Peptide Skincare & BeautySkin science and ingredient guides

Skin science article

COSRX The Peptide Collagen Hydrogel Eye Patch Versus COSRX The Peptide Collagen Lifting Glow Hydrogel Mask

COSRX The Peptide Collagen Hydrogel Eye Patch Versus COSRX The Peptide Collagen Lifting Glow Hydrogel Mask This anti-aging eye mask is formulated around Niacinamide and Acetyl Hexapeptide-8 to soften the look of wrinkles. This anti-aging sheet mask is formulat

COSRX The Peptide Collagen Hydrogel Eye Patch Versus COSRX The Peptide Collagen Lifting Glow Hydrogel Mask

This anti-aging eye mask is formulated around Niacinamide and Acetyl Hexapeptide-8 to soften the look of wrinkles.

This anti-aging sheet mask is formulated around Niacinamide and Acetyl Hexapeptide-8 to soften the look of wrinkles.

What's inside

Key Ingredients

Benefits

Concerns

Ingredients Side-by-side

Water

Dipropylene Glycol

Glycerin

Niacinamide

Ceratonia Siliqua Gum

Chondrus Crispus Powder

Chondrus Crispus

Cellulose Gum

Hydroxyacetophenone

Algin

Caprylyl Glycol

Potassium Chloride

Betaine

Panthenol

Sucrose

Ethylhexylglycerin

Sodium Polyacrylate

Polyglyceryl-10 Laurate

Adenosine

Polyglyceryl-10 Myristate

Maltodextrin

Caffeine

Collagen

Butylene Glycol

Cyanocobalamin

1,2-Hexanediol

Sodium Hyaluronate

Dipotassium Glycyrrhizate

Pantolactone

Pentylene Glycol

Acetyl Hexapeptide-8

Dunaliella Salina Extract

Sh-Polypeptide-121

Palmitoyl Tripeptide-5

Hydrolyzed Hyaluronic Acid

Hyaluronic Acid

Potassium Hyaluronate

Hydrolyzed Sodium Hyaluronate

Acetyl Tetrapeptide-5

Citric Acid

Disodium EDTA

Water, Dipropylene Glycol, Glycerin, Niacinamide, Ceratonia Siliqua Gum, Chondrus Crispus Powder, Chondrus Crispus, Cellulose Gum, Hydroxyacetophenone, Algin, Caprylyl Glycol, Potassium Chloride, Betaine, Panthenol, Sucrose, Ethylhexylglycerin, Sodium Polyacrylate, Polyglyceryl-10 Laurate, Adenosine, Polyglyceryl-10 Myristate, Maltodextrin, Caffeine, Collagen, Butylene Glycol, Cyanocobalamin, 1,2-Hexanediol, Sodium Hyaluronate, Dipotassium Glycyrrhizate, Pantolactone, Pentylene Glycol, Acetyl Hexapeptide-8, Dunaliella Salina Extract, Sh-Polypeptide-121, Palmitoyl Tripeptide-5, Hydrolyzed Hyaluronic Acid, Hyaluronic Acid, Potassium Hyaluronate, Hydrolyzed Sodium Hyaluronate, Acetyl Tetrapeptide-5, Citric Acid, Disodium EDTA

