Skin science article
Drunk Elephant Protini Polypeptide Cream Versus Drunk Elephant Bora Barrier Repair Cream
Drunk Elephant Protini Polypeptide Cream Versus Drunk Elephant Bora Barrier Repair Cream This anti-aging moisturizer is formulated around Sclerocarya Birrea Seed Oil and Sh-Oligopeptide-1 to soften the look of wrinkles and hydrate skin. This barrier-repair moi
Drunk Elephant Protini Polypeptide Cream Versus Drunk Elephant Bora Barrier Repair Cream
This anti-aging moisturizer is formulated around Sclerocarya Birrea Seed Oil and Sh-Oligopeptide-1 to soften the look of wrinkles and hydrate skin.
This barrier-repair moisturizer is formulated around Butyrospermum Parkii Butter and Glucosyl Ceramide to strengthen the skin barrier and hydrate skin.
What's inside
Key Ingredients
Benefits
Concerns
Ingredients Side-by-side
Water
Dicaprylyl Carbonate
Glycerin
Cetearyl Alcohol
Cetearyl Olivate
Sorbitan Olivate
Sclerocarya Birrea Seed Oil
Bacillus/Folic Acid Ferment Filtrate Extract
Nymphaea Alba Root Extract
Sh-Oligopeptide-1
Sh-Oligopeptide-2
Sh-Polypeptide-1
Sh-Polypeptide-9
Sh-Polypeptide-11
Copper Palmitoyl Heptapeptide-14
Heptapeptide-15 Palmitate
Palmitoyl Tetrapeptide-7
Palmitoyl Tripeptide-1
Alanine
Arginine
Glycine
Histidine
Isoleucine
Phenylalanine
Proline
Serine
Threonine
Valine
Acetyl Glutamine
Coconut Alkanes
Coco-Caprylate/Caprate
Sodium Hyaluronate
Aspartic Acid
Linoleic Acid
Linolenic Acid
Lecithin
Butylene Glycol
Polyvinyl Alcohol
Sodium Lactate
Sodium PCA
PCA
Sorbitan Isostearate
Carbomer
Polysorbate 20
Polysorbate 60
Lactic Acid/Glycolic Acid Copolymer
Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer
Xanthan Gum
Isomalt
1,2-Hexanediol
Caprylyl Glycol
Chlorphenesin
Phenoxyethanol
Tocopherol
Sodium Benzoate
Phenylpropanol
Glyceryl Caprylate
Symphytum Officinale Callus Culture Extract
Water, Dicaprylyl Carbonate, Glycerin, Cetearyl Alcohol, Cetearyl Olivate, Sorbitan Olivate, Sclerocarya Birrea Seed Oil, Bacillus/Folic Acid Ferment Filtrate Extract, Nymphaea Alba Root Extract, Sh-Oligopeptide-1, Sh-Oligopeptide-2, Sh-Polypeptide-1, Sh-Polypeptide-9, Sh-Polypeptide-11, Copper Palmitoyl Heptapeptide-14, Heptapeptide-15 Palmitate, Palmitoyl Tetrapeptide-7, Palmitoyl Tripeptide-1, Alanine, Arginine, Glycine, Histidine, Isoleucine, Phenylalanine, Proline, Serine, Threonine, Valine, Acetyl Glutamine, Coconut Alkanes, Coco-Caprylate/Caprate, Sodium Hyaluronate, Aspartic Acid, Linoleic Acid, Linolenic Acid, Lecithin, Butylene Glycol, Polyvinyl Alcohol, Sodium Lactate, Sodium PCA, PCA, Sorbitan Isostearate, Carbomer, Polysorbate 20, Polysorbate 60, Lactic Acid/Glycolic Acid Copolymer, Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, Xanthan Gum, Isomalt, 1,2-Hexanediol, Caprylyl Glycol, Chlorphenesin, Phenoxyethanol, Tocopherol, Sodium Benzoate, Phenylpropanol, Glyceryl Caprylate, Symphytum Officinale Callus Culture Extract
Propanediol
Ethylhexyl Olivate
Butyrospermum Parkii Butter
C10-18 Triglycerides
Beta-Sitosterol
Oenothera Biennis Oil
Simmondsia Chinensis Seed Oil
Calophyllum Inophyllum Seed Oil
Oleic Acid
Squalane
Glucosyl Ceramide
Glycosphingolipids
Rosa Canina Fruit Oil
Moringa Oleifera Seed Oil
Alpha-Glucan
Resveratrol
Epigallocatechin Gallate
Magnesium Aspartate
Zinc Gluconate
Copper Gluconate
Acacia Senegal Gum
Haematococcus Pluvialis Extract
Quercetin
Astaxanthin
Magnesium Ascorbyl Phosphate
Ceramide AP
Ceramide NP
Ceramide EOP
Dextrin
