Glymed Plus Brilliant Tone Versus Allies of Skin Azelaic & Kojic Advanced Clarifying Serum

Glymed Plus Brilliant Tone Versus Allies of Skin Azelaic & Kojic Advanced Clarifying Serum

This brightening serum is formulated around Arbutin and Arctostaphylos Uva-Ursi Leaf Extract to fade the look of dark spots and brighten dull-looking skin.

This brightening serum is formulated around Azelaic Acid and Kojic Acid to fade the look of dark spots and clear breakouts.

What's inside

Key Ingredients

Benefits

Concerns

Ingredients Side-by-side

Aloe Barbadensis Leaf Juice

Arbutin

Arctostaphylos Uva-Ursi Leaf Extract

Butylene Glycol

Caprylic/Capric Triglyceride

Ethylhexylglycerin

Glycerin

Glycyrrhiza Glabra Root Extract

Hydroxyethylcellulose

Kojic Acid

Ascorbic Acid

Lactic Acid

Magnesium Ascorbyl Phosphate

Niacinamide

Pentylene Glycol

Phenoxyethanol

Polysorbate 20

Propanediol

Sodium Hydroxide

Water

Citrus Unshiu Peel Extract

Diacetyl Boldine

Rumex Occidentalis Extract

Aloe Barbadensis Leaf Juice, Arbutin, Arctostaphylos Uva-Ursi Leaf Extract, Butylene Glycol, Caprylic/Capric Triglyceride, Ethylhexylglycerin, Glycerin, Glycyrrhiza Glabra Root Extract, Hydroxyethylcellulose, Kojic Acid, Ascorbic Acid, Lactic Acid, Magnesium Ascorbyl Phosphate, Niacinamide, Pentylene Glycol, Phenoxyethanol, Polysorbate 20, Propanediol, Sodium Hydroxide, Water, Citrus Unshiu Peel Extract, Diacetyl Boldine, Rumex Occidentalis Extract

Azelaic Acid

Caprylyl Glycol

Hexylresorcinol

Ethyl Linoleate

Leuconostoc/Radish Root Ferment Filtrate

Dodecane

Xanthan Gum

Helianthus Annuus Seed Oil

Squalane

Bisabolol

Glyceryl Laurate

Glyceryl Undecylenate

Allantoin

Ribose

Sodium Acetate

Bakuchiol

Cellulose

Water, Azelaic Acid, Butylene Glycol, Aloe Barbadensis Leaf Juice, Propanediol, Caprylic/Capric Triglyceride, Kojic Acid, Polysorbate 20, Glycerin, Caprylyl Glycol, Hexylresorcinol, Ethyl Linoleate, Leuconostoc/Radish Root Ferment Filtrate, Dodecane, Hydroxyethylcellulose, Xanthan Gum, Helianthus Annuus Seed Oil, Squalane, Bisabolol, Glyceryl Laurate, Glyceryl Undecylenate, Allantoin, Ribose, Sodium Acetate, Bakuchiol, Glycyrrhiza Glabra Root Extract, Cellulose, Phenoxyethanol

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Alternatives

Ingredients Explained

These ingredients are found in both products.

Ingredients higher up in an ingredient list are typically present in a larger amount.

Aloe Barbadensis Leaf Juice is the filtered, stabilized liquid pressed from the inner gel of the aloe vera leaf.

In cosmetics, it shows up as either soothing active or a water-replacement base. It is roughly 98-99% water and the last 1-2% is an interesting mix of polysaccharides, amino acids, vitamins, minerals, and enzymes.

The polysaccharides do most of the work: they bind water at the skin surface for a light, non-greasy hydration boost. And one of the polysaccharides, glycomannan, is linked to fibroblast stimulation + collagen synthesis. This is also why aloe has such a long track record in wound and burn healing.

This ingredient is also calming with anti-inflammatory and mild antimicrobial activity, making it a great pick for sensitive, irritated, or post-sun skin.

Realistic expectations matter though; the solid evidence is mostly limited to hydration, soothing, and wound support. Deeper claims about anti-aging or sun protection are not well backed, and science reviews note it does not prevent radiation-induced skin injury.

Because it plays well with almost everything, it's commonly used as a base alongside other actives like niacinamide or vitamin C.

Typical usage concentrations range from 0.5% (where hydration benefits already show up) all the way to 90%+ (where it replaces water as the main base).

The safety for this ingredient is well-establish as well. Overall, this is a great supporting ingredient for those who want a boost in hydration.

Butylene Glycol (or BG) is used within cosmetic products for a few different reasons:

Overall, Butylene Glycol is a safe and well-rounded ingredient that works well with other ingredients.

Though this ingredient works well with most skin types, some people with sensitive skin may experience a reaction such as allergic rashes, closed comedones, or itchiness.

Caprylic/Capric Triglyceride (aka MCT Oil) is a lightweight emollient, solvent, and texture enhancer. It is considered a skin-softener by helping to prevent moisture loss.

Though it behaves like an oil, it is not technically one due to its chemical composition. One perk of this ingredient is that it is very stable, resistant to oxidation, and unlikely to go rancid.

In practice, that translates to a long shelf life and a consistently elegant skin feel.

While there is an assumption Caprylic Triglyceride can clog pores due to it being derived from coconut oil, there is no research supporting this. Just patch test if you have concerns.

