Skin science article
Dermalogica Pro-Collagen Banking Serum Versus Drunk Elephant Protini Powerpeptide Resurfacing Serum
Dermalogica Pro-Collagen Banking Serum Versus Drunk Elephant Protini Powerpeptide Resurfacing Serum This anti-aging serum is formulated around Trehalose and Carnosine to soften the look of wrinkles and strengthen the skin barrier. This smoothing serum is formu
Dermalogica Pro-Collagen Banking Serum Versus Drunk Elephant Protini Powerpeptide Resurfacing Serum
This anti-aging serum is formulated around Trehalose and Carnosine to soften the look of wrinkles and strengthen the skin barrier.
This smoothing serum is formulated around Lactic Acid and Sh-Oligopeptide-1 to refine skin texture and soften the look of wrinkles.
What's inside
Key Ingredients
Benefits
Concerns
Ingredients Side-by-side
Water
Pentylene Glycol
Coco-Caprylate/Caprate
Glycerin
Propanediol
Simmondsia Chinensis Seed Oil
Trehalose
Oryza Sativa Bran Water
Butylene Glycol
Ethoxydiglycol
Triheptanoin
Arginine PCA
Diglycerin
Dipotassium Glycyrrhizate
Sodium Hyaluronate
Collagen Amino Acids
Glycine Soja Oil
Helianthus Annuus Seed Oil
Citrus Aurantium Dulcis Peel Oil
Citrus Aurantium Bergamia Fruit Oil
Citrus Paradisi Peel Oil
Rosmarinus Officinalis Leaf Extract
Cupressus Sempervirens Leaf/Nut/Stem Oil
Santalum Album Oil
Citrus Limon Peel Oil
Rosa Damascena Flower Oil
Jasminum Sambac Flower Extract
Hydrolyzed Jojoba Esters
Oryza Sativa Bran Extract
Aloe Barbadensis Leaf Extract
Tephrosia Purpurea Seed Extract
Helianthus Annuus Extract
Juniperus Virginiana Oil
Tagetes Minuta Flower Oil
Rosmarinus Officinalis Leaf Oil
Cistus Ladaniferus Leaf/Stem Extract
Hydrolyzed Rice Protein
Tocopheryl Acetate
Tocopherol
Phospholipids
Carnosine
Glyceryl Stearate Citrate
Caprylyl Glycol
Polyglutamic Acid
Glycolipids
Glycine Soja Sterols
Acrylates/C10-30 Alkyl Acrylate Crosspolymer
Glyceryl Caprylate
Sclerotium Gum
Polyquaternium-80
Didecyldimonium Chloride
Dianthus Caryophyllus Flower Extract
Xanthan Gum
Methylpropanediol
Cetearyl Alcohol
PEG-40 Hydrogenated Castor Oil
Ammonium Acryloyldimethyltaurate/Beheneth-25 Methacrylate Crosspolymer
Phytic Acid
Polysorbate 20
Tetrasodium Glutamate Diacetate
Citric Acid
Sodium Hydroxide
Sodium Polyacryloyldimethyl Taurate
Sodium Benzoate
Potassium Sorbate
Limonene
Linalool
Water, Pentylene Glycol, Coco-Caprylate/Caprate, Glycerin, Propanediol, Simmondsia Chinensis Seed Oil, Trehalose, Oryza Sativa Bran Water, Butylene Glycol, Ethoxydiglycol, Triheptanoin, Arginine PCA, Diglycerin, Dipotassium Glycyrrhizate, Sodium Hyaluronate, Collagen Amino Acids, Glycine Soja Oil, Helianthus Annuus Seed Oil, Citrus Aurantium Dulcis Peel Oil, Citrus Aurantium Bergamia Fruit Oil, Citrus Paradisi Peel Oil, Rosmarinus Officinalis Leaf Extract, Cupressus Sempervirens Leaf/Nut/Stem Oil, Santalum Album Oil, Citrus Limon Peel Oil, Rosa Damascena Flower Oil, Jasminum Sambac Flower Extract, Hydrolyzed Jojoba Esters, Oryza Sativa Bran Extract, Aloe Barbadensis Leaf Extract, Tephrosia Purpurea Seed Extract, Helianthus Annuus Extract, Juniperus Virginiana Oil, Tagetes Minuta Flower Oil, Rosmarinus Officinalis Leaf