Skin science article
Dr. Althea 345 Relief Cream Versus Beauty of Joseon Relief Sun Aqua-Fresh Rice + B5 SPF 50+
Dr. Althea 345 Relief Cream Versus Beauty of Joseon Relief Sun Aqua-Fresh Rice + B5 SPF 50+ This calming moisturizer is formulated around Niacinamide and Panthenol to calm redness and strengthen the skin barrier. This chemical sunscreen covers the full UV rang
Dr. Althea 345 Relief Cream Versus Beauty of Joseon Relief Sun Aqua-Fresh Rice + B5 SPF 50+
This calming moisturizer is formulated around Niacinamide and Panthenol to calm redness and strengthen the skin barrier.
This chemical sunscreen covers the full UV range and blocks ~98% of UVB at SPF 50.
What's inside
Key Ingredients
Benefits
Concerns
Ingredients Side-by-side
Water
Propanediol
Glycerin
Cyclohexasiloxane
1,2-Hexanediol
Niacinamide
Caprylic/Capric Triglyceride
Polyglycerin-3
Panthenol
Polyglyceryl-10 Stearate
Hydrogenated Polydecene
Hydrogenated Poly(C6-14 Olefin)
Dicaprylyl Carbonate
Ammonium Acryloyldimethyltaurate/Vp Copolymer
C14-22 Alcohols
Polymethylsilsesquioxane
C12-20 Alkyl Glucoside
Butylene Glycol
Acrylates/C10-30 Alkyl Acrylate Crosspolymer
Ethylhexylglycerin
Polyquaternium-51
Tromethamine
Sodium Hyaluronate
Coptis Japonica Root Extract
Houttuynia Cordata Extract
Oenothera Biennis Flower Extract
Beta-Glucan
Resveratrol
Gardenia Florida Fruit Extract
Lavandula Angustifolia Flower Extract
Opuntia Ficus-Indica Stem Extract
Hydrolyzed Hyaluronic Acid
Centella Asiatica Leaf Extract
Phenoxyethanol
Hibiscus Sabdariffa Flower Extract
Tocopherol
Corallina Officinalis Extract
Ceramide NP
Water, Propanediol, Glycerin, Cyclohexasiloxane, 1,2-Hexanediol, Niacinamide, Caprylic/Capric Triglyceride, Polyglycerin-3, Panthenol, Polyglyceryl-10 Stearate, Hydrogenated Polydecene, Hydrogenated Poly(C6-14 Olefin), Dicaprylyl Carbonate, Ammonium Acryloyldimethyltaurate/Vp Copolymer, C14-22 Alcohols, Polymethylsilsesquioxane, C12-20 Alkyl Glucoside, Butylene Glycol, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Ethylhexylglycerin, Polyquaternium-51, Tromethamine, Sodium Hyaluronate, Coptis Japonica Root Extract, Houttuynia Cordata Extract, Oenothera Biennis Flower Extract, Beta-Glucan, Resveratrol, Gardenia Florida Fruit Extract, Lavandula Angustifolia Flower Extract, Opuntia Ficus-Indica Stem Extract, Hydrolyzed Hyaluronic Acid, Centella Asiatica Leaf Extract, Phenoxyethanol, Hibiscus Sabdariffa Flower Extract, Tocopherol, Corallina Officinalis Extract, Ceramide NP
Oryza Sativa Seed Water
Dibutyl Adipate
Butyloctyl Salicylate
Ethylhexyl Triazone
Drometrizole Trisiloxane
Polyglyceryl-3 Distearate
Terephthalylidene Dicamphor Sulfonic Acid
Diethylamino Hydroxybenzoyl Hexyl Benzoate
Pentylene Glycol
Glyceryl Stearate
Silica
Caprylyl Methicone
Avena Sativa Kernel Extract
Cynara Scolymus Leaf Extract
Camellia Sinensis Leaf Water
Hydrogenated Lecithin
Oryza Sativa Bran Oil
Bis-Ethylhexyloxyphenol Methoxyphenyl Triazine
Potassium Cetyl Phosphate
Poly C10-30 Alkyl Acrylate
Methylpropanediol
Carbomer
Xanthan Gum
Polyether-1
Biosaccharide Gum-1
Inositol
Ferulic Acid
Citric Acid
Phytosphingosine
Rice Amino Acids
Rice Sh-Oligopeptide-1
Water, Oryza Sativa Seed Water, Dibutyl Adipate, Butyloctyl Salicylate, Ethylhexyl Triazone, 1,2-Hexanediol, Drometrizole Trisiloxane, Polyglyceryl-3 Distearate, Terephthalylidene Dicamphor Sulfonic Acid, Diethylamino Hydroxybenzoyl Hexyl Benzoate, Polymethylsilsesquioxane, Tromethamine, Panthenol, Pentylene Glycol, Glyceryl Stearate, Silica, Caprylyl Methicone, Avena Sativa Kernel Extract, Cynara Scolymus Leaf Extract, Camellia Sinensis Leaf Water, Hydrogenated Lecithin, Oryza Sativa Bran Oil, Sodium Hyaluronate, Bis-Ethylhexyloxyphenol Methoxyphenyl Triazine, Propanediol, Potassium Cetyl Phosphate, Poly C10-30 Alkyl Acrylate, Methylpropanediol, Carbomer, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Ethylhexylglycerin, Xanthan Gum, Glycerin, Polyether-1, Polyquaternium-51, Beta-Glucan, Biosaccharide Gum-1, Inositol, Tocopherol, Ferulic Acid, Citric Acid, Ceramide NP, Phytosphingosine, Rice Amino Acids, Rice Sh-Oligopeptide-1
