Epionce Medical Barrier Cream Versus Skinfix Barrier+ Triple Lipid-Peptide Cream

Epionce Medical Barrier Cream Versus Skinfix Barrier+ Triple Lipid-Peptide Cream

This barrier-repair moisturizer is formulated around Petrolatum and Phytosphingosine to strengthen the skin barrier and hydrate skin.

This barrier-repair moisturizer is formulated around Butyrospermum Parkii Butter and Ceramide NP to strengthen the skin barrier and hydrate skin.

What's inside

Key Ingredients

No key ingredients

Benefits

Concerns

Ingredients Side-by-side

Water

Petrolatum

Glycerin

Butylene Glycol

Carthamus Tinctorius Seed Oil

Limnanthes Alba Seed Oil

Hydrogenated Polyisobutene

PPG-2 Myristyl Ether Propionate

Cyclopentasiloxane

Linum Usitatissimum Seed Oil

Butyrospermum Parkii Butter

Cetyl Alcohol

Cetearyl Glucoside

C10-30 Cholesterol/Lanosterol Esters

Cyclohexasiloxane

Acrylates/C10-30 Alkyl Acrylate Crosspolymer

Allium Fistulosum Bulb Extract

Arachidyl Alcohol

Arachidyl Glucoside

Behenyl Alcohol

Beeswax

C12-15 Alkyl Benzoate

Caprylyl Glycol

Cyclomethicone

Dimethiconol

Disodium EDTA

Ethylhexylglycerin

Glyceryl Stearate

Hexylene Glycol

Olea Europaea Oil Unsaponifiables

PEG-100 Stearate

Persea Gratissima Oil

Phenoxyethanol

Phytosphingosine

Phytosterols

Rosa Canina Fruit Oil

Triethanolamine

Water, Petrolatum, Glycerin, Butylene Glycol, Carthamus Tinctorius Seed Oil, Limnanthes Alba Seed Oil, Hydrogenated Polyisobutene, PPG-2 Myristyl Ether Propionate, Cyclopentasiloxane, Linum Usitatissimum Seed Oil, Butyrospermum Parkii Butter, Cetyl Alcohol, Cetearyl Glucoside, C10-30 Cholesterol/Lanosterol Esters, Cyclohexasiloxane, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Allium Fistulosum Bulb Extract, Arachidyl Alcohol, Arachidyl Glucoside, Behenyl Alcohol, Beeswax, C12-15 Alkyl Benzoate, Caprylyl Glycol, Cyclomethicone, Dimethiconol, Disodium EDTA, Ethylhexylglycerin, Glyceryl Stearate, Hexylene Glycol, Olea Europaea Oil Unsaponifiables, PEG-100 Stearate, Persea Gratissima Oil, Phenoxyethanol, Phytosphingosine, Phytosterols, Rosa Canina Fruit Oil, Triethanolamine

Caprylic/Capric Triglyceride

Olus Oil

Cetyl Lactate

Propanediol

C12-16 Alcohols

Caprylyl Caprylate/Caprate

Jojoba Oil/Macadamia Seed Oil Esters

Glyceryl Stearate Citrate

Palmitic Acid

Hydrogenated Lecithin

Oryza Sativa Bran Extract

Dilinoleic Acid/Propanediol Copolymer

Squalene

Ophiopogon Japonicus Root Extract

Xanthan Gum

Phytosteryl Sunflowerseedate

Glycine Soja Extract

Pentylene Glycol

Ceramide NP

Ceramide AP

Ceramide EOP

Hydrolyzed Rice Protein

Chondrus Crispus Extract

Hydrogenated Vegetable Glycerides

Helianthus Annuus Extract

Sodium Hyaluronate

Citric Acid

Phytosteryl Macadamiate

Tocopherol

Rosmarinus Officinalis Leaf Extract

Aloe Barbadensis Leaf Juice

Trisodium Ethylenediamine Disuccinate

Sodium Lauroyl Lactylate

Gluconolactone

Phenethyl Alcohol

Cholesterol

Carbomer

Potassium Sorbate

Sodium Benzoate

Water, Caprylic/Capric Triglyceride, Glycerin, Butyrospermum Parkii Butter, Olus Oil, Cetyl Lactate, Propanediol, C12-16 Alcohols, Caprylyl Caprylate/Caprate, Jojoba Oil/Macadamia Seed Oil Esters, Glyceryl Stearate Citrate, Palmitic Acid, Hydrogenated Lecithin, Oryza Sativa Bran Extract, Dilinoleic Acid/Propanediol Copolymer, Squalene, Ophiopogon Japonicus Root Extract, Xanthan Gum, Phytosteryl Sunflowerseedate, Glycine Soja Extract, Pentylene Glycol, Ceramide NP, Ceramide AP, Ceramide EOP, Hydrolyzed Rice Protein, Chondrus Crispus Extract, Hydrogenated Vegetable Glycerides, Helianthus Annuus Extract, Sodium Hyaluronate, Citric Acid, Phytosteryl Macadamiate, Tocopherol, Rosmarinus Officinalis Leaf Extract, Aloe Barbadensis Leaf Juice, Trisodium Ethylenediamine Disuccinate, Phytosterols, Sodium Lauroyl Lactylate, Gluconolactone, Phenethyl Alcohol, Phytosphingosine, Cholesterol, Carbomer, Potassium Sorbate, Ethylhexylglycerin, Sodium Benzoate, Phenoxyethanol

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Alternatives

Ingredients Explained

These ingredients are found in both products.

