Cosmetic Peptides

Cosmetic Peptide Overview

The peptides found naturally in the human skin play essential roles in specific biological activities as signaling molecules of different physiological processes (i.e., homeostasis, defense, immunity). Due to their great biological activity, peptides are considered promising compounds with potential applications for certain cosmetic products.

Peptides are crucial in formulating cosmetic products, especially in renowned international brands, primarily targeting anti-aging purposes. Some of the benefits of using peptide-based cosmetic products include:

• Wound Healing: Skin collagen-regeneration stimulates cell growth and wound healing (e.g., Palmitoyl pentapeptide-3).
• Nourishing: Skin is radiantly alive with fewer dark spots (e.g., Oligopeptide-68).
• Resilience: improve skin elasticity (e.g., Peptamide-6).
• Line Reducing: Skin looks smoother, with wrinkles significantly reduced (e.g., DipeptideDiaminobutyroyl, Benzylamide Diacetate).
• Hair Growth: Fight inflammation and boost healing as cell-signaling agents (e.g., Myristoyl Tetrapeptide-12, Myristoyl Hexapeptide-16, and Myristoyl Pentapeptide-17).

WHY CHOOSE CPC SCIENTIFIC?

With over 20 years of experience, CPC Scientific is a leading peptide CRDMO with capabilities to support your large-scale cosmetic manufacturing needs. Recognizing client’s diversity, we are capable of synthesizing simple to more complex cosmetic peptide ingredients based on your needs with our robust expertise and experience in peptide manufacturing.

CPC Scientific has the manufacturing capacity to support your cosmetic projects from early discovery (mg quantities) through commercialization (100 kgs).

Delivery time is a critical component of your project’s success. We have the capacity and flexibility to accept new projects and initiate production sooner than many leading peptide manufacturers.

Green Chemistry, including minimal-protection strategies, is an important way to minimize the use of harsh solvents like diethyl ether and trifluoroacetic acid and reduce risk to the environment.

We have over 20 years of peptide manufacturing experience. We can incorporate most cosmetic-based modifications (e.g., lipid moieties including, palmitoyl, dipalmitoyl, myristic acid, geranyl, farnesyl, and geranylgeranyl).

Building resilient supply chains will protect the United States from experiencing shortages of critical therapeutic products. CPC Scientific’s Rocklin, CA manufacturing facility will address the critical supply chain needs for peptide API’s beginning in 2026.

Learn More

With over 20 years of expertise in peptide production, CPC Scientific has a proven track record in custom synthesis, process development, and bulk-scale manufacturing. We have experience in product development and commercial production of cosmetic peptides.

COSMETIC PEPTIDE MANUFACTURING
CAPACITY

Partner with a developer and manufacturer who can support you throughout the entire cosmetic product lifecycle.

CPC Scientific possesses the manufacturing capabilities to assist with your cosmetic peptide projects, ranging from early discovery (mg quantities) to commercialization (100 kgs). Our pre-qualified workspace and adaptable approach enable us to expedite process development and commence production earlier than many other manufacturers.

Synthesis Equipment

• Large solid- and solution-phase peptide synthesis reactors (sizes: 20-50L, 150L, 500L, and 1000L)
• Hybrid synthesis reactor

Purification Equipment

• Preparative HPLC systems with multiple flow rates
• Chromatography columns with various diameters (8, 12, 20, and 30 inch)
• Fast protein liquid chromatography (FPLC) systems
• Multiple isolated purification suites

Isolation Equipment

• Blenders and evaporators
• Manifold lyophilizers
• Tray lyophilizers (sizes: 200 L, 500 L, and 1000 L)

RELATED POSTS & RESOURCES

ISO 22716:2007(E) Cosmetic Certification

We are excited to share that CPC Scientific Inc. has officially received the Good Manufacturing Practice (GMP) Certificate in accordance with the ISO 22716:2007(E) Cosmetic Guidelines.

Green Synthesis of Goserelin Impurity E

In this case study, we demonstrate the synthesis of a Goserelin peptide API impurity through a convergent peptide fragment strategy, expanding our approach to include the unprotected side chains of histidine, tryptophan, and arginine...

Minimal Protection Strategies in SPPS Poster

This poster introduces two methodology case studies involving minimal side-chain protection strategies for solid-phase peptide synthesis (SPPS). SPPS approaches require protecting the side chains of specific amino acids...

Minimal Protection Group Strategies for SPPS

Solid-phase peptide synthesis approaches require that the side chains of certain amino acids be protected from undesired reactivity during synthesis. The installation and removal of these protection groups results in a lower atom economy…

• ISO 22716:2007(E) Cosmetic Certification

  We are excited to share that CPC Scientific Inc. has officially received the Good Manufacturing Practice (GMP) Certificate in accordance with the ISO 22716:2007(E) Cosmetic Guidelines.

