Skin science article
Doa Kozmetik Retinol %0,05 Krem Versus IMAGE skincare Vital C Hydrating Repair Cream
Doa Kozmetik Retinol %0,05 Krem Versus IMAGE skincare Vital C Hydrating Repair Cream This anti-aging night moisturizer is formulated around Niacinamide and Retinol to soften the look of wrinkles and refine skin texture. This barrier-repair night moisturizer is
Doa Kozmetik Retinol %0,05 Krem Versus IMAGE skincare Vital C Hydrating Repair Cream
This anti-aging night moisturizer is formulated around Niacinamide and Retinol to soften the look of wrinkles and refine skin texture.
This barrier-repair night moisturizer is formulated around Aloe Barbadensis Leaf Juice and Tetrahexyldecyl Ascorbate to strengthen the skin barrier and hydrate skin.
What's inside
Key Ingredients
Benefits
Concerns
Ingredients Side-by-side
Water
Cetearyl Alcohol
Niacinamide
Glyceryl Stearate
Caprylic/Capric Triglyceride
C12-15 Alkyl Benzoate
Cyclopentasiloxane
Dimethicone
Dimethicone/Vinyl Dimethicone Crosspolymer
Ceteareth-29
Cetyl Palmitate
Ceteareth-12
Ceteareth-20
PEG-100
Caffeine
Propylene Glycol
Glycerin
Dimethyl Sulfone
Aloe Barbadensis Leaf Juice
Saccharide Isomerate
Phenoxyethanol
Sodium Hyaluronate
Potassium Cetyl Phosphate
Macadamia Ternifolia Seed Oil
Trehalose
Squalane
Tocopheryl Acetate
Bisabolol
Retinyl Palmitate
Copernicia Cerifera Cera
Retinol
Propanediol
BHT
Sodium Cocoamphoacetate
Xanthan Gum
Caprylyl Glycol
Sodium Citrate
Citric Acid
Disodium EDTA
Water, Cetearyl Alcohol, Niacinamide, Glyceryl Stearate, Caprylic/Capric Triglyceride, C12-15 Alkyl Benzoate, Cyclopentasiloxane, Dimethicone, Dimethicone/Vinyl Dimethicone Crosspolymer, Ceteareth-29, Cetyl Palmitate, Ceteareth-12, Ceteareth-20, PEG-100, Caffeine, Propylene Glycol, Glycerin, Dimethyl Sulfone, Aloe Barbadensis Leaf Juice, Saccharide Isomerate, Phenoxyethanol, Sodium Hyaluronate, Potassium Cetyl Phosphate, Macadamia Ternifolia Seed Oil, Trehalose, Squalane, Tocopheryl Acetate, Bisabolol, Retinyl Palmitate, Copernicia Cerifera Cera, Retinol, Propanediol, BHT, Sodium Cocoamphoacetate, Xanthan Gum, Caprylyl Glycol, Sodium Citrate, Citric Acid, Disodium EDTA
Isostearyl Neopentanoate
PEG-100 Stearate
Simmondsia Chinensis Seed Oil
Citrus Aurantium Dulcis Oil
Limonene
Brassica Campestris/Aleurites Fordi Oil Copolymer
Cetyl Alcohol
Tetrahexyldecyl Ascorbate
Stearyl Alcohol
Tocopherol
Ceteth-10 Phosphate
Dicetyl Phosphate
Magnesium Ascorbyl Phosphate
Panthenol
Glycine Soja Sterols
Linoleic Acid
Phospholipids
Ethylhexylglycerin
Glucosamine Hcl
Hexylene Glycol
Magnesium Aluminum Silicate
PEG-8
Butylene Glycol
Phytic Acid
Sodium Hydroxide
Pisum Sativum Extract
Allantoin
Bambusa Vulgaris Leaf/Stem Extract
Citrus Nobilis Peel Oil
Yeast Polysaccharides
Dipotassium Glycyrrhizate
Benzoic Acid
Ascorbyl Palmitate
Pyruvic Acid
Tremella Fuciformis Sporocarp Extract
Ascorbic Acid
Vitis Vinifera Seed Extract
