Glymed Plus Comfort Cream With Aloe Vera Versus Paula's Choice Moisture Boost Hydrating Treatment Cream

Glymed Plus Comfort Cream With Aloe Vera Versus Paula's Choice Moisture Boost Hydrating Treatment Cream

This calming moisturizer is formulated around Allantoin and Aloe Barbadensis Leaf Juice to calm redness and hydrate skin.

This barrier-repair moisturizer is formulated around Simmondsia Chinensis Seed Oil and Sodium Hyaluronate to strengthen the skin barrier and hydrate skin.

What's inside

Key Ingredients

Benefits

Concerns

Ingredients Side-by-side

Allantoin

Aloe Barbadensis Leaf Juice

Anthemis Nobilis Flower Extract

Arbutin

Calendula Officinalis Flower Extract

Carbomer

Cetyl Alcohol

Epigallocatechin Gallatyl Glucoside

Ethylhexylglycerin

Gallyl Glucoside

Glycerin

Glyceryl Stearate

Glycyrrhiza Glabra Root Extract

Hyaluronic Acid

PEG-100 Stearate

Petrolatum

Phenoxyethanol

Propyl Gallate

Sodium Hydroxide

Squalane

Tetrahydrodiferuloylmethane

Water

Allantoin, Aloe Barbadensis Leaf Juice, Anthemis Nobilis Flower Extract, Arbutin, Calendula Officinalis Flower Extract, Carbomer, Cetyl Alcohol, Epigallocatechin Gallatyl Glucoside, Ethylhexylglycerin, Gallyl Glucoside, Glycerin, Glyceryl Stearate, Glycyrrhiza Glabra Root Extract, Hyaluronic Acid, PEG-100 Stearate, Petrolatum, Phenoxyethanol, Propyl Gallate, Sodium Hydroxide, Squalane, Tetrahydrodiferuloylmethane, Water

Ethylhexyl Stearate

Simmondsia Chinensis Seed Oil

Butylene Glycol

Cetearyl Alcohol

Dipentaerythrityl Hexacaprylate/Hexacaprate

Tridecyl Trimellitate

Sodium Hyaluronate

Ceramide NP

Cholesterol

Tocopherol

Magnesium Ascorbyl Phosphate

Dimethicone

Niacinamide

Polysorbate 60

Hydrolyzed Jojoba Protein

Hydrolyzed Wheat Protein

Avena Sativa Kernel Extract

Hydrogenated Lecithin

Whey Protein

Tridecyl Stearate

Neopentyl Glycol Dicaprylate/Dicaprate

Phenyl Trimethicone

Myristyl Myristate

Linoleic Acid

Linolenic Acid

Decarboxy Carnosine Hcl

Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer

Acrylates/C10-30 Alkyl Acrylate Crosspolymer

Cetearyl Glucoside

Polyglyceryl-3 Beeswax

Aminomethyl Propanol

Disodium EDTA

Benzoic Acid

Chlorphenesin

Sorbic Acid

Water, Ethylhexyl Stearate, Simmondsia Chinensis Seed Oil, Butylene Glycol, Glycerin, Petrolatum, Cetearyl Alcohol, Dipentaerythrityl Hexacaprylate/Hexacaprate, Tridecyl Trimellitate, Sodium Hyaluronate, Ceramide NP, Cholesterol, Tocopherol, Squalane, Magnesium Ascorbyl Phosphate, Dimethicone, Niacinamide, Polysorbate 60, Hydrolyzed Jojoba Protein, Hydrolyzed Wheat Protein, Avena Sativa Kernel Extract, Hydrogenated Lecithin, Whey Protein, Tridecyl Stearate, Neopentyl Glycol Dicaprylate/Dicaprate, Phenyl Trimethicone, Myristyl Myristate, Linoleic Acid, Linolenic Acid, Decarboxy Carnosine Hcl, Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Cetearyl Glucoside, Cetyl Alcohol, Polyglyceryl-3 Beeswax, Aminomethyl Propanol, Disodium EDTA, Benzoic Acid, Chlorphenesin, Sorbic Acid, Phenoxyethanol

Reviews

Alternatives

Ingredients Explained

These ingredients are found in both products.

Ingredients higher up in an ingredient list are typically present in a larger amount.

Cetyl Alcohol is a fatty alcohol. Fatty Alcohols are most often used as an emollient or to thicken a product.

Its main roles are:

Though it has "alcohol" in the name, it is not related to denatured alcohol or ethyl alcohol.

