Skin science article
Dieux Skin Instant Angel Versus Paula's Choice Resist Intensive Repair Cream
Dieux Skin Instant Angel Versus Paula's Choice Resist Intensive Repair Cream This barrier-repair moisturizer is formulated around Squalane and Linoleic Acid to strengthen the skin barrier and hydrate skin. This anti-aging moisturizer is formulated around Retin
Dieux Skin Instant Angel Versus Paula's Choice Resist Intensive Repair Cream
This barrier-repair moisturizer is formulated around Squalane and Linoleic Acid to strengthen the skin barrier and hydrate skin.
This anti-aging moisturizer is formulated around Retinol and Simmondsia Chinensis Seed Oil to soften the look of wrinkles and hydrate skin.
What's inside
Key Ingredients
Benefits
Concerns
Ingredients Side-by-side
Water
Glycerin
Squalane
Caprylic/Capric Triglyceride
Coconut Alkanes
Glyceryl Stearate
Meadowfoam Estolide
PEG-100 Stearate
Cetearyl Alcohol
C12-15 Alkyl Benzoate
Phytosteryl Macadamiate
Triheptanoin
Coco-Caprylate/Caprate
Methylpropanediol
Linoleic Acid
Phospholipids
Phytosterols
Sodium Polyacrylate
Tribehenin
Caprylyl Glycol
Phenoxyethanol
Dipalmitoyl Hydroxyproline
Sodium PCA
Urea
Dilinoleic Acid/Butanediol Copolymer
Hydroxyproline Palmitamide
Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer
Isohexadecane
Ceramide Ng
Trehalose
Sodium Phytate
PEG-10 Phytosterol
Hexylene Glycol
Polysorbate 60
Palmitic Acid
Lactic Acid
Polyquaternium-51
Tocopherol
Triacetin
Castor Oil/Ipdi Copolymer
Sorbitan Isostearate
Sodium Hyaluronate
Palmitoyl Hexapeptide-12
Water, Glycerin, Squalane, Caprylic/Capric Triglyceride, Coconut Alkanes, Glyceryl Stearate, Meadowfoam Estolide, PEG-100 Stearate, Cetearyl Alcohol, C12-15 Alkyl Benzoate, Phytosteryl Macadamiate, Triheptanoin, Coco-Caprylate/Caprate, Methylpropanediol, Linoleic Acid, Phospholipids, Phytosterols, Sodium Polyacrylate, Tribehenin, Caprylyl Glycol, Phenoxyethanol, Dipalmitoyl Hydroxyproline, Sodium PCA, Urea, Dilinoleic Acid/Butanediol Copolymer, Hydroxyproline Palmitamide, Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, Isohexadecane, Ceramide Ng, Trehalose, Sodium Phytate, PEG-10 Phytosterol, Hexylene Glycol, Polysorbate 60, Palmitic Acid, Lactic Acid, Polyquaternium-51, Tocopherol, Triacetin, Castor Oil/Ipdi Copolymer, Sorbitan Isostearate, Sodium Hyaluronate, Palmitoyl Hexapeptide-12
Ethylhexyl Stearate
Simmondsia Chinensis Seed Oil
Butylene Glycol
Petrolatum
Dimethicone
Dipentaerythrityl Hexacaprylate/Hexacaprate
Tridecyl Trimellitate
Phenyl Trimethicone
Retinol
Adenosine
Palmitoyl Tetrapeptide-7
Palmitoyl Tripeptide-1
Magnesium Ascorbyl Phosphate
Niacinamide
Lecithin
Linolenic Acid
Retinyl Palmitate
Glycyrrhiza Glabra Root Extract
Camellia Oleifera Leaf Extract
Citrullus Lanatus Fruit Extract
Lens Esculenta Fruit Extract
Pyrus Malus Fruit Extract
Glycine Soja Sterols
Magnesium Aluminum Silicate
Sodium Lactate
Pullulan
Xanthan Gum
Sodium Hydroxide
Neopentyl Glycol Dicaprylate/Dicaprate
Cetearyl Glucoside
Tridecyl Stearate
Behenyl Alcohol
Sclerotium Gum
Carbomer
Polysorbate 20
Disodium EDTA
Sorbic Acid
Chlorphenesin
Benzoic Acid
Water, Ethylhexyl Stearate, Simmondsia Chinensis Seed Oil, Butylene Glycol, Glycerin, Caprylic/Capric Triglyceride, Petrolatum, Cetearyl Alcohol, Dimethicone, Dipentaerythrityl Hexacaprylate/Hexacaprate, Glyceryl Stearate, Tridecyl Trimellitate, PEG-100 Stearate, Phenyl Trimethicone, Retinol, Adenosine, Palmitoyl Tetrapeptide-7, Palmitoyl Hexapeptide-12, Palmitoyl Tripeptide-1, Ceramide Ng, Sodium Hyaluronate, Magnesium Ascorbyl Phosphate, Niacinamide, Tocopherol, Lecithin, Linoleic Acid, Linolenic Acid, Retinyl Palmitate, Glycyrrhiza Glabra Root Extract, Camellia Oleifera Leaf Extract, Citrullus Lanatus Fruit Extract, Lens Esculenta Fruit Extract, Pyrus Malus Fruit Extract, Glycine Soja Sterols, Tribehenin, PEG-10 Phytosterol, Magnesium Aluminum Silicate, Sodium PCA, Sodium Lactate, Pullulan, Xanthan Gum, Sodium Hydroxide, Neopentyl Glycol Dicaprylate/Dicaprate, Cetearyl Glucoside, Tridecyl Stearate, Behenyl Alcohol, Sclerotium Gum, Carbomer, C12-15 Alkyl Benzoate, Polysorbate 20, Disodium EDTA, Sorbic Acid, Phenoxyethanol, Chlorphenesin, Benzoic Acid
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Alternatives
Ingredients Explained
These ingredients are found in both products.
