Clinique Moisture Surge 72-Hour Auto-Replenishing Hydrator Versus Neutrogena Hydro Boost Vitamin E & Hyaluronic Acid Serum

Clinique Moisture Surge 72-Hour Auto-Replenishing Hydrator Versus Neutrogena Hydro Boost Vitamin E & Hyaluronic Acid Serum

This barrier-repair moisturizer is formulated around Sodium Hyaluronate to strengthen the skin barrier and hydrate skin.

This hydrating serum is formulated around Niacinamide and Sodium Hyaluronate to hydrate skin and strengthen the skin barrier.

What's inside

Key Ingredients

Benefits

Concerns

Ingredients Side-by-side

Water

Dimethicone

Butylene Glycol

Glycerin

Trisiloxane

Trehalose

Sucrose

Ammonium Acryloyldimethyltaurate/Vp Copolymer

Hydroxyethyl Urea

Camellia Sinensis Leaf Extract

Silybum Marianum Extract

Betula Alba Bark Extract

Saccharomyces Lysate Extract

Aloe Barbadensis Leaf Water

Thermus Thermophillus Ferment

Caffeine

Sorbitol

Palmitoyl Hexapeptide-12

Sodium Hyaluronate

Caprylyl Glycol

Oleth-10

Sodium Polyaspartate

Saccharide Isomerate

Hydrogenated Lecithin

Tocopheryl Acetate

Acrylates/C10-30 Alkyl Acrylate Crosspolymer

Glyceryl Polymethacrylate

Tromethamine

PEG-8

Hexylene Glycol

Magnesium Ascorbyl Phosphate

Disodium EDTA

BHT

Phenoxyethanol

CI 14700

CI 19140

Water, Dimethicone, Butylene Glycol, Glycerin, Trisiloxane, Trehalose, Sucrose, Ammonium Acryloyldimethyltaurate/Vp Copolymer, Hydroxyethyl Urea, Camellia Sinensis Leaf Extract, Silybum Marianum Extract, Betula Alba Bark Extract, Saccharomyces Lysate Extract, Aloe Barbadensis Leaf Water, Thermus Thermophillus Ferment, Caffeine, Sorbitol, Palmitoyl Hexapeptide-12, Sodium Hyaluronate, Caprylyl Glycol, Oleth-10, Sodium Polyaspartate, Saccharide Isomerate, Hydrogenated Lecithin, Tocopheryl Acetate, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Glyceryl Polymethacrylate, Tromethamine, PEG-8, Hexylene Glycol, Magnesium Ascorbyl Phosphate, Disodium EDTA, BHT, Phenoxyethanol, CI 14700, CI 19140

Propanediol

Pentylene Glycol

Niacinamide

PEG-60 Hydrogenated Castor Oil

Ethylhexylglycerin

Chondrus Crispus Powder

Ceramide AP

1,2-Hexanediol

Panthenol

Synthetic Fluorphlogopite

Agar

Gellan Gum

Parfum

Algin

Chondrus Crispus Extract

Arginine

PCA

Serine

Alanine

Citric Acid

Threonine

Mourera Fluviatilis Extract

Titanium Dioxide

Mica

Water, Propanediol, Glycerin, Pentylene Glycol, Niacinamide, Phenoxyethanol, Butylene Glycol, PEG-60 Hydrogenated Castor Oil, Ammonium Acryloyldimethyltaurate/Vp Copolymer, Caprylyl Glycol, Ethylhexylglycerin, Chondrus Crispus Powder, Ceramide AP, 1,2-Hexanediol, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Tromethamine, Panthenol, Sodium Hyaluronate, Synthetic Fluorphlogopite, Agar, Gellan Gum, Parfum, Disodium EDTA, Tocopheryl Acetate, Algin, Sucrose, Chondrus Crispus Extract, Arginine, PCA, Serine, Alanine, Citric Acid, Threonine, Mourera Fluviatilis Extract, Titanium Dioxide, Mica

Alternatives

Ingredients Explained

These ingredients are found in both products.

Ingredients higher up in an ingredient list are typically present in a larger amount.

Acrylates/C10-30 Alkyl Acrylate Crosspolymer is a synthetic polymer. It is used to thicken, emulsify, and improve the texture of products.

As an emulsifier, it helps stabilize oil-in-water emulsions to give products an elegant feel when applied.

It can also form a thin protective film on skin. One study found that a formula using this polymer helped slow down how quickly other ingredients (like DEET) were absorbed through skin.

A 2024 study of over 1,300 patients confirmed that sensitization to this ingredient is rare. It is also non-mutagenic and has a clean track record.

Ammonium Acryloyldimethyltaurate/Vp Copolymer is a synthetically created polymer. It's used as a film-forming agent and used to thicken the consistency of products.

Think of it as a supportive ingredient that helps your gel-creams feel silky, "cloud cream-like", and spread evenly without being greasy.

The Cosmetic Ingredient Review (CIR) Expert Panel evaluated it (along with 22 other acryloyldimethyltaurate polymers) and concluded it's:

Due to its large molecular size, it sits on the surface of skin rather than penetrating it.

Butylene Glycol (or BG) is used within cosmetic products for a few different reasons:

Overall, Butylene Glycol is a safe and well-rounded ingredient that works well with other ingredients.

Though this ingredient works well with most skin types, some people with sensitive skin may experience a reaction such as allergic rashes, closed comedones, or itchiness.

