Clinique Moisture Surge Intense 72H Lipid-Replenishing Hydrator Moisturizer Versus Olay Regenerist Hyaluronic + Peptide 24 Gel Face Moisturizer

Clinique Moisture Surge Intense 72H Lipid-Replenishing Hydrator Moisturizer Versus Olay Regenerist Hyaluronic + Peptide 24 Gel Face Moisturizer

This barrier-repair moisturizer is formulated around Squalane and Sodium Hyaluronate to strengthen the skin barrier and hydrate skin.

This anti-aging moisturizer is formulated around Niacinamide and Sodium Hyaluronate to soften the look of wrinkles and hydrate skin.

What's inside

Key Ingredients

Benefits

Concerns

Ingredients Side-by-side

Water

Glycerin

Dimethicone

Isopropyl Isostearate

Dipropylene Glycol

Squalane

PEG/PPG-18/18 Dimethicone

Silica

Tocopheryl Acetate

Sodium Hyaluronate

Olea Europaea Fruit Extract

Centella Asiatica Extract

Aloe Barbadensis Leaf Water

Palmitoyl Hexapeptide-12

Triticum Vulgare Bran Extract

Caffeine

Methyl Trimethicone

Sorbitol

Sodium Polyaspartate

Petrolatum

Trehalose

Whey Protein

Linoleic Acid

Pyridoxine Dipalmitate

Butylene Glycol

Cholesterol

Sucrose

Polysilicone-11

Glyceryl Polymethacrylate

PEG-150

PEG-8

Hydroxyethyl Urea

Hydroxyacetophenone

BHT

Disodium EDTA

Sodium Hexametaphosphate

Sodium Benzoate

Potassium Sorbate

Phenoxyethanol

Water, Glycerin, Dimethicone, Isopropyl Isostearate, Dipropylene Glycol, Squalane, PEG/PPG-18/18 Dimethicone, Silica, Tocopheryl Acetate, Sodium Hyaluronate, Olea Europaea Fruit Extract, Centella Asiatica Extract, Aloe Barbadensis Leaf Water, Palmitoyl Hexapeptide-12, Triticum Vulgare Bran Extract, Caffeine, Methyl Trimethicone, Sorbitol, Sodium Polyaspartate, Petrolatum, Trehalose, Whey Protein, Linoleic Acid, Pyridoxine Dipalmitate, Butylene Glycol, Cholesterol, Sucrose, Polysilicone-11, Glyceryl Polymethacrylate, PEG-150, PEG-8, Hydroxyethyl Urea, Hydroxyacetophenone, BHT, Disodium EDTA, Sodium Hexametaphosphate, Sodium Benzoate, Potassium Sorbate, Phenoxyethanol

Niacinamide

Palmitoyl Pentapeptide-4

Panthenol

Ethylhexylglycerin

C13-14 Isoparaffin

Dimethiconol

Polysorbate 20

Laureth-4

Laureth-7

Polyacrylamide

Acrylates/C10-30 Alkyl Acrylate Crosspolymer

Aminomethyl Propanol

Avena Sativa Peptide

Water, Glycerin, Dimethicone, Niacinamide, Sodium Hyaluronate, Palmitoyl Pentapeptide-4, Panthenol, Ethylhexylglycerin, Hydroxyacetophenone, C13-14 Isoparaffin, Dimethiconol, Polysorbate 20, Laureth-4, Laureth-7, Disodium EDTA, Polyacrylamide, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Aminomethyl Propanol, Phenoxyethanol, Avena Sativa Peptide

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Alternatives

Ingredients Explained

These ingredients are found in both products.

Ingredients higher up in an ingredient list are typically present in a larger amount.

Dimethicone is a type of synthetic silicone created from natural materials such as quartz. It is also known as polydimethylsiloxane.

What it does:

Dimethicone comes in different viscosities:

Depending on the viscosity, dimethicone has different properties.

Ingredients lists don't always show which type is used, so we recommend reaching out to the brand if you have questions about the viscosity.

This ingredient is unlikely to cause irritation because it does not get absorbed into skin. However, people with silicone allergies should be careful about using this ingredient.

