Peptide Skincare & BeautySkin science and ingredient guides

Skin science article

Dear, Klairs Midnight Blue Calming Cream Versus Niod Copper Amino Isolate Serum 2:1 (CAIS2)

Dear, Klairs Midnight Blue Calming Cream Versus Niod Copper Amino Isolate Serum 2:1 (CAIS2) This calming moisturizer is formulated around Centella Asiatica Extract and Ceramide NP to calm redness and strengthen the skin barrier. This serum is formulated around

Dear, Klairs Midnight Blue Calming Cream Versus Niod Copper Amino Isolate Serum 2:1 (CAIS2)

This calming moisturizer is formulated around Centella Asiatica Extract and Ceramide NP to calm redness and strengthen the skin barrier.

This serum is formulated around Lactococcus Ferment Lysate to support the skin barrier and reduce redness.

What's inside

Key Ingredients

Benefits

Concerns

Ingredients Side-by-side

Water

Cetyl Ethylhexanoate

Butylene Glycol

Glycerin

Sodium Hyaluronate

Caprylic/Capric Triglyceride

Centella Asiatica Extract

Sorbitan Stearate

Cetyl Alcohol

Butyrospermum Parkii Butter

Argania Spinosa Kernel Oil

Simmondsia Chinensis Seed Oil

Sorbitan Sesquioleate

Glyceryl Stearate

Stearic Acid

Portulaca Oleracea Extract

Anthemis Nobilis Flower Extract

Ceramide NP

Polysorbate 60

Candelilla Cera

Chlorphenesin

Tocopheryl Acetate

Xanthan Gum

Acrylates/C10-30 Alkyl Acrylate Crosspolymer

Morus Alba Root Extract

Tromethamine

Brassica Oleracea Italica Extract

Guaiazulene

Acetyl Hexapeptide-8

Lecithin

Acetyl Glutamine

Sh-Oligopeptide-1

Sh-Oligopeptide-2

Sh-Polypeptide-1

Sh-Polypeptide-9

Sh-Polypeptide-11

Bacillus/Folic Acid/Soybean Ferment Extract

Caprylyl Glycol

1,2-Hexanediol

Water, Cetyl Ethylhexanoate, Butylene Glycol, Glycerin, Sodium Hyaluronate, Caprylic/Capric Triglyceride, Centella Asiatica Extract, Sorbitan Stearate, Cetyl Alcohol, Butyrospermum Parkii Butter, Argania Spinosa Kernel Oil, Simmondsia Chinensis Seed Oil, Sorbitan Sesquioleate, Glyceryl Stearate, Stearic Acid, Portulaca Oleracea Extract, Anthemis Nobilis Flower Extract, Ceramide NP, Polysorbate 60, Candelilla Cera, Chlorphenesin, Tocopheryl Acetate, Xanthan Gum, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Morus Alba Root Extract, Tromethamine, Brassica Oleracea Italica Extract, Guaiazulene, Acetyl Hexapeptide-8, Lecithin, Acetyl Glutamine, Sh-Oligopeptide-1, Sh-Oligopeptide-2, Sh-Polypeptide-1, Sh-Polypeptide-9, Sh-Polypeptide-11, Bacillus/Folic Acid/Soybean Ferment Extract, Caprylyl Glycol, 1,2-Hexanediol