Oil, Cistus Ladaniferus Leaf/Stem Extract, Hydrolyzed Rice Protein, Tocopheryl Acetate, Tocopherol, Phospholipids, Carnosine, Glyceryl Stearate Citrate, Caprylyl Glycol, Polyglutamic Acid, Glycolipids, Glycine Soja Sterols, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Glyceryl Caprylate, Sclerotium Gum, Polyquaternium-80, Didecyldimonium Chloride, Dianthus Caryophyllus Flower Extract, Xanthan Gum, Methylpropanediol, Cetearyl Alcohol, PEG-40 Hydrogenated Castor Oil, Ammonium Acryloyldimethyltaurate/Beheneth-25 Methacrylate Crosspolymer, Phytic Acid, Polysorbate 20, Tetrasodium Glutamate Diacetate, Citric Acid, Sodium Hydroxide, Sodium Polyacryloyldimethyl Taurate, Sodium Benzoate, Potassium Sorbate, Limonene, Linalool
Lactic Acid
Dicaprylyl Carbonate
Squalane
Glycine Max Seed Extract
Sclerocarya Birrea Seed Oil
Camellia Sinensis Seed Oil
Sodium PCA
Caprylic/Capric Triglyceride
Borago Officinalis Seed Oil
Tremella Fuciformis Polysaccharide
Tocotrienols
Sh-Oligopeptide-1
Sh-Oligopeptide-2
Sh-Polypeptide-1
Sh-Polypeptide-9
Sh-Polypeptide-11
Copper Palmitoyl Heptapeptide-14
Heptapeptide-15 Palmitate
Palmitoyl Tetrapeptide-7
Palmitoyl Tripeptide-1
Palmitoyl Tripeptide-38
Palmitoyl Hexapeptide-12
Tripeptide-1
Pyrus Malus Fruit Extract
Panthenol
Sodium Hyaluronate Crosspolymer
Sodium Lactate
PCA
Alanine
Arginine
Glycine
Histidine
Isoleucine
Phenylalanine
Proline
Serine
Threonine
Valine
Adenosine
Nymphaea Alba Root Extract
Bacillus/Folic Acid Ferment Filtrate Extract
Symphytum Officinale Callus Culture Extract
Dextran
Oryza Sativa Bran Oil
Linoleic Acid
Linolenic Acid
Acetyl Glutamine
Coconut Alkanes
Isomalt
Lecithin
Aspartic Acid
Phytosphingosine
Lactic Acid/Glycolic Acid Copolymer
Polyvinyl Alcohol
Phenoxyethanol
Hydroxypropyl Cyclodextrin
Phenylpropanol
Chlorphenesin
Carbomer
Ethylhexylglycerin
Water, Glycerin, Lactic Acid, Dicaprylyl Carbonate, Squalane, Sodium Hydroxide, Glycine Max Seed Extract, Sclerocarya Birrea Seed Oil, Camellia Sinensis Seed Oil, Sodium PCA, Caprylic/Capric Triglyceride, Borago Officinalis Seed Oil, Tremella Fuciformis Polysaccharide, Tocotrienols, Sh-Oligopeptide-1, Sh-Oligopeptide-2, Sh-Polypeptide-1, Sh-Polypeptide-9, Sh-Polypeptide-11, Copper Palmitoyl Heptapeptide-14, Heptapeptide-15 Palmitate, Palmitoyl Tetrapeptide-7, Palmitoyl Tripeptide-1, Palmitoyl Tripeptide-38, Palmitoyl Hexapeptide-12, Tripeptide-1, Pyrus Malus Fruit Extract, Propanediol, Sodium Hyaluronate, Panthenol, Sodium Hyaluronate Crosspolymer, Sodium Lactate, PCA, Alanine, Arginine, Glycine, Histidine, Isoleucine, Phenylalanine, Proline, Serine, Threonine, Valine, Adenosine, Nymphaea Alba Root Extract, Bacillus/Folic Acid Ferment Filtrate Extract, Symphytum Officinale Callus Culture Extract, Dextran, Oryza Sativa Bran Oil, Linoleic Acid, Linolenic Acid, Butylene Glycol, Acetyl Glutamine, Coconut Alkanes, Coco-Caprylate/Caprate, Pentylene Glycol, Isomalt, Lecithin, Xanthan Gum, Aspartic Acid, Phytosphingosine, Phospholipids, Glycine Soja Sterols, Tocopherol, Citric Acid, Lactic Acid/Glycolic Acid Copolymer, Polyvinyl Alcohol, Phenoxyethanol, Sodium Benzoate, Hydroxypropyl Cyclodextrin, Polysorbate 20, Caprylyl Glycol, Phenylpropanol, Chlorphenesin, Carbomer, Glyceryl Caprylate, Ethylhexylglycerin
