Peptide Skincare & BeautySkin science and ingredient guides

Skin science article

COSRX Advanced Snail 96 Mucin Power Essence Versus Coxir Intensive EGF Peptides Serum

COSRX Advanced Snail 96 Mucin Power Essence Versus Coxir Intensive EGF Peptides Serum This hydrating essence is formulated around Snail Secretion Filtrate and Allantoin to hydrate skin and calm redness. This anti-aging serum is formulated around Niacinamide an

COSRX Advanced Snail 96 Mucin Power Essence Versus Coxir Intensive EGF Peptides Serum

This hydrating essence is formulated around Snail Secretion Filtrate and Allantoin to hydrate skin and calm redness.

This anti-aging serum is formulated around Niacinamide and Acetyl Hexapeptide-8 to soften the look of wrinkles and refine skin texture.

What's inside

Key Ingredients

Benefits

Concerns

No concerns

Ingredients Side-by-side

Snail Secretion Filtrate

Betaine

Butylene Glycol

1,2-Hexanediol

Sodium Polyacrylate

Phenoxyethanol

Sodium Hyaluronate

Allantoin

Ethyl Hexanediol

Carbomer

Panthenol

Arginine

Water

Snail Secretion Filtrate, Betaine, Butylene Glycol, 1,2-Hexanediol, Sodium Polyacrylate, Phenoxyethanol, Sodium Hyaluronate, Allantoin, Ethyl Hexanediol, Carbomer, Panthenol, Arginine, Water

Glycerin

Niacinamide

PEG/PPG-18/4 Copolymer

Acetyl Hexapeptide-8

Palmitoyl Pentapeptide-4

Tripeptide-1

Pentapeptide-13

Nonapeptide-1

Copper Tripeptide-1

Sh-Oligopeptide-1

PPG-26-Buteth-26

PEG-40 Hydrogenated Castor Oil

Ethylhexylglycerin

Adenosine

Glyceryl Acrylate/Acrylic Acid Copolymer

Pvm/Ma Copolymer

Polyglyceryl-10 Laurate

Theobroma Cacao Extract

Pyrus Malus Leaf Extract

Vanilla Planifolia Fruit Extract

Caprylyl Glycol

Thymus Vulgaris Extract

Fragaria Chiloensis Fruit Extract

Camellia Sinensis Callus Culture Extract

Prunus Persica Fruit Extract

Musa Sapientum Fruit Extract

Bambusa Vulgaris Callus Culture Extract

Hydrogenated Lecithin

Leontopodium Alpinum Extract

Cocos Nucifera Oil

Prunus Domestica Fruit Extract

Hydrolyzed Collagen

Malva Sylvestris Flower Extract

Tropolone

Water, Butylene Glycol, Glycerin, 1,2-Hexanediol, Niacinamide, Betaine, PEG/PPG-18/4 Copolymer, Acetyl Hexapeptide-8, Palmitoyl Pentapeptide-4, Tripeptide-1, Pentapeptide-13, Nonapeptide-1, Copper Tripeptide-1, Sh-Oligopeptide-1, Carbomer, Arginine, Allantoin, PPG-26-Buteth-26, PEG-40 Hydrogenated Castor Oil, Ethylhexylglycerin, Adenosine, Glyceryl Acrylate/Acrylic Acid Copolymer, Pvm/Ma Copolymer, Polyglyceryl-10 Laurate, Theobroma Cacao Extract, Pyrus Malus Leaf Extract, Vanilla Planifolia Fruit Extract, Caprylyl Glycol, Thymus Vulgaris Extract, Fragaria Chiloensis Fruit Extract, Camellia Sinensis Callus Culture Extract, Prunus Persica Fruit Extract, Musa Sapientum Fruit Extract, Bambusa Vulgaris Callus Culture Extract, Hydrogenated Lecithin, Leontopodium Alpinum Extract, Cocos Nucifera Oil, Prunus Domestica Fruit Extract, Hydrolyzed Collagen, Malva Sylvestris Flower Extract, Snail Secretion Filtrate, Tropolone

Reviews

Alternatives

Ingredients Explained

These ingredients are found in both products.

Ingredients higher up in an ingredient list are typically present in a larger amount.

1,2-Hexanediol is a synthetic liquid and another multi-functional powerhouse.

It is a:

Humectant, drawing moisture into the skin

Emollient, helping to soften skin

Solvent, dispersing and stabilizing formulas

Preservative booster, enhancing the antimicrobial activity of other preservatives

Allantoin is a soothing ingredient known for its protective and moisturizing properties; it's basically a quiet workhorse ingredient you can find in a huge range of cosmetics.

Though it can be derived from the comfrey plant, allantoin is produced synthetically for cosmetic products to ensure purity.

Research shows it can encourage your skin cells to turn over and renew by stimulating keratinocyte and fibroblast proliferation.

It also has mild keratolytic properties to help loosen and shed dead skin cells without being harsh.

Studies also suggest allantoin can help calm inflammation by dialing down some of the chemical signals your skin sends out when it is irritated.

This ingredient is typically used in the 0.1-0.5% range, and the FDA recognizes it as a skin protectant in OTC products up to 2%.

Overall, allantoin is a wonderful addition to most routines; it is stable across a wide pH range (~4-8), works well with other ingredients, and is considered non-sensitizing/non-irritating.

Fun fact: Allantoin is naturally occurring in comfrey root, beets, chamomile, and wheat sprouts. Our bodies even produce it as a byproduct of uric acid metabolism.

