Skin science article
Drunk Elephant Protini Polypeptide Cream Versus Biossance Squalane + Probiotic Gel Moisturizer
Drunk Elephant Protini Polypeptide Cream Versus Biossance Squalane + Probiotic Gel Moisturizer This anti-aging moisturizer is formulated around Sclerocarya Birrea Seed Oil and Sh-Oligopeptide-1 to soften the look of wrinkles and hydrate skin. This barrier-repa
Drunk Elephant Protini Polypeptide Cream Versus Biossance Squalane + Probiotic Gel Moisturizer
This anti-aging moisturizer is formulated around Sclerocarya Birrea Seed Oil and Sh-Oligopeptide-1 to soften the look of wrinkles and hydrate skin.
This barrier-repair moisturizer is formulated around Squalane to strengthen the skin barrier and hydrate skin.
What's inside
Key Ingredients
Benefits
Concerns
Ingredients Side-by-side
Water
Dicaprylyl Carbonate
Glycerin
Cetearyl Alcohol
Cetearyl Olivate
Sorbitan Olivate
Sclerocarya Birrea Seed Oil
Bacillus/Folic Acid Ferment Filtrate Extract
Nymphaea Alba Root Extract
Sh-Oligopeptide-1
Sh-Oligopeptide-2
Sh-Polypeptide-1
Sh-Polypeptide-9
Sh-Polypeptide-11
Copper Palmitoyl Heptapeptide-14
Heptapeptide-15 Palmitate
Palmitoyl Tetrapeptide-7
Palmitoyl Tripeptide-1
Alanine
Arginine
Glycine
Histidine
Isoleucine
Phenylalanine
Proline
Serine
Threonine
Valine
Acetyl Glutamine
Coconut Alkanes
Coco-Caprylate/Caprate
Sodium Hyaluronate
Aspartic Acid
Linoleic Acid
Linolenic Acid
Lecithin
Butylene Glycol
Polyvinyl Alcohol
Sodium Lactate
Sodium PCA
PCA
Sorbitan Isostearate
Carbomer
Polysorbate 20
Polysorbate 60
Lactic Acid/Glycolic Acid Copolymer
Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer
Xanthan Gum
Isomalt
1,2-Hexanediol
Caprylyl Glycol
Chlorphenesin
Phenoxyethanol
Tocopherol
Sodium Benzoate
Phenylpropanol
Glyceryl Caprylate
Symphytum Officinale Callus Culture Extract
Water, Dicaprylyl Carbonate, Glycerin, Cetearyl Alcohol, Cetearyl Olivate, Sorbitan Olivate, Sclerocarya Birrea Seed Oil, Bacillus/Folic Acid Ferment Filtrate Extract, Nymphaea Alba Root Extract, Sh-Oligopeptide-1, Sh-Oligopeptide-2, Sh-Polypeptide-1, Sh-Polypeptide-9, Sh-Polypeptide-11, Copper Palmitoyl Heptapeptide-14, Heptapeptide-15 Palmitate, Palmitoyl Tetrapeptide-7, Palmitoyl Tripeptide-1, Alanine, Arginine, Glycine, Histidine, Isoleucine, Phenylalanine, Proline, Serine, Threonine, Valine, Acetyl Glutamine, Coconut Alkanes, Coco-Caprylate/Caprate, Sodium Hyaluronate, Aspartic Acid, Linoleic Acid, Linolenic Acid, Lecithin, Butylene Glycol, Polyvinyl Alcohol, Sodium Lactate, Sodium PCA, PCA, Sorbitan Isostearate, Carbomer, Polysorbate 20, Polysorbate 60, Lactic Acid/Glycolic Acid Copolymer, Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, Xanthan Gum, Isomalt, 1,2-Hexanediol, Caprylyl Glycol, Chlorphenesin, Phenoxyethanol, Tocopherol, Sodium Benzoate, Phenylpropanol, Glyceryl Caprylate, Symphytum Officinale Callus Culture Extract
Squalane
Lepidium Sativum Sprout Extract
Sodium Acrylates Copolymer
Caprylic/Capric Triglyceride
Capryloyl Glycerin/Sebacic Acid Copolymer
Diheptyl Succinate
Isoeicosane
Allantoin
Bisabolol
Sodium Phytate
Glycine Soja Sterols
Phospholipids
Hansenula/Kloeckera/Lactobacillus/Lactococcus/Leuconostoc/Pediococcus/Saccharomyces/Fig/Lemon Ferment
Chondrus Crispus Extract
Sorbitan Oleate
Cellulose Gum
Chitosan
Citric Acid
Potassium Sorbate
Water, Glycerin, Squalane, Lepidium Sativum Sprout Extract, Sodium Acrylates Copolymer, Caprylic/Capric Triglyceride, Phenoxyethanol, Capryloyl Glycerin/Sebacic Acid Copolymer, Lecithin, Caprylyl Glycol, Diheptyl Succinate, Isoeicosane, Allantoin, Bisabolol, Sodium Phytate, Glycine Soja Sterols, Linoleic Acid, Phospholipids, Hansenula/Kloeckera/Lactobacillus/Lactococcus/Leuconostoc/Pediococcus/Saccharomyces/Fig/Lemon Ferment, Chondrus Crispus Extract, Sorbitan Oleate, Cellulose Gum, Chitosan, 1,2-Hexanediol, Sodium Hyaluronate, Citric Acid, Potassium Sorbate
Reviews
Alternatives
Ingredients Explained
These ingredients are found in both products.