The FDA allows products labeled "alcohol-free" to have fatty alcohols.

This ingredient may not be fungal acne safe. It is a primary fatty alcohol with a chain length above 12 carbons. A study from 2019 show Malassezia can feed on fatty alcohols in this range, so it may trigger fungal acne in those prone to it.

Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.

Topically, glycerin does several things at once:

Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.

Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.

This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.

Just know very high concentrations (>40%) can feel tacky in low humidity.

Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.

Petrolatum is more commonly known as petroleum jelly. It is created by mixing waxes and mineral oils.

This ingredient is effective at reducing water loss by 99%. This is because it is an occlusive. Occlusives create a hydrophobic barrier on the skin to prevent evaporation. This property makes it great for hydrating dry skin.

Pro tip: Use occlusives, such as this ingredient, on damp skin for the best results.

The quality or origin of petrolatum is only known when disclosed by the brand. Most cosmetic petrolatum has gone through several purification stages.

Another benefit of occlusives is it protects your skin against infection or allergies.

Petrolatum is fungal acne safe. It is a hydrocarbon with no fatty acid structure, so Malassezia cannot metabolize it. In-vitro studies support negligible growth stimulation as well.

It's also worth noting that petrolatum has a comedogenic rating of 0. In updated rabbit ear testing (and in human testing), petrolatum was found to be not comedogenic. This means it didn’t promote comedone formation in standard models.

Phenoxyethanol is one of the most widely used preservatives in skincare (and for good reason!).

It has a large spectrum of antimicrobial activity and especially effective bacteria, yeast, and mold while only having a weak effect on your skin's natural microbiome.

On a cellular level, it disrupts the cell membranes of microbes by poking holes that make the cell leak. This shuts down the chemical reactions the microbe needs to make energy so it can no longer survive.

Another perk of this ingredient is that it stays functional across a wide pH range (3-10).

You'll often see it paired with boosters like Ethylhexylglycerin; one study showed that a 1:9 ratio of Ethylhexylglycerin to Phenoxyethanol damages bacterial membranes as effectively as doubling the Phenoxyethanol concentration on its own.

Typical use concentrations range from 0.3-1% depending on the formula, and this ingredient is capped at 1% int the EU.

Safety-wise, the fear mongering does not hold up to the evidence. The EU's Scientific Committee on Consumer Safety and FDA consider it safe as a preservative at up to 1%, including for children of all ages.

Adverse systemic effects only showed up in animal studies at exposures roughly 200x higher than what people get from cosmetics. And despite its very widespread use, this ingredient is a rare sensitizer and allergic reactions are uncommon.

Squalane is the hydrogenated and shelf-stable form of squalene (a lipid that naturally occurs in human sebum).

It is an emollient and skin conditioning agent that is able to integrate seamlessly into the skin's lipid barrier without clogging pores.

This is due to how structurally similar it is to what your skin already produces.

Though it is mostly an emollient that helps soften and hydrate skin, it also has some humectant and occlusive action. Humectants help the skin retain moisture while occlusives seal it in, making squalane a triple-threat moisturizer.

Research shows it has antioxidant capabilities that help protect against stressors like UV exposure, specifically UVA induced oxidative stress. This study also found that it supports collagen biosynthesis in human dermal fibroblasts.

No clinical study has reported significant adverse effects and irritation reactions are very rare from this ingredient (even at 100% concentration).

Overall, it's a fantastic ingredient for hydration and is suitable for all skin types.

This depends on the source. Squalane can be derived from both plants and animals. Most squalane used in skincare comes from plants.

Please note: the source of squalane is only known if disclosed by the brand. We recommend reaching out to the brand if you have any questions about their squalane.

Read more about squalene with an "e".

Though squalane is often called an oil, it’s technically not one. It is a hydrocarbon, meaning it is only made of carbon and hydrogen. True oils are triglycerides and made of fatty acids and glycerol.

The term “oil-free” isn’t regulated so companies can define it however they want. Some exclude all oils, while others just avoid mineral oil or comedogenic oils.

Squalane has a comedogenic rating of 1 from the original 1972 study that tested raw ingredients under occlusion on rabbit ears. This system is not standardized or peer-reviewed, and using the raw ingredients is very different from how diluted cosmetic formulations are used on human skin.

A comedogenic rating of 1 means it is "unlikely to clog pores" according to the original rating system.

The overall formula of a product matters more than the individual ingredients on whether or not it will cause clogged pores.

Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.

So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.

You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!

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