Reviews
Alternatives
Ingredients Explained
These ingredients are found in both products.
Ingredients higher up in an ingredient list are typically present in a larger amount.
1,2-Hexanediol is a synthetic liquid and another multi-functional powerhouse.
It is a:
Humectant, drawing moisture into the skin
Emollient, helping to soften skin
Solvent, dispersing and stabilizing formulas
Preservative booster, enhancing the antimicrobial activity of other preservatives
Acrylates/C10-30 Alkyl Acrylate Crosspolymer is a synthetic polymer. It is used to thicken, emulsify, and improve the texture of products.
As an emulsifier, it helps stabilize oil-in-water emulsions to give products an elegant feel when applied.
It can also form a thin protective film on skin. One study found that a formula using this polymer helped slow down how quickly other ingredients (like DEET) were absorbed through skin.
A 2024 study of over 1,300 patients confirmed that sensitization to this ingredient is rare. It is also non-mutagenic and has a clean track record.
Beta-Glucan is a soluble polysaccharide (a chain of glucose sugars) sourced from the cells walls of oats, baker's yeast, mushrooms, and seaweed.
It's a rare ingredient that pulls double-duty as a heavy-duty hydrator and skin-soothing repair agent.
On the surface, it acts as a humectant that holds water in place and reduces moisture loss for a plumper, smoother feel, while its anti-inflammatory and antioxidant properties make it a great pick for calming redness or sensitive skin
The more interesting story is underneath:
Despite its large molecular size, oat beta-glucan has been shown to penetrate the epidermis and reach the dermis by slipping between skin cells. Here, it interacts with fibroblasts and macrophages to nudge collagen synthesis and support wound repair.
A small 2005 split-face clinical study of 27 subjects found topical beta-glucan produced measurable reductions in wrinkle depth, height, and roughness after 8 weeks of use.
It is worth noting the trial was small and the penetration testing used frozen, irradiated skin so the anti-aging data is encouraging rather than definitive.
This ingredient gets along with pretty much everything and is typically used around 0.1-1%.
Fungal acne: This ingredient is not a food source for the Malassezia yeast because it is a glucose polysaccharide with no fatty acid or ester component.
Ceramide NP (formerly known as Ceramide 3) is one of the skin's naturally occurring lipids.
Since ceramides are the major lipid components of the skin, they are crucial for maintaining skin barrier and hydration. Ceramide NP most closely mirrors the dominant kind in human skin amongst ceramide subtypes.
This ceramide works by slotting into gaps within the stratum corneum's lipid matrix to limit trans-epidermal water loss (TEWL) and shield the skin against external irritants.
A study with 312 patients found that using a ceramide-containing routine for 4 weeks reduced the severity of atopic dermatitis by over 61%.
Another clinical study in subjects aged 60 and older found that a ceramide body wash and moisturizer improved skin dryness and itchy skin in 15 days.
Overall, ceramides are considered non-irritating and safety tests have found little to no observable adverse effects from using this ingredient.