Lactococcus Ferment Lysate

Ethyl Linoleate

Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer

Hexanoyl Dipeptide-3 Norleucine Acetate

Myristoyl Nonapeptide-3

Yeast Extract

Soy Amino Acids

Bisabolol

Pseudoalteromonas Exopolysaccharides

Sorbitan Isostearate

Isohexadecane

Polyacrylate Crosspolymer-6

Trisodium Ethylenediamine Disuccinate

Sodium Salicylate

Citric Acid

Sodium Chloride

Potassium Sorbate

Sodium Benzoate

Pentylene Glycol

Ethoxydiglycol

Phenoxyethanol

Water, Lactococcus Ferment Lysate, Glycerin, Ethyl Linoleate, Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, Hexanoyl Dipeptide-3 Norleucine Acetate, Myristoyl Nonapeptide-3, Yeast Extract, Soy Amino Acids, Bisabolol, Pseudoalteromonas Exopolysaccharides, Lecithin, Sorbitan Isostearate, Isohexadecane, Polysorbate 60, Polyacrylate Crosspolymer-6, Trisodium Ethylenediamine Disuccinate, Sodium Salicylate, Citric Acid, Sodium Chloride, Potassium Sorbate, Sodium Benzoate, Pentylene Glycol, Ethoxydiglycol, Phenoxyethanol, Chlorphenesin

Reviews

Be the first to review

Alternatives

Ingredients Explained

These ingredients are found in both products.

Ingredients higher up in an ingredient list are typically present in a larger amount.

Chlorphenesin is a synthetic preservative. It helps protect a product against bacteria in order to extend shelf life. In most cases, Chlorphenesin is paired with other preservatives such as phenoxyethanol and caprylyl glycol.

Chlorphenesin is a biocide. This means it is able to help fight the microorganisms on our skin. It is also able to fight odor-releasing bacteria.

Chlorphenesin is soluble in both water and glycerin.

Studies show Chlorphenesin is easily absorbed by our skin. You should speak with a skincare professional if you have concerns about using Chlorphenesin.

Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.

Topically, glycerin does several things at once:

Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.

Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.

This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.

Just know very high concentrations (>40%) can feel tacky in low humidity.

Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.

Lecithin is a term for a group of substances found in the cell membranes of plants, animals, and humans. They are made up of phospholipids.

Thanks to its amphiphilic structure (water-loving head and oil-loving tail), it is a true multitasker:

It plays well with most ingredients and is typically used at 0.1-1%. However, concentrations up to 50% have been reported in moisturizers.

Polysorbate 60 is used to help stabilize products. It is a surfactant and emulsifier. These properties help keep ingredients together in a product. Surfactants help reduce surface tension between ingredients with different states, such as liquids and solids. Emulsifiers help prevent oils and waters from separating.

Polysorbate 60 is sorbitol-based and created from the ethoxylation of sorbitan. Ethoxylation is a chemical reaction used to add ethylene oxide. Sorbitan is a the dehydrated version of sorbitol, a sugar found in fruits.

In this case, the 60 comes from reacting 60 units of ethylene oxide with sorbitan.

Polysorbates are commonly used in medicine and foods.

Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.

So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.

You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!

Similar Comparisons

The reference edit

Ingredients, questions
& further reading.

Connected source records selected through this article’s public topic index.

01

Formula cabinet

Ingredients & structured notes

Ingredient index

Ingredients Explained

  1. 01These ingredients are found in both products.
  2. 02Ingredients higher up in an ingredient list are typically present in a larger amount.
  3. 03Caprylyl Glycol is a humectant, skin conditioner, emollient, and preservative booster derived from either caprylic acid or synthetically created.
  4. 04Typical use levels vary from 0.3-1% as a preservative booster and go up to 2% to condition skin.
  5. 05Because it is not a free-fatty acid, this ingredient is fungal acne safe (there's nothing for Malassezia to feed on).
  6. 06Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.
  7. 07Topically, glycerin does several things at once:
  8. 08Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.
  9. 09Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.
  10. 10This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.
  11. 11Just know very high concentrations (>40%) can feel tacky in low humidity.
  12. 12Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.
  13. 13Propanediol is an all-star ingredient. It softens, hydrates, and smooths the skin.
  14. 14It’s often used to:
  15. 15Propanediol is not likely to cause sensitivity and considered safe to use. It is derived from corn or petroleum with a clear color and no scent.
  16. 16Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.
  17. 17So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.
  18. 18You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!
Source · skinsort.com
02

Product index

Related product references

03

Comparison edit

Read side by side