Ingredients higher up in an ingredient list are typically present in a larger amount.
C12-15 Alkyl Benzoate is a lightweight emollient made by combinig benzoic acid with fatty alcohols that are 12-15 carbons long.
In cosmetics, it plays several roles:
The Cosmetic Review Expert Panel has concluded the alkyl benzoate group to be safe as used in cosmetics; it wasn't found to be a skin irritant and unlikely to be absorbed due to its low water solubility.
This report recorded almost 1000 reported uses with concentrations up to 59% in leave-on products but your cosmetics will typically use 0.5-15% depending on the product.
It's often called a "SPF booster": this is because it keeps UV filters properly dissolved and evenly distributed to support a sunscreen's performance. It doesn't actually raise SPF on its own.
Overall, this ingredient is well tolerated.
This ingredient is fungal acne safe because it is an ester of benzoic acid.
Think of this ingredient as two parts stuck together: an oily part and an acid part. Malassezia only gets a meal when it can snip off a fatty acid to eat. With C12-15 Alkyl Benzoate, the acid part is benzoic acid, which isn't a fatty acid and which the yeast can't use as food.
Benzoic acid is actually used as a preservative to stop yeast from growing.
The oily part is a blend of C12-15 fatty alcohols but fatty alcohols in this size range can support only a little Malassezia growth (mostly for one species of Malassezia as well).
In the ingredient, those alcohols stay locked inside the molecule. The yeast can only reach them by snipping the benzoate bond, and that type of bond is harder for it to cut than a normal fatty bond.
So not much gets released. And whatever does get snipped comes packaged with benzoic acid, which discourages yeast growth.
Caprylic/Capric Triglyceride (aka MCT Oil) is a lightweight emollient, solvent, and texture enhancer. It is considered a skin-softener by helping to prevent moisture loss.
Though it behaves like an oil, it is not technically one due to its chemical composition. One perk of this ingredient is that it is very stable, resistant to oxidation, and unlikely to go rancid.
In practice, that translates to a long shelf life and a consistently elegant skin feel.
While there is an assumption Caprylic Triglyceride can clog pores due to it being derived from coconut oil, there is no research supporting this. Just patch test if you have concerns.
Fractionated coconut oil and MCT Oil are both listed as Caprylic/Capric Triglyceride according to INCI. This is because INCI names are based on the ingredient’s final chemical composition and not its marketing name or source.
This ingredient is treated as the gold standard fungal acne safe oil. Even though it is coconut derived, the problematic lauric acid is stripped out.
This leaves just caprylic (C8) and capric (C10) acid. These chain lengths actually trend antifungal; a 2020 study found caprylic acid was enough to disrupt Malassezia furfur cell membrane, with a caprylic acid derivative damaging membrane structures at concentrations as low as 0.2%.
Ceramide NG is a type of Ceramide. The NG stands for a sphinganine base.
Ceramides are intercellular lipids naturally found in our skin that bonds dead skin cells together to create a barrier. They are known for their ability to hold water and thus are a great ingredient for dry skin.
Ceramides are an important building block for our skin barrier. A stronger barrier helps the skin look more firm and hydrated. By bolstering the skin ceramides act as a barrier against irritating ingredients. This can help with inflammation as well.
If you would like to eat ceramides, sweet potatoes contain a small amount.
