Peptide Skincare & BeautySkin science and ingredient guides

Skin science article

ISANA Peptide Serum Versus ISANA Calming Barrier Serum

ISANA Peptide Serum Versus ISANA Calming Barrier Serum This anti-aging serum is formulated around Hydrolyzed Hyaluronic Acid and Acetyl Hexapeptide-8 to soften the look of wrinkles and hydrate skin. This barrier-repair serum is formulated around Niacinamide an

ISANA Peptide Serum Versus ISANA Calming Barrier Serum

This anti-aging serum is formulated around Hydrolyzed Hyaluronic Acid and Acetyl Hexapeptide-8 to soften the look of wrinkles and hydrate skin.

This barrier-repair serum is formulated around Niacinamide and Panthenol to strengthen the skin barrier and calm redness.

What's inside

Key Ingredients

Benefits

Concerns

Ingredients Side-by-side

Water

Methylpropanediol

Glycerin

Propylene Glycol

Hydrogenated Starch Hydrolysate

Hydrolyzed Hyaluronic Acid

Acetyl Hexapeptide-8

Ethylhexylglycerin

Xanthan Gum

Aspartic Acid

Soluble Collagen

Sodium Salicylate

Caprylyl Glycol

Sodium Benzoate

Citric Acid

Sodium Hydroxide

Tetrasodium Iminodisuccinate

Fumaric Acid

Sodium Citrate

Maleic Acid

Malic Acid

Water, Methylpropanediol, Glycerin, Propylene Glycol, Hydrogenated Starch Hydrolysate, Hydrolyzed Hyaluronic Acid, Acetyl Hexapeptide-8, Ethylhexylglycerin, Xanthan Gum, Aspartic Acid, Soluble Collagen, Sodium Salicylate, Caprylyl Glycol, Sodium Benzoate, Citric Acid, Sodium Hydroxide, Tetrasodium Iminodisuccinate, Fumaric Acid, Sodium Citrate, Maleic Acid, Malic Acid

Octyldodecanol

Niacinamide

Distarch Phosphate

Dicaprylyl Carbonate

Pectin

Phenoxyethanol

Panthenol

Hydroxyacetophenone

Dicaprylyl Ether

Lauryl Alcohol

Allantoin

Pentylene Glycol

Chondrus Crispus Powder

Madecassoside

Phospholipids

Cyanocobalamin

Sphingolipids

P-Anisic Acid

Tocopherol

Water, Glycerin, Octyldodecanol, Niacinamide, Distarch Phosphate, Dicaprylyl Carbonate, Xanthan Gum, Pectin, Phenoxyethanol, Panthenol, Hydroxyacetophenone, Dicaprylyl Ether, Lauryl Alcohol, Allantoin, Pentylene Glycol, Chondrus Crispus Powder, Madecassoside, Phospholipids, Cyanocobalamin, Sphingolipids, Sodium Citrate, P-Anisic Acid, Sodium Hydroxide, Tocopherol

Reviews

Alternatives

Ingredients Explained

These ingredients are found in both products.

Ingredients higher up in an ingredient list are typically present in a larger amount.

Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.

Topically, glycerin does several things at once:

Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.

Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.

This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.

Just know very high concentrations (>40%) can feel tacky in low humidity.

Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.

Sodium Citrate is the sodium salts of citric acid. In skincare, it is used to alter pH levels and acts as a preservative.

Its main functions are to maintain the pH of a product and neutralize metal ions.

The acidity of our skin is maintained by our glands and skin biome; normal pH level of skin is slightly acidic (~4.75-5.5).

Being slightly acidic allows our skin to create an "acid mantle". This acid mantle is a thin barrier that protects our skin from bacteria and contaminants.

Sodium Hydroxide is also known as lye or caustic soda. It is used to adjust the pH of products; many ingredients require a specific pH to be effective.

In small amounts, sodium hydroxide is considered safe to use. However, large amounts may cause chemical burns due to its high alkaline.

Your skin has a natural pH and acid mantle. This acid mantle helps prevent harmful bacteria from breaking through. The acid mantle also helps keep your skin hydrated.

"Alkaline" refers to a high pH level. A low pH level would be considered acidic.

Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.

So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.

You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!

Xanthan gum is used as a stabilizer and thickener within cosmetic products. It helps give products a sticky, thick feeling - preventing them from being too runny.

On the technical side of things, xanthan gum is a polysaccharide - a combination consisting of multiple sugar molecules bonded together.

Xanthan gum is a pretty common and great ingredient. It is a natural, non-toxic, non-irritating ingredient that is also commonly used in food products.

Similar Comparisons

The reference edit

Ingredients, questions
& further reading.

Connected source records selected through this article’s public topic index.

01

Formula cabinet

Ingredients & structured notes

02

Product index

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Comparison edit

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