Acrylates Copolymer

Agar

Erythritol

Sclerotium Gum

Allantoin

Xanthan Gum

Sodium Phytate

Hydrolyzed Collagen

Hydrogenated Lecithin

Cetearyl Alcohol

Stearic Acid

Tocopherol

Acetyl Glucosamine

Ceramide NP

Sodium Hyaluronate Crosspolymer

Ceramide Ns

Phytosphingosine

Cholesterol

Ceramide AP

Ceramide As

Dipeptide Diaminobutyroyl Benzylamide Diacetate

Copper Tripeptide-1

Acetyl Tetrapeptide-2

Dextran

Palmitoyl Tripeptide-8

Ceramide EOP

Water, Glycerin, Acrylates Copolymer, Niacinamide, 1,2-Hexanediol, Ceratonia Siliqua Gum, Chondrus Crispus, Agar, Erythritol, Sclerotium Gum, Potassium Chloride, Sucrose, Cellulose Gum, Polyglyceryl-10 Laurate, Panthenol, Ethylhexylglycerin, Allantoin, Xanthan Gum, Adenosine, Sodium Phytate, Hydrolyzed Collagen, Hydrogenated Lecithin, Cetearyl Alcohol, Cyanocobalamin, Stearic Acid, Tocopherol, Acetyl Hexapeptide-8, Butylene Glycol, Pentylene Glycol, Acetyl Glucosamine, Ceramide NP, Sodium Hyaluronate, Sodium Hyaluronate Crosspolymer, Hydrolyzed Hyaluronic Acid, Ceramide Ns, Palmitoyl Tripeptide-5, Phytosphingosine, Cholesterol, Hyaluronic Acid, Ceramide AP, Ceramide As, Caprylyl Glycol, Dipeptide Diaminobutyroyl Benzylamide Diacetate, Hydrolyzed Sodium Hyaluronate, Copper Tripeptide-1, Acetyl Tetrapeptide-2, Dextran, Palmitoyl Tripeptide-8, Ceramide EOP

Reviews

Be the first to review

Alternatives

Ingredients Explained

These ingredients are found in both products.

Ingredients higher up in an ingredient list are typically present in a larger amount.

1,2-Hexanediol is a synthetic liquid and another multi-functional powerhouse.

It is a:

Humectant, drawing moisture into the skin

Emollient, helping to soften skin

Solvent, dispersing and stabilizing formulas

Preservative booster, enhancing the antimicrobial activity of other preservatives

Acetyl Hexapeptide-8 (also known as Argireline) is a synthetic hexapeptide that is often called a "topical Botox alternative".

It works by mimicking how Botox relaxes muscles; it interferes with the signaling process that tells your facial muscles to contract. This can help soften expression lines like forehead wrinkles or crow's feet over time.

The comparison to Botox does have limits because the molecule is water-loving and relatively large.

Acetyl Hexapeptide-8 has a hard time absorbing deeply enough through the skin's outer barrier to actually reach the muscles.

So whether it truly works the way Botox does at a biological level is still up for debate, but early clinical outcomes are fairly encouraging.

A 12 week human study of a multi-ingredient regimen containing this ingredient saw:

While some studies have observed improvements in wrinkle appearance, it is important to note that more consistent results are seen in multi-ingredient formulations (vs just Acetyl Hexapeptide-8 alone).

Some research studies also used higher concentrations (up to 10%) while this ingredient is usually found in concentrations up to 0.005% in leave-on formulations.

Adenosine is a purine nucleoside that your body already makes in every cell. In skincare, it acts mainly as a skin conditioning and anti-aging agent.

The way it works is fairly well mapped out:

Your skin has cells called fibroblasts that build collagen (the stuff that keeps skin firm and smooth). Adenosine basically flips a switch on these cells that tells them to get to work making more collagen and other proteins. These cells slow down on their own as skin ages, so Adenosine helps give them a little nudge to keep going.

The clinical backing is pretty solid too.

A blind, randomized, placebo-controlled trial of 126 women aged 45-65 tested a 0.1% cream twice daily and found real improvements in crow's feet and frown lines using a precise 3D skin-mapping technique; these changes showed up by week 3 and held at 2 months.

A later study using Adenosine-loaded dissolving microneedle patches reported gains in wrinkle depth, dermal density, elasticity, and hydration.

On concentrations, South Korea's Ministry of Food and Drug Safety has set 0.04% as the approved functional anti-wrinkle level. You'll typically see this ingredient used somewhere in the 0.04-0.1% range since it works at low doses.

This ingredient has been found safe for cosmetics with the data showing no irritation or sensitization.

Overall, this is a great ingredient for any anti-aging routine and has no photosensitizing effect, so it suits both AM and PM use.

Butylene Glycol (or BG) is used within cosmetic products for a few different reasons:

Overall, Butylene Glycol is a safe and well-rounded ingredient that works well with other ingredients.

Though this ingredient works well with most skin types, some people with sensitive skin may experience a reaction such as allergic rashes, closed comedones, or itchiness.

Caprylyl Glycol is a humectant, skin conditioner, emollient, and preservative booster derived from either caprylic acid or synthetically created.

Typical use levels vary from 0.3-1% as a preservative booster and go up to 2% to condition skin.

Because it is not a free-fatty acid, this ingredient is fungal acne safe (there's nothing for Malassezia to feed on).

Cellulose Gum is a water-soluble polymer that comes from cellulose. It is used to change the texture of a product and to help stabilize emulsions.

As an emulsifier, cellulose gum specifically thicken the texture of water-based products.

This ingredient is considered hypoallergenic and non-toxic. Cellulose Gum can be found in cosmetics, food, and other household goods such as paper products.

Ceratonia Siliqua Gum is extracted from the seeds of the carob tree. You might know this ingredient as Carob Gum or Locust Bean Gum. It is used to stabilize other ingredients and improve the texture of products.