Read more about other common types of ceramides here: Ceramide AP Ceramide EOP Ceramide NP
Cetearyl alcohol is a waxy mixture of two fatty alcohols: cetyl alcohol and stearyl alcohol. It is an emollient and emulsifier.
Despite having "alcohol" in its name, it has nothing to do with drying solvent alcohols; the FDA also allows "alcohol-free" products to contain fatty alcohols like this ingredient.
It plays several roles in a formula:
Typical use levels for this ingredient sit around 1-10% and the Cosmetic Ingredient Review Expert Panel has affirmed safety at concentrations up to 25% in leave-on products.
Multiple assessments have found it to be non-irritating and non-sensitizing to most people.
However, there have been some cases of allergic contact dermatitis in patients with chronically compromised skin barriers.
Cetearyl alcohol has a comedogenic rating of 2 and irritancy rating of 1. Both of these numbers come from the 1989 study that used rabbit ears; a "2" means mildly comedogenic and a "1" means low irritancy.
Here's the catch: rabbit skin is more sensitive than human skin and throws a lot of false positives. A 1996 reappraisal found that ingredients rated 1-2 in the rabbit ear tests are generally safe for humans.
Remember comedogenic ratings are unable to assess the entire formula of a product or how it will react on your skin. Just be sure to patch test if you are unsure about certain ingredients.
This ingredient is not fungal acne safe. Cetearyl alcohol is a fatty alcohol with chain lengths that fall within the range that Malassezia can metabolize.
A 2019 study has also observed Malassezia growth in the presence of this ingredient, confirming it to be not-fungal acne safe.
Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.
Topically, glycerin does several things at once:
Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.
Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.
This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.
Just know very high concentrations (>40%) can feel tacky in low humidity.
Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.
Glyceryl Stearate is made by reacting glycerin with stearic acid (typically sourced from plant oils like palm or coconut). It's an emulsifier, emollient, and mild occlusive.
Emulsifiers help ingredients like oil and water stay mixed so your formula stays nicely blended and uniform in texture.
This ingredient is typically used in concentrations between 1-10%. Studies have found it to be non-sensitizing, non-phototoxic, and non-photoallergenic.
A close cousin of this ingredient is Glyceryl Stearate SE ("self-emulsifying"). This just has a small amount of sodium or potassium stearate added so it can emulsify without a co-emulsifier.
Since this ingredient is an ester of a C18 fatty acid, it may not be fungal acne safe. The Malassezia yeast can potentially metabolize within the C11-C24 range.
Fun fact: The human body also creates Glyceryl Stearate naturally.
Linoleic Acid is also known as Vitamin F. It is a fatty acid with emollient and skin conditioning properties.
Our top layer of skin, or epidermis, naturally contains high amounts of linoleic acid.
Your body uses linoleic acid to build ceramides and prostaglandins. Ceramides keep your skin's barrier hydrated and strong while prosaglandins help control inflammation and healing.
Needless to say, linoleic acid is crucial for having a strong skin barrier.
One study found applying linoleic acid rich sunflower oil to be more effective at repairing the skin barrier than olive oil.
This ingredient can also help treat acne by softening sebum to prevent clogged pores. Another study found using 2.5% linoleic acid gel for 4 weeks showed a 25% reduction in small comedones.
Studies show it can also help lighten hyperpigmentation or sun spots by disrupting the melanin production process. It also helps your skin shed melanin pigment from your skin caused by UV exposure.
Due to its role in the production of the fatty acid prostaglandin, linoleic acid can also help reduce inflammation and support wound healing.
Fun fact: Linoleic acid is an essential fatty acid. This means our bodies cannot create it on its own and we need to get it through foods such as nuts and vegetable oils.
Just know this ingredient is not always fungal-acne safe because it is a long-chain fatty acid (with 18 carbon atoms) that directly feeds the Malassezia yeast responsible for fungal acne.
Palmitoyl Hexapeptide-12 is a synthetic lipopeptide. This just means it's a short chain of six amino acids with a palmitic acid molecule attached to one end.
The palmitoyl group increases the lipophilicity, helping it penetrate the lipid-rich outer layer of skin more effectively.
Once inside, it helps with keeping skin springy and firm. It works by mimicking the skin repair signals your skin naturally sends out when it's damaged and telling it to kick into rebuild mode.
Studies have shown it can help strengthen the skin barrier as well so it's useful beyond just anti-aging.
In vitro studies suggest it can switch on genes that help skin cells grow, move around, and rebuild skin structure. Just keep in mind most of the strong evidence is from lab studies rather than large-scale clinical trials.
Lab studies suggest it can switch on genes that help skin cells grow, move around, and rebuild skin structure.
This ingredient is usually used at very low concentrations (0.002% in leave-on products).
