Skin science article
Divi Scalp Serum Versus The Ordinary Multi-Peptide Serum for Hair Density
Divi Scalp Serum Versus The Ordinary Multi-Peptide Serum for Hair Density What's inside Key Ingredients Benefits Concerns Ingredients Side-by-side Water Glycerin Melaleuca Alternifolia Leaf Oil Acetyl Tetrapeptide-3 Copper Tripeptide-1 Caffeine Sodium PCA Sodi
Divi Scalp Serum Versus The Ordinary Multi-Peptide Serum for Hair Density
What's inside
Key Ingredients
Benefits
Concerns
Ingredients Side-by-side
Water
Glycerin
Melaleuca Alternifolia Leaf Oil
Acetyl Tetrapeptide-3
Copper Tripeptide-1
Caffeine
Sodium PCA
Sodium Lactate
Arginine
Hyaluronic Acid
Aspartic Acid
PCA
Biotin
Glycine
Alanine
Mentha Piperita Oil
Eucalyptus Globulus Oil
Serine
Menthol
Tocopherol
Valine
Proline
Threonine
Isoleucine
Rosmarinus Officinalis Leaf Extract
Camellia Sinensis Leaf Extract
Histidine
Phenylalanine
Copper Gluconate
Ascorbic Acid
Phenylpropanol
Ethylhexylglycerin
Water, Glycerin, Melaleuca Alternifolia Leaf Oil, Acetyl Tetrapeptide-3, Copper Tripeptide-1, Caffeine, Sodium PCA, Sodium Lactate, Arginine, Hyaluronic Acid, Aspartic Acid, PCA, Biotin, Glycine, Alanine, Mentha Piperita Oil, Eucalyptus Globulus Oil, Serine, Menthol, Tocopherol, Valine, Proline, Threonine, Isoleucine, Rosmarinus Officinalis Leaf Extract, Camellia Sinensis Leaf Extract, Histidine, Phenylalanine, Copper Gluconate, Ascorbic Acid, Phenylpropanol, Ethylhexylglycerin
Propanediol
Butylene Glycol
Biotinoyl Tripeptide-1
Larix Europaea Wood Extract
Pisum Sativum Extract
Scutellaria Baicalensis Root Extract
Triticum Vulgare Germ Extract
Glycine Soja Germ Extract
Trifolium Pratense Flower Extract
Apigenin
Oleanolic Acid
Calcium Gluconate
Zinc Chloride
Lactic Acid
Gluconolactone
Dextran
Maltodextrin
Hydroxyethylcellulose
Xanthan Gum
Pentylene Glycol
Dimethyl Isosorbide
Polysorbate 20
PPG-26-Buteth-26
PEG-40 Hydrogenated Castor Oil
Trisodium Ethylenediamine Disuccinate
Sodium Metabisulfite
Sodium Benzoate
Phenoxyethanol
Chlorphenesin
Water, Propanediol, Butylene Glycol, Glycerin, Caffeine, Biotinoyl Tripeptide-1, Acetyl Tetrapeptide-3, Larix Europaea Wood Extract, Pisum Sativum Extract, Scutellaria Baicalensis Root Extract, Triticum Vulgare Germ Extract, Glycine Soja Germ Extract, Trifolium Pratense Flower Extract, Camellia Sinensis Leaf Extract, Apigenin, Oleanolic Acid, Arginine, Glycine, Calcium Gluconate, Zinc Chloride, Lactic Acid, Gluconolactone, Dextran, Maltodextrin, Hydroxyethylcellulose, Xanthan Gum, Pentylene Glycol, Dimethyl Isosorbide, Polysorbate 20, PPG-26-Buteth-26, PEG-40 Hydrogenated Castor Oil, Trisodium Ethylenediamine Disuccinate, Sodium Metabisulfite, Sodium Benzoate, Phenoxyethanol, Chlorphenesin
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Alternatives
Ingredients Explained
These ingredients are found in both products.
Ingredients higher up in an ingredient list are typically present in a larger amount.
This biometic peptide is designed to support hair growth.