Note: Dimethicone may contribute to pilling. This is because it is not oil or water soluble, so pilling may occur when layered with products. When mixed with heavy oils in a formula, the outcome is also quite greasy.

Disodium EDTA is a chelating agent. It grabs onto and deactivates metal ions that sneak into your products from water, packaging, or air.

This ingredient mainly works behind the scenes and helps with:

On top of that, this ingredient can counteract the effects of hard water by binding to the minerals in it.

One thing worth knowing is that Disodium EDTA has been shown to be a mild penetration enhancer. It can help other ingredients absorb into skin more effectively which can be a double-edged sword (great for actives, but can also make the active too strong if you have sensitive skin).

Clinical patch testing showed no significant skin irritation at typical use concentrations and minimal dermal absorption.

You'll most likely see this ingredient near the end of an ingredient list. It's typically found in concentrations less than 1%.

Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.

Topically, glycerin does several things at once:

Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.

Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.

This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.

Just know very high concentrations (>40%) can feel tacky in low humidity.

Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.

Hydroxyacetophenone is a small phenolic molecule that earns its place in a formulas as an antioxidant and preservative booster.

As a phenol, it is able to neutralize free radicals to protect both the product and the skin from oxidative stress.

Though it can't kill microbes on its own, it works as a good supporting agent when combined with other preservatives like Phenoxyethanol or 1,2-Hexanediol.

This ingredient naturally occurs as piceol in Norwegian spruce needles (~0.4-1.1% dry weight and in cloudberries). Though the cosmetic-grade material is synthesized for purity and consistency.

You'll usually see it used at low levels and suppliers recommend up to 1% added to a water phase.

Safety testing was done at concentrations like 0.05% in SPF products and 0.5% in a Human Repeated Insult Patch Test. The safety evidence is assuring; this ingredient is safe for cosmetics in current use and also holds safety status as a food flavoring as well.

An honest caveat: the "soothing" and "anti-inflammatory" claims come mostly from supplier marketing rather than published clinical trials. The Cosmetic Ingredient Review's own literature search found no useful efficacy studies on this ingredient.

So the antioxidant and preservative-boosting roles are the well supported ones while the calming benefit is plausible but thinly evidenced.

Overall, this is a well-tolerated, low-irritation multitasker that quietly helps a formula stay fresh and stable.

Phenoxyethanol is one of the most widely used preservatives in skincare (and for good reason!).

It has a large spectrum of antimicrobial activity and especially effective bacteria, yeast, and mold while only having a weak effect on your skin's natural microbiome.

On a cellular level, it disrupts the cell membranes of microbes by poking holes that make the cell leak. This shuts down the chemical reactions the microbe needs to make energy so it can no longer survive.

Another perk of this ingredient is that it stays functional across a wide pH range (3-10).

You'll often see it paired with boosters like Ethylhexylglycerin; one study showed that a 1:9 ratio of Ethylhexylglycerin to Phenoxyethanol damages bacterial membranes as effectively as doubling the Phenoxyethanol concentration on its own.

Typical use concentrations range from 0.3-1% depending on the formula, and this ingredient is capped at 1% int the EU.

Safety-wise, the fear mongering does not hold up to the evidence. The EU's Scientific Committee on Consumer Safety and FDA consider it safe as a preservative at up to 1%, including for children of all ages.

Adverse systemic effects only showed up in animal studies at exposures roughly 200x higher than what people get from cosmetics. And despite its very widespread use, this ingredient is a rare sensitizer and allergic reactions are uncommon.

Sodium Hyaluronate is the salt form of hyaluronic acid. It is a long sugar chain that is naturally found in your skin, joints, and connective tissue that maintains hydration and elasticity.

In skincare, it works as a humectant. It pulls water from the environment and deeper layers of skin and binds it to the surface.

Interestingly, the size of the molecule affects its behavior:

Some clinical evidence links low molecular weight versions to improved wrinkle depth, elasticity, anti-inflammatory effects, and barrier repair.

Many serums use a blend of both weights so you can get surface hydration plus longer-lasting and deeper effects.

You'll typically see concentrations between 0.1-2% for this ingredient.

Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.

So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.

You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!

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