Ingredients higher up in an ingredient list are typically present in a larger amount.
1,2-Hexanediol is a synthetic liquid and another multi-functional powerhouse.
It is a:
Humectant, drawing moisture into the skin
Emollient, helping to soften skin
Solvent, dispersing and stabilizing formulas
Preservative booster, enhancing the antimicrobial activity of other preservatives
Caprylyl Glycol is a humectant, skin conditioner, emollient, and preservative booster derived from either caprylic acid or synthetically created.
Typical use levels vary from 0.3-1% as a preservative booster and go up to 2% to condition skin.
Because it is not a free-fatty acid, this ingredient is fungal acne safe (there's nothing for Malassezia to feed on).
Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.
Topically, glycerin does several things at once:
Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.
Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.
This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.
Just know very high concentrations (>40%) can feel tacky in low humidity.
Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.
Lecithin is a term for a group of substances found in the cell membranes of plants, animals, and humans. They are made up of phospholipids.
Thanks to its amphiphilic structure (water-loving head and oil-loving tail), it is a true multitasker:
It plays well with most ingredients and is typically used at 0.1-1%. However, concentrations up to 50% have been reported in moisturizers.
Linoleic Acid is also known as Vitamin F. It is a fatty acid with emollient and skin conditioning properties.
Our top layer of skin, or epidermis, naturally contains high amounts of linoleic acid.
Your body uses linoleic acid to build ceramides and prostaglandins. Ceramides keep your skin's barrier hydrated and strong while prosaglandins help control inflammation and healing.
Needless to say, linoleic acid is crucial for having a strong skin barrier.
One study found applying linoleic acid rich sunflower oil to be more effective at repairing the skin barrier than olive oil.
This ingredient can also help treat acne by softening sebum to prevent clogged pores. Another study found using 2.5% linoleic acid gel for 4 weeks showed a 25% reduction in small comedones.
Studies show it can also help lighten hyperpigmentation or sun spots by disrupting the melanin production process. It also helps your skin shed melanin pigment from your skin caused by UV exposure.
Due to its role in the production of the fatty acid prostaglandin, linoleic acid can also help reduce inflammation and support wound healing.
Fun fact: Linoleic acid is an essential fatty acid. This means our bodies cannot create it on its own and we need to get it through foods such as nuts and vegetable oils.
Just know this ingredient is not always fungal-acne safe because it is a long-chain fatty acid (with 18 carbon atoms) that directly feeds the Malassezia yeast responsible for fungal acne.
Phenoxyethanol is one of the most widely used preservatives in skincare (and for good reason!).
It has a large spectrum of antimicrobial activity and especially effective bacteria, yeast, and mold while only having a weak effect on your skin's natural microbiome.
On a cellular level, it disrupts the cell membranes of microbes by poking holes that make the cell leak. This shuts down the chemical reactions the microbe needs to make energy so it can no longer survive.
Another perk of this ingredient is that it stays functional across a wide pH range (3-10).
You'll often see it paired with boosters like Ethylhexylglycerin; one study showed that a 1:9 ratio of Ethylhexylglycerin to Phenoxyethanol damages bacterial membranes as effectively as doubling the Phenoxyethanol concentration on its own.
Typical use concentrations range from 0.3-1% depending on the formula, and this ingredient is capped at 1% int the EU.
Safety-wise, the fear mongering does not hold up to the evidence. The EU's Scientific Committee on Consumer Safety and FDA consider it safe as a preservative at up to 1%, including for children of all ages.
Adverse systemic effects only showed up in animal studies at exposures roughly 200x higher than what people get from cosmetics. And despite its very widespread use, this ingredient is a rare sensitizer and allergic reactions are uncommon.
Sodium Hyaluronate is the salt form of hyaluronic acid. It is a long sugar chain that is naturally found in your skin, joints, and connective tissue that maintains hydration and elasticity.
In skincare, it works as a humectant. It pulls water from the environment and deeper layers of skin and binds it to the surface.
Interestingly, the size of the molecule affects its behavior:
Some clinical evidence links low molecular weight versions to improved wrinkle depth, elasticity, anti-inflammatory effects, and barrier repair.
Many serums use a blend of both weights so you can get surface hydration plus longer-lasting and deeper effects.
You'll typically see concentrations between 0.1-2% for this ingredient.
Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.
So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.
You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!