Aloe Barbadensis Leaf Juice, Water, Glycerin, Dimethicone, C12-15 Alkyl Benzoate, Glyceryl Stearate, Isostearyl Neopentanoate, PEG-100 Stearate, Simmondsia Chinensis Seed Oil, Caprylic/Capric Triglyceride, Cetearyl Alcohol, Citrus Aurantium Dulcis Oil, Limonene, Brassica Campestris/Aleurites Fordi Oil Copolymer, Cetyl Alcohol, Tetrahexyldecyl Ascorbate, Stearyl Alcohol, Phenoxyethanol, Cyclopentasiloxane, Tocopherol, Ceteth-10 Phosphate, Dicetyl Phosphate, Magnesium Ascorbyl Phosphate, Panthenol, Squalane, Caprylyl Glycol, Glycine Soja Sterols, Linoleic Acid, Phospholipids, Ethylhexylglycerin, Glucosamine Hcl, Hexylene Glycol, Xanthan Gum, Magnesium Aluminum Silicate, PEG-8, Butylene Glycol, Phytic Acid, Sodium Hydroxide, Pisum Sativum Extract, Allantoin, Retinyl Palmitate, Bambusa Vulgaris Leaf/Stem Extract, Citrus Nobilis Peel Oil, Yeast Polysaccharides, Dipotassium Glycyrrhizate, Disodium EDTA, Sodium Hyaluronate, Benzoic Acid, Ascorbyl Palmitate, Pyruvic Acid, Tremella Fuciformis Sporocarp Extract, Citric Acid, Ascorbic Acid, Vitis Vinifera Seed Extract
Alternatives
Ingredients Explained
These ingredients are found in both products.
Ingredients higher up in an ingredient list are typically present in a larger amount.
Aloe Barbadensis Leaf Juice is the filtered, stabilized liquid pressed from the inner gel of the aloe vera leaf.
In cosmetics, it shows up as either soothing active or a water-replacement base. It is roughly 98-99% water and the last 1-2% is an interesting mix of polysaccharides, amino acids, vitamins, minerals, and enzymes.
The polysaccharides do most of the work: they bind water at the skin surface for a light, non-greasy hydration boost. And one of the polysaccharides, glycomannan, is linked to fibroblast stimulation + collagen synthesis. This is also why aloe has such a long track record in wound and burn healing.
This ingredient is also calming with anti-inflammatory and mild antimicrobial activity, making it a great pick for sensitive, irritated, or post-sun skin.
Realistic expectations matter though; the solid evidence is mostly limited to hydration, soothing, and wound support. Deeper claims about anti-aging or sun protection are not well backed, and science reviews note it does not prevent radiation-induced skin injury.
Because it plays well with almost everything, it's commonly used as a base alongside other actives like niacinamide or vitamin C.
Typical usage concentrations range from 0.5% (where hydration benefits already show up) all the way to 90%+ (where it replaces water as the main base).
The safety for this ingredient is well-establish as well. Overall, this is a great supporting ingredient for those who want a boost in hydration.
C12-15 Alkyl Benzoate is a lightweight emollient made by combinig benzoic acid with fatty alcohols that are 12-15 carbons long.
In cosmetics, it plays several roles:
The Cosmetic Review Expert Panel has concluded the alkyl benzoate group to be safe as used in cosmetics; it wasn't found to be a skin irritant and unlikely to be absorbed due to its low water solubility.
This report recorded almost 1000 reported uses with concentrations up to 59% in leave-on products but your cosmetics will typically use 0.5-15% depending on the product.
It's often called a "SPF booster": this is because it keeps UV filters properly dissolved and evenly distributed to support a sunscreen's performance. It doesn't actually raise SPF on its own.