Arginine is a semi-essential amino acid. This just means our bodies can product a bit on its own, but sometimes needs a little boost from food sources.

It is a part of your skin's natural moisturizing factor (NMF), or the water-loving molecules in your outermost layer of skin (stratum corneum) that keeps everything hydrated and happy.

Here's an interesting thing about Arginine: your skin converts it into urea through the Krebs-Henseleit urea cycle. Urea is one of the most effective humectants your skin naturally produces.

A clinical study showed applying 2.5% arginine hydrochloride to atopic dermatitis skin showed significant urea levels in the stratum corneum and improved moisture in just four weeks.

Arginine is also a precursor to nitric oxide; nitric oxide improves microcirculation and supports wound healing and collagen synthesis.

One study found that an amino acid complex containing Arginine reduced skin irritation, improved hydration, and accelerated skin repair in clinical / in-vivo studies.

Arginine itself is an amino acid and not a fatty acid, oil, or ester. On its own, it's not a direct food source for Malassezia, or the yeast that causes fungal acne.

Betaine is a humectant. Like hyaluronic acid, it helps attract and retain moisture in the skin. It’s known for being gentle and for helping the skin maintain balanced hydration.

Betaine is mainly used to improve hydration and support calmer skin. It helps skin cells regulate water balance because it functions as an osmolyte.

Some studies suggest betaine may support making skin tone more even.

Fun fact: Betaine naturally exists in the skin and the body. In cosmetic products, it can be either plant-derived (most commonly from sugar beets) or synthetically produced for consistency and stability.

Betaine is also known as trimethylglycine.

Butylene Glycol (or BG) is used within cosmetic products for a few different reasons:

Overall, Butylene Glycol is a safe and well-rounded ingredient that works well with other ingredients.

Though this ingredient works well with most skin types, some people with sensitive skin may experience a reaction such as allergic rashes, closed comedones, or itchiness.

Carbomer is a synthetic thickening and gelling agent. It's basically the ingredient that gives a lot of serums, gels, creams, and sunscreens their smooth, non-sticky texture.

Although legally permitted at very high levels, carbomers are normally used at concentrations below 1%.

It also needs to be neutralized to actually thicken, and because it is a large molecule, it doesn't really penetrate the skin barrier.

Allergy-wise, the risk is very low. Clinical studies show carbomers have low potential for skin irritation/sensitization even at concentrations up to 100%.

A 2024 UK study patch-tested 1,302 patients and found true allergy to the parent group of carbomer to be rare with no confirmed relevant reactions.

Snail Secretion Filtrate (the slimy mucus that garden snails produce) is a multitasking ingredient that shows up in "skin repair" formulas.

This ingredient works because it's a grab bag of skin-friendly stuff like:

In a formula, it acts as a humectant and barrier-supporting soother and the research backs this up as well.

A 2025 systematic review of human clinical trials found that snail-derived ingredients improved signs of aging, increased skin hydration, decreased transepidermal water loss, and improved healing after radiation therapy/fractional laser treatment.

Lab studies have also shown the secretion promotes the proliferation, migration, and survival of the cells that rebuild skin (keratinocytes and dermal fibroblasts).

There's also a placebo-controlled study where a serum containing it helped with mask-related acne.

Overall, this is a gentle, water-based multitasker that works great for hydrating and supporting the skin barrier. However, please see the section below if you have dust mite or shellfish allergies.

You'll see snail filtrate listed at very different percentages depending on the product. Some Korean serums list it near the top of the ingredients at 90% or more while other products use just a few percent.

This doesn't mean the high-percentage ones are far stronger. Raw snail filtrate is mostly water to begin with so using a lot of it isn't the same thing as using a lot of the active ingredients.

Other products use a concentrated version so a small amount goes a long way. Either approach can work well. Just know the percentage on the label isn't a reliable way to judge how effective a snail product will be.

Being cruelty-free means a brand does not experiment on animals. If you're worried about the well-being of the snails, we recommend looking more into the company of the product. Many brands claim to have developed humane methods to collect snail mucin.

There is much debate on this subject. On one hand, this ingredient comes from an animal. On the other hand, many will argue the ingredient is naturally secreted (like a natural by-product) and therefore vegan. If you have reservations, you can look into Galactomyces Ferment Filtrate or Centella Asiatica Extract as alternatives.

This ingredient is fungal acne safe. Its core composition lacks the fatty acid/ester triggers that Malassezia depends on.

True allergy to Snail Secretion Filtrate is uncommon and most documented cases are linked to a dust mite allergy.

Snail proteins (including Tropomyosin) are similar enough to dust mite proteins that the immune system can confuse them.

In most documented cases, the dust mite was the original trigger and tropomyosin turned out to be only a minor player in some studies (so this has not been fully confirmed).

Another thing to know is that nearly all the evidence comes from eating snails or inhaling the protein and not from cosmetics.

However, the allergenic proteins can survive filtration into a finished product; a topical reaction is biologically plausible but there's little published evidence of it actually happening.

People who are allergic to dust mites (or sometimes shellfish) are the most likely to react.

Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.

So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.

You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!

Similar Comparisons

The reference edit

Ingredients, questions
& further reading.

Connected source records selected through this article’s public topic index.

02

Product index

Related product references

Product

Coxir Intensive EGF Peptides Serum

Coxir Intensive EGF Peptides Serum Ingredients in Coxir Intensive EGF Peptides Serum explained: benefits, concerns, and detailed analysis of 42 ingredients including Water, Butylene Glycol,…

Source: skinsort.comView reference →
03

Comparison edit

Read side by side