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Skin science article

Cocokind Ceramide Barrier Serum Versus Mad Hippie Corrective Peptide Serum

Cocokind Ceramide Barrier Serum Versus Mad Hippie Corrective Peptide Serum This barrier-repair serum is formulated around Aloe Barbadensis Leaf Juice and Beta-Glucan to strengthen the skin barrier and hydrate skin. This anti-aging serum is formulated around Pa

Cocokind Ceramide Barrier Serum Versus Mad Hippie Corrective Peptide Serum

This barrier-repair serum is formulated around Aloe Barbadensis Leaf Juice and Beta-Glucan to strengthen the skin barrier and hydrate skin.

This anti-aging serum is formulated around Palmitoyl Tripeptide-38 and Ceramide NP to soften the look of wrinkles and strengthen the skin barrier.

What's inside

Key Ingredients

Benefits

Concerns

Ingredients Side-by-side

Aloe Barbadensis Leaf Juice

Water

Propanediol

Glycerin

Simmondsia Chinensis Seed Oil

Squalane

Beta-Glucan

Lysolecithin

Sclerotium Gum

Pullulan

Xanthan Gum

Ceramide NP

Ceramide Ns

Ceramide AP

Ceramide Eos

Ceramide EOP

Sodium Levulinate

Sodium Anisate

Tocopherol

Cetyl Alcohol

Caprylyl Glycol

Ceteareth-25

Silica

Caprooyl Phytosphingosine

Caprooyl Sphingosine

Cholesterol

Helianthus Annuus Seed Oil

Glyceryl Caprylate

Phenoxyethanol

Sodium Benzoate

Ethylhexylglycerin

1,2-Hexanediol

Citric Acid

Behenic Acid

Aloe Barbadensis Leaf Juice, Water, Propanediol, Glycerin, Simmondsia Chinensis Seed Oil, Squalane, Beta-Glucan, Lysolecithin, Sclerotium Gum, Pullulan, Xanthan Gum, Ceramide NP, Ceramide Ns, Ceramide AP, Ceramide Eos, Ceramide EOP, Sodium Levulinate, Sodium Anisate, Tocopherol, Cetyl Alcohol, Caprylyl Glycol, Ceteareth-25, Silica, Caprooyl Phytosphingosine, Caprooyl Sphingosine, Cholesterol, Helianthus Annuus Seed Oil, Glyceryl Caprylate, Phenoxyethanol, Sodium Benzoate, Ethylhexylglycerin, 1,2-Hexanediol, Citric Acid, Behenic Acid

Caprylic/Capric Triglyceride

Chenopodium Quinoa Seed Extract

Potassium Cetyl Phosphate

Acetyl Tetrapeptide-2

Sodium Hyaluronate

Apium Graveolens Seed Extract

Linum Usitatissimum Seed Extract

Hydroxypropyl Cyclodextrin

Palmitoyl Tripeptide-38

Tremella Fuciformis Polysaccharide

Hydrolyzed Yeast Extract

Sorbitan Trioleate

Cetyl Hydroxyethylcellulose

Polyglucuronic Acid

Acetyl Tetrapeptide-22

Avena Sativa Meal Extract

Phenethyl Alcohol

Stearyl Alcohol

Polyglutamic Acid

Hydroxyethylcellulose

Citrus Aurantium Dulcis Peel Oil

Lecithin

Water, Glycerin, Caprylic/Capric Triglyceride, Chenopodium Quinoa Seed Extract, Propanediol, Potassium Cetyl Phosphate, Acetyl Tetrapeptide-2, Sodium Hyaluronate, Apium Graveolens Seed Extract, Linum Usitatissimum Seed Extract, Hydroxypropyl Cyclodextrin, Palmitoyl Tripeptide-38, Tremella Fuciformis Polysaccharide, Squalane, Hydrolyzed Yeast Extract, Sorbitan Trioleate, Cetyl Hydroxyethylcellulose, Polyglucuronic Acid, Acetyl Tetrapeptide-22, Avena Sativa Meal Extract, Phenethyl Alcohol, Caprylyl Glycol, Ethylhexylglycerin, Stearyl Alcohol, Polyglutamic Acid, Hydroxyethylcellulose, Citrus Aurantium Dulcis Peel Oil, Lecithin, Ceramide NP, Tocopherol

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Alternatives

Ingredients Explained

These ingredients are found in both products.

Ingredients higher up in an ingredient list are typically present in a larger amount.

Caprylyl Glycol is a humectant, skin conditioner, emollient, and preservative booster derived from either caprylic acid or synthetically created.

Typical use levels vary from 0.3-1% as a preservative booster and go up to 2% to condition skin.

Because it is not a free-fatty acid, this ingredient is fungal acne safe (there's nothing for Malassezia to feed on).

Ceramide NP (formerly known as Ceramide 3) is one of the skin's naturally occurring lipids.

Since ceramides are the major lipid components of the skin, they are crucial for maintaining skin barrier and hydration. Ceramide NP most closely mirrors the dominant kind in human skin amongst ceramide subtypes.

This ceramide works by slotting into gaps within the stratum corneum's lipid matrix to limit trans-epidermal water loss (TEWL) and shield the skin against external irritants.

A study with 312 patients found that using a ceramide-containing routine for 4 weeks reduced the severity of atopic dermatitis by over 61%.