Ceramide NP is usually sourced from plants (like soybean or rice bran), or produced synthetically.
Ethylhexylglycerin is created from glycerin. It is a multitasker ingredient that:
The CIR Expert Panel found minimal skin absorption or sensitization of any kind in a safety assessment. Though this ingredient is considered well-tolerated, a small number of cases of allergic dermatitis have been published since 2002. Just be sure to patch test if you are unsure.
Industry-reported use ranges from 8% in rinse-off products and 2% in leave-on formulations.
Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.
Topically, glycerin does several things at once:
Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.
Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.
This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.
Just know very high concentrations (>40%) can feel tacky in low humidity.
Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.
Panthenol is a common ingredient that helps hydrate and soothe the skin. It is found naturally in our skin and hair.
There are two forms of panthenol: D and L.
D-panthenol is also known as dexpanthenol. Most cosmetics use dexpanthenol or a mixture of D and L-panthenol.
Panthenol is famous due to its ability to go deeper into the skin's layers. Using this ingredient has numerous pros (and no cons):
Like hyaluronic acid, panthenol is a humectant. Humectants are able to bind and hold large amounts of water to keep skin hydrated.
This ingredient works well for wound healing. It works by increasing tissue in the wound and helps close open wounds.
Once oxidized, panthenol converts to pantothenic acid. Panthothenic acid is found in all living cells.
This ingredient is also referred to as pro-vitamin B5.
Polymethylsilsesquioxane is a silicone used as a film forming agent.
When applied to the skin, this ingredient creates an invisible film on the surface. This film still allows oxygen to pass through, but prevents moisture from escaping. This can help condition and hydrate the skin. It also leaves a silky feel when applied.
Polymethylsilsesquioxane has not been shown to clog pores. It has been deemed safe to use up to 55%, but most cosmetics use much less.
If you have concerns about using this ingredient, we recommend speaking with a professional.
Polyquaternium-51 is a polymer salt. It helps hydrate the skin by creating a film on top. This film traps moisture in, keeping your skin soft and hydrated.
Propanediol is an all-star ingredient. It softens, hydrates, and smooths the skin.
It’s often used to:
Propanediol is not likely to cause sensitivity and considered safe to use. It is derived from corn or petroleum with a clear color and no scent.
Sodium Hyaluronate is the salt form of hyaluronic acid. It is a long sugar chain that is naturally found in your skin, joints, and connective tissue that maintains hydration and elasticity.
In skincare, it works as a humectant. It pulls water from the environment and deeper layers of skin and binds it to the surface.
Interestingly, the size of the molecule affects its behavior:
Some clinical evidence links low molecular weight versions to improved wrinkle depth, elasticity, anti-inflammatory effects, and barrier repair.
Many serums use a blend of both weights so you can get surface hydration plus longer-lasting and deeper effects.
You'll typically see concentrations between 0.1-2% for this ingredient.
Tocopherol is a fat-soluble antioxidant known as Vitamin E.
You'll find this ingredient in the vast majority of skincare (for good reason). It works to neutralize free radicals, or unstable molecules generated by UV exposure, pollution, and other environmental stressors, before they can cause oxidative damage to your skin cells.
Topically applied tocopherol has been shown to protect against UV damage by ramping up the skin's own natural defense enzymes.
It also acts as a skin conditioning agent; some studies show that regular topical use can improve the skin's water-binding capacity over 2-4 weeks.
This ingredient is especially loved for being a team player. When combined with Vitamin C, the photoprotective effect of both ingredients roughly doubles and the combo also helps reduce UV-induced DNA damage.
This ingredient has some brightening potential but it's more of a prevention ingredient than spot-fader. Cell studies show it can slow down melanin production but it's worth noting that it's not the most powerful brightener out there.
In formulations, it also serves as a stabilizer that helps protect other oxidation-prone ingredients from degrading.
Concentrations usually range from 0.1-1% in most leave-on products.
Tromethamine (aka THAM) is a synthetic amino acid that shows up in skincare as a helper ingredient.
It functions as a pH adjuster to help neutralize acidic ingredients and set a formula's pH to the right spot.
This matters a lot because a lot of actives (like vitamin C) needs a specific pH to work well and feel comfortable on skin.
Concentration use ranges from 0.1-1.0% depending on the formula.
Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.
So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.
You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!