Alternatives
Ingredients Explained
These ingredients are found in both products.
Ingredients higher up in an ingredient list are typically present in a larger amount.
Butylene Glycol (or BG) is used within cosmetic products for a few different reasons:
Overall, Butylene Glycol is a safe and well-rounded ingredient that works well with other ingredients.
Though this ingredient works well with most skin types, some people with sensitive skin may experience a reaction such as allergic rashes, closed comedones, or itchiness.
Caprylyl Glycol is a humectant, skin conditioner, emollient, and preservative booster derived from either caprylic acid or synthetically created.
Typical use levels vary from 0.3-1% as a preservative booster and go up to 2% to condition skin.
Because it is not a free-fatty acid, this ingredient is fungal acne safe (there's nothing for Malassezia to feed on).
Citric Acid is an alpha hydroxy acid (AHA) naturally found in citrus fruits like oranges, lemons, and limes.
Like other AHAs, citric acid can exfoliate skin by breaking down the bonds that hold dead skin cells together. This helps reveal smoother and brighter skin underneath.
However, this exfoliating effect only happens at high concentrations (20%) which can be hard to find in cosmetic products.
Due to this, citric acid is usually included in small amounts as a pH adjuster. This helps keep products slightly more acidic and compatible with skin's natural pH.
In skincare formulas, citric acid can:
While it can provide some skin benefits, research shows lactic acid and glycolic acid are generally more effective and less irritating exfoliants.
Most citric acid used in skincare today is made by fermenting sugars (usually from molasses). This synthetic version is identical to the natural citrus form but easier to stabilize and use in formulations.
Rosacea skin has a lower threshold for acids generally, with 62.5% of rosacea subjects in one study reacting to lactic acid in a sting test. This is why we mark citric acid as a potential rosacea trigger.
However, this ingredient shows up as a pH adjuster or chelator at roughly 0.1-1% in many products. These low levels are unlikely to be an issue for rosacea skin and becomes a potential trigger at exfoliating concentrations (20%). Because everybody's skin is unique, we recommend a patch test if you are unsure.
Coco-Caprylate/Caprate is a lightweight ester created from coconut oil fatty acids, caprylic acid, and capric acid.
It is an emollient that helps soften skin and reduce transepidermal water loss (TEWL). What sets it apart from heavier emollients is its ultralight, non-greasy feel.
Once applied, this ingredient dries down quickly and leaves a dry, silky finish behind. This also helps improve spreadability and texture.
This ingredient has an excellent safety-record and is non-irritating.
Typical concentrations for cosmetics range from 0.5-62%.
Research on Malassezia growth found no growth on fatty acid esters with chain lengths shorter than 12 carbons (it prefers C11-24).