Palmitic Acid
Coco-Glucoside
Stearic Acid
Pentylene Glycol
Brassica Campestris Seed Oil
Tetrahexyldecyl Ascorbate
Sodium Lauroyl Lactylate
Phytosphingosine
Cholesterol
Tetrasodium Glutamate Diacetate
Citric Acid
Sodium Hydroxide
Ethylhexylglycerin
Water, Glycerin, Propanediol, Ethylhexyl Olivate, Butyrospermum Parkii Butter, C10-18 Triglycerides, Cetearyl Alcohol, Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, Cetearyl Olivate, Sorbitan Olivate, Beta-Sitosterol, Oenothera Biennis Oil, Sclerocarya Birrea Seed Oil, Simmondsia Chinensis Seed Oil, Calophyllum Inophyllum Seed Oil, Oleic Acid, Squalane, Butylene Glycol, Glucosyl Ceramide, Linoleic Acid, Linolenic Acid, Glycosphingolipids, Rosa Canina Fruit Oil, Moringa Oleifera Seed Oil, Alpha-Glucan, Resveratrol, Epigallocatechin Gallate, Magnesium Aspartate, Zinc Gluconate, Copper Gluconate, Acacia Senegal Gum, Sodium PCA, Palmitoyl Tripeptide-1, Palmitoyl Tetrapeptide-7, Sorbitan Isostearate, Haematococcus Pluvialis Extract, Quercetin, Astaxanthin, Magnesium Ascorbyl Phosphate, Ceramide AP, Ceramide NP, Ceramide EOP, Dextrin, Palmitic Acid, Coco-Glucoside, Sodium Lactate, Stearic Acid, Pentylene Glycol, Brassica Campestris Seed Oil, Tetrahexyldecyl Ascorbate, Sodium Lauroyl Lactylate, Phytosphingosine, Cholesterol, Xanthan Gum, Tetrasodium Glutamate Diacetate, Citric Acid, Phenoxyethanol, Sodium Hydroxide, Tocopherol, Polysorbate 60, Carbomer, Ethylhexylglycerin
Reviews
Alternatives
Ingredients Explained
These ingredients are found in both products.
Ingredients higher up in an ingredient list are typically present in a larger amount.
Butylene Glycol (or BG) is used within cosmetic products for a few different reasons:
Overall, Butylene Glycol is a safe and well-rounded ingredient that works well with other ingredients.
Though this ingredient works well with most skin types, some people with sensitive skin may experience a reaction such as allergic rashes, closed comedones, or itchiness.
Carbomer is a synthetic thickening and gelling agent. It's basically the ingredient that gives a lot of serums, gels, creams, and sunscreens their smooth, non-sticky texture.
Although legally permitted at very high levels, carbomers are normally used at concentrations below 1%.
It also needs to be neutralized to actually thicken, and because it is a large molecule, it doesn't really penetrate the skin barrier.
Allergy-wise, the risk is very low. Clinical studies show carbomers have low potential for skin irritation/sensitization even at concentrations up to 100%.
A 2024 UK study patch-tested 1,302 patients and found true allergy to the parent group of carbomer to be rare with no confirmed relevant reactions.
Cetearyl alcohol is a waxy mixture of two fatty alcohols: cetyl alcohol and stearyl alcohol. It is an emollient and emulsifier.
Despite having "alcohol" in its name, it has nothing to do with drying solvent alcohols; the FDA also allows "alcohol-free" products to contain fatty alcohols like this ingredient.
It plays several roles in a formula:
Typical use levels for this ingredient sit around 1-10% and the Cosmetic Ingredient Review Expert Panel has affirmed safety at concentrations up to 25% in leave-on products.
Multiple assessments have found it to be non-irritating and non-sensitizing to most people.
However, there have been some cases of allergic contact dermatitis in patients with chronically compromised skin barriers.