According to a manufacturer, it stimulates hair growth by:
The manufacturer has found combining this ingredient with red clover extract (Capixyl) boosted benefits. Not only does it enforce the scalp's extracellular matrix, it also inhibits the enzyme that creates DHT, a hormone that leads to hair loss.
While this ingredient is promising, more research is still needed to confirm its full effectiveness.
Arginine is a semi-essential amino acid. This just means our bodies can product a bit on its own, but sometimes needs a little boost from food sources.
It is a part of your skin's natural moisturizing factor (NMF), or the water-loving molecules in your outermost layer of skin (stratum corneum) that keeps everything hydrated and happy.
Here's an interesting thing about Arginine: your skin converts it into urea through the Krebs-Henseleit urea cycle. Urea is one of the most effective humectants your skin naturally produces.
A clinical study showed applying 2.5% arginine hydrochloride to atopic dermatitis skin showed significant urea levels in the stratum corneum and improved moisture in just four weeks.
Arginine is also a precursor to nitric oxide; nitric oxide improves microcirculation and supports wound healing and collagen synthesis.
One study found that an amino acid complex containing Arginine reduced skin irritation, improved hydration, and accelerated skin repair in clinical / in-vivo studies.
Arginine itself is an amino acid and not a fatty acid, oil, or ester. On its own, it's not a direct food source for Malassezia, or the yeast that causes fungal acne.
Caffeine is a naturally occurring plant compound found in coffee beans, tea leaves, cocoa pods, and guarana.
As an antioxidant, caffeine protects your skin from free radical damage caused by UV exposure and envionrmnetal stressors.
Early research also shows that caffeine can help calm redness, soothe irritated skin, and support hair growth by stimulating microcirculation in the scalp.
You might have seen eye creams marketing caffeine as a depuffing ingredient. This is because it is a vasoconstrictor meaning it can temporarily constrict blood vessels, though clinical evidence for this specific use is still limited.
Most skincare products contain this ingredient at concentrations between 1-6%. It is able to penetrate skin easily regardless of skin type or thickness.
Just so you know, a very small number of case reports describe caffeine-induced allergy. This ingredient is generally well-tolerated, non-irritating, and non-sensitizing for the majority of people.
Camellia Sinensis Leaf Extract (tea extract) is one of the most well-researched plant extracts in skincare with an impressive resume.
Black tea, green tea, and oolong tea are all harvested from the Camellia Sinensis plant.
Studies show green tea extract and its catechins (like epigallocatechin gallate (EGCG)) help your skin cells product energy more efficiently and reducing the number of free-radicals that can damage your skin from the inside.
In lab-grown skin models, this translated to younger, healthier, and stronger skin.
There's also good sun protection data; researchers saw less DNA damage and redness on human skin when green tea was applied before UVB exposure. And the more they applied, the better the protection.
Needless to say, this ingredient shouldn't replace your sunscreen. But it is a great supportive ingredient that you can already find in many sunscreens and antioxidant serums.
A 2009 study found a 2% green tea lotion was effective for mild-to-moderate acne thanks to its anti-inflammatory and mild antimicrobial activity.
The quality of the extract matters a lot here:
Good extracts contain 50-90% catechins while lower quality ones are mostly there for marketing. We recommend reaching out to the brand if you have questions about the quality or source of their ingredients.
Human Repeated Insult Patch Testing showed no irritation or sensitization at use concentrations (0.86% in leave-on products and up to 30% as leaf water).
Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.
Topically, glycerin does several things at once:
Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.
Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.
This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.
Just know very high concentrations (>40%) can feel tacky in low humidity.
Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.
Glycine is the smallest amino acid and a key building block of collagen. It's part if your skin's Natural Moisturizing Factor (NMF), or the water-loving molecules in your outermost layer of skin (stratum corneum) that keeps everything hydrated and happy.
A study from 2022 found that an amino acid complex featuring taurine, arginine, and glycine significantly reduced skin irritation, improved redness, and accelerated the skin repair process.
Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.
So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.
You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!