Dermorepubliq 5% Potassium Azeloyl Diglycinate + 2% Niacinamide + Hyaluronic Acid Serum Versus Anua Azelaic Acid 15+ Intense Calming Serum

Dermorepubliq 5% Potassium Azeloyl Diglycinate + 2% Niacinamide + Hyaluronic Acid Serum Versus Anua Azelaic Acid 15+ Intense Calming Serum

This calming serum is formulated around Potassium Azeloyl Diglycinate and Niacinamide to calm redness and fade the look of dark spots.

This calming serum is formulated around Azelaic Acid and Centella Asiatica Extract to calm redness and clear breakouts.

What's inside

Key Ingredients

Benefits

Concerns

Ingredients Side-by-side

Water

Potassium Azeloyl Diglycinate

Propylene Glycol

Niacinamide

Centella Asiatica Leaf

Extracts

Snail Secretion Filtrate

Glycerin

Ethylhexylglycerin

Phenoxyethanol

Hamamelis Virginiana Leaf Extract

Hydroxyethylcellulose

Sodium Hyaluronate

Allantoin

Water, Potassium Azeloyl Diglycinate, Propylene Glycol, Niacinamide, Centella Asiatica Leaf, Extracts, Snail Secretion Filtrate, Glycerin, Ethylhexylglycerin, Phenoxyethanol, Hamamelis Virginiana Leaf Extract, Hydroxyethylcellulose, Sodium Hyaluronate, Allantoin

Azelaic Acid

Sodium Hydroxide

1,2-Hexanediol

Centella Asiatica Extract

Dipropylene Glycol

Butylene Glycol

Panthenol

Melia Azadirachta Leaf Extract

Salicylic Acid

Biosaccharide Gum-1

Dipotassium Glycyrrhizate

Melia Azadirachta Flower Extract

Melaleuca Alternifolia Leaf Oil

Succinic Acid

Totarol

Beta-Glucan

Dextrin

Theobroma Cacao Extract

Centella Asiatica Leaf Extract

Centella Asiatica Root Extract

Madecassoside

Asiaticoside

Asiatic Acid

Madecassic Acid

Tocopherol

Squalane

Zinc PCA

Chlorella Vulgaris Extract

Ceramide NP

Sodium Hyaluronate Dimethylsilanol

Hydrolyzed Hyaluronic Acid

Hydrolyzed Sodium Hyaluronate

Hyaluronic Acid

Potassium Hyaluronate

Hydroxypropyltrimonium Hyaluronate

Sodium Hyaluronate Crosspolymer

Sodium Acetylated Hyaluronate

Water, Propylene Glycol, Azelaic Acid, Sodium Hydroxide, 1,2-Hexanediol, Centella Asiatica Extract, Dipropylene Glycol, Butylene Glycol, Panthenol, Hydroxyethylcellulose, Glycerin, Ethylhexylglycerin, Melia Azadirachta Leaf Extract, Salicylic Acid, Biosaccharide Gum-1, Allantoin, Dipotassium Glycyrrhizate, Melia Azadirachta Flower Extract, Sodium Hyaluronate, Melaleuca Alternifolia Leaf Oil, Succinic Acid, Totarol, Beta-Glucan, Dextrin, Theobroma Cacao Extract, Centella Asiatica Leaf Extract, Centella Asiatica Root Extract, Madecassoside, Asiaticoside, Asiatic Acid, Madecassic Acid, Tocopherol, Squalane, Zinc PCA, Chlorella Vulgaris Extract, Ceramide NP, Sodium Hyaluronate Dimethylsilanol, Hydrolyzed Hyaluronic Acid, Hydrolyzed Sodium Hyaluronate, Hyaluronic Acid, Potassium Hyaluronate, Hydroxypropyltrimonium Hyaluronate, Sodium Hyaluronate Crosspolymer, Sodium Acetylated Hyaluronate

Reviews

Alternatives

Ingredients Explained

These ingredients are found in both products.

Ingredients higher up in an ingredient list are typically present in a larger amount.

Allantoin is a soothing ingredient known for its protective and moisturizing properties; it's basically a quiet workhorse ingredient you can find in a huge range of cosmetics.

Though it can be derived from the comfrey plant, allantoin is produced synthetically for cosmetic products to ensure purity.

Research shows it can encourage your skin cells to turn over and renew by stimulating keratinocyte and fibroblast proliferation.

It also has mild keratolytic properties to help loosen and shed dead skin cells without being harsh.

Studies also suggest allantoin can help calm inflammation by dialing down some of the chemical signals your skin sends out when it is irritated.

This ingredient is typically used in the 0.1-0.5% range, and the FDA recognizes it as a skin protectant in OTC products up to 2%.

Overall, allantoin is a wonderful addition to most routines; it is stable across a wide pH range (~4-8), works well with other ingredients, and is considered non-sensitizing/non-irritating.

Fun fact: Allantoin is naturally occurring in comfrey root, beets, chamomile, and wheat sprouts. Our bodies even produce it as a byproduct of uric acid metabolism.

Ethylhexylglycerin is created from glycerin. It is a multitasker ingredient that:

The CIR Expert Panel found minimal skin absorption or sensitization of any kind in a safety assessment. Though this ingredient is considered well-tolerated, a small number of cases of allergic dermatitis have been published since 2002. Just be sure to patch test if you are unsure.

Industry-reported use ranges from 8% in rinse-off products and 2% in leave-on formulations.

Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.

Topically, glycerin does several things at once:

Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.

Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.

This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.

Just know very high concentrations (>40%) can feel tacky in low humidity.

Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.

Hydroxyethylcellulose is used to improve the texture of products. It is created from a chemical reaction involving ethylene oxide and alkali-cellulose. Cellulose is a sugar found in plant cell walls and help give plants structure.

This ingredient helps stabilize products by preventing ingredients from separating. It can also help thicken the texture of a product.

This ingredient can also be found in pill medicines to help our bodies digest other ingredients.

Propylene Glycol is a synthetic, colorless, odorless liquid that has been a staple in cosmetics for decades. It is a skin conditioning agent, humectant, and solvent.

As a humectant, it draw water to the skin to reduce flaking and restore suppleness. It's also a solvent that helps dissolve other actives and keeps formulas stable across temperature changes.

The CIR Expert Panel has confirmed this ingredient to be nontoxic and clinical studies show no sensitization at cosmetic use concentrations.

True allergic reactions are quite rare: a 15-year retrospective study of 6,751 patients found only 0.31% had a positive reaction (and less than half were considered clinically relevant).

It seemed that when sensitization does occur, it's most commonly linked to topical medication (like corticosteroids) and not cosmetics. Allergic contact dermatitis also appears largely limited to individuals with underlying skin conditions.

Overall, propylene glycol is a well-studied ingredient that most people can tolerate without issue.

Sodium Hyaluronate is the salt form of hyaluronic acid. It is a long sugar chain that is naturally found in your skin, joints, and connective tissue that maintains hydration and elasticity.

In skincare, it works as a humectant. It pulls water from the environment and deeper layers of skin and binds it to the surface.

Interestingly, the size of the molecule affects its behavior:

Some clinical evidence links low molecular weight versions to improved wrinkle depth, elasticity, anti-inflammatory effects, and barrier repair.

Many serums use a blend of both weights so you can get surface hydration plus longer-lasting and deeper effects.

You'll typically see concentrations between 0.1-2% for this ingredient.

Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.

So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.

You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!

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