Skin science article
Epionce Renewal Facial Cream Versus Paula's Choice Clinical Ultra-Rich Moisturizer
Epionce Renewal Facial Cream Versus Paula's Choice Clinical Ultra-Rich Moisturizer This moisturizer is formulated around Petrolatum and Carthamus Tinctorius Seed Oil to hydrate skin. This barrier-repair moisturizer is formulated around Butyrospermum Parkii But
Epionce Renewal Facial Cream Versus Paula's Choice Clinical Ultra-Rich Moisturizer
This moisturizer is formulated around Petrolatum and Carthamus Tinctorius Seed Oil to hydrate skin.
This barrier-repair moisturizer is formulated around Butyrospermum Parkii Butter Unsaponifiables and Ceramide NP to strengthen the skin barrier and hydrate skin.
What's inside
Key Ingredients
Benefits
Concerns
Ingredients Side-by-side
Water
Butylene Glycol
Trisiloxane
Petrolatum
Limnanthes Alba Seed Oil
Carthamus Tinctorius Seed Oil
C10-30 Cholesterol/Lanosterol Esters
Glycerin
PPG-2 Myristyl Ether Propionate
Beeswax
Olea Europaea Fruit Oil
C13-14 Isoparaffin
Laureth-7
Polyacrylamide
Glyceryl Stearate
Malic Acid
PEG-100 Stearate
Pyrus Malus Fruit Extract
C12-15 Alkyl Benzoate
Camphor
Caprylyl Glycol
Cetearyl Alcohol
Cetyl Alcohol
Citral
Citrus Aurantium Dulcis Peel Oil
Citrus Limon Peel Oil
Cymbopogon Citratus Leaf Oil
Ethylene Brassylate
Ethylhexylglycerin
Hexylene Glycol
Lavandula Hybrida Oil
Limonene
Linalool
Linalyl Acetate
Linum Usitatissimum Seed Oil
Litsea Cubeba Fruit Oil
Octanal
Persea Gratissima Oil
Phenoxyethanol
Phoenix Dactylifera Fruit Extract
Phytosphingosine
Phytosterols
Pinene
Polysorbate 60
Quercetin
Rosa Canina Fruit Oil
Sodium Hyaluronate
Sodium Hydroxide
Water, Butylene Glycol, Trisiloxane, Petrolatum, Limnanthes Alba Seed Oil, Carthamus Tinctorius Seed Oil, C10-30 Cholesterol/Lanosterol Esters, Glycerin, PPG-2 Myristyl Ether Propionate, Beeswax, Olea Europaea Fruit Oil, C13-14 Isoparaffin, Laureth-7, Polyacrylamide, Glyceryl Stearate, Malic Acid, PEG-100 Stearate, Pyrus Malus Fruit Extract, C12-15 Alkyl Benzoate, Camphor, Caprylyl Glycol, Cetearyl Alcohol, Cetyl Alcohol, Citral, Citrus Aurantium Dulcis Peel Oil, Citrus Limon Peel Oil, Cymbopogon Citratus Leaf Oil, Ethylene Brassylate, Ethylhexylglycerin, Hexylene Glycol, Lavandula Hybrida Oil, Limonene, Linalool, Linalyl Acetate, Linum Usitatissimum Seed Oil, Litsea Cubeba Fruit Oil, Octanal, Persea Gratissima Oil, Phenoxyethanol, Phoenix Dactylifera Fruit Extract, Phytosphingosine, Phytosterols, Pinene, Polysorbate 60, Quercetin, Rosa Canina Fruit Oil, Sodium Hyaluronate, Sodium Hydroxide
Butyrospermum Parkii Butter Unsaponifiables
Caprylic/Capric Triglyceride
Glyceryl Stearate Se
Dimethicone
Stearic Acid
Mangifera Indica Seed Butter
Cocos Nucifera Fruit Extract
Ceramide NP
Ceramide AP
Ceramide EOP
Sphingolipids
Phospholipids
Squalene
Cholesterol
Tocopherol
Simmondsia Chinensis Seed Oil
Glycine Soja Oil
Oryza Sativa Bran Extract
Avena Sativa Kernel Extract
Panthenol
Ascorbyl Palmitate
Beta-Sitosterol
Hydrogenated Vegetable Glycerides Citrate
Propylene Glycol
Sodium Lauroyl Lactylate
Xanthan Gum
Carbomer
Disodium EDTA
Water, Butyrospermum Parkii Butter Unsaponifiables, Caprylic/Capric Triglyceride, Glyceryl Stearate Se, Olea Europaea Fruit Oil, Dimethicone, Stearic Acid, Glyceryl Stearate, Mangifera Indica Seed Butter, Cetyl Alcohol, Cocos Nucifera Fruit Extract, Ceramide NP, Ceramide AP, Ceramide EOP, Sphingolipids, Phospholipids, Phytosphingosine, Squalene, Cholesterol, Tocopherol, Simmondsia Chinensis Seed Oil, Persea Gratissima Oil, Glycine Soja Oil, Oryza Sativa Bran Extract, Avena Sativa Kernel Extract, Glycerin, Panthenol, Ascorbyl Palmitate, Beta-Sitosterol, Hydrogenated Vegetable Glycerides Citrate, Propylene Glycol, Sodium Lauroyl Lactylate, Xanthan Gum, Carbomer, Disodium EDTA, Ethylhexylglycerin, Phenoxyethanol
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Alternatives
Ingredients Explained
These ingredients are found in both products.
Ingredients higher up in an ingredient list are typically present in a larger amount.
Cetyl Alcohol is a fatty alcohol. Fatty Alcohols are most often used as an emollient or to thicken a product.