Overall, this ingredient is well tolerated.
This ingredient is fungal acne safe because it is an ester of benzoic acid.
Think of this ingredient as two parts stuck together: an oily part and an acid part. Malassezia only gets a meal when it can snip off a fatty acid to eat. With C12-15 Alkyl Benzoate, the acid part is benzoic acid, which isn't a fatty acid and which the yeast can't use as food.
Benzoic acid is actually used as a preservative to stop yeast from growing.
The oily part is a blend of C12-15 fatty alcohols but fatty alcohols in this size range can support only a little Malassezia growth (mostly for one species of Malassezia as well).
In the ingredient, those alcohols stay locked inside the molecule. The yeast can only reach them by snipping the benzoate bond, and that type of bond is harder for it to cut than a normal fatty bond.
So not much gets released. And whatever does get snipped comes packaged with benzoic acid, which discourages yeast growth.
Caprylic/Capric Triglyceride (aka MCT Oil) is a lightweight emollient, solvent, and texture enhancer. It is considered a skin-softener by helping to prevent moisture loss.
Though it behaves like an oil, it is not technically one due to its chemical composition. One perk of this ingredient is that it is very stable, resistant to oxidation, and unlikely to go rancid.
In practice, that translates to a long shelf life and a consistently elegant skin feel.
While there is an assumption Caprylic Triglyceride can clog pores due to it being derived from coconut oil, there is no research supporting this. Just patch test if you have concerns.
Fractionated coconut oil and MCT Oil are both listed as Caprylic/Capric Triglyceride according to INCI. This is because INCI names are based on the ingredient’s final chemical composition and not its marketing name or source.
This ingredient is treated as the gold standard fungal acne safe oil. Even though it is coconut derived, the problematic lauric acid is stripped out.
This leaves just caprylic (C8) and capric (C10) acid. These chain lengths actually trend antifungal; a 2020 study found caprylic acid was enough to disrupt Malassezia furfur cell membrane, with a caprylic acid derivative damaging membrane structures at concentrations as low as 0.2%.
Caprylyl Glycol is a humectant, skin conditioner, emollient, and preservative booster derived from either caprylic acid or synthetically created.
Typical use levels vary from 0.3-1% as a preservative booster and go up to 2% to condition skin.
Because it is not a free-fatty acid, this ingredient is fungal acne safe (there's nothing for Malassezia to feed on).
Cetearyl alcohol is a waxy mixture of two fatty alcohols: cetyl alcohol and stearyl alcohol. It is an emollient and emulsifier.
Despite having "alcohol" in its name, it has nothing to do with drying solvent alcohols; the FDA also allows "alcohol-free" products to contain fatty alcohols like this ingredient.
It plays several roles in a formula:
Typical use levels for this ingredient sit around 1-10% and the Cosmetic Ingredient Review Expert Panel has affirmed safety at concentrations up to 25% in leave-on products.
Multiple assessments have found it to be non-irritating and non-sensitizing to most people.
However, there have been some cases of allergic contact dermatitis in patients with chronically compromised skin barriers.
Cetearyl alcohol has a comedogenic rating of 2 and irritancy rating of 1. Both of these numbers come from the 1989 study that used rabbit ears; a "2" means mildly comedogenic and a "1" means low irritancy.
Here's the catch: rabbit skin is more sensitive than human skin and throws a lot of false positives. A 1996 reappraisal found that ingredients rated 1-2 in the rabbit ear tests are generally safe for humans.
Remember comedogenic ratings are unable to assess the entire formula of a product or how it will react on your skin. Just be sure to patch test if you are unsure about certain ingredients.
This ingredient is not fungal acne safe. Cetearyl alcohol is a fatty alcohol with chain lengths that fall within the range that Malassezia can metabolize.
