Skin science article
COSRX Advanced Snail 92 All In One Cream Versus Lancôme Rénergie H.P.N. 300-Peptide Cream
COSRX Advanced Snail 92 All In One Cream Versus Lancôme Rénergie H.P.N. 300-Peptide Cream This barrier-repair moisturizer is formulated around Snail Secretion Filtrate and Allantoin to strengthen the skin barrier and hydrate skin. This anti-aging moisturizer i
COSRX Advanced Snail 92 All In One Cream Versus Lancôme Rénergie H.P.N. 300-Peptide Cream
This barrier-repair moisturizer is formulated around Snail Secretion Filtrate and Allantoin to strengthen the skin barrier and hydrate skin.
This anti-aging moisturizer is formulated around Niacinamide and Adenosine to soften the look of wrinkles and refine skin texture.
What's inside
Key Ingredients
Benefits
Concerns
Ingredients Side-by-side
Snail Secretion Filtrate
Betaine
Caprylic/Capric Triglyceride
Butylene Glycol
Cetearyl Olivate
Sorbitan Olivate
Cetearyl Alcohol
Carbomer
Ethyl Hexanediol
Phenoxyethanol
Arginine
Dimethicone
Sodium Polyacrylate
Sodium Hyaluronate
Allantoin
Palmitic Acid
Panthenol
Xanthan Gum
Stearic Acid
Adenosine
Water
Myristic Acid
Snail Secretion Filtrate, Betaine, Caprylic/Capric Triglyceride, Butylene Glycol, Cetearyl Olivate, Sorbitan Olivate, Cetearyl Alcohol, Carbomer, Ethyl Hexanediol, Phenoxyethanol, Arginine, Dimethicone, Sodium Polyacrylate, Sodium Hyaluronate, Allantoin, Palmitic Acid, Panthenol, Xanthan Gum, Stearic Acid, Adenosine, Water, Myristic Acid
Glycerin
Theobroma Grandiflorum Seed Butter
Alcohol Denat.
Cetearyl Isononanoate
Niacinamide
Glyceryl Stearate
PEG-100 Stearate
Isopropyl Palmitate
Octyldodecanol
Cyclodextrin
Hydrolyzed Lupine Protein
Pisum Sativum Extract
Capryloyl Salicylic Acid
Hydrolyzed Hyaluronic Acid
Hydrolyzed Linseed Extract
Pentaerythrityl Tetra-Di-T-Butyl Hydroxyhydrocinnamate
Trisodium Ethylenediamine Disuccinate
Tocopheryl Acetate
Cera Alba
Orbignya Oleifera Seed Oil
Simmondsia Chinensis Butter
Cetearyl Glucoside
Citric Acid
Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer
Polysorbate 60
Potassium Cetyl Phosphate
Sorbitan Isostearate
Tocopherol
Dimethicone/Polyglycerin-3 Crosspolymer
Benzyl Alcohol
Geraniol
Limonene
Chlorphenesin
Dipropylene Glycol
Sodium Benzoate
Parfum
Water, Glycerin, Dimethicone, Cetearyl Alcohol, Theobroma Grandiflorum Seed Butter, Alcohol Denat., Cetearyl Isononanoate, Niacinamide, Glyceryl Stearate, PEG-100 Stearate, Isopropyl Palmitate, Octyldodecanol, Cyclodextrin, Hydrolyzed Lupine Protein, Pisum Sativum Extract, Adenosine, Capryloyl Salicylic Acid, Hydrolyzed Hyaluronic Acid, Hydrolyzed Linseed Extract, Pentaerythrityl Tetra-Di-T-Butyl Hydroxyhydrocinnamate, Trisodium Ethylenediamine Disuccinate, Tocopheryl Acetate, Cera Alba, Orbignya Oleifera Seed Oil, Simmondsia Chinensis Butter, Cetearyl Glucoside, Citric Acid, Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, Polysorbate 60, Potassium Cetyl Phosphate, Sorbitan Isostearate, Tocopherol, Dimethicone/Polyglycerin-3 Crosspolymer, Benzyl Alcohol, Geraniol, Limonene, Chlorphenesin, Dipropylene Glycol, Phenoxyethanol, Sodium Benzoate, Parfum
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Alternatives
Ingredients Explained
These ingredients are found in both products.
Ingredients higher up in an ingredient list are typically present in a larger amount.
Adenosine is a purine nucleoside that your body already makes in every cell. In skincare, it acts mainly as a skin conditioning and anti-aging agent.
