Skin science article
Estée Lauder Perfectionist CP+R Wrinkle Lifting/Firming Serum Versus Olay Regenerist Collagen Peptide 24 Serum (Fragrance Free)
Estée Lauder Perfectionist CP+R Wrinkle Lifting/Firming Serum Versus Olay Regenerist Collagen Peptide 24 Serum (Fragrance Free) This anti-aging serum is formulated around Acetyl Hexapeptide-8 and Palmitoyl Oligopeptide to soften the look of wrinkles and hydrat
Estée Lauder Perfectionist CP+R Wrinkle Lifting/Firming Serum Versus Olay Regenerist Collagen Peptide 24 Serum (Fragrance Free)
This anti-aging serum is formulated around Acetyl Hexapeptide-8 and Palmitoyl Oligopeptide to soften the look of wrinkles and hydrate skin.
This anti-aging serum is formulated around Niacinamide and Panthenol to soften the look of wrinkles and refine skin texture.
What's inside
Key Ingredients
Benefits
Concerns
Ingredients Side-by-side
Dimethicone
Water
Polysilicone-11
Hdi/Trimethylol Hexyllactone Crosspolymer
Silica
Butylene Glycol
Caprylyl Methicone
Sigesbeckia Orientalis Extract
Salvia Sclarea Extract
Coleus Forskohlii Root Extract
Chamomilla Recutita Flower Extract
PEG-10 Dimethicone
Hydrolyzed Collagen
Palmaria Palmata Extract
Glycyrrhiza Glabra Root Extract
Silybum Marianum Extract
Hordeum Vulgare Extract
Padina Pavonica Thallus Extract
Artemia Extract
Pantethine
Algae Extract
Chlorella Vulgaris Extract
Cholesterol
Squalane
Boswellia Serrata Extract
Zea Mays Kernel Extract
Glycine Soja Protein
Caffeine
Whey Protein
Linoleic Acid
Lecithin
Collagen
Acetyl Hexapeptide-8
Palmitoyl Oligopeptide
Glycerin
Faex Extract
Polyquaternium-51
Phytosphingosine
Triticum Vulgare Germ Oil
Decarboxy Carnosine Hcl
Polysorbate 40
Pentylene Glycol
Propanediol
Lauryl PEG-9 Polydimethylsiloxyethyl Dimethicone
Ethylhexylglycerin
Ammonium Acryloyldimethyltaurate/Vp Copolymer
Sodium PCA
Polymethylsilsesquioxane
Glyceryl Polymethacrylate
Zinc PCA
Propylene Glycol Dicaprate
Sodium Chondroitin Sulfate
Sodium Hyaluronate
Isohexadecane
PEG-8
Tocopheryl Acetate
Polysorbate 80
Disodium Distyrylbiphenyl Disulfonate
Laureth-12
Acrylamide/Sodium Acryloyldimethyltaurate Copolymer
Caprylyl Glycol
Aminopropyl Ascorbyl Phosphate
Xanthan Gum
Sodium Beta-Sitosteryl Sulfate
Sodium Chloride
Sodium Hydroxide
Parfum
Disodium EDTA
BHT
Phenoxyethanol
Mica
CI 77891
Dimethicone, Water, Polysilicone-11, Hdi/Trimethylol Hexyllactone Crosspolymer, Silica, Butylene Glycol, Caprylyl Methicone, Sigesbeckia Orientalis Extract, Salvia Sclarea Extract, Coleus Forskohlii Root Extract, Chamomilla Recutita Flower Extract, PEG-10 Dimethicone, Hydrolyzed Collagen, Palmaria Palmata Extract, Glycyrrhiza Glabra Root Extract, Silybum Marianum Extract, Hordeum Vulgare Extract, Padina Pavonica Thallus Extract, Artemia Extract, Pantethine, Algae Extract, Chlorella Vulgaris Extract, Cholesterol, Squalane, Boswellia Serrata Extract, Zea Mays Kernel Extract, Glycine Soja Protein, Caffeine, Whey Protein, Linoleic Acid, Lecithin, Collagen, Acetyl Hexapeptide-8, Palmitoyl Oligopeptide, Glycerin, Faex Extract, Polyquaternium-51, Phytosphingosine, Triticum Vulgare Germ Oil, Decarboxy Carnosine Hcl, Polysorbate 40, Pentylene Glycol, Propanediol, Lauryl PEG-9 Polydimethylsiloxyethyl Dimethicone, Ethylhexylglycerin, Ammonium Acryloyldimethyltaurate/Vp Copolymer, Sodium PCA, Polymethylsilsesquioxane, Glyceryl Polymethacrylate, Zinc PCA, Propylene Glycol Dicaprate, Sodium Chondroitin Sulfate, Sodium Hyaluronate, Isohexadecane, PEG-8, Tocopheryl Acetate, Polysorbate 80, Disodium Distyrylbiphenyl Disulfonate, Laureth-12, Acrylamide/Sodium Acryloyldimethyltaurate Copolymer, Caprylyl Glycol, Aminopropyl Ascorbyl Phosphate, Xanthan Gum, Sodium Beta-Sitosteryl Sulfate, Sodium Chloride, Sodium Hydroxide, Parfum, Disodium EDTA, BHT, Phenoxyethanol, Mica, CI 77891
Niacinamide
Panthenol
Palmitoyl Pentapeptide-4
Tremella Fuciformis Sporocarp Extract
Hydroxyacetophenone
C13-14 Isoparaffin
Laureth-4
Polysorbate 20
Laureth-7
Polyacrylamide
Dimethicone Crosspolymer