A 2019 study has also observed Malassezia growth in the presence of this ingredient, confirming it to be not-fungal acne safe.
Citric Acid is an alpha hydroxy acid (AHA) naturally found in citrus fruits like oranges, lemons, and limes.
Like other AHAs, citric acid can exfoliate skin by breaking down the bonds that hold dead skin cells together. This helps reveal smoother and brighter skin underneath.
However, this exfoliating effect only happens at high concentrations (20%) which can be hard to find in cosmetic products.
Due to this, citric acid is usually included in small amounts as a pH adjuster. This helps keep products slightly more acidic and compatible with skin's natural pH.
In skincare formulas, citric acid can:
While it can provide some skin benefits, research shows lactic acid and glycolic acid are generally more effective and less irritating exfoliants.
Most citric acid used in skincare today is made by fermenting sugars (usually from molasses). This synthetic version is identical to the natural citrus form but easier to stabilize and use in formulations.
Rosacea skin has a lower threshold for acids generally, with 62.5% of rosacea subjects in one study reacting to lactic acid in a sting test. This is why we mark citric acid as a potential rosacea trigger.
However, this ingredient shows up as a pH adjuster or chelator at roughly 0.1-1% in many products. These low levels are unlikely to be an issue for rosacea skin and becomes a potential trigger at exfoliating concentrations (20%). Because everybody's skin is unique, we recommend a patch test if you are unsure.
Cyclopentasiloxane (D5) is a lightweight silicone that mostly acts as an emollient and solvent in cosmetics. Its the reason your products feel silky, fast-spreading, and non-greasy.
Since D5 is volatile, it does its thing and then evaporates off the skin quickly.
The safety profile of this ingredient is reassuring; the US CIR Expert Panel concluded D5 is safe as used in cosmetics and Health Canada concluded that D5 is not harmful to human health or the environment as currently used in cosmetics
There's a study that people mention about D5 in a rat study showing tumors. This study is related to long-term inhalation of high D5 levels.
Regulatory bodies have judged this study to be not applicable in topical skincare since skin absorption of D5 is very low and we're not really inhaling huge amounts of D5.
The only restriction for this ingredient is environmental. The European Chemicals Agency (ECHA) restricted D5 in wash-off cosmetics at or above 0.1% due to their persistence in water.
Dimethicone is a type of synthetic silicone created from natural materials such as quartz. It is also known as polydimethylsiloxane.
What it does:
Dimethicone comes in different viscosities:
Depending on the viscosity, dimethicone has different properties.
Ingredients lists don't always show which type is used, so we recommend reaching out to the brand if you have questions about the viscosity.
This ingredient is unlikely to cause irritation because it does not get absorbed into skin. However, people with silicone allergies should be careful about using this ingredient.
Note: Dimethicone may contribute to pilling. This is because it is not oil or water soluble, so pilling may occur when layered with products. When mixed with heavy oils in a formula, the outcome is also quite greasy.
Disodium EDTA is a chelating agent. It grabs onto and deactivates metal ions that sneak into your products from water, packaging, or air.
This ingredient mainly works behind the scenes and helps with:
On top of that, this ingredient can counteract the effects of hard water by binding to the minerals in it.
One thing worth knowing is that Disodium EDTA has been shown to be a mild penetration enhancer. It can help other ingredients absorb into skin more effectively which can be a double-edged sword (great for actives, but can also make the active too strong if you have sensitive skin).
Clinical patch testing showed no significant skin irritation at typical use concentrations and minimal dermal absorption.
You'll most likely see this ingredient near the end of an ingredient list. It's typically found in concentrations less than 1%.
Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.
Topically, glycerin does several things at once:
Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.
Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.
This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.
Just know very high concentrations (>40%) can feel tacky in low humidity.
Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.
Glyceryl Stearate is made by reacting glycerin with stearic acid (typically sourced from plant oils like palm or coconut). It's an emulsifier, emollient, and mild occlusive.