The way it works is fairly well mapped out:
Your skin has cells called fibroblasts that build collagen (the stuff that keeps skin firm and smooth). Adenosine basically flips a switch on these cells that tells them to get to work making more collagen and other proteins. These cells slow down on their own as skin ages, so Adenosine helps give them a little nudge to keep going.
The clinical backing is pretty solid too.
A blind, randomized, placebo-controlled trial of 126 women aged 45-65 tested a 0.1% cream twice daily and found real improvements in crow's feet and frown lines using a precise 3D skin-mapping technique; these changes showed up by week 3 and held at 2 months.
A later study using Adenosine-loaded dissolving microneedle patches reported gains in wrinkle depth, dermal density, elasticity, and hydration.
On concentrations, South Korea's Ministry of Food and Drug Safety has set 0.04% as the approved functional anti-wrinkle level. You'll typically see this ingredient used somewhere in the 0.04-0.1% range since it works at low doses.
This ingredient has been found safe for cosmetics with the data showing no irritation or sensitization.
Overall, this is a great ingredient for any anti-aging routine and has no photosensitizing effect, so it suits both AM and PM use.
Cetearyl alcohol is a waxy mixture of two fatty alcohols: cetyl alcohol and stearyl alcohol. It is an emollient and emulsifier.
Despite having "alcohol" in its name, it has nothing to do with drying solvent alcohols; the FDA also allows "alcohol-free" products to contain fatty alcohols like this ingredient.
It plays several roles in a formula:
Typical use levels for this ingredient sit around 1-10% and the Cosmetic Ingredient Review Expert Panel has affirmed safety at concentrations up to 25% in leave-on products.
Multiple assessments have found it to be non-irritating and non-sensitizing to most people.
However, there have been some cases of allergic contact dermatitis in patients with chronically compromised skin barriers.
Cetearyl alcohol has a comedogenic rating of 2 and irritancy rating of 1. Both of these numbers come from the 1989 study that used rabbit ears; a "2" means mildly comedogenic and a "1" means low irritancy.
Here's the catch: rabbit skin is more sensitive than human skin and throws a lot of false positives. A 1996 reappraisal found that ingredients rated 1-2 in the rabbit ear tests are generally safe for humans.
Remember comedogenic ratings are unable to assess the entire formula of a product or how it will react on your skin. Just be sure to patch test if you are unsure about certain ingredients.
This ingredient is not fungal acne safe. Cetearyl alcohol is a fatty alcohol with chain lengths that fall within the range that Malassezia can metabolize.
A 2019 study has also observed Malassezia growth in the presence of this ingredient, confirming it to be not-fungal acne safe.
Dimethicone is a type of synthetic silicone created from natural materials such as quartz. It is also known as polydimethylsiloxane.
What it does:
Dimethicone comes in different viscosities:
Depending on the viscosity, dimethicone has different properties.
Ingredients lists don't always show which type is used, so we recommend reaching out to the brand if you have questions about the viscosity.
This ingredient is unlikely to cause irritation because it does not get absorbed into skin. However, people with silicone allergies should be careful about using this ingredient.
Note: Dimethicone may contribute to pilling. This is because it is not oil or water soluble, so pilling may occur when layered with products. When mixed with heavy oils in a formula, the outcome is also quite greasy.
Phenoxyethanol is one of the most widely used preservatives in skincare (and for good reason!).
It has a large spectrum of antimicrobial activity and especially effective bacteria, yeast, and mold while only having a weak effect on your skin's natural microbiome.
On a cellular level, it disrupts the cell membranes of microbes by poking holes that make the cell leak. This shuts down the chemical reactions the microbe needs to make energy so it can no longer survive.
Another perk of this ingredient is that it stays functional across a wide pH range (3-10).
You'll often see it paired with boosters like Ethylhexylglycerin; one study showed that a 1:9 ratio of Ethylhexylglycerin to Phenoxyethanol damages bacterial membranes as effectively as doubling the Phenoxyethanol concentration on its own.
Typical use concentrations range from 0.3-1% depending on the formula, and this ingredient is capped at 1% int the EU.
Safety-wise, the fear mongering does not hold up to the evidence. The EU's Scientific Committee on Consumer Safety and FDA consider it safe as a preservative at up to 1%, including for children of all ages.
Adverse systemic effects only showed up in animal studies at exposures roughly 200x higher than what people get from cosmetics. And despite its very widespread use, this ingredient is a rare sensitizer and allergic reactions are uncommon.
Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.
So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.
You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!