Since Coco-Caprylate/Caprate is built on C8 and C10 fatty acids, it is out of the range that Malassezia metabolizes, and therefore safe for fungal acne.
Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.
Topically, glycerin does several things at once:
Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.
Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.
This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.
Just know very high concentrations (>40%) can feel tacky in low humidity.
Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.
Glyceryl Caprylate comes from glycerin and caprylic acid. It is an emollient, co-emulsifier, and preservative booster.
Its short C8 fatty acid chain makes it behave differently from its longer-chain emollient cousins like Glyceryl Stearate. It feels more lightweight, fast-absorbing, and silky instead of rich and waxy.
As a co-emulsifier, its "head" and "tail" sit at the oil-water interface. But overall, the short C8 tail and not being water soluble means it doesn't really have the muscle to emulsify a formula on its own. That's why you'll often see it paired with a primary emulsifier like Cetearyl Glucoside.
Interestingly, Glyceryl Caprylate acts as a preservative booster. This is because its fatty-acid backbone disrupts microbial lipid membranes. It shows excellent activity against bacteria and yeast but is weaker against mold.
Typical concentrations range from 0.5-1% and this ingredient is generally non-irritating.
Because this ingredient has a C8 fatty acid chain, it is outside the range that the Malassezia yeast metabolizes (making it fungal acne safe).
Glycine Soja Sterols are plant-derived fatty alcohols (phytosterols) from soybean.
You can think of them like the plant world's version of cholesterol; they're structurally similar enough to slot into your skin's lipid barrier and help it do its job.
Phytosterols aid skin barrier recovery by traveling deeper into the skin rather than just sitting on top of it. Once inside, they reduce transepidermal water loss (TEWL) and keep skin feeling soft / supple.
Research on phytosterols in keratinocyte and macrophase models has shown meaningful inhibition of pro-inflammatory mediators. This supports their reputation as a calming ingredient for reactive or sensitive skin.
Subjects with soy allergies did not show a reaction to phytosterols in safety tests, but it wouldn't hurt to patch test if you do have a soy allergy.
Fungal acne: Malassezia uses sterols to build its own cell walls so there's a theoretical concern that it could also make use of sterol ingredients in skincare.
Though no study has actually proven this happens with topical products, we err on the side of caution and list this ingredient as not safe for fungal acne. However, it may not be a trigger for everyone.
Pentylene Glycol (1,2-pentanediol) is a multitasking little diol with three main roles in a formula:
Research on alkanediols (the family pentylene glycol belongs to) show they work by disrupting microbial cell membranes. This disruption helps the primary preservative system in a product work more effectively at lower doses.
On the safety side, the Cosmetic Ingredient Review Expert Panel has concluded this ingredient to be safe as used in current cosmetic practices + concentrations.
Typical use levels in a formula run about 1-5%.
Phospholipids are a family of skin-identical lipids that makeup the structural backbone of every cell membrane in your body.
In cosmetics, they function as skin conditioning agents with emulsifier and surfactant properties. They're typically sourced from soybean or sunflower lecithin (or sometimes egg yolk or marine sources).
Because they mirror the lipids naturally found in the deeper layers of your skin, topical phospholipids help reinforce the lipid matrix, reduce transepidermal water loss, and leave skin feeling conditioned.
They're also used to form liposomes, or tiny self-assembling vesible used to stabilize actives like vitamin c or retinol. This helps these ingredients integrate into the upper layers of skin more easily.
Phospholipids are compatible with everything and the CIR Expert Panel has concluded them to be safe at current use levels.
Some types of phospholipids include:
Polysorbate 20 is a gentle, water-soluble emulsifier and mild surfactant. It stops oil and water from separating to keep your formulas blended and stable.
It also acts as a mild penetration enhancer by helping active ingredients absorb slightly better.
The common safety discussion around this ingredient involves a manufacturing byproduct called 1,4-dioxane.