Ingredients higher up in an ingredient list are typically present in a larger amount.

This ingredient is also known as shea butter. It is a plant-derived extract from the nuts of the Africa shea tree and one of the most well-studied emollients.

Because it has a high concentration of fatty acids (primarily oleic, stearic, and linoleic) it is able to form a protective barrier on the skin's surface. This helps seal in moisture and prevents transepidermal water loss (TEWL).

In vitro research found an increase in skin hydration by 58% and a decrease in TEWL by 37.8% after 24 hours of applying this ingredient (pretty impressive for a single ingredient!).

Besides hydration, shea butter also contains triterpenes that have anti-inflammatory potential. In particule, lupeol cinnamate has shown the highest anti-inflammatory activity in vivo.

Shea butter also contains vitamins A and E which may contribute to antioxidant activity.

While Shea Butter has an SPF rating of about 3-4, it is not a sunscreen replacement.

This ingredient may not be fungal acne safe because its fatty acids fall within the C11-C24 range that the Malassezia yeast can metabolize.

Ethylhexylglycerin is created from glycerin. It is a multitasker ingredient that:

The CIR Expert Panel found minimal skin absorption or sensitization of any kind in a safety assessment. Though this ingredient is considered well-tolerated, a small number of cases of allergic dermatitis have been published since 2002. Just be sure to patch test if you are unsure.

Industry-reported use ranges from 8% in rinse-off products and 2% in leave-on formulations.

Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.

Topically, glycerin does several things at once:

Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.

Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.

This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.

Just know very high concentrations (>40%) can feel tacky in low humidity.

Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.

Phenoxyethanol is one of the most widely used preservatives in skincare (and for good reason!).

It has a large spectrum of antimicrobial activity and especially effective bacteria, yeast, and mold while only having a weak effect on your skin's natural microbiome.

On a cellular level, it disrupts the cell membranes of microbes by poking holes that make the cell leak. This shuts down the chemical reactions the microbe needs to make energy so it can no longer survive.

Another perk of this ingredient is that it stays functional across a wide pH range (3-10).

You'll often see it paired with boosters like Ethylhexylglycerin; one study showed that a 1:9 ratio of Ethylhexylglycerin to Phenoxyethanol damages bacterial membranes as effectively as doubling the Phenoxyethanol concentration on its own.

Typical use concentrations range from 0.3-1% depending on the formula, and this ingredient is capped at 1% int the EU.

Safety-wise, the fear mongering does not hold up to the evidence. The EU's Scientific Committee on Consumer Safety and FDA consider it safe as a preservative at up to 1%, including for children of all ages.

Adverse systemic effects only showed up in animal studies at exposures roughly 200x higher than what people get from cosmetics. And despite its very widespread use, this ingredient is a rare sensitizer and allergic reactions are uncommon.

Phytosphingosine is a phospholipid naturally found in our skin as a building block for ceramides.. It helps moisturize, soothe, and protect skin.

Phytosphingosine contributes to your skin's natural moisturizing factor (NMF). The NMF is responsible for hydration, a strong barrier, and plasticity. Our NMF decreases with age. Increasing NMF leads to more healthy and hydrated skin.

Studies show products formulated with NMF ingredients help strengthen our skin's barrier. Having a healthy skin barrier reduces irritation and increases hydration. Our skin barrier is responsible for having plump and firm skin. It also helps protect our skin against infection, allergies, and inflammation.

Fun fact: Phytosphingosine is abundant in plants and fungi.

More ingredients that help boost collagen in skin:

Phytosterols are plant-derived sterols (you can think of them as the plant world's version of cholesterol). In cosmetics, this ingredient is usually sourced from soybean, rice bran, shea, sunflower, and other seed oils.

The main actors in this group are β-sitosterol, campesterol, and stigmasterol (the CIR covers 27 phytosterols).

They work by fitting perfectly into your stratum corneum's lipid matrix since they're structurally similar to cholesterol. Here, they reinforce your skin's barrier.

One small in vivo human study showed topical soybean phytosterols sped up barrier recovery within three days on tape-stripped skin.

Broader research credits them with:

Formulation use typically sit under 5%.

Testing in soy-allergic subjects found no sensitization signals, but be sure to patch test if you are unsure or have existing allergies.

Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.

So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.

You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!

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