at very high levels, carbomers are normally used at concentrations below 1%.

It also needs to be neutralized to actually thicken, and because it is a large molecule, it doesn't really penetrate the skin barrier.

Allergy-wise, the risk is very low. Clinical studies show carbomers have low potential for skin irritation/sensitization even at concentrations up to 100%.

A 2024 UK study patch-tested 1,302 patients and found true allergy to the parent group of carbomer to be rare with no confirmed relevant reactions.

Ceramide AP is is a skin-identical lipid that mimics what your skin already makes naturally. Ceramides help maintain epidermal integrity and barrier function.

You'll often see this ingredient paired with other ceramides (like ceramide NP), cholesterol, or fatty acids because this combination best mimics the natural lipid mix your skin already has.

The skin's ability to produce ceramides gets disrupted in skin conditions like eczema. This in turn weakens the skin barrier and applying ceramides topically has been shown to replenish what's been lost to restore barrier function.

Most of the studies with Ceramide AP test it as part of a multi-ceramide complex; studies reinforce ceramide AP's role in rebalancing ceramides in skin and improving skin hydration.

Ceramide EOP is formally known as Ceramide 1.

It is naturally found in skin and part of the intercellular "mortar" holding everything together in your outermost layer.

EOP stands for a linked Ester fatty acid, a linked Omega hydroxy fatty acid, and the Phytosphingosine base.

What makes Ceramide EOP special is its ultra-long fatty acid chain; this unique structure allows it to bridge the lipid layers in your skin barrier to prevent water loss (something no other ceramide can do).

Low levels of Ceramide EOP have been found in people with eczema and psoriasis.

Using it together with other ceramides, cholesterol, and linoleic acid have been shown to meaningfully improve hydration and reduce water loss.

In one clinical study, a regimen using Ceramide EOP, NP, and AP led to significant symptom improvements in patients with eczema, psoriasis, and dry skin in just 4 weeks.

You'll usually see concentrations between 0.1-0.5% in formulations. Overall, this is a well-tolerated and safe ingredient for cosmetic use.

Ceramide NP (formerly known as Ceramide 3) is one of the skin's naturally occurring lipids.

Since ceramides are the major lipid components of the skin, they are crucial for maintaining skin barrier and hydration. Ceramide NP most closely mirrors the dominant kind in human skin amongst ceramide subtypes.

This ceramide works by slotting into gaps within the stratum corneum's lipid matrix to limit trans-epidermal water loss (TEWL) and shield the skin against external irritants.

A study with 312 patients found that using a ceramide-containing routine for 4 weeks reduced the severity of atopic dermatitis by over 61%.

Another clinical study in subjects aged 60 and older found that a ceramide body wash and moisturizer improved skin dryness and itchy skin in 15 days.

Overall, ceramides are considered non-irritating and safety tests have found little to no observable adverse effects from using this ingredient.

Ceramide NP is usually sourced from plants (like soybean or rice bran), or produced synthetically.

Cholesterol is a lipid that is naturally found in human skin and is one of the three key components of your skin barrier. In skincare, it is an emollient and barrier-repairing ingredient.

It works by fitting directly into the lipid layers of skin to help restore structure and reduce transepidermal water loss (TEWL).

This is a great ingredient for dry, compromised, or aging skin; our skin starts to produce less cholesterol with age.

Research shows cholesterol works best in combination with ceramides and fatty acids, the other two major components in your skin barrier.

Cholesterol is also a well-establish penetration enhancer and can help other actives absorb more effectively.

Cosmetic-grade cholesterol is usually derived from lanolin but plant and synthetic options also exist. We recommend reaching out to the brand if you have questions about their source of cholesterol.

Citric Acid is an alpha hydroxy acid (AHA) naturally found in citrus fruits like oranges, lemons, and limes.

Like other AHAs, citric acid can exfoliate skin by breaking down the bonds that hold dead skin cells together. This helps reveal smoother and brighter skin underneath.

However, this exfoliating effect only happens at high concentrations (20%) which can be hard to find in cosmetic products.

Due to this, citric acid is usually included in small amounts as a pH adjuster. This helps keep products slightly more acidic and compatible with skin's natural pH.

In skincare formulas, citric acid can:

While it can provide some skin benefits, research shows lactic acid and glycolic acid are generally more effective and less irritating exfoliants.

Most citric acid used in skincare today is made by fermenting sugars (usually from molasses). This synthetic version is identical to the natural citrus form but easier to stabilize and use in formulations.

Rosacea skin has a lower threshold for acids generally, with 62.5% of rosacea subjects in one study reacting to lactic acid in a sting test. This is why we mark citric acid as a potential rosacea trigger.

However, this ingredient shows up as a pH adjuster or chelator at roughly 0.1-1% in many products. These low levels are unlikely to be an issue for rosacea skin and becomes a potential trigger at exfoliating concentrations (20%). Because everybody's skin is unique, we recommend a patch test if you are unsure.

Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.

Topically, glycerin does several things at once:

Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.

Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.

This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.

Just know very high concentrations (>40%) can feel tacky in low humidity.

Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.

Hydrogenated Lecithin is a more stable version of lecithin.

It's made by taking lecithin (a phospholipid commonly found in soybeans and egg yolks) and hydrogenating it. This just means the unsaturated fatty acids are turned into saturated ones so they don't go bad as easily.

This ingredient is an emollient, emulsifier, and penetration enhancer. As an emollient, it helps soften and hydrate skin by trapping moisture within. As an emulsifier, it prevents oil and water ingredients from separating.

Hydrogenated Lecithin can form tiny spherical structures made of phospholipid bilayers called liposomes. These liposomes are able to capture compounds inside their structure and deliver them through the skin barrier.