Emulsifiers help ingredients like oil and water stay mixed so your formula stays nicely blended and uniform in texture.
This ingredient is typically used in concentrations between 1-10%. Studies have found it to be non-sensitizing, non-phototoxic, and non-photoallergenic.
A close cousin of this ingredient is Glyceryl Stearate SE ("self-emulsifying"). This just has a small amount of sodium or potassium stearate added so it can emulsify without a co-emulsifier.
Since this ingredient is an ester of a C18 fatty acid, it may not be fungal acne safe. The Malassezia yeast can potentially metabolize within the C11-C24 range.
Fun fact: The human body also creates Glyceryl Stearate naturally.
Phenoxyethanol is one of the most widely used preservatives in skincare (and for good reason!).
It has a large spectrum of antimicrobial activity and especially effective bacteria, yeast, and mold while only having a weak effect on your skin's natural microbiome.
On a cellular level, it disrupts the cell membranes of microbes by poking holes that make the cell leak. This shuts down the chemical reactions the microbe needs to make energy so it can no longer survive.
Another perk of this ingredient is that it stays functional across a wide pH range (3-10).
You'll often see it paired with boosters like Ethylhexylglycerin; one study showed that a 1:9 ratio of Ethylhexylglycerin to Phenoxyethanol damages bacterial membranes as effectively as doubling the Phenoxyethanol concentration on its own.
Typical use concentrations range from 0.3-1% depending on the formula, and this ingredient is capped at 1% int the EU.
Safety-wise, the fear mongering does not hold up to the evidence. The EU's Scientific Committee on Consumer Safety and FDA consider it safe as a preservative at up to 1%, including for children of all ages.
Adverse systemic effects only showed up in animal studies at exposures roughly 200x higher than what people get from cosmetics. And despite its very widespread use, this ingredient is a rare sensitizer and allergic reactions are uncommon.
Retinyl Palmitate is a form of retinoid. Retinoids are the superstar class of anti-aging ingredients that include Tretinoin and Retinol.
This particular ingredient has had a bumpy year with its rise and fall in popularity.
First, Retinyl Palmitate is created from Palmitic Acid and Retinol. It is a Retinol ester and considered one of the weaker forms of retinoid.
This is because all retinoids have to be converted to Tretinoin, AKA Retinoic Acid.
Retinyl Palmitate is pretty far down the line and has to go through multiple conversions before its effects are seen. Once it's on your skin, enzymes called esterases convert it into Retinol, then into Retinal, and finally into Retinoic Acid; that's three steps with a little lost at each one.
The benefits of Retinyl Palmitate are debated due to this long and ineffective conversion line.
So why use it at all?
The answer is stability. Retinol and Retinoic Acid break down fast when they hit light, heat, and air, and Retinoic Acid can be pretty irritating on top of that.
Retinyl Palmitate is much more stable and gentler, making it easier to formulate with and easier on sensitive skin (even if it's weaker gram for gram).
Studies show Retinyl Palmitate to help:
Newer research from 2023-2025 also found that Retinyl Palmitate works especially well when paired with Retinol. The two seem to cover each other's weak spots; retinol brings the potency while Retinyl Palmitate brings the stability and gentleness. Together, they repair UV damage better than either one does alone.
This ingredient used to be found in sunscreens to boost the efficacy of sunscreen filters.
The downfall of Retinyl Palmitate was due to released reports about the ingredient being correlated to sun damage and skin tumors.
Most of this traces back to a 2012 US National Toxicology Program (NTP) study where hairless mice coated in Retinyl Palmitate cream and exposed to UV light developed skin tumors faster.
Here's the nuance, though.
When the Cosmetic Ingredient Review (CIR) Expert Panel went back through that study, they found methodological flaws and decided the results couldn't be interpreted as proof of extra risk.
The EU's Scientific Committee on Consumer Safety (SCCS) said the mouse findings might point to a concern but they're hard to apply to humans since hairless mouse skin and human skin behave differently.