Cetearyl alcohol has a comedogenic rating of 2 and irritancy rating of 1. Both of these numbers come from the 1989 study that used rabbit ears; a "2" means mildly comedogenic and a "1" means low irritancy.
Here's the catch: rabbit skin is more sensitive than human skin and throws a lot of false positives. A 1996 reappraisal found that ingredients rated 1-2 in the rabbit ear tests are generally safe for humans.
Remember comedogenic ratings are unable to assess the entire formula of a product or how it will react on your skin. Just be sure to patch test if you are unsure about certain ingredients.
This ingredient is not fungal acne safe. Cetearyl alcohol is a fatty alcohol with chain lengths that fall within the range that Malassezia can metabolize.
A 2019 study has also observed Malassezia growth in the presence of this ingredient, confirming it to be not-fungal acne safe.
Cetearyl Olivate is a plant-derived emulsifier and texture enhancer. It helps keep the oil and water phases from separating so your formulas stay stable.
You'll likely see it combined with Sorbitan Olivate (together sold as the trade name Olivem 1000). This combination generates a liquid crystal structure that closely resemble the lipid organization of the stratum corneum.
These "skin-like" liquid crystals improve skin barrier integrity and promote the delivery of actives into the skin.
This ingredient is well-tolerated and has no significant sensitization data.
Because it is derived from the fatty acids in olive oil, this ingredient may not be fungal acne safe.
Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.
Topically, glycerin does several things at once:
Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.
Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.
This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.
Just know very high concentrations (>40%) can feel tacky in low humidity.
Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.
This is a synthetic polymer. It helps improve the texture of products by adding thickness and gel-like feel.
It is also an emulsifer, meaning it prevents ingredients such as oil and water from separating. It also helps evenly disperse other ingredients.
Linoleic Acid is also known as Vitamin F. It is a fatty acid with emollient and skin conditioning properties.
Our top layer of skin, or epidermis, naturally contains high amounts of linoleic acid.
Your body uses linoleic acid to build ceramides and prostaglandins. Ceramides keep your skin's barrier hydrated and strong while prosaglandins help control inflammation and healing.
Needless to say, linoleic acid is crucial for having a strong skin barrier.
One study found applying linoleic acid rich sunflower oil to be more effective at repairing the skin barrier than olive oil.
This ingredient can also help treat acne by softening sebum to prevent clogged pores. Another study found using 2.5% linoleic acid gel for 4 weeks showed a 25% reduction in small comedones.
Studies show it can also help lighten hyperpigmentation or sun spots by disrupting the melanin production process. It also helps your skin shed melanin pigment from your skin caused by UV exposure.
Due to its role in the production of the fatty acid prostaglandin, linoleic acid can also help reduce inflammation and support wound healing.
Fun fact: Linoleic acid is an essential fatty acid. This means our bodies cannot create it on its own and we need to get it through foods such as nuts and vegetable oils.
Just know this ingredient is not always fungal-acne safe because it is a long-chain fatty acid (with 18 carbon atoms) that directly feeds the Malassezia yeast responsible for fungal acne.
Linolenic Acid is also known as "ALA" or alpha-linolenic acid. It is a key fatty acid.
Our skin uses this ingredient for maintaining a healthy skin barrier, regulating inflammation, and supporting keratinocyte function.
ALA is a great skin hydrator because it has the ability to restore lipids in our stratum corneum, or outermost layer of our skin; it also helps prevent transepidermal water loss.
This ingredient also helps soothe irritated skin by downregulating inflammation.
Chia seed oil is one of the highest natural sources of ALA. Research shows topical chia seed oil significantly improves skin hydration, reduces itch, and strengthens the barrier in both healthy and extremely dry skin.
Additionally, in-vivo and in-vitro studies show ALA exhibits antioxidant properties, reduces UV-induced inflammation, and supports wound healing.
Early research showed a fatty-acid deficiency in animals leads to abnormal skin barrier function. It is believed a deficiency in linolenic acid may be linked to skin disorders like eczema.
Fun fact: This ingredient is considered an essential fatty acid for humans. This means our bodies cannot naturally produce it and we must get it from food. Some foods rich in linolenic acid include walnuts, fish oils, soy, and canola.
Palmitoyl Tetrapeptide-7 (formerly Palmitoyl Tetrapeptide-3) is a synthetic peptide. Its main job is to fight what researchers call "inflammaging".