Because phospholipids are a natural component of our cell membranes, this ingredient is inherently compatible with skin.

A 2021 study found lecithin-based surfactants were less harsh and more tolerable comared to Sodium Lauryl Sulfate (SLS).

Palmitic Acid is a fatty acid naturally found in our skin and in many plant and animal sources.

In cosmetics, it is usually derived from palm oil. It serves many purposes in skincare, acting as a cleanser, emollient, and emulsifier.

Interestingly, topically applied Palmitic Acid can be elongated into longer chain fatty acids and ceramides. A 2019 study found low levels of Palmitic Acid lead to slower development of cells, suggesting it plays a role in keeping your skin's renewal process on track.

The CIR (Cosmetic Ingredient Review) panel determined it safe as used in cosmetics at concentrations up to 13%. It is non-irritating and non-sensitizing in clinical studies.

The culprit behind fungal acne, the Malassezia yeast, feeds on fatty acids with carbon chain lengths between C11-C24. Palmitic Acid, at C16, falls right into that sweet spot.

In vitro studies have shown that Palmitic Acid is one of the fatty acids that induce rapid Malassezia growth in lab settings.

It's worth noting that what feeds yeast in a lab doesn't necessarily feed it on your face since formulation and your skin's chemistry play a bigger role.

Phenoxyethanol is one of the most widely used preservatives in skincare (and for good reason!).

It has a large spectrum of antimicrobial activity and especially effective bacteria, yeast, and mold while only having a weak effect on your skin's natural microbiome.

On a cellular level, it disrupts the cell membranes of microbes by poking holes that make the cell leak. This shuts down the chemical reactions the microbe needs to make energy so it can no longer survive.

Another perk of this ingredient is that it stays functional across a wide pH range (3-10).

You'll often see it paired with boosters like Ethylhexylglycerin; one study showed that a 1:9 ratio of Ethylhexylglycerin to Phenoxyethanol damages bacterial membranes as effectively as doubling the Phenoxyethanol concentration on its own.

Typical use concentrations range from 0.3-1% depending on the formula, and this ingredient is capped at 1% int the EU.

Safety-wise, the fear mongering does not hold up to the evidence. The EU's Scientific Committee on Consumer Safety and FDA consider it safe as a preservative at up to 1%, including for children of all ages.

Adverse systemic effects only showed up in animal studies at exposures roughly 200x higher than what people get from cosmetics. And despite its very widespread use, this ingredient is a rare sensitizer and allergic reactions are uncommon.

Phytosphingosine is a phospholipid naturally found in our skin as a building block for ceramides.. It helps moisturize, soothe, and protect skin.

Phytosphingosine contributes to your skin's natural moisturizing factor (NMF). The NMF is responsible for hydration, a strong barrier, and plasticity. Our NMF decreases with age. Increasing NMF leads to more healthy and hydrated skin.

Studies show products formulated with NMF ingredients help strengthen our skin's barrier. Having a healthy skin barrier reduces irritation and increases hydration. Our skin barrier is responsible for having plump and firm skin. It also helps protect our skin against infection, allergies, and inflammation.

Fun fact: Phytosphingosine is abundant in plants and fungi.

More ingredients that help boost collagen in skin:

Propanediol is an all-star ingredient. It softens, hydrates, and smooths the skin.

It’s often used to:

Propanediol is not likely to cause sensitivity and considered safe to use. It is derived from corn or petroleum with a clear color and no scent.

Sodium Hyaluronate is the salt form of hyaluronic acid. It is a long sugar chain that is naturally found in your skin, joints, and connective tissue that maintains hydration and elasticity.

In skincare, it works as a humectant. It pulls water from the environment and deeper layers of skin and binds it to the surface.

Interestingly, the size of the molecule affects its behavior:

Some clinical evidence links low molecular weight versions to improved wrinkle depth, elasticity, anti-inflammatory effects, and barrier repair.

Many serums use a blend of both weights so you can get surface hydration plus longer-lasting and deeper effects.

You'll typically see concentrations between 0.1-2% for this ingredient.

Sodium Lauroyl Lactylate (SLL) is a mild, plant-derived surfactant made by combining lauric acid with lactic acid.

It has two main jobs in a formula:

A perk of this ingredient is that it leaves skin feeling soft and silky after rinsing. This is why you'll even see it in baby washes.

Another perk? The lauric acid backbone gives it mild antimicrobial activity and lauric acid itself has been shown to suppress acne-causing bacteria in lab studies.

In 2023, scientists took a close look at how SLL behaves and found it can break apart the fatty outer layers of cells. This is basically why it cleans well and can fight off certain microbes.

The Cosmetic Ingredient Review (CIR) Expert Panel has reviewed it and concluded it's safe as used.

A 2017 survey showed concentrations up to 10% are used in rinse-off cleansers and roughly 0.5-5% being typical in skincare.

Animal and reconstructed-skin testing found it to be non-irritating at 10%, and it's well tolerated even on sensitive skin. The only caveat is to patch test if you have a lactic acid allergy.

As a lactylate salt used at low co-emulsifier concentrations, this ingredient is less likely to break down and release free lauric acid on skin. This ingredient is fungal acne safe.

Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.

So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.

You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!

Xanthan gum is used as a stabilizer and thickener within cosmetic products. It helps give products a sticky, thick feeling - preventing them from being too runny.

On the technical side of things, xanthan gum is a polysaccharide - a combination consisting of multiple sugar molecules bonded together.

Xanthan gum is a pretty common and great ingredient. It is a natural, non-toxic, non-irritating ingredient that is also commonly used in food products.

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