Carob gum is made up of long-chain polysaccharides. This makes it a natural thickener.

Yes! This ingredient comes from the seeds of a tree. The name 'Locust Bean Gum' can be misleading.

Chondrus Crispus is a red algae native to the northern Atlantic ocean.

It is rich in antioxidants. The polysaccharides, peptides, and amino acid content helps moisturize skin.

Antioxidants present in chondrus crispus include lutein and zeaxanthin. Lutein has the ability to filter blue light from screens.

Cyanocobalamin is the manufactured version of vitamin B12. It has skin soothing, antioxidant, and barrier protecting properties. Topical cyanocobalamin is used to treat skin irritation and atopic dermatitis.

Ethylhexylglycerin is created from glycerin. It is a multitasker ingredient that:

The CIR Expert Panel found minimal skin absorption or sensitization of any kind in a safety assessment. Though this ingredient is considered well-tolerated, a small number of cases of allergic dermatitis have been published since 2002. Just be sure to patch test if you are unsure.

Industry-reported use ranges from 8% in rinse-off products and 2% in leave-on formulations.

Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.

Topically, glycerin does several things at once:

Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.

Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.

This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.

Just know very high concentrations (>40%) can feel tacky in low humidity.

Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.

Hyaluronic acid (HA) is a glycosaminoglycan (basically a long sugar chain) that your skin already makes on its own. In your skin, HA lives in the extracellular matrix and acts as the body's moisture reservoir.

Topically, HA is a humectant that binds water and helps skin look more plump, smooth, and hydrated.

The only catch is that HA isn't a single thing; it actually comes in a wide range of molecular weights (~50 - 2,000+ kDA) and size matters.

Some clinical evidence links low molecular weight versions to improved wrinkle depth, elasticity, anti-inflammatory effects, and barrier repair.

This is why the best HA serums blend the two sizes together so you get the best of both worlds.

The majority of cosmetic HA is produced by bacterial fermentation, typically using Streptococcus or Bacillus strains. Typical use levels in skincare sit around 0.1-2%.

A clinical study using a 0.2% low-molecular weight HA gel showed improvement in facial seborrheic dermatitis with excellent tolerance.

These are some other common types of Hyaluronic Acid:

Hydrolyzed Hyaluronic Acid is hyaluronic acid (HA) that is broken down into lower molecular weight fragments.

It's a humectant that pulls and holds water in the skin to help with hydration, plumpness, and reduce transepidermal water loss.

Because hydrolyzed hyaluronic acid is smaller in size, it can slip past your outermost layer of skin more easily than full-sized HA.

Most formulations will combine all sizes to get the best of both worlds.

Typical usage levels range from 0.01-1%. Any percentage higher than 2% might become goopy and tacky.

This ingredient is created by putting sodium hyaluronate through hydrolysis.

You might know this as 'mini' or 'ultra low-molecular weight' hyaluronic acid. The small molecule size means it is able to travel deeper in the skin.

According to studies, low molecular-weight hyaluronic acid can:

One study from 2011 found ultra-low weight HA to show pro-inflammatory properties. Another study from 2022 found it to downregulate UV-B induced inflammation.

Hydrolysis is a process of changing a molecule using water or enzymes.

This ingredient is water-soluble.

Niacinamide is a multitasking form of vitamin B3 that strengthens the skin barrier, reduces pores and dark spots, regulates oil, and improves signs of aging.

And the best part? It's gentle and well-tolerated by most skin types, including sensitive and reactive skin.

You might have heard of "niacin flush", or the reddening of skin that causes itchiness. Niacinamide has not been found to cause this.

In very rare cases, some individuals may not be able to tolerate niacinamide at all or experience an allergic reaction to it.

If you are experiencing flaking, irritation, and dryness with this ingredient, be sure to double check all your products as this ingredient can be found in all categories of skincare.

When incorporating niacinamide into your routine, look out for concentration amounts. Typically, 5% niacinamide provides benefits such as fading dark spots. However, if you have sensitive skin, it is better to begin with a smaller concentration.

When you apply niacinamide to your skin, your body converts it into nicotinamide adenine dinucleotide (NAD). NAD is an essential coenzyme that is already found in your cells as "fuel" and powers countless biological processes.

In your skin, NAD helps repair cell damage, produce new healthy cells, support collagen production, strengthen the skin barrier, and fight environmental stressors (like UV and pollution).