"Inflammaging" is the slow, low-grade chronic inflammation that quietly breaks down collagen as we age.
This ingredient calms down a specific inflammation signal in your skin cells (called IL-6). When left unchecked, this signal triggers enzymes that break down collagen and elastin.
Clinical testing showed statistically significant improvements in:
Studies also found the more of this ingredient used, the more your skin produces Collagen I, fibronectin, and hyaluronic acid.
You'll likely see this ingredient paired with Palmitoyl Tripeptide-1 in the well-known Matrixyl 3000 complex for enhanced anti-aging effects.
A 3% concentration applied twice daily for two months showed meaningful skin rejuvenation results in clinical panels.
Fungal acne note: Usually a palmitic acid component can feed Malassezia in unbound form, but here is is covalently bonded to the peptide. This means it is very difficult for Malassezia to access, and therefore very unlikely to cause fungal acne.
Palmitoyl Tripeptide-1 (aka Pal-GHK) is a synthetic signal peptide made of three amino acids attached to palmitic acid.
That fatty acid attachment is the key: it boosts the peptide's ability to penetrate the skin barrier. This puts it closer to the dermal cells where it can actually make a difference.
Once there, it acts as a matrikine, a signaling peptide that prompts fibroblasts to produce more collagen, fibronectin, and hyaluronic acid.
In vitro studies show it can boost collagen production in skin cells even when UV-damaged skin samples were treated with it at a tiny concentration (it almost fully restored dermal collagen at 5ppm). It achieved this at 100x lower concentration than retinoic acid, which needed 500 ppm to do the same thing.
Human clinical data is promising, but modest:
A study of 23 female volunteers found a small but statistically significant increase (~4%) in skin thickness after treatment at 4 ppm.
A separate small trial of 15 women showed statistically significant reductions in wrinkle length, depth, and skin roughness after applying it twice daily for four weeks.
You'll likely see Pal-GHK paired with Palmitoyl Tetrapeptide-7 as part of the Matrixyl 3000 complex.
Phenoxyethanol is one of the most widely used preservatives in skincare (and for good reason!).
It has a large spectrum of antimicrobial activity and especially effective bacteria, yeast, and mold while only having a weak effect on your skin's natural microbiome.
On a cellular level, it disrupts the cell membranes of microbes by poking holes that make the cell leak. This shuts down the chemical reactions the microbe needs to make energy so it can no longer survive.
Another perk of this ingredient is that it stays functional across a wide pH range (3-10).
You'll often see it paired with boosters like Ethylhexylglycerin; one study showed that a 1:9 ratio of Ethylhexylglycerin to Phenoxyethanol damages bacterial membranes as effectively as doubling the Phenoxyethanol concentration on its own.
Typical use concentrations range from 0.3-1% depending on the formula, and this ingredient is capped at 1% int the EU.
Safety-wise, the fear mongering does not hold up to the evidence. The EU's Scientific Committee on Consumer Safety and FDA consider it safe as a preservative at up to 1%, including for children of all ages.
Adverse systemic effects only showed up in animal studies at exposures roughly 200x higher than what people get from cosmetics. And despite its very widespread use, this ingredient is a rare sensitizer and allergic reactions are uncommon.
Polysorbate 60 is used to help stabilize products. It is a surfactant and emulsifier. These properties help keep ingredients together in a product. Surfactants help reduce surface tension between ingredients with different states, such as liquids and solids. Emulsifiers help prevent oils and waters from separating.
Polysorbate 60 is sorbitol-based and created from the ethoxylation of sorbitan. Ethoxylation is a chemical reaction used to add ethylene oxide. Sorbitan is a the dehydrated version of sorbitol, a sugar found in fruits.
In this case, the 60 comes from reacting 60 units of ethylene oxide with sorbitan.
Polysorbates are commonly used in medicine and foods.
Sclerocarya Birrea Seed Oil (aka marula oil) is a skin hydrating ingredient.
Its fatty acid profile is dominated by oleic acid (~69%), palmitic acid (~15%), linoleic acid (~9%), and palmitoleic acid (~4%).
These fatty acids are very similar to those naturally found in the epidermis, making this oil biomimetic; basically, your skin recognizes it.
Clinical testing found this ingredient to be moisturizing and non-irritating, with noteworthy effects on reducing transepidermal water loss (TEWL).