Caprylyl Glycol is a humectant, skin conditioner, emollient, and preservative booster derived from either caprylic acid or synthetically created.

Typical use levels vary from 0.3-1% as a preservative booster and go up to 2% to condition skin.

Because it is not a free-fatty acid, this ingredient is fungal acne safe (there's nothing for Malassezia to feed on).

Disodium EDTA is a chelating agent. It grabs onto and deactivates metal ions that sneak into your products from water, packaging, or air.

This ingredient mainly works behind the scenes and helps with:

On top of that, this ingredient can counteract the effects of hard water by binding to the minerals in it.

One thing worth knowing is that Disodium EDTA has been shown to be a mild penetration enhancer. It can help other ingredients absorb into skin more effectively which can be a double-edged sword (great for actives, but can also make the active too strong if you have sensitive skin).

Clinical patch testing showed no significant skin irritation at typical use concentrations and minimal dermal absorption.

You'll most likely see this ingredient near the end of an ingredient list. It's typically found in concentrations less than 1%.

Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.

Topically, glycerin does several things at once:

Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.

Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.

This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.

Just know very high concentrations (>40%) can feel tacky in low humidity.

Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.

Phenoxyethanol is one of the most widely used preservatives in skincare (and for good reason!).

It has a large spectrum of antimicrobial activity and especially effective bacteria, yeast, and mold while only having a weak effect on your skin's natural microbiome.

On a cellular level, it disrupts the cell membranes of microbes by poking holes that make the cell leak. This shuts down the chemical reactions the microbe needs to make energy so it can no longer survive.

Another perk of this ingredient is that it stays functional across a wide pH range (3-10).

You'll often see it paired with boosters like Ethylhexylglycerin; one study showed that a 1:9 ratio of Ethylhexylglycerin to Phenoxyethanol damages bacterial membranes as effectively as doubling the Phenoxyethanol concentration on its own.

Typical use concentrations range from 0.3-1% depending on the formula, and this ingredient is capped at 1% int the EU.

Safety-wise, the fear mongering does not hold up to the evidence. The EU's Scientific Committee on Consumer Safety and FDA consider it safe as a preservative at up to 1%, including for children of all ages.

Adverse systemic effects only showed up in animal studies at exposures roughly 200x higher than what people get from cosmetics. And despite its very widespread use, this ingredient is a rare sensitizer and allergic reactions are uncommon.

Sodium Hyaluronate is the salt form of hyaluronic acid. It is a long sugar chain that is naturally found in your skin, joints, and connective tissue that maintains hydration and elasticity.

In skincare, it works as a humectant. It pulls water from the environment and deeper layers of skin and binds it to the surface.

Interestingly, the size of the molecule affects its behavior:

Some clinical evidence links low molecular weight versions to improved wrinkle depth, elasticity, anti-inflammatory effects, and barrier repair.

Many serums use a blend of both weights so you can get surface hydration plus longer-lasting and deeper effects.

You'll typically see concentrations between 0.1-2% for this ingredient.

Sucrose is a natural sugar found in fruits, vegetables, and nuts. It is the main constituent of white sugar.

In skincare, sucrose is a humectant and can be a mild exfoliant.

Sucrose is hydrophilic, meaning it attracts water. This makes it an effective humectant and helps hydrate the skin.

Studies show sugars may worsen acne-prone skin due to it disrupting the skin's natural biome. We recommend speaking with a professional if you have any concerns.

In some products such as body scrubs, sucrose is used as an gentle exfoliant.

The term 'sucrose' comes from the french word for sugar, 'sucre'.

Tocopheryl Acetate is a stable, shelf-friendly form of vitamin E.

Formulators love it because plain vitamin E oxidizes quickly once it hits air. This acetate version stays stable and resists going off, helping to extend a product's shelf life.

It's actually inactive on its own and works like a slow-release "storage" form; the enzymes in your skin called esterases gradually convert it into active vitamin E over time.

One in vivo study showed 5% of the acetate in the living layer of the epidermis converted to vitamin E after 5 days of application. This study also found the skin gained protection against UV damage even though the conversion was slow and small.

Once converted, vitamin E acts as a skin's main fat-soluble antioxidant that fights free radicals to protect skin from damage.

Topical vitamin E generally boosts the skin's photoprotection, and it reduced UV-damage in animal models.

This ingredient has some brightening potential but it's more of a prevention ingredient than spot-fader. Cell studies show it can slow down melanin production but it's worth noting that it's not the most powerful brightener out there.

Overall, it has a pretty solid safety profile and has been found to be non-irritating and non-comedogenic. Allergic reactions may happen but stay rare due to how widely the ingredient gets used.

The concentration will vary depending on the formula; industry data shows 0.1% in baby lotions, 3% in lipsticks, and 5% in foot powders. You can also find this ingredient at 100% in a pure vitamin E oil.

Most leave-on skincare keeps it at the lower end, often between 0.5-1%.

Tromethamine (aka THAM) is a synthetic amino acid that shows up in skincare as a helper ingredient.

It functions as a pH adjuster to help neutralize acidic ingredients and set a formula's pH to the right spot.

This matters a lot because a lot of actives (like vitamin C) needs a specific pH to work well and feel comfortable on skin.

Concentration use ranges from 0.1-1.0% depending on the formula.

Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.

So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.

You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!

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