Another clinical study in subjects aged 60 and older found that a ceramide body wash and moisturizer improved skin dryness and itchy skin in 15 days.

Overall, ceramides are considered non-irritating and safety tests have found little to no observable adverse effects from using this ingredient.

Ceramide NP is usually sourced from plants (like soybean or rice bran), or produced synthetically.

Ethylhexylglycerin is created from glycerin. It is a multitasker ingredient that:

The CIR Expert Panel found minimal skin absorption or sensitization of any kind in a safety assessment. Though this ingredient is considered well-tolerated, a small number of cases of allergic dermatitis have been published since 2002. Just be sure to patch test if you are unsure.

Industry-reported use ranges from 8% in rinse-off products and 2% in leave-on formulations.

Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.

Topically, glycerin does several things at once:

Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.

Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.

This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.

Just know very high concentrations (>40%) can feel tacky in low humidity.

Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.

Propanediol is an all-star ingredient. It softens, hydrates, and smooths the skin.

It’s often used to:

Propanediol is not likely to cause sensitivity and considered safe to use. It is derived from corn or petroleum with a clear color and no scent.

Squalane is the hydrogenated and shelf-stable form of squalene (a lipid that naturally occurs in human sebum).

It is an emollient and skin conditioning agent that is able to integrate seamlessly into the skin's lipid barrier without clogging pores.

This is due to how structurally similar it is to what your skin already produces.

Though it is mostly an emollient that helps soften and hydrate skin, it also has some humectant and occlusive action. Humectants help the skin retain moisture while occlusives seal it in, making squalane a triple-threat moisturizer.

Research shows it has antioxidant capabilities that help protect against stressors like UV exposure, specifically UVA induced oxidative stress. This study also found that it supports collagen biosynthesis in human dermal fibroblasts.

No clinical study has reported significant adverse effects and irritation reactions are very rare from this ingredient (even at 100% concentration).

Overall, it's a fantastic ingredient for hydration and is suitable for all skin types.

This depends on the source. Squalane can be derived from both plants and animals. Most squalane used in skincare comes from plants.

Please note: the source of squalane is only known if disclosed by the brand. We recommend reaching out to the brand if you have any questions about their squalane.

Read more about squalene with an "e".

Though squalane is often called an oil, it’s technically not one. It is a hydrocarbon, meaning it is only made of carbon and hydrogen. True oils are triglycerides and made of fatty acids and glycerol.

The term “oil-free” isn’t regulated so companies can define it however they want. Some exclude all oils, while others just avoid mineral oil or comedogenic oils.

Squalane has a comedogenic rating of 1 from the original 1972 study that tested raw ingredients under occlusion on rabbit ears. This system is not standardized or peer-reviewed, and using the raw ingredients is very different from how diluted cosmetic formulations are used on human skin.

A comedogenic rating of 1 means it is "unlikely to clog pores" according to the original rating system.

The overall formula of a product matters more than the individual ingredients on whether or not it will cause clogged pores.

Tocopherol is a fat-soluble antioxidant known as Vitamin E.

You'll find this ingredient in the vast majority of skincare (for good reason). It works to neutralize free radicals, or unstable molecules generated by UV exposure, pollution, and other environmental stressors, before they can cause oxidative damage to your skin cells.

Topically applied tocopherol has been shown to protect against UV damage by ramping up the skin's own natural defense enzymes.

It also acts as a skin conditioning agent; some studies show that regular topical use can improve the skin's water-binding capacity over 2-4 weeks.

This ingredient is especially loved for being a team player. When combined with Vitamin C, the photoprotective effect of both ingredients roughly doubles and the combo also helps reduce UV-induced DNA damage.

This ingredient has some brightening potential but it's more of a prevention ingredient than spot-fader. Cell studies show it can slow down melanin production but it's worth noting that it's not the most powerful brightener out there.

In formulations, it also serves as a stabilizer that helps protect other oxidation-prone ingredients from degrading.

Concentrations usually range from 0.1-1% in most leave-on products.

Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.

So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.

You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!

Similar Comparisons

The reference edit

Ingredients, questions
& further reading.

Connected source records selected through this article’s public topic index.

01

Formula cabinet

Ingredients & structured notes

Ingredient index

Ingredients Explained

  1. 01These ingredients are found in both products.
  2. 02Ingredients higher up in an ingredient list are typically present in a larger amount.
  3. 03Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.
  4. 04Topically, glycerin does several things at once:
  5. 05Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.
  6. 06Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.
  7. 07This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.
  8. 08Just know very high concentrations (>40%) can feel tacky in low humidity.
  9. 09Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.
  10. 10Sodium Hyaluronate is the salt form of hyaluronic acid. It is a long sugar chain that is naturally found in your skin, joints, and connective tissue that maintains hydration and elasticity.
  11. 11In skincare, it works as a humectant. It pulls water from the environment and deeper layers of skin and binds it to the surface.
  12. 12Interestingly, the size of the molecule affects its behavior:
  13. 13Some clinical evidence links low molecular weight versions to improved wrinkle depth, elasticity, anti-inflammatory effects, and barrier repair.
  14. 14Many serums use a blend of both weights so you can get surface hydration plus longer-lasting and deeper effects.
  15. 15You'll typically see concentrations between 0.1-2% for this ingredient.
Source · skinsort.com
02

Product index

Related product references

Product

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03

Comparison edit

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