• Green Synthesis of Goserelin Impurity E

  In this case study, we demonstrate the synthesis of a Goserelin peptide API impurity through a convergent peptide fragment strategy, expanding our approach to include the unprotected side chains of histidine, tryptophan, and arginine...

• Minimal Protection Strategies in SPPS Poster

  This poster introduces two methodology case studies involving minimal side-chain protection strategies for solid-phase peptide synthesis (SPPS). SPPS approaches require protecting the side chains of specific amino acids...

• Minimal Protection Group Strategies for SPPS

  Solid-phase peptide synthesis approaches require that the side chains of certain amino acids be protected from undesired reactivity during synthesis. The installation and removal of these protection groups results in a lower atom economy…

COSMETIC PEPTIDES CITATIONS

CPC Scientific peptide products manufactured for Cosmetic Applications.

• Senotherapeutic Peptide 14 Suppresses Th1 and M1 Human T Cell and Monocyte Subsets In Vitro.

  Alencar-Silva, Thuany, Stefhani Martins de Barcelos, Amandda Silva-Carvalho, Mauricio Gonçalves da Costa Sousa, Taia Maria Berto Rezende, Robert Pogue, Felipe Saldanha-Araújo et al. Cells 13, no. 10 (2024): 813.

  Pep 14 (ETAKHWLKGI) was synthesized by CPC Scientific (Sunnyvale, CA, USA) and reconstituted in ultrapure water. The peptide was aliquoted and stored at −20 °C until use.

• Understanding Malassezia secreted proteases in host-microbial crosstalk in skin health

  Goh, Joleen Pei Zhen. Nanyang Technological University (2023)

  9 generic fluorogenic substrates (CPC Scientific) (Figure S4) were added to the final concentration of 20 μM. Fluorescence was measured at Excitation/Emission=330/390 nm on BioTek Synergy H1 microplate reader and proteolytic activity was calculated as a change in relative fluorescence units per sec using the slope of the linear range for this signal.

• Senotherapeutic peptide treatment reduces biological age and senescence burden in human skin models.

  Zonari, A.; Brace, L. E.; Al-Katib, K.; Porto, W. F.; Foyt, D.; Guiang, M.; Cruz, E. A. O.; Marshall, B.; Gentz, M.; Guimaraes, G. R.; Franco, O. L.; Oliveira, C. R.; Boroni, M.; Carvalho, J. L., NPJ Aging 2023, 9 (1), 10.

  The top hit peptides selected (Pep 14, 144, 156, 195, and 393) from the screening and the fluorescence labeled peptide (5FAM-PEG2-Pep 14) were purchased from CPC Scientific Inc. (USA), which synthesized the peptide by solid phase (Fmoc) on a Rink amide resin, with >95% purity, in the form of acetate salt.

• In vitro and in vivo toxicity assessment of the senotherapeutic Peptide 14

  Zonari, A., Brace, L.E., Alencar-Silva, T., Porto, W.F., Foyt, D., Guiang, M., Cruz, E.A.O., Franco, O.L., Oliveira, C.R., Boroni, M. and Carvalho, J.L. Toxicology Reports 9 (2022): 1632-1638.

  Peptide 14 (ETAKHWLKGI) (Sup. Fig. 1) was purchased from CPC Scientific Inc. (USA), which synthesized the peptide by solid phase (Fmoc) on a Rink amide resin, with > 95% purity, in the form of acetate salt.

• Synthetic Antibiotic Derived from Sequences Encrypted in a Protein from Human Plasma

  Cesaro, Angela, Marcelo DT Torres, Rosa Gaglione, Eliana Dell’Olmo, Rocco Di Girolamo, Andrea Bosso, Elio Pizzo et al. ACS Nano 16, no. 2 (2022): 1880-1895.

  Expression and isolation of recombinant peptides were carried out as previously described.20 CATH-2 and (ri)-r(P)ApoBSPro peptides were obtained from CPC Scientific Inc. (Sunnyvale, CA) and CASLO ApS (Kongens Lyngby, Denmark), respectively.

• Senotherapeutic peptide reduces skin biological age and improves skin health markers.

  Zonari, A.; Brace, L. E.; Al-Katib, K. Z.; Porto, W. F.; Foyt, D.; Guiang, M.; Cruz, E. A. O.; Marshall, B.; Salgueiro, W. G.; Inan, M. D., bioRxiv 2020, 2020.10. 30.362822.

  The top hits peptides selected (peptide 14, 144, 156, 195, and 393) from the screening were purchased from CPC Scientific Inc.