Fungal acne note: Usually a palmitic acid component can feed Malassezia in unbound form, but here is is covalently bonded to the peptide. This means it is very difficult for Malassezia to access, and therefore very unlikely to cause fungal acne.
We don't have a description for PEG-10 Phytosterol yet.
Peg-100 Stearate is an emollient and emulsifier. As an emollient, it helps keep skin soft by trapping moisture in. On the other hand, emulsifiers help prevent oil and water from separating in a product.
PEGS are a hydrophilic polyether compound . There are 100 ethylene oxide monomers in Peg-100 Stearate. Peg-100 Stearate is polyethylene glycol ester of stearic acid.
Phenoxyethanol is one of the most widely used preservatives in skincare (and for good reason!).
It has a large spectrum of antimicrobial activity and especially effective bacteria, yeast, and mold while only having a weak effect on your skin's natural microbiome.
On a cellular level, it disrupts the cell membranes of microbes by poking holes that make the cell leak. This shuts down the chemical reactions the microbe needs to make energy so it can no longer survive.
Another perk of this ingredient is that it stays functional across a wide pH range (3-10).
You'll often see it paired with boosters like Ethylhexylglycerin; one study showed that a 1:9 ratio of Ethylhexylglycerin to Phenoxyethanol damages bacterial membranes as effectively as doubling the Phenoxyethanol concentration on its own.
Typical use concentrations range from 0.3-1% depending on the formula, and this ingredient is capped at 1% int the EU.
Safety-wise, the fear mongering does not hold up to the evidence. The EU's Scientific Committee on Consumer Safety and FDA consider it safe as a preservative at up to 1%, including for children of all ages.
Adverse systemic effects only showed up in animal studies at exposures roughly 200x higher than what people get from cosmetics. And despite its very widespread use, this ingredient is a rare sensitizer and allergic reactions are uncommon.
Sodium Hyaluronate is the salt form of hyaluronic acid. It is a long sugar chain that is naturally found in your skin, joints, and connective tissue that maintains hydration and elasticity.
In skincare, it works as a humectant. It pulls water from the environment and deeper layers of skin and binds it to the surface.
Interestingly, the size of the molecule affects its behavior:
Some clinical evidence links low molecular weight versions to improved wrinkle depth, elasticity, anti-inflammatory effects, and barrier repair.
Many serums use a blend of both weights so you can get surface hydration plus longer-lasting and deeper effects.
You'll typically see concentrations between 0.1-2% for this ingredient.
Sodium PCA (the salt of PCA) is one of the most well-established humectants in skincare.
Why is it so special? Your skin already makes it naturally; it's a natural component of your skin's Natural Moisturizing Factor (NMF), or the mix of water-binding compounds inside your skin cells that keeps things soft and hydrated.
As a cosmetic ingredient, it grabs water and holds it in the upper layers of skin to smooth roughness and ease dehydration.
There's some clinical support for the NMF approach with a study showing that a cream built to mimic the skin's NMF significantly boosted hydration.
Safety-wise, this ingredient non-irritating, non-comedogenic, and non-phototoxic in testing, with minimal skin absorption.
It also works really well with other hydrators like glycerin or hyaluronic acid, and typical usage is somewhere between 0.2-4%.
Tocopherol is a fat-soluble antioxidant known as Vitamin E.
You'll find this ingredient in the vast majority of skincare (for good reason). It works to neutralize free radicals, or unstable molecules generated by UV exposure, pollution, and other environmental stressors, before they can cause oxidative damage to your skin cells.
Topically applied tocopherol has been shown to protect against UV damage by ramping up the skin's own natural defense enzymes.
It also acts as a skin conditioning agent; some studies show that regular topical use can improve the skin's water-binding capacity over 2-4 weeks.
This ingredient is especially loved for being a team player. When combined with Vitamin C, the photoprotective effect of both ingredients roughly doubles and the combo also helps reduce UV-induced DNA damage.
This ingredient has some brightening potential but it's more of a prevention ingredient than spot-fader. Cell studies show it can slow down melanin production but it's worth noting that it's not the most powerful brightener out there.
In formulations, it also serves as a stabilizer that helps protect other oxidation-prone ingredients from degrading.
Concentrations usually range from 0.1-1% in most leave-on products.
Tribehenin is the triglyceride of glycerin and behenic acid. It is an emollient that helps soften and condition skin.
Safety-wise, this is a well-vetted ingredient. Repeated-insult patch tests of 0.38% tribehenin did not trigger sensitization.
This ingredient may not be fungal acne safe because behenic acid falls into the chain-length range that Malassezia yeasts can feed on.
Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.
So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.
You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!