Fractionated coconut oil and MCT Oil are both listed as Caprylic/Capric Triglyceride according to INCI. This is because INCI names are based on the ingredient’s final chemical composition and not its marketing name or source.

This ingredient is treated as the gold standard fungal acne safe oil. Even though it is coconut derived, the problematic lauric acid is stripped out.

This leaves just caprylic (C8) and capric (C10) acid. These chain lengths actually trend antifungal; a 2020 study found caprylic acid was enough to disrupt Malassezia furfur cell membrane, with a caprylic acid derivative damaging membrane structures at concentrations as low as 0.2%.

Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.

Topically, glycerin does several things at once:

Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.

Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.

This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.

Just know very high concentrations (>40%) can feel tacky in low humidity.

Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.

Glycyrrhiza Glabra Root Extract is an extract of the roots of Licorice. It has been found to have several benefits such as skin hydrating, conditioning, and soothing.

One component, glabridin, has extra potent antioxidant and soothing properties. It has also been found to block pigmentation from UVB rays in guinea pigs.

Licorice Root also contains a flavonoid. Flavonoids are a natural substance from in plants. Flavonoids also have antioxidant properties.

Another component, glycyrrhizin, has been found to have anti-inflammatory and antimicrobial benefits. This may make licorice root extract effective at treating acne. However, more research is needed to support this.

Liquiritin is one of the flavone compounds found in licorice. It has been found to help lighten skin by preventing tyrosinase from reacting with tyrosine. When the two react, protein is converted to melanin. Melanin is the substance in your body that gives your features pigmentation.

Hydroxyethylcellulose is used to improve the texture of products. It is created from a chemical reaction involving ethylene oxide and alkali-cellulose. Cellulose is a sugar found in plant cell walls and help give plants structure.

This ingredient helps stabilize products by preventing ingredients from separating. It can also help thicken the texture of a product.

This ingredient can also be found in pill medicines to help our bodies digest other ingredients.

Kojic Acid is a naturally occurring organic acid that is produced during the fermentation of certain fungi. It is one of the most well-studied brightening ingredients (tyrosinase inhibitors) out there.

That's why you'll see Kojic Acid in products that target dark spots, hyperpigmentation, and general uneven skin tone. It also pairs well with other brightening actives like Alpha Arbutin, Glycolic Acid, and Vitamin C derivatives.

By latching onto the copper that the enzyme tyrosinase needs to function, Kojic Acid prevents less pigment from being made. It's so well-established that researchers regularly use it as the go-to benchmark when testing new brightening ingredients.

Some other perks include documented antioxidant and antimicrobial properties. The The CIR (Cosmetic Ingredient Review) Expert Panel concluded Kojic Acid is safe for use in cosmetic products at concentrations up to 1% and the EU's SCCS (Scientific Committee on Consumer Safety) considers it safe as a skin lightening agent at concentrations up to 0.7%.

One thing to know about Kojic Acid is that stability is its weak spot; it is sensitive to light, heat, and air exposure and will oxidize/turn brown in formulations. Its derivative, Kojic Dipalmitate, was developed as a stable alternative.

Some individuals have reported contact sensitization so be sure to patch test if you have reactive or sensitive skin.

Fun fact: It was first discovered in 1907 and naturally occurs in the production of sake, soy sauce, and miso.

Phenoxyethanol is one of the most widely used preservatives in skincare (and for good reason!).

It has a large spectrum of antimicrobial activity and especially effective bacteria, yeast, and mold while only having a weak effect on your skin's natural microbiome.

On a cellular level, it disrupts the cell membranes of microbes by poking holes that make the cell leak. This shuts down the chemical reactions the microbe needs to make energy so it can no longer survive.

Another perk of this ingredient is that it stays functional across a wide pH range (3-10).

You'll often see it paired with boosters like Ethylhexylglycerin; one study showed that a 1:9 ratio of Ethylhexylglycerin to Phenoxyethanol damages bacterial membranes as effectively as doubling the Phenoxyethanol concentration on its own.

Typical use concentrations range from 0.3-1% depending on the formula, and this ingredient is capped at 1% int the EU.

Safety-wise, the fear mongering does not hold up to the evidence. The EU's Scientific Committee on Consumer Safety and FDA consider it safe as a preservative at up to 1%, including for children of all ages.

Adverse systemic effects only showed up in animal studies at exposures roughly 200x higher than what people get from cosmetics. And despite its very widespread use, this ingredient is a rare sensitizer and allergic reactions are uncommon.

Polysorbate 20 is a gentle, water-soluble emulsifier and mild surfactant. It stops oil and water from separating to keep your formulas blended and stable.

It also acts as a mild penetration enhancer by helping active ingredients absorb slightly better.

The common safety discussion around this ingredient involves a manufacturing byproduct called 1,4-dioxane.

Trace amounts can form during production but the EU's Scientific Committee on Consumer Safety has concluded that levels at/below 10 ppm in finished products are safe (commercial products consistently fall within acceptable margins).

True allergic reactions are uncommon and the CIR Expert Panel has confirmed this ingredient to be safe as used in cosmetics.

Because it is derived from lauric acid, it may not be fungal acne safe.

Propanediol is an all-star ingredient. It softens, hydrates, and smooths the skin.

It’s often used to:

Propanediol is not likely to cause sensitivity and considered safe to use. It is derived from corn or petroleum with a clear color and no scent.

Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.

So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.

You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!

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