Cosmetic Peptides Flyer Request

The peptides found naturally in the human skin play essential roles in specific biological activities as signaling molecules of different physiological processes (i.e., homeostasis, defense, immunity). Due to their great biological activity, peptides are considered promising compounds with potential applications for certain cosmetic products. CPC Scientific possesses the manufacturing capabilities to assist with your cosmetic peptide projects, ranging from early discovery (mg quantities) to commercialization (100 kgs). Our pre-qualified workspace and adaptable approach enable us to expedite process development and commence production earlier than many other manufacturers.

Flyer Request Form

LIPOPEPTIDE CITATIONS

CPC Scientific peptide products manufactured with lipidation modifications.

• Inhibition of Escherichia coli lipoprotein diacylglyceryl transferase is insensitive to resistance caused by deletion of Braun’s lipoprotein.

  Diao, J., Komura, R., Sano, T., Pantua, H., Storek, K.M., Inaba, H., Ogawa, H., Noland, C.L., Peng, Y., Gloor, S.L. and Yan, D. Journal of Bacteriology 203, no. 13 (2021): 10-1128.

  • Departments of Infectious Diseases, Structural Biology, Biochemical and Cellular Pharmacology, Translational Immunology, Pathology, Protein Chemistry, Early Discovery Biochemistry, Genentech, South San Francisco, California, USA

  For the Lgt biochemical assay, the Pal-IAAC and Pal-IAAA peptides were synthesized by CPC Scientific.

• Unstable Mechanisms of Resistance to Inhibitors of Escherichia coli Lipoprotein Signal Peptidase.

  Pantua, H., Skippington, E., Braun, M.G., Noland, C.L., Diao, J., Peng, Y., Gloor, S.L., Yan, D., Kang, J., Katakam, A.K. and Reeder, J. MBio 11, no. 5 (2020): 10-1128.

  • Departments of Infectious Diseases, OMNI Bioinformatics, Chemistry, Structural Biology, Biochemical and Cellular Pharmacology, Translational Immunology, Pathology, Molecular Biology, Genentech, South San Francisco, California, USA

  MQLNKV-L(U13C6,15N)-KGL(U13C6,15N)MIALPVMAIAA-dipalmitoyl2C-SSNKNGG-K-biotin, which upon cleavage by LspA, yields the product peptide dipalmitoyl2C-SSNKNGG-K-biotin. A product standard [dipalmitoyl2C-SSNKNAAK-(NHCH2CH2NH)-biotin; CPC Scientific] was in the reaction mixture as an internal standard for normalization of product quantitation.

• iRGD-guided tumor penetrating nanocomplexes for therapeutic siRNA delivery to pancreatic cancer.

  Lo, J.H., Hao, L., Muzumdar, M.D., Raghavan, S., Kwon, E.J., Pulver, E.M., Hsu, F., Aguirre, A.J., Wolpin, B.M., Fuchs, C.S. and Hahn, W.C. Molecular Cancer Therapeutics 17, no. 11 (2018): 2377-2388.

  pTP-TAMRA-iRGD (CH3(CH)15-[GWTLNSAGYLLGKINLKALAALAKKIL-GGK(TAMRA)GGCRGDKGPDC, Cys-Cys bridge]) used in all figures except Fig. S1 was synthesized by CPC Scientific.

• Structural insights into lipoprotein N-acylation by Escherichia coli apolipoprotein N-acyltransferase.

  Noland, Cameron L., et al. Proceedings of the National Academy of Sciences 114.30 (2017): E6044-E6053.

  • Departments of Structural Biology, Infectious Diseases, Biochemical and Cellular Pharmacology, Pathology, Translational Immunology, and Biomolecular Resource Group, Genentech, Inc., South San Francisco, CA 94080.

  "..peptide substrates were synthesized based on the Pal lipoprotein, Pal peptideshort (Pam2Cys-SSNKNGGK-Biotin; CPC Scientific, Inc.).."

• A comparison of modular PEG incorporation strategies for stabilization of peptide-siRNA nanocomplexes.

  Lo, Justin H., et al. Bioconjugate Chemistry (2016).

  "Myristoyl-transportan−LyP-1 tandem peptide was synthesized by CPC Scientific (sequence: myr-GGWTLNSAGYLLGKINLKALAALAKKIL-GGGG-CGNKRTRGC, Cys−Cys bridge). FAM-labeled LyP-1 bearing an azide (azidoacetyl-GGG-cyclo-(EGNKRTRGK)), FAM-labeled LyP-1 bearing a cysteine (C-K(5FAM)-C6-cyclo-(CGNKRTRGC)) and transportan bearing a C-terminal cysteine (myristic acid-GGWTLNSAGYLLGKINLKALAALAKKILC) were synthesized by CPC Scientific, Inc."