Skin science article
Dermorepubliq 5% Potassium Azeloyl Diglycinate + 2% Niacinamide + Hyaluronic Acid Serum Versus Ellana Mineral Cosmetics Clear Clarifying Skin Serum
Dermorepubliq 5% Potassium Azeloyl Diglycinate + 2% Niacinamide + Hyaluronic Acid Serum Versus Ellana Mineral Cosmetics Clear Clarifying Skin Serum This calming serum is formulated around Potassium Azeloyl Diglycinate and Niacinamide to calm redness and fade t
Dermorepubliq 5% Potassium Azeloyl Diglycinate + 2% Niacinamide + Hyaluronic Acid Serum Versus Ellana Mineral Cosmetics Clear Clarifying Skin Serum
This calming serum is formulated around Potassium Azeloyl Diglycinate and Niacinamide to calm redness and fade the look of dark spots.
This calming serum is formulated around Potassium Azeloyl Diglycinate and Centella Asiatica Extract to calm redness and balance excess oil.
What's inside
Key Ingredients
Benefits
Concerns
No concerns
Ingredients Side-by-side
Water
Potassium Azeloyl Diglycinate
Propylene Glycol
Niacinamide
Centella Asiatica Leaf
Extracts
Snail Secretion Filtrate
Glycerin
Ethylhexylglycerin
Phenoxyethanol
Hamamelis Virginiana Leaf Extract
Hydroxyethylcellulose
Sodium Hyaluronate
Allantoin
Water, Potassium Azeloyl Diglycinate, Propylene Glycol, Niacinamide, Centella Asiatica Leaf, Extracts, Snail Secretion Filtrate, Glycerin, Ethylhexylglycerin, Phenoxyethanol, Hamamelis Virginiana Leaf Extract, Hydroxyethylcellulose, Sodium Hyaluronate, Allantoin
Sodium Lactate
Sodium Glutamate
Butylene Glycol
Centella Asiatica Extract
Polygonum Cuspidatum Root Extract
Scutellaria Baicalensis Root Extract
Camellia Sinensis Leaf Extract
Glycyrrhiza Glabra Root Extract
Chamomilla Recutita Flower Extract
Rosmarinus Officinalis Leaf Extract
Xanthan Gum
Sodium Citrate
Water, Potassium Azeloyl Diglycinate, Sodium Lactate, Sodium Glutamate, Butylene Glycol, Centella Asiatica Extract, Polygonum Cuspidatum Root Extract, Scutellaria Baicalensis Root Extract, Camellia Sinensis Leaf Extract, Glycyrrhiza Glabra Root Extract, Chamomilla Recutita Flower Extract, Rosmarinus Officinalis Leaf Extract, Xanthan Gum, Ethylhexylglycerin, Phenoxyethanol, Allantoin, Sodium Citrate
Reviews
Alternatives
Ingredients Explained
These ingredients are found in both products.
Ingredients higher up in an ingredient list are typically present in a larger amount.
Allantoin is a soothing ingredient known for its protective and moisturizing properties; it's basically a quiet workhorse ingredient you can find in a huge range of cosmetics.
Though it can be derived from the comfrey plant, allantoin is produced synthetically for cosmetic products to ensure purity.
Research shows it can encourage your skin cells to turn over and renew by stimulating keratinocyte and fibroblast proliferation.
It also has mild keratolytic properties to help loosen and shed dead skin cells without being harsh.
Studies also suggest allantoin can help calm inflammation by dialing down some of the chemical signals your skin sends out when it is irritated.
This ingredient is typically used in the 0.1-0.5% range, and the FDA recognizes it as a skin protectant in OTC products up to 2%.
Overall, allantoin is a wonderful addition to most routines; it is stable across a wide pH range (~4-8), works well with other ingredients, and is considered non-sensitizing/non-irritating.
Fun fact: Allantoin is naturally occurring in comfrey root, beets, chamomile, and wheat sprouts. Our bodies even produce it as a byproduct of uric acid metabolism.
Ethylhexylglycerin is created from glycerin. It is a multitasker ingredient that:
The CIR Expert Panel found minimal skin absorption or sensitization of any kind in a safety assessment. Though this ingredient is considered well-tolerated, a small number of cases of allergic dermatitis have been published since 2002. Just be sure to patch test if you are unsure.
Industry-reported use ranges from 8% in rinse-off products and 2% in leave-on formulations.
Phenoxyethanol is one of the most widely used preservatives in skincare (and for good reason!).
It has a large spectrum of antimicrobial activity and especially effective bacteria, yeast, and mold while only having a weak effect on your skin's natural microbiome.
On a cellular level, it disrupts the cell membranes of microbes by poking holes that make the cell leak. This shuts down the chemical reactions the microbe needs to make energy so it can no longer survive.
Another perk of this ingredient is that it stays functional across a wide pH range (3-10).
You'll often see it paired with boosters like Ethylhexylglycerin; one study showed that a 1:9 ratio of Ethylhexylglycerin to Phenoxyethanol damages bacterial membranes as effectively as doubling the Phenoxyethanol concentration on its own.
Typical use concentrations range from 0.3-1% depending on the formula, and this ingredient is capped at 1% int the EU.
Safety-wise, the fear mongering does not hold up to the evidence. The EU's Scientific Committee on Consumer Safety and FDA consider it safe as a preservative at up to 1%, including for children of all ages.
Adverse systemic effects only showed up in animal studies at exposures roughly 200x higher than what people get from cosmetics. And despite its very widespread use, this ingredient is a rare sensitizer and allergic reactions are uncommon.
Potassium Azeloyl Diglycinate (PAD) comes from the condensation of azelaic acid mixed with glycine.
This ingredient has similar properties to azelaic acid; it can help reduce sebum production and soothe skin. PAD also inhibits tyrosinase activity to help brighten skin. Tyrosinase is an enzyme that controls melanin production.
A study from 2023 found 5% PAD combined with nicotinamide (a form of niacin) effectively reduced melanin production after 6 weeks.
Several studies from the 2010's also show PAD to be effective in alleviating symptoms of Rosacea.
Though this ingredient is considered a gentle active, higher amounts may result in irritation.
Unlike azelaic acid, this ingredient is water-soluble. This property makes it easier to formulate into skincare products.
Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.
So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.
You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!