Besides fatty acids, marula oil is also rich in oxidative stabilizers like vitamin E, vitamin C precursors, and polyphenols. This gives it excellent shelf stability compared to most facial oils.
This is a great ingredient for dry, dull, or barrier-compromised skin.
Just know it may not be fungal acne safe due to the oleic and palmitic acid content. These fatty acids can as as a food source for the Malassezia yeast.
Sodium Lactate is the sodium salt of lactic acid, an AHA. It is a humectant and sometimes used to adjust the pH of a product.
This ingredient is part of our skin's NMF, or natural moisturizing factor. Our NMF is essential for the hydration of our top skin layers and plasticity of skin. NMF also influences our skin's natural acid mantle and pH, which protects our skin from harmful bacteria.
High percentages of Sodium Lactate can have an exfoliating effect.
Fun fact: Sodium Lactate is produced from fermented sugar.
Sodium PCA (the salt of PCA) is one of the most well-established humectants in skincare.
Why is it so special? Your skin already makes it naturally; it's a natural component of your skin's Natural Moisturizing Factor (NMF), or the mix of water-binding compounds inside your skin cells that keeps things soft and hydrated.
As a cosmetic ingredient, it grabs water and holds it in the upper layers of skin to smooth roughness and ease dehydration.
There's some clinical support for the NMF approach with a study showing that a cream built to mimic the skin's NMF significantly boosted hydration.
Safety-wise, this ingredient non-irritating, non-comedogenic, and non-phototoxic in testing, with minimal skin absorption.
It also works really well with other hydrators like glycerin or hyaluronic acid, and typical usage is somewhere between 0.2-4%.
Sorbitan Isostearate is an emulsifer. It is created from isostearic acid and sorbitol.
As an emulsifier, it keeps the water and oil ingredients from separating. This keeps formulas stable and smooth.
In a 24 hour occlusive patch test on 56 subjects, 10% sorbitan isostearate was completely non-irritating. Most formulas use less than 10%.
Because it's a fatty acid ester, it may not be fungal acne safe since the Malassezia yeast can utilize it as a nutrient source.
Sorbitan Olivate is created from the fatty acids in olive oil and sorbitol.
This ingredient is an oil in water emulsifier. It helps stabilize a product by preventing oils and waters from separating. Sorbitan Olivate also helps hydrate the skin.
This ingredient is also known as part of Olivem 1000, with Cetearyl Olivate being the other part.
According to a manufacturer, this ingredient helps preserve the natural microbiome of skin. Having a healthy microbiome helps keep our skin healthy and protects against harmful bacteria.
Please note, having a healthy microbiome is different from fungal acne; a healthy microbiome includes small amounts of yeast that normally live on your skin without causing problems.
Fungal acne happens when one type of yeast (Malassezia) grows out of control. This is usually because it's feeding on certain oils or fatty acids. Due to the olive oil base, this ingredient may not be fungal acne safe.
Tocopherol is a fat-soluble antioxidant known as Vitamin E.
You'll find this ingredient in the vast majority of skincare (for good reason). It works to neutralize free radicals, or unstable molecules generated by UV exposure, pollution, and other environmental stressors, before they can cause oxidative damage to your skin cells.
Topically applied tocopherol has been shown to protect against UV damage by ramping up the skin's own natural defense enzymes.
It also acts as a skin conditioning agent; some studies show that regular topical use can improve the skin's water-binding capacity over 2-4 weeks.
This ingredient is especially loved for being a team player. When combined with Vitamin C, the photoprotective effect of both ingredients roughly doubles and the combo also helps reduce UV-induced DNA damage.
This ingredient has some brightening potential but it's more of a prevention ingredient than spot-fader. Cell studies show it can slow down melanin production but it's worth noting that it's not the most powerful brightener out there.
In formulations, it also serves as a stabilizer that helps protect other oxidation-prone ingredients from degrading.
Concentrations usually range from 0.1-1% in most leave-on products.
Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.
So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.
You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!
Xanthan gum is used as a stabilizer and thickener within cosmetic products. It helps give products a sticky, thick feeling - preventing them from being too runny.
On the technical side of things, xanthan gum is a polysaccharide - a combination consisting of multiple sugar molecules bonded together.
Xanthan gum is a pretty common and great ingredient. It is a natural, non-toxic, non-irritating ingredient that is also commonly used in food products.