Trace amounts can form during production but the EU's Scientific Committee on Consumer Safety has concluded that levels at/below 10 ppm in finished products are safe (commercial products consistently fall within acceptable margins).
True allergic reactions are uncommon and the CIR Expert Panel has confirmed this ingredient to be safe as used in cosmetics.
Because it is derived from lauric acid, it may not be fungal acne safe.
Propanediol is an all-star ingredient. It softens, hydrates, and smooths the skin.
It’s often used to:
Propanediol is not likely to cause sensitivity and considered safe to use. It is derived from corn or petroleum with a clear color and no scent.
Sodium Benzoate is a preservative. It's used in both cosmetic and food products to inhibit the growth of mold and bacteria. It is typically produced synthetically.
Both the US FDA and EU Health Committee have approved the use of sodium benzoate. In the US, levels of 0.1% (of the total product) are allowed.
Sodium benzoate works as a preservative by inhibiting the growth of bacteria inside of cells. It prevents the cell from fermenting a type of sugar using an enzyme called phosphofructokinase.
It is the salt of benzoic acid. Foods containing sodium benzoate include soda, salad dressings, condiments, fruit juices, wines, and snack foods.
Studies for using ascorbic acid and sodium benzoate in cosmetics are lacking, especially in skincare routines with multiple steps.
We always recommend speaking with a professional, such as a dermatologist, if you have any concerns.
Sodium Hyaluronate is the salt form of hyaluronic acid. It is a long sugar chain that is naturally found in your skin, joints, and connective tissue that maintains hydration and elasticity.
In skincare, it works as a humectant. It pulls water from the environment and deeper layers of skin and binds it to the surface.
Interestingly, the size of the molecule affects its behavior:
Some clinical evidence links low molecular weight versions to improved wrinkle depth, elasticity, anti-inflammatory effects, and barrier repair.
Many serums use a blend of both weights so you can get surface hydration plus longer-lasting and deeper effects.
You'll typically see concentrations between 0.1-2% for this ingredient.
Sodium Hydroxide is also known as lye or caustic soda. It is used to adjust the pH of products; many ingredients require a specific pH to be effective.
In small amounts, sodium hydroxide is considered safe to use. However, large amounts may cause chemical burns due to its high alkaline.
Your skin has a natural pH and acid mantle. This acid mantle helps prevent harmful bacteria from breaking through. The acid mantle also helps keep your skin hydrated.
"Alkaline" refers to a high pH level. A low pH level would be considered acidic.
Tocopherol is a fat-soluble antioxidant known as Vitamin E.
You'll find this ingredient in the vast majority of skincare (for good reason). It works to neutralize free radicals, or unstable molecules generated by UV exposure, pollution, and other environmental stressors, before they can cause oxidative damage to your skin cells.
Topically applied tocopherol has been shown to protect against UV damage by ramping up the skin's own natural defense enzymes.
It also acts as a skin conditioning agent; some studies show that regular topical use can improve the skin's water-binding capacity over 2-4 weeks.
This ingredient is especially loved for being a team player. When combined with Vitamin C, the photoprotective effect of both ingredients roughly doubles and the combo also helps reduce UV-induced DNA damage.
This ingredient has some brightening potential but it's more of a prevention ingredient than spot-fader. Cell studies show it can slow down melanin production but it's worth noting that it's not the most powerful brightener out there.
In formulations, it also serves as a stabilizer that helps protect other oxidation-prone ingredients from degrading.
Concentrations usually range from 0.1-1% in most leave-on products.
Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.
So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.
You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!
Xanthan gum is used as a stabilizer and thickener within cosmetic products. It helps give products a sticky, thick feeling - preventing them from being too runny.
On the technical side of things, xanthan gum is a polysaccharide - a combination consisting of multiple sugar molecules bonded together.
Xanthan gum is a pretty common and great ingredient. It is a natural, non-toxic, non-irritating ingredient that is also commonly used in food products.