While there is a study showing this ingredient to cause DNA damage when exposed to UVA, there is no concrete proof of it being linked to skin cancer. It is completely safe to use when used correctly.
Both the CIR and the SCCS consider it safe at the concentrations used in cosmetics; the SCCS specifically cleared retinoids up to 0.05% in body lotions and 0.3% in face creams, hand creams, and rinse-off products.
As of 2025, the EU has written those limits into law, plus a label warning about your total Vitamin A intake from all sources.
All retinoids increase your skin's sensitivity to the sun in the first few months of usage. Be especially careful with reapplying sunscreen when using any form of retinoid.
One more note: if you're pregnant, high doses of Vitamin A can be a concern, so a lot of people skip topical retinoids (including Retinyl Palmitate) during pregnancy just to be safe. Check with your doctor if you're unsure.
Fun fact: This ingredient is often added to low-fat milk to increase the levels of Vitamin A.
Sodium Hyaluronate is the salt form of hyaluronic acid. It is a long sugar chain that is naturally found in your skin, joints, and connective tissue that maintains hydration and elasticity.
In skincare, it works as a humectant. It pulls water from the environment and deeper layers of skin and binds it to the surface.
Interestingly, the size of the molecule affects its behavior:
Some clinical evidence links low molecular weight versions to improved wrinkle depth, elasticity, anti-inflammatory effects, and barrier repair.
Many serums use a blend of both weights so you can get surface hydration plus longer-lasting and deeper effects.
You'll typically see concentrations between 0.1-2% for this ingredient.
Squalane is the hydrogenated and shelf-stable form of squalene (a lipid that naturally occurs in human sebum).
It is an emollient and skin conditioning agent that is able to integrate seamlessly into the skin's lipid barrier without clogging pores.
This is due to how structurally similar it is to what your skin already produces.
Though it is mostly an emollient that helps soften and hydrate skin, it also has some humectant and occlusive action. Humectants help the skin retain moisture while occlusives seal it in, making squalane a triple-threat moisturizer.
Research shows it has antioxidant capabilities that help protect against stressors like UV exposure, specifically UVA induced oxidative stress. This study also found that it supports collagen biosynthesis in human dermal fibroblasts.
No clinical study has reported significant adverse effects and irritation reactions are very rare from this ingredient (even at 100% concentration).
Overall, it's a fantastic ingredient for hydration and is suitable for all skin types.
This depends on the source. Squalane can be derived from both plants and animals. Most squalane used in skincare comes from plants.
Please note: the source of squalane is only known if disclosed by the brand. We recommend reaching out to the brand if you have any questions about their squalane.
Read more about squalene with an "e".
Though squalane is often called an oil, it’s technically not one. It is a hydrocarbon, meaning it is only made of carbon and hydrogen. True oils are triglycerides and made of fatty acids and glycerol.
The term “oil-free” isn’t regulated so companies can define it however they want. Some exclude all oils, while others just avoid mineral oil or comedogenic oils.
Squalane has a comedogenic rating of 1 from the original 1972 study that tested raw ingredients under occlusion on rabbit ears. This system is not standardized or peer-reviewed, and using the raw ingredients is very different from how diluted cosmetic formulations are used on human skin.
A comedogenic rating of 1 means it is "unlikely to clog pores" according to the original rating system.
The overall formula of a product matters more than the individual ingredients on whether or not it will cause clogged pores.
Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.
So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.
You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!
Xanthan gum is used as a stabilizer and thickener within cosmetic products. It helps give products a sticky, thick feeling - preventing them from being too runny.
On the technical side of things, xanthan gum is a polysaccharide - a combination consisting of multiple sugar molecules bonded together.
Xanthan gum is a pretty common and great ingredient. It is a natural, non-toxic, non-irritating ingredient that is also commonly used in food products.