Its main roles are:
Though it has "alcohol" in the name, it is not related to denatured alcohol or ethyl alcohol.
The FDA allows products labeled "alcohol-free" to have fatty alcohols.
This ingredient may not be fungal acne safe. It is a primary fatty alcohol with a chain length above 12 carbons. A study from 2019 show Malassezia can feed on fatty alcohols in this range, so it may trigger fungal acne in those prone to it.
Ethylhexylglycerin is created from glycerin. It is a multitasker ingredient that:
The CIR Expert Panel found minimal skin absorption or sensitization of any kind in a safety assessment. Though this ingredient is considered well-tolerated, a small number of cases of allergic dermatitis have been published since 2002. Just be sure to patch test if you are unsure.
Industry-reported use ranges from 8% in rinse-off products and 2% in leave-on formulations.
Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.
Topically, glycerin does several things at once:
Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.
Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.
This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.
Just know very high concentrations (>40%) can feel tacky in low humidity.
Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.
Glyceryl Stearate is made by reacting glycerin with stearic acid (typically sourced from plant oils like palm or coconut). It's an emulsifier, emollient, and mild occlusive.
Emulsifiers help ingredients like oil and water stay mixed so your formula stays nicely blended and uniform in texture.
This ingredient is typically used in concentrations between 1-10%. Studies have found it to be non-sensitizing, non-phototoxic, and non-photoallergenic.
A close cousin of this ingredient is Glyceryl Stearate SE ("self-emulsifying"). This just has a small amount of sodium or potassium stearate added so it can emulsify without a co-emulsifier.
Since this ingredient is an ester of a C18 fatty acid, it may not be fungal acne safe. The Malassezia yeast can potentially metabolize within the C11-C24 range.
Fun fact: The human body also creates Glyceryl Stearate naturally.
This ingredient is also known as olive oil. It has been used in skincare for centuries and science largely backs up its reputation as a nourishing emollient.
The main components of olive oil are oleic acid (55-83%), linoleic acid (3.5-20%), and palmitic acid (7-20%). Oleic acid promotes skin regeneration and helps regulate inflammatory responses.
Squalene is also naturally present in olive oil and exhibits moisturizing and antioxidant properties.
The polyphenols in olive oil also show anti-aging promise; one clinical study found a measurable improvement in skin appearance after 30 days of topical serum use.
Just be aware that applying olive oil directly to skin can weaken the barrier and cause redness. One study with volunteers found even people without sensitive skin experienced a significant reduction in stratum corneum integrity and induced mild erythema.
It's best to use this ingredient as part of a carefully crafted formula (instead of putting it on skin directly from the bottle).
Because it has a 2-3 on the comedogenic scale, it is a moderate risk for acne-prone skin. However, the overall formulation of a product matters more than a few ingredients with comedogenic ratings.
This ingredient may not be fungal acne safe because of the oleic and palmitic acid content. These fall within the C11-24 fatty acid range that the Malassezia yeast can metabolize to grow.
Overall, olive oil is a well-studied and nourishing skincare ingredient.
This ingredient is also known as Avocado oil. It's the cold-pressed oil from the flesh of the avocado fruit packed with fatty acids (mostly oleic acid).
The rich fatty acid profile allows it to function as a skin conditioning agent and emollient; it helps soften and smooth skin while reducing water loss.
Preclinical research has found that topical avocado oil increased collagen synthesis and reduced inflammation during wound healing, giving it some skin-repairing credibility.
The unsaponifiable fraction of the oil is also interesting: studies on avocado unsaponifiables showed that it helped skin produce more collagen and other structural compounds that support healing.
The CIR Expert Panel has found this ingredient to be non-irritating in formulations.
It's a great ingredient for dry or compromised skin. Just know it may not be fungal acne safe. This is because the oleic acid content falls within the range that Malassezia can use as a food source.
Phenoxyethanol is one of the most widely used preservatives in skincare (and for good reason!).
It has a large spectrum of antimicrobial activity and especially effective bacteria, yeast, and mold while only having a weak effect on your skin's natural microbiome.
On a cellular level, it disrupts the cell membranes of microbes by poking holes that make the cell leak. This shuts down the chemical reactions the microbe needs to make energy so it can no longer survive.
Another perk of this ingredient is that it stays functional across a wide pH range (3-10).
You'll often see it paired with boosters like Ethylhexylglycerin; one study showed that a 1:9 ratio of Ethylhexylglycerin to Phenoxyethanol damages bacterial membranes as effectively as doubling the Phenoxyethanol concentration on its own.
Typical use concentrations range from 0.3-1% depending on the formula, and this ingredient is capped at 1% int the EU.
Safety-wise, the fear mongering does not hold up to the evidence. The EU's Scientific Committee on Consumer Safety and FDA consider it safe as a preservative at up to 1%, including for children of all ages.
Adverse systemic effects only showed up in animal studies at exposures roughly 200x higher than what people get from cosmetics. And despite its very widespread use, this ingredient is a rare sensitizer and allergic reactions are uncommon.
Phytosphingosine is a phospholipid naturally found in our skin as a building block for ceramides.. It helps moisturize, soothe, and protect skin.
Phytosphingosine contributes to your skin's natural moisturizing factor (NMF). The NMF is responsible for hydration, a strong barrier, and plasticity. Our NMF decreases with age. Increasing NMF leads to more healthy and hydrated skin.
Studies show products formulated with NMF ingredients help strengthen our skin's barrier. Having a healthy skin barrier reduces irritation and increases hydration. Our skin barrier is responsible for having plump and firm skin. It also helps protect our skin against infection, allergies, and inflammation.
Fun fact: Phytosphingosine is abundant in plants and fungi.
More ingredients that help boost collagen in skin:
Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.
So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.
You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!