Skin science article
Differin Daily Refreshing Cleanser Versus Paula's Choice Clear Pore Normalizing Cleanser
Differin Daily Refreshing Cleanser Versus Paula's Choice Clear Pore Normalizing Cleanser This salicylic acid gel cleanser is formulated around Salicylic Acid to clear breakouts and unclog pores. What's inside Key Ingredients No key ingredients Benefits Concern
Differin Daily Refreshing Cleanser Versus Paula's Choice Clear Pore Normalizing Cleanser
This salicylic acid gel cleanser is formulated around Salicylic Acid to clear breakouts and unclog pores.
What's inside
Key Ingredients
No key ingredients
Benefits
Concerns
Ingredients Side-by-side
Water
Glycerin
PEG-200 Hydrogenated Glyceryl Palmate
Butylene Glycol
Sodium Lauroyl Sarcosinate
Acrylates/Steareth-20 Methacrylate Copolymer
PEG-7 Glyceryl Cocoate
Sodium Laureth Sulfate
Phenoxyethanol
Methylparaben
Disodium EDTA
PEG-60 Hydrogenated Castor Oil
Panthenol
Parfum
Water, Glycerin, PEG-200 Hydrogenated Glyceryl Palmate, Butylene Glycol, Sodium Lauroyl Sarcosinate, Acrylates/Steareth-20 Methacrylate Copolymer, PEG-7 Glyceryl Cocoate, Sodium Laureth Sulfate, Phenoxyethanol, Methylparaben, Disodium EDTA, PEG-60 Hydrogenated Castor Oil, Panthenol, Parfum
Salicylic Acid
Arginine
Citric Acid
Sodium Citrate
Caprylyl Glycol
Chlorphenesin
Salicylic Acid, Water, Sodium Lauroyl Sarcosinate, Acrylates/Steareth-20 Methacrylate Copolymer, Glycerin, PEG-200 Hydrogenated Glyceryl Palmate, Sodium Laureth Sulfate, Arginine, Butylene Glycol, PEG-7 Glyceryl Cocoate, Panthenol, Disodium EDTA, Citric Acid, PEG-60 Hydrogenated Castor Oil, Sodium Citrate, Phenoxyethanol, Caprylyl Glycol, Chlorphenesin
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Alternatives
Ingredients Explained
These ingredients are found in both products.
Ingredients higher up in an ingredient list are typically present in a larger amount.
We don't have a description for Acrylates/Steareth-20 Methacrylate Copolymer yet.
Butylene Glycol (or BG) is used within cosmetic products for a few different reasons:
Overall, Butylene Glycol is a safe and well-rounded ingredient that works well with other ingredients.
Though this ingredient works well with most skin types, some people with sensitive skin may experience a reaction such as allergic rashes, closed comedones, or itchiness.
Disodium EDTA is a chelating agent. It grabs onto and deactivates metal ions that sneak into your products from water, packaging, or air.
This ingredient mainly works behind the scenes and helps with:
On top of that, this ingredient can counteract the effects of hard water by binding to the minerals in it.
One thing worth knowing is that Disodium EDTA has been shown to be a mild penetration enhancer. It can help other ingredients absorb into skin more effectively which can be a double-edged sword (great for actives, but can also make the active too strong if you have sensitive skin).
Clinical patch testing showed no significant skin irritation at typical use concentrations and minimal dermal absorption.
You'll most likely see this ingredient near the end of an ingredient list. It's typically found in concentrations less than 1%.
Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.
Topically, glycerin does several things at once:
Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.
Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.
This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.
Just know very high concentrations (>40%) can feel tacky in low humidity.
Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.
Panthenol is a common ingredient that helps hydrate and soothe the skin. It is found naturally in our skin and hair.
There are two forms of panthenol: D and L.
D-panthenol is also known as dexpanthenol. Most cosmetics use dexpanthenol or a mixture of D and L-panthenol.
Panthenol is famous due to its ability to go deeper into the skin's layers. Using this ingredient has numerous pros (and no cons):
Like hyaluronic acid, panthenol is a humectant. Humectants are able to bind and hold large amounts of water to keep skin hydrated.
This ingredient works well for wound healing. It works by increasing tissue in the wound and helps close open wounds.
Once oxidized, panthenol converts to pantothenic acid. Panthothenic acid is found in all living cells.
This ingredient is also referred to as pro-vitamin B5.
PEG-200 Hydrogenated Glyceryl Palmate isn't fungal acne safe.
Peg-60 Hydrogenated Castor Oil comes from hydrogenated castor oil. It is a solubilizer and emulsifier.
As a solubilizer, it helps dissolve ingredients into a water-based version. It is also an emulsifer. Emulsifier help prevent oils and water from separating. Both these properties help create evenly-spread and uniform products.
Basically, Peg-60 Hydrogenated Castor Oil helps hold ingredients together.
PEG-7 Glyceryl Cocoate is a synthetic, water-soluble surfactant and emulsifier.
It's a "superfatting" agent that helps replenish some of your skin's oils after they're stripped away by other surfactants.
This is why "gentle" and "moisturizing" cleansers feel less stripping than basic ones.
Typical concentrations range from 1-10% and it has a solid safety record. The CIR Expert Panel has concluded this ingredient to be safe at concentrations up to 10% in leave-on products.
Dermal application tests at 50% also did not produce irritation in two studies.
This ingredient may not be fungal acne safe and in vitro studies have shown Malassezia can metabolize it.
Phenoxyethanol is one of the most widely used preservatives in skincare (and for good reason!).
It has a large spectrum of antimicrobial activity and especially effective bacteria, yeast, and mold while only having a weak effect on your skin's natural microbiome.
On a cellular level, it disrupts the cell membranes of microbes by poking holes that make the cell leak. This shuts down the chemical reactions the microbe needs to make energy so it can no longer survive.
Another perk of this ingredient is that it stays functional across a wide pH range (3-10).
You'll often see it paired with boosters like Ethylhexylglycerin; one study showed that a 1:9 ratio of Ethylhexylglycerin to Phenoxyethanol damages bacterial membranes as effectively as doubling the Phenoxyethanol concentration on its own.
Typical use concentrations range from 0.3-1% depending on the formula, and this ingredient is capped at 1% int the EU.
Safety-wise, the fear mongering does not hold up to the evidence. The EU's Scientific Committee on Consumer Safety and FDA consider it safe as a preservative at up to 1%, including for children of all ages.
Adverse systemic effects only showed up in animal studies at exposures roughly 200x higher than what people get from cosmetics. And despite its very widespread use, this ingredient is a rare sensitizer and allergic reactions are uncommon.
Sodium Laureth Sulfate (SLES) is a foaming, cleansing, and emulsifying ingredient. It is created from palm kernel oil or coconut oil. SLES is not the same as sodium lauryl sulfate. It is much milder and less likely to irritate.
SLES helps create foam in personal products. It also prevents ingredients from separating, helping to elongate the shelf life.
Sodium Laureth Sulfate is a type of sulfate. It can be drying. We recommend speaking with a professional about using this ingredient if you have concerns.
Sodium Lauroyl Sarcosinate is a cleansing agent and emulsifier. It is a surfactant derived from sarcosine, and a common source is coconut oil.
As a surfactant, Sodium Lauroyl Sarcosinate helps lift dirts, oil, and other molecules to be washed away. In leave-on products, this ingredient is used as an emulsifier. Emulsifier help prevent ingredients such as oils and waters from separating.
Sodium Lauroyl Sarcosinate is also commonly found as a foaming agent in shampoo, toothpaste, and shaving foam. It is amphiphilic, meaning it loves both water and fats.
Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.
So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.
You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!