Our natural NAD levels start to decline with age, leading to slower skin repair, visible aging, and a weaker skin barrier. By providing your skin niacinamide, you're recharging your skin's NAD levels. This leads to stronger, healthier, and younger looking skin.

Another name for vitamin B3 is nicotinamide. This vitamin is water-soluble and our bodies don't store it. We obtain Vitamin B3 from either food or skincare. Meat, fish, wheat, yeast, and leafy greens contain vitamin B3.

The type of niacinamide used in skincare is synthetically created.

Palmitoyl Tripeptide-5 is a synthetic signal lipopeptide. This just means it is a three amino acid chain bolted onto a palmitic acid tail so it can slip through the skin's lipid barrier.

This peptide has a "build more, lose less" approach.

It's designed to mimic the collagen-stimulating activity in your skin by copying a snippet of one of your skin's own matrix proteins. This nudges fibroblasts into making more collagen while inhibiting the enzyme that breaks down skin protein.

The manufacturer's in vivo study of 45 volunteers found 1% and 2.5% reduced the appearance of wrinkles by 7% and 12% respectively, after using it twice daily for 84 days.

This is in the expected range for peptides; they're slow and cumulative actives and not overnight fixers.

Typical use levels range from 1-3% and this ingredient gets along with pretty much everything.

On the fungal acne front: Although palmitic acid sits in the chain length that Malassezia can feed on, this ingredient has it locked in an amine bond. This makes it hard for Malassezia to access as a source of food, and therefore fungal acne safe.

Panthenol is a common ingredient that helps hydrate and soothe the skin. It is found naturally in our skin and hair.

There are two forms of panthenol: D and L.

D-panthenol is also known as dexpanthenol. Most cosmetics use dexpanthenol or a mixture of D and L-panthenol.

Panthenol is famous due to its ability to go deeper into the skin's layers. Using this ingredient has numerous pros (and no cons):

Like hyaluronic acid, panthenol is a humectant. Humectants are able to bind and hold large amounts of water to keep skin hydrated.

This ingredient works well for wound healing. It works by increasing tissue in the wound and helps close open wounds.

Once oxidized, panthenol converts to pantothenic acid. Panthothenic acid is found in all living cells.

This ingredient is also referred to as pro-vitamin B5.

Pentylene Glycol (1,2-pentanediol) is a multitasking little diol with three main roles in a formula:

Research on alkanediols (the family pentylene glycol belongs to) show they work by disrupting microbial cell membranes. This disruption helps the primary preservative system in a product work more effectively at lower doses.

On the safety side, the Cosmetic Ingredient Review Expert Panel has concluded this ingredient to be safe as used in current cosmetic practices + concentrations.

Typical use levels in a formula run about 1-5%.

Polyglyceryl-10 Laurate is a cleansing agent and emulsifier.

It rounds up dirt, oil, and grime, so they can be rinsed off easily as a cleanser.

On the emulsifier side, it keeps your formula smooth and well-mixed by playing peacekeeper for ingredients that don't naturally get along (like oil and water).

Because it has a C12 (lauric acid) fatty acid chain, this ingredient can potentially feed the Malassezia yeast that causes fungal acne. The Malassezia yeast prefers esters with C11-C24 fatty acids.

This ingredient is an ester of lauric acid and Polyglycerin-10.

We don't have a description for Potassium Chloride yet.

Sodium Hyaluronate is the salt form of hyaluronic acid. It is a long sugar chain that is naturally found in your skin, joints, and connective tissue that maintains hydration and elasticity.

In skincare, it works as a humectant. It pulls water from the environment and deeper layers of skin and binds it to the surface.

Interestingly, the size of the molecule affects its behavior:

Many serums use a blend of both weights so you can get surface hydration plus longer-lasting and deeper effects.

You'll typically see concentrations between 0.1-2% for this ingredient.

Sucrose is a natural sugar found in fruits, vegetables, and nuts. It is the main constituent of white sugar.

In skincare, sucrose is a humectant and can be a mild exfoliant.

Sucrose is hydrophilic, meaning it attracts water. This makes it an effective humectant and helps hydrate the skin.

Studies show sugars may worsen acne-prone skin due to it disrupting the skin's natural biome. We recommend speaking with a professional if you have any concerns.

In some products such as body scrubs, sucrose is used as an gentle exfoliant.

The term 'sucrose' comes from the french word for sugar, 'sucre'.

Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.

So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.

You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!

Similar Comparisons

The reference edit

Ingredients, questions
& further reading.

Connected source records selected through this article’s public topic index.

02

Product index

Related product references

03

Comparison edit

Read side by side