Water, Dimethicone, Niacinamide, Glycerin, Panthenol, Palmitoyl Pentapeptide-4, Tremella Fuciformis Sporocarp Extract, Hydroxyacetophenone, C13-14 Isoparaffin, Laureth-4, Polysorbate 20, Laureth-7, Disodium EDTA, Polyacrylamide, Dimethicone Crosspolymer, Phenoxyethanol
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Alternatives
Ingredients Explained
These ingredients are found in both products.
Ingredients higher up in an ingredient list are typically present in a larger amount.
Dimethicone is a type of synthetic silicone created from natural materials such as quartz. It is also known as polydimethylsiloxane.
What it does:
Dimethicone comes in different viscosities:
Depending on the viscosity, dimethicone has different properties.
Ingredients lists don't always show which type is used, so we recommend reaching out to the brand if you have questions about the viscosity.
This ingredient is unlikely to cause irritation because it does not get absorbed into skin. However, people with silicone allergies should be careful about using this ingredient.
Note: Dimethicone may contribute to pilling. This is because it is not oil or water soluble, so pilling may occur when layered with products. When mixed with heavy oils in a formula, the outcome is also quite greasy.
Disodium EDTA is a chelating agent. It grabs onto and deactivates metal ions that sneak into your products from water, packaging, or air.
This ingredient mainly works behind the scenes and helps with:
On top of that, this ingredient can counteract the effects of hard water by binding to the minerals in it.
One thing worth knowing is that Disodium EDTA has been shown to be a mild penetration enhancer. It can help other ingredients absorb into skin more effectively which can be a double-edged sword (great for actives, but can also make the active too strong if you have sensitive skin).
Clinical patch testing showed no significant skin irritation at typical use concentrations and minimal dermal absorption.
You'll most likely see this ingredient near the end of an ingredient list. It's typically found in concentrations less than 1%.
Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.
Topically, glycerin does several things at once:
Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.
Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.
This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.
Just know very high concentrations (>40%) can feel tacky in low humidity.
Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.
Phenoxyethanol is one of the most widely used preservatives in skincare (and for good reason!).
It has a large spectrum of antimicrobial activity and especially effective bacteria, yeast, and mold while only having a weak effect on your skin's natural microbiome.
On a cellular level, it disrupts the cell membranes of microbes by poking holes that make the cell leak. This shuts down the chemical reactions the microbe needs to make energy so it can no longer survive.
Another perk of this ingredient is that it stays functional across a wide pH range (3-10).
You'll often see it paired with boosters like Ethylhexylglycerin; one study showed that a 1:9 ratio of Ethylhexylglycerin to Phenoxyethanol damages bacterial membranes as effectively as doubling the Phenoxyethanol concentration on its own.
Typical use concentrations range from 0.3-1% depending on the formula, and this ingredient is capped at 1% int the EU.
Safety-wise, the fear mongering does not hold up to the evidence. The EU's Scientific Committee on Consumer Safety and FDA consider it safe as a preservative at up to 1%, including for children of all ages.
Adverse systemic effects only showed up in animal studies at exposures roughly 200x higher than what people get from cosmetics. And despite its very widespread use, this ingredient is a rare sensitizer and allergic reactions